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The map label for this gene is phoR [H]

Identifier: 169824517

GI number: 169824517

Start: 890466

End: 891815

Strand: Direct

Name: phoR [H]

Synonym: FMG_0820

Alternate gene names: 169824517

Gene position: 890466-891815 (Clockwise)

Preceding gene: 169824516

Following gene: 169824557

Centisome position: 49.54

GC content: 25.7

Gene sequence:

>1350_bases
ATGAAGCTTAAATCTGAAATTTTGTATGAATTTTTAAGAGCTATTCTATTTCCTATTTTATTATTATCATTTATTGCTGT
TTTTGTTTTTCAATTTTCATTTAAAAATTTTGTTGATAATGAAGAGTTAAATAGACGAAATAAGATAGAACAATTAACAA
AAAATTTATTTATAGATCACCAACAAGGGTTAAGTAAAAAAAGAATAGATCAATATATGTGGTATCTAAGCGAACTAGAC
TTAGATGTAATTTTCTATGATAATAACGAAAAAGAACTATACAGTTTTTCTGAGGGCTTTGAATTAGCTAAGAAAACATC
TCTTTATAATACTATTGTAAAAGATGTTTATGATAAGAACAATAAAAAAATAGGTCAAATAAAATATATCTATAGAGTTA
ATAATAATTTCAAAAAAAGAAGCGAAGTTTTTATAACTAATCTTTTTAGATTTATAATTTTATCCTTGTTTCTATCTTAC
TTTACAGGATTAATAATTTCTATATATCTTTCACGTAAAATAACCAACCCAATAGAAGAACTCACACAAGCAACTGTTAA
TATCAGAAAACAGATTTACGCTGTGCCTGATATAAAAAGTAGAATTGTTGAAGTAAATCAACTATCTCAAAACATAAACT
ATATGGCAAATTCATTAAAATCACAAGAGTTTAATAGAAAACAGTATGCTCAAAACATCAGCCATGAATTAAGAACACCT
CTTACCAATATAAGAGTTAACTTAGAGTTAATGCAAGATGGTATTATGGAAACGAATGAAGAAAATGTAAATATGCTTCT
TGTGGAAATTGACCGACTTACAAGTTTAATTAATCAATTAAATAATACATTTAAAAAATCTACACCTGAGACAATTTATA
ATCCTTCTAAATTCAATTTATCAGATTTTCTAAATGAAATATACAAATCAATGAAGACTCAATATGATAATTCAGGAGTT
TTGTTCGATTTAGAAATCTCAGAGAATTTGGACATTATTACTGACAGAGAAAAATTAGCAAATATTATTATTAACTTGTT
GTCTAACGCATTAAAAGCATGTAAAAAAGGAGACTCAGTTTTATTAAGAGCAAGACACATTAACAAAAAAATTGTGATAT
CTGTAAAAGATACTGGTATTGGAATTAGCGAAGAAAATAAGCCTAAAATTTTCGAAAGATTTTTCAGAGTTGATGACTGC
AGAAATACCAAAACAAATGGTTATGGACTCGGTTTATCTATTGTAAAAAATTATACTGACATAATCGGAGCAAACATTTC
AGTAAACTCAAAATTAAACTTAGGAACTGTAATGTTGGTTTCCTTTGATGATAGTATAATTACGAAATAA

Upstream 100 bases:

>100_bases
ACTCATATAAAAAACATTAGGCATAAAATTGAAGATAATCCTAAAAAACCTCGATATATAAAAACTATATATGGTGTAGG
CTACAAATTGGGTGTTTACG

Downstream 100 bases:

>100_bases
AAAAAAGATTGGTAACAGCAATGCTACCAATCTTTTTTTATGACCAAATCTATAAGCCGTGTTCTGTATTTGATAATCAT
CTATCTAGACTAATTGTTAC

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MKLKSEILYEFLRAILFPILLLSFIAVFVFQFSFKNFVDNEELNRRNKIEQLTKNLFIDHQQGLSKKRIDQYMWYLSELD
LDVIFYDNNEKELYSFSEGFELAKKTSLYNTIVKDVYDKNNKKIGQIKYIYRVNNNFKKRSEVFITNLFRFIILSLFLSY
FTGLIISIYLSRKITNPIEELTQATVNIRKQIYAVPDIKSRIVEVNQLSQNINYMANSLKSQEFNRKQYAQNISHELRTP
LTNIRVNLELMQDGIMETNEENVNMLLVEIDRLTSLINQLNNTFKKSTPETIYNPSKFNLSDFLNEIYKSMKTQYDNSGV
LFDLEISENLDIITDREKLANIIINLLSNALKACKKGDSVLLRARHINKKIVISVKDTGIGISEENKPKIFERFFRVDDC
RNTKTNGYGLGLSIVKNYTDIIGANISVNSKLNLGTVMLVSFDDSIITK

Sequences:

>Translated_449_residues
MKLKSEILYEFLRAILFPILLLSFIAVFVFQFSFKNFVDNEELNRRNKIEQLTKNLFIDHQQGLSKKRIDQYMWYLSELD
LDVIFYDNNEKELYSFSEGFELAKKTSLYNTIVKDVYDKNNKKIGQIKYIYRVNNNFKKRSEVFITNLFRFIILSLFLSY
FTGLIISIYLSRKITNPIEELTQATVNIRKQIYAVPDIKSRIVEVNQLSQNINYMANSLKSQEFNRKQYAQNISHELRTP
LTNIRVNLELMQDGIMETNEENVNMLLVEIDRLTSLINQLNNTFKKSTPETIYNPSKFNLSDFLNEIYKSMKTQYDNSGV
LFDLEISENLDIITDREKLANIIINLLSNALKACKKGDSVLLRARHINKKIVISVKDTGIGISEENKPKIFERFFRVDDC
RNTKTNGYGLGLSIVKNYTDIIGANISVNSKLNLGTVMLVSFDDSIITK
>Mature_449_residues
MKLKSEILYEFLRAILFPILLLSFIAVFVFQFSFKNFVDNEELNRRNKIEQLTKNLFIDHQQGLSKKRIDQYMWYLSELD
LDVIFYDNNEKELYSFSEGFELAKKTSLYNTIVKDVYDKNNKKIGQIKYIYRVNNNFKKRSEVFITNLFRFIILSLFLSY
FTGLIISIYLSRKITNPIEELTQATVNIRKQIYAVPDIKSRIVEVNQLSQNINYMANSLKSQEFNRKQYAQNISHELRTP
LTNIRVNLELMQDGIMETNEENVNMLLVEIDRLTSLINQLNNTFKKSTPETIYNPSKFNLSDFLNEIYKSMKTQYDNSGV
LFDLEISENLDIITDREKLANIIINLLSNALKACKKGDSVLLRARHINKKIVISVKDTGIGISEENKPKIFERFFRVDDC
RNTKTNGYGLGLSIVKNYTDIIGANISVNSKLNLGTVMLVSFDDSIITK

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=251, Percent_Identity=28.2868525896414, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1786600, Length=230, Percent_Identity=29.5652173913043, Blast_Score=108, Evalue=7e-25,
Organism=Escherichia coli, GI1786783, Length=261, Percent_Identity=24.5210727969349, Blast_Score=102, Evalue=7e-23,
Organism=Escherichia coli, GI1787894, Length=310, Percent_Identity=26.1290322580645, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1789149, Length=354, Percent_Identity=24.2937853107345, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1790551, Length=275, Percent_Identity=26.9090909090909, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI145693157, Length=251, Percent_Identity=27.4900398406374, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI1789808, Length=297, Percent_Identity=25.5892255892256, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI48994928, Length=226, Percent_Identity=27.8761061946903, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI1790346, Length=253, Percent_Identity=26.8774703557312, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI87082128, Length=281, Percent_Identity=24.5551601423488, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI87081816, Length=259, Percent_Identity=24.3243243243243, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1787374, Length=241, Percent_Identity=22.8215767634855, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1788549, Length=208, Percent_Identity=27.8846153846154, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1790436, Length=210, Percent_Identity=24.2857142857143, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1788713, Length=224, Percent_Identity=23.2142857142857, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1790861, Length=218, Percent_Identity=22.4770642201835, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52313; Mature: 52313

Theoretical pI: Translated: 9.46; Mature: 9.46

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLKSEILYEFLRAILFPILLLSFIAVFVFQFSFKNFVDNEELNRRNKIEQLTKNLFIDH
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCH
QQGLSKKRIDQYMWYLSELDLDVIFYDNNEKELYSFSEGFELAKKTSLYNTIVKDVYDKN
HHCCCHHHHHHHHHHHHHCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NKKIGQIKYIYRVNNNFKKRSEVFITNLFRFIILSLFLSYFTGLIISIYLSRKITNPIEE
CCCEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
LTQATVNIRKQIYAVPDIKSRIVEVNQLSQNINYMANSLKSQEFNRKQYAQNISHELRTP
HHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LTNIRVNLELMQDGIMETNEENVNMLLVEIDRLTSLINQLNNTFKKSTPETIYNPSKFNL
HHHHEEEHHHHHCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCH
SDFLNEIYKSMKTQYDNSGVLFDLEISENLDIITDREKLANIIINLLSNALKACKKGDSV
HHHHHHHHHHHHHCCCCCCEEEEEEECCCCCEEECHHHHHHHHHHHHHHHHHHHHCCCCE
LLRARHINKKIVISVKDTGIGISEENKPKIFERFFRVDDCRNTKTNGYGLGLSIVKNYTD
EEEHEECCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
IIGANISVNSKLNLGTVMLVSFDDSIITK
HHCCCEEECCCCCCCEEEEEEECHHHCCC
>Mature Secondary Structure
MKLKSEILYEFLRAILFPILLLSFIAVFVFQFSFKNFVDNEELNRRNKIEQLTKNLFIDH
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCH
QQGLSKKRIDQYMWYLSELDLDVIFYDNNEKELYSFSEGFELAKKTSLYNTIVKDVYDKN
HHCCCHHHHHHHHHHHHHCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NKKIGQIKYIYRVNNNFKKRSEVFITNLFRFIILSLFLSYFTGLIISIYLSRKITNPIEE
CCCEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
LTQATVNIRKQIYAVPDIKSRIVEVNQLSQNINYMANSLKSQEFNRKQYAQNISHELRTP
HHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LTNIRVNLELMQDGIMETNEENVNMLLVEIDRLTSLINQLNNTFKKSTPETIYNPSKFNL
HHHHEEEHHHHHCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCH
SDFLNEIYKSMKTQYDNSGVLFDLEISENLDIITDREKLANIIINLLSNALKACKKGDSV
HHHHHHHHHHHHHCCCCCCEEEEEEECCCCCEEECHHHHHHHHHHHHHHHHHHHHCCCCE
LLRARHINKKIVISVKDTGIGISEENKPKIFERFFRVDDCRNTKTNGYGLGLSIVKNYTD
EEEHEECCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
IIGANISVNSKLNLGTVMLVSFDDSIITK
HHCCCEEECCCCCCCEEEEEEECHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]