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The map label for this gene is pyrE

Identifier: 169824423

GI number: 169824423

Start: 787592

End: 788164

Strand: Direct

Name: pyrE

Synonym: FMG_0726

Alternate gene names: 169824423

Gene position: 787592-788164 (Clockwise)

Preceding gene: 169824422

Following gene: 169824424

Centisome position: 43.81

GC content: 31.24

Gene sequence:

>573_bases
ATGGATAGAGTTGTTGAATTATTAAAAGAAAGTAATGCATTATTAGAAGGTCATTTCTTATTATCATCTGGAAATCACAG
TGATAAATACTGCCAATGTGCAAAGTTATTACAATATCCAGACAAAGCTGAGGAAGTAATAAAAGTTATTGCTGATAAGC
TTAAAGATGTTGAATTTGATACTGTTGTCGGACCTGCTATGGGTGGAATAATTGTAGCTTATGAGTTAGGTAGACAACTA
CATAAACCAGCTATATTTACTGAAAGAAAAGATGGAGAAATGTGTTTAAGAAGAGGTTTTGAAGTAAGAAAAGGCGAGAA
AGTTATTATTTCAGAAGATGTTGTAACAACTGCAAAATCTTCATATGAAACTAAAAAAGTTTTGGAAGATTTGGGAGCGG
AAGTAGTAGGAATTTGTTGCCTAGTAGATAGAAGTGTAAATCTGGATATTGATTTACCATTGTATAGTGCAACAAAAATA
GACATAGAAATTTTTAAACCTGAAGAATGTCCATTATGTAAGAAAGGAATAGATTTGGTTAAACCAGGTTCGAGAGAAAT
TAAAACTAAATAG

Upstream 100 bases:

>100_bases
AATGTTATGGTTGAGATAGCAAATGGTATGGAAAACTATTTAAAAGAAAATGGTTTTAAATCTATAGAAGAAATAAGGAA
TATTATTTAGGGGGAAAATT

Downstream 100 bases:

>100_bases
TTATTATAAAAATAAGCCTAATTTGAGGATTTCTTCTAGAAAAACACAAAAATGAAGGCTTATTTTTTGTGTTGAAAAAT
ATTAAAATATGATACAATAA

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase [H]

Number of amino acids: Translated: 190; Mature: 190

Protein sequence:

>190_residues
MDRVVELLKESNALLEGHFLLSSGNHSDKYCQCAKLLQYPDKAEEVIKVIADKLKDVEFDTVVGPAMGGIIVAYELGRQL
HKPAIFTERKDGEMCLRRGFEVRKGEKVIISEDVVTTAKSSYETKKVLEDLGAEVVGICCLVDRSVNLDIDLPLYSATKI
DIEIFKPEECPLCKKGIDLVKPGSREIKTK

Sequences:

>Translated_190_residues
MDRVVELLKESNALLEGHFLLSSGNHSDKYCQCAKLLQYPDKAEEVIKVIADKLKDVEFDTVVGPAMGGIIVAYELGRQL
HKPAIFTERKDGEMCLRRGFEVRKGEKVIISEDVVTTAKSSYETKKVLEDLGAEVVGICCLVDRSVNLDIDLPLYSATKI
DIEIFKPEECPLCKKGIDLVKPGSREIKTK
>Mature_190_residues
MDRVVELLKESNALLEGHFLLSSGNHSDKYCQCAKLLQYPDKAEEVIKVIADKLKDVEFDTVVGPAMGGIIVAYELGRQL
HKPAIFTERKDGEMCLRRGFEVRKGEKVIISEDVVTTAKSSYETKKVLEDLGAEVVGICCLVDRSVNLDIDLPLYSATKI
DIEIFKPEECPLCKKGIDLVKPGSREIKTK

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) [H]

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023031
- InterPro:   IPR006273
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.10 [H]

Molecular weight: Translated: 21172; Mature: 21172

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
3.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRVVELLKESNALLEGHFLLSSGNHSDKYCQCAKLLQYPDKAEEVIKVIADKLKDVEFD
CHHHHHHHHHCCCEEEEEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCH
TVVGPAMGGIIVAYELGRQLHKPAIFTERKDGEMCLRRGFEVRKGEKVIISEDVVTTAKS
HHHCHHHCHHHHHHHHHHHHCCCCCEECCCCHHHHHHCCCCCCCCCEEEEECCHHHHHHH
SYETKKVLEDLGAEVVGICCLVDRSVNLDIDLPLYSATKIDIEIFKPEECPLCKKGIDLV
HHHHHHHHHHHCHHHHHHHHEECCCCCEEECCCCCCCEEEEEEEECCCCCCCCCCCCCCC
KPGSREIKTK
CCCCCCCCCC
>Mature Secondary Structure
MDRVVELLKESNALLEGHFLLSSGNHSDKYCQCAKLLQYPDKAEEVIKVIADKLKDVEFD
CHHHHHHHHHCCCEEEEEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCH
TVVGPAMGGIIVAYELGRQLHKPAIFTERKDGEMCLRRGFEVRKGEKVIISEDVVTTAKS
HHHCHHHCHHHHHHHHHHHHCCCCCEECCCCHHHHHHCCCCCCCCCEEEEECCHHHHHHH
SYETKKVLEDLGAEVVGICCLVDRSVNLDIDLPLYSATKIDIEIFKPEECPLCKKGIDLV
HHHHHHHHHHHCHHHHHHHHEECCCCCEEECCCCCCCEEEEEEEECCCCCCCCCCCCCCC
KPGSREIKTK
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA