Click here to switch to the map view.

The map label for this gene is uppS [H]

Identifier: 169824424

GI number: 169824424

Start: 788292

End: 788996

Strand: Direct

Name: uppS [H]

Synonym: FMG_0727

Alternate gene names: 169824424

Gene position: 788292-788996 (Clockwise)

Preceding gene: 169824423

Following gene: 169824425

Centisome position: 43.85

GC content: 29.5

Gene sequence:

>705_bases
ATGGATTTATCAAATTTAGATCAAGATAGATTGCCTAAGCATATTGCCATAATAATGGATGGAAATGGTAGATGGGCTAC
GAATAGAAATAAACCAAGAGTATTTGGACACAATGAAGGTATGAAAAGAGTTGTTGATGTTGTCGAAAACTCATTAAATA
TTGGGATAAAATATTTGTCCTTGTACGCTTTTTCAACAGAAAATTGGAAAAGGCCACAAAAAGAAATAGATTTTTTGATG
CAAATTCTAATAAAGTATATAGATGACCAACTAAATAAATTAGTAACTCAGGGAGTTAAAATTAATATCTTGGGTGATAT
TAGTGTACTTCCAAAAAAAGTAATTCAAAAGATAGAATATGCATTAGATTCAACAAAAGATAATAATAAATTAATTCTCA
ACATTGCGATTAATTATGGATCGAGACAAGAGATTTTACTAGCTGTAAATAATGCAATTGAAAATGGTCAAATCTTGACT
GAGAATGAGTTCTCAAATCTATTATATACTAGAAATCAACCTGACGTTGATTTACTAATAAGACCAGGTGGTGAAAAAAG
GCTAAGCAATTTCTTGCTTTACCAAATGTCTTATGCAGAACTTTATTTTTCTGACACTTATTGGCCTGATTTCAAATTGG
ACTCATTAGTAGATGCAATTTATTGGTATCAAAATAGGAATAGAAGATTTGGTGGATTAAAATGA

Upstream 100 bases:

>100_bases
GATTTCTTCTAGAAAAACACAAAAATGAAGGCTTATTTTTTGTGTTGAAAAATATTAAAATATGATACAATAAATAAGAA
TAAACTAAAAGGAATTTAAA

Downstream 100 bases:

>100_bases
AATTTGTAAAAAGAACTCTTACAGGAATAGTTATATTATTGCTGTCTATTCTTTGCATTTCTAAGGGTGGTGTTTATCTA
TTAATTATGAACTTATTCCT

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 234; Mature: 234

Protein sequence:

>234_residues
MDLSNLDQDRLPKHIAIIMDGNGRWATNRNKPRVFGHNEGMKRVVDVVENSLNIGIKYLSLYAFSTENWKRPQKEIDFLM
QILIKYIDDQLNKLVTQGVKINILGDISVLPKKVIQKIEYALDSTKDNNKLILNIAINYGSRQEILLAVNNAIENGQILT
ENEFSNLLYTRNQPDVDLLIRPGGEKRLSNFLLYQMSYAELYFSDTYWPDFKLDSLVDAIYWYQNRNRRFGGLK

Sequences:

>Translated_234_residues
MDLSNLDQDRLPKHIAIIMDGNGRWATNRNKPRVFGHNEGMKRVVDVVENSLNIGIKYLSLYAFSTENWKRPQKEIDFLM
QILIKYIDDQLNKLVTQGVKINILGDISVLPKKVIQKIEYALDSTKDNNKLILNIAINYGSRQEILLAVNNAIENGQILT
ENEFSNLLYTRNQPDVDLLIRPGGEKRLSNFLLYQMSYAELYFSDTYWPDFKLDSLVDAIYWYQNRNRRFGGLK
>Mature_234_residues
MDLSNLDQDRLPKHIAIIMDGNGRWATNRNKPRVFGHNEGMKRVVDVVENSLNIGIKYLSLYAFSTENWKRPQKEIDFLM
QILIKYIDDQLNKLVTQGVKINILGDISVLPKKVIQKIEYALDSTKDNNKLILNIAINYGSRQEILLAVNNAIENGQILT
ENEFSNLLYTRNQPDVDLLIRPGGEKRLSNFLLYQMSYAELYFSDTYWPDFKLDSLVDAIYWYQNRNRRFGGLK

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580742, Length=224, Percent_Identity=38.3928571428571, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI45580738, Length=224, Percent_Identity=38.3928571428571, Blast_Score=157, Evalue=1e-38,
Organism=Escherichia coli, GI1786371, Length=237, Percent_Identity=41.3502109704641, Blast_Score=190, Evalue=8e-50,
Organism=Caenorhabditis elegans, GI71993029, Length=229, Percent_Identity=31.0043668122271, Blast_Score=107, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6319474, Length=209, Percent_Identity=34.4497607655502, Blast_Score=123, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6323748, Length=218, Percent_Identity=32.1100917431193, Blast_Score=116, Evalue=4e-27,
Organism=Drosophila melanogaster, GI18857969, Length=223, Percent_Identity=33.1838565022422, Blast_Score=153, Evalue=7e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 27224; Mature: 27224

Theoretical pI: Translated: 9.04; Mature: 9.04

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLSNLDQDRLPKHIAIIMDGNGRWATNRNKPRVFGHNEGMKRVVDVVENSLNIGIKYLS
CCCCCCCHHCCCCEEEEEECCCCEECCCCCCCEEECCCCHHHHHHHHHHHHHHCCEEEEE
LYAFSTENWKRPQKEIDFLMQILIKYIDDQLNKLVTQGVKINILGDISVLPKKVIQKIEY
EEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCHHHHHHHHHHHHH
ALDSTKDNNKLILNIAINYGSRQEILLAVNNAIENGQILTENEFSNLLYTRNQPDVDLLI
HHCCCCCCCEEEEEEEECCCCCCEEEEEEECCCCCCEEEECCCCCCEEEECCCCCEEEEE
RPGGEKRLSNFLLYQMSYAELYFSDTYWPDFKLDSLVDAIYWYQNRNRRFGGLK
CCCCHHHHHHHHHHEEEHHEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MDLSNLDQDRLPKHIAIIMDGNGRWATNRNKPRVFGHNEGMKRVVDVVENSLNIGIKYLS
CCCCCCCHHCCCCEEEEEECCCCEECCCCCCCEEECCCCHHHHHHHHHHHHHHCCEEEEE
LYAFSTENWKRPQKEIDFLMQILIKYIDDQLNKLVTQGVKINILGDISVLPKKVIQKIEY
EEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCHHHHHHHHHHHHH
ALDSTKDNNKLILNIAINYGSRQEILLAVNNAIENGQILTENEFSNLLYTRNQPDVDLLI
HHCCCCCCCEEEEEEEECCCCCCEEEEEEECCCCCCEEEECCCCCCEEEECCCCCEEEEE
RPGGEKRLSNFLLYQMSYAELYFSDTYWPDFKLDSLVDAIYWYQNRNRRFGGLK
CCCCHHHHHHHHHHEEEHHEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]