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The map label for this gene is pyrD [H]

Identifier: 169824422

GI number: 169824422

Start: 786685

End: 787581

Strand: Direct

Name: pyrD [H]

Synonym: FMG_0725

Alternate gene names: 169824422

Gene position: 786685-787581 (Clockwise)

Preceding gene: 169824421

Following gene: 169824423

Centisome position: 43.76

GC content: 31.1

Gene sequence:

>897_bases
ATGCTTAAAACGAATTTCTGTGGAGTAGAATTCAAAAATCCTGTTGTTGGAGCTTCTGGTACTTTTGGATTTGGAAGAGA
ATATGAAAATTTTACAGATTTAAATAAATTAGGAGGTATCTCCACAAAAGGATTAACCATTCAAGCTAAAGATGGGAATA
CTGGTTTAAGAATTTATGAAACACCTTCTGGAATTATGAATAGCATAGGACTACAAAATCCATCGGTTCAAGAATTTATT
AATAGAGACCTGGACTATATGTTATCCTTGGATACTGTTACTATTGCAAACATTGGTGGTTCCGATATAAAAAGTTATAT
TGAAGCTGTTGAACTTATATCAAGCACTGACATAAAAATAATTGAGTTAAATATTTCTTGTCCAAATGTTAAAGAGGGTG
GAATGGCTTTTGGAATAAAATGCGATATAGCACAAAATGTCGTTTCAGAAGTAAGAAAACATACAGACAAAATTTTAATG
GTAAAATTATCTCCTAATGCTAATGATATTGTAGAAATGGCAAAGACTTGTGAAGATTCTGGAGCGGATGCTATCAGCCT
TGTTAATACTTTTAATGCACTAGCAATAGATATTAATAAAAGGAAAGCTGTATTTGATAATATAACTGCCGGTCTTTCAG
GTCCTTGTATAAAGCCAATAGCGTTAAGAATGTGTAGAGATGTTTGCAAAAATGTTAAAATTCCAGTTTGTGGTATGGGT
GGAATACAAAATTACAAAGATGCTTTAGAATTTATAATGGTCGGATGTCATTTAGTTCAAGTTGGTACAGCAAACTTTGT
TAATCCAAATGTTATGGTTGAGATAGCAAATGGTATGGAAAACTATTTAAAAGAAAATGGTTTTAAATCTATAGAAGAAA
TAAGGAATATTATTTAG

Upstream 100 bases:

>100_bases
GGGATAGGGGCGTGTTTAGGGTGTACTGTTCATACAACAAGTGGTCTTAAAAGAGTTTGCAAAGATGGCCCTGTTTTTGA
AAAAAATGAGGTGATATTTG

Downstream 100 bases:

>100_bases
GGGGAAAATTATGGATAGAGTTGTTGAATTATTAAAAGAAAGTAATGCATTATTAGAAGGTCATTTCTTATTATCATCTG
GAAATCACAGTGATAAATAC

Product: dihydroorotate dehydrogenase

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MLKTNFCGVEFKNPVVGASGTFGFGREYENFTDLNKLGGISTKGLTIQAKDGNTGLRIYETPSGIMNSIGLQNPSVQEFI
NRDLDYMLSLDTVTIANIGGSDIKSYIEAVELISSTDIKIIELNISCPNVKEGGMAFGIKCDIAQNVVSEVRKHTDKILM
VKLSPNANDIVEMAKTCEDSGADAISLVNTFNALAIDINKRKAVFDNITAGLSGPCIKPIALRMCRDVCKNVKIPVCGMG
GIQNYKDALEFIMVGCHLVQVGTANFVNPNVMVEIANGMENYLKENGFKSIEEIRNII

Sequences:

>Translated_298_residues
MLKTNFCGVEFKNPVVGASGTFGFGREYENFTDLNKLGGISTKGLTIQAKDGNTGLRIYETPSGIMNSIGLQNPSVQEFI
NRDLDYMLSLDTVTIANIGGSDIKSYIEAVELISSTDIKIIELNISCPNVKEGGMAFGIKCDIAQNVVSEVRKHTDKILM
VKLSPNANDIVEMAKTCEDSGADAISLVNTFNALAIDINKRKAVFDNITAGLSGPCIKPIALRMCRDVCKNVKIPVCGMG
GIQNYKDALEFIMVGCHLVQVGTANFVNPNVMVEIANGMENYLKENGFKSIEEIRNII
>Mature_298_residues
MLKTNFCGVEFKNPVVGASGTFGFGREYENFTDLNKLGGISTKGLTIQAKDGNTGLRIYETPSGIMNSIGLQNPSVQEFI
NRDLDYMLSLDTVTIANIGGSDIKSYIEAVELISSTDIKIIELNISCPNVKEGGMAFGIKCDIAQNVVSEVRKHTDKILM
VKLSPNANDIVEMAKTCEDSGADAISLVNTFNALAIDINKRKAVFDNITAGLSGPCIKPIALRMCRDVCKNVKIPVCGMG
GIQNYKDALEFIMVGCHLVQVGTANFVNPNVMVEIANGMENYLKENGFKSIEEIRNII

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=226, Percent_Identity=28.3185840707965, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI45006951, Length=317, Percent_Identity=24.2902208201893, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI87082059, Length=315, Percent_Identity=27.3015873015873, Blast_Score=111, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI71984108, Length=169, Percent_Identity=28.9940828402367, Blast_Score=74, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6322633, Length=309, Percent_Identity=27.831715210356, Blast_Score=94, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24640763, Length=151, Percent_Identity=31.7880794701987, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI18858217, Length=151, Percent_Identity=31.7880794701987, Blast_Score=72, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.3.1 [H]

Molecular weight: Translated: 32334; Mature: 32334

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKTNFCGVEFKNPVVGASGTFGFGREYENFTDLNKLGGISTKGLTIQAKDGNTGLRIYE
CCCCCCCCCEECCCEECCCCCCCCCCCCCCHHHHHHHCCCCCCCEEEEECCCCCCEEEEE
TPSGIMNSIGLQNPSVQEFINRDLDYMLSLDTVTIANIGGSDIKSYIEAVELISSTDIKI
CCHHHHHHHCCCCCCHHHHHCCCHHHEEEECEEEEECCCCHHHHHHHHHHHHHCCCCEEE
IELNISCPNVKEGGMAFGIKCDIAQNVVSEVRKHTDKILMVKLSPNANDIVEMAKTCEDS
EEEEECCCCCCCCCEEEEEEEHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHCCC
GADAISLVNTFNALAIDINKRKAVFDNITAGLSGPCIKPIALRMCRDVCKNVKIPVCGMG
CCCHHHHHHHCCEEEEEECCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCEECCC
GIQNYKDALEFIMVGCHLVQVGTANFVNPNVMVEIANGMENYLKENGFKSIEEIRNII
CCHHHHHHHHHHHHHHHHEEECCCCCCCCCEEEEEHHHHHHHHHHCCHHHHHHHHHCC
>Mature Secondary Structure
MLKTNFCGVEFKNPVVGASGTFGFGREYENFTDLNKLGGISTKGLTIQAKDGNTGLRIYE
CCCCCCCCCEECCCEECCCCCCCCCCCCCCHHHHHHHCCCCCCCEEEEECCCCCCEEEEE
TPSGIMNSIGLQNPSVQEFINRDLDYMLSLDTVTIANIGGSDIKSYIEAVELISSTDIKI
CCHHHHHHHCCCCCCHHHHHCCCHHHEEEECEEEEECCCCHHHHHHHHHHHHHCCCCEEE
IELNISCPNVKEGGMAFGIKCDIAQNVVSEVRKHTDKILMVKLSPNANDIVEMAKTCEDS
EEEEECCCCCCCCCEEEEEEEHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHCCC
GADAISLVNTFNALAIDINKRKAVFDNITAGLSGPCIKPIALRMCRDVCKNVKIPVCGMG
CCCHHHHHHHCCEEEEEECCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCEECCC
GIQNYKDALEFIMVGCHLVQVGTANFVNPNVMVEIANGMENYLKENGFKSIEEIRNII
CCHHHHHHHHHHHHHHHHEEECCCCCCCCCEEEEEHHHHHHHHHHCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA