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The map label for this gene is map [H]

Identifier: 169824381

GI number: 169824381

Start: 746564

End: 747319

Strand: Direct

Name: map [H]

Synonym: FMG_0684

Alternate gene names: 169824381

Gene position: 746564-747319 (Clockwise)

Preceding gene: 169824380

Following gene: 169824383

Centisome position: 41.53

GC content: 35.19

Gene sequence:

>756_bases
ATGATTATTATAAAAAATAAAGACGAAATAGAAAAAATGGACATTTCTGGAAATGTAATTTCGGGTATGCACGAAGCGTT
AAGAGAATATGTTAAACCGGGATTAACTACAATGCAAGTCAATGATTTTTGCGAAAAATTTATTAGGAGCAAAGGAGCAA
TTCCTGCTCAAATTGGTTATGAAGGGTTCCCATATGCTACATGCTGCTGTGTCAATGACGAAATATGTCATGGATATCCA
TCTGATTATGTTTTAAAATCTGGAGATTTGCTAAAAGTAGATACAGTGGTTGAATTGAATGGCTGGATGAGCGATTCATG
TTGGAGCTATGCCGTTGGTGAAGTTGATGAAGAAACTAAAAAGCTAATGGAAGTTACAAGAGAGTGCATGTACGAAGGAA
TTAAATTAGCCGTTATTGGCAATAGATTAGGTGATATCGGAGCAAGAATTCAATCTATTGCTGAAGCAAATGGTTATTCA
GTAGTACGTGAATTTACAGGACATGGAATTGGTAGAGGCATGCATGAAGATCCAATGGTTCTTCATTACGGAAAAGAACA
CAGAGGTCTTAGATTACAAGAGGGAATGGTATTAACTATCGAACCAATGATAAATATGGGAACTCATAAGTTGAAAATTG
ATAAAAATGGATGGACAGCAAGAACTATTGATGGTAAAAAATCATGTCAATATGAGCATACACTAGCAATCACTAAGGAT
GGTCCAAGAATTTTGACAAAACAACAAGGACAATAA

Upstream 100 bases:

>100_bases
ATATTGATGGAGTTTTGTACAATATAATTTTTGTAGAAGATAAAAGGATTAAAAAGGTAAAAATTACATTACCTAAGAAC
TTTTTTGAACAGGTGAGTAA

Downstream 100 bases:

>100_bases
AAAAATAGAGAATATTTTGGGGTTACCCGAATATTCTCTATTTTTTTATTACTGGAAAATCATAAAAATCATTAACTTTT
CTTGTCGAGTAAATTAGTCT

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 251; Mature: 251

Protein sequence:

>251_residues
MIIIKNKDEIEKMDISGNVISGMHEALREYVKPGLTTMQVNDFCEKFIRSKGAIPAQIGYEGFPYATCCCVNDEICHGYP
SDYVLKSGDLLKVDTVVELNGWMSDSCWSYAVGEVDEETKKLMEVTRECMYEGIKLAVIGNRLGDIGARIQSIAEANGYS
VVREFTGHGIGRGMHEDPMVLHYGKEHRGLRLQEGMVLTIEPMINMGTHKLKIDKNGWTARTIDGKKSCQYEHTLAITKD
GPRILTKQQGQ

Sequences:

>Translated_251_residues
MIIIKNKDEIEKMDISGNVISGMHEALREYVKPGLTTMQVNDFCEKFIRSKGAIPAQIGYEGFPYATCCCVNDEICHGYP
SDYVLKSGDLLKVDTVVELNGWMSDSCWSYAVGEVDEETKKLMEVTRECMYEGIKLAVIGNRLGDIGARIQSIAEANGYS
VVREFTGHGIGRGMHEDPMVLHYGKEHRGLRLQEGMVLTIEPMINMGTHKLKIDKNGWTARTIDGKKSCQYEHTLAITKD
GPRILTKQQGQ
>Mature_251_residues
MIIIKNKDEIEKMDISGNVISGMHEALREYVKPGLTTMQVNDFCEKFIRSKGAIPAQIGYEGFPYATCCCVNDEICHGYP
SDYVLKSGDLLKVDTVVELNGWMSDSCWSYAVGEVDEETKKLMEVTRECMYEGIKLAVIGNRLGDIGARIQSIAEANGYS
VVREFTGHGIGRGMHEDPMVLHYGKEHRGLRLQEGMVLTIEPMINMGTHKLKIDKNGWTARTIDGKKSCQYEHTLAITKD
GPRILTKQQGQ

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI40385867, Length=246, Percent_Identity=36.1788617886179, Blast_Score=174, Evalue=7e-44,
Organism=Homo sapiens, GI164420681, Length=247, Percent_Identity=36.8421052631579, Blast_Score=169, Evalue=3e-42,
Organism=Escherichia coli, GI1786364, Length=250, Percent_Identity=40, Blast_Score=204, Evalue=4e-54,
Organism=Caenorhabditis elegans, GI71996291, Length=231, Percent_Identity=40.6926406926407, Blast_Score=166, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6323273, Length=249, Percent_Identity=36.9477911646586, Blast_Score=167, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24583427, Length=246, Percent_Identity=35.7723577235772, Blast_Score=173, Evalue=8e-44,
Organism=Drosophila melanogaster, GI21355531, Length=248, Percent_Identity=35.4838709677419, Blast_Score=157, Evalue=9e-39,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 28084; Mature: 28084

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
8.0 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
8.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIIKNKDEIEKMDISGNVISGMHEALREYVKPGLTTMQVNDFCEKFIRSKGAIPAQIGY
CEEECCCCCHHEECCCCCHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHCCCCCCCCCCC
EGFPYATCCCVNDEICHGYPSDYVLKSGDLLKVDTVVELNGWMSDSCWSYAVGEVDEETK
CCCCCEEEEEECCHHHCCCCCCEEECCCCEEEEEEEEEECCCCCCCCHHHHCCCCCHHHH
KLMEVTRECMYEGIKLAVIGNRLGDIGARIQSIAEANGYSVVREFTGHGIGRGMHEDPMV
HHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCEE
LHYGKEHRGLRLQEGMVLTIEPMINMGTHKLKIDKNGWTARTIDGKKSCQYEHTLAITKD
EEECCCCCCEEECCCEEEEEECCCCCCCEEEEEECCCCEEEEECCCCCCCEEEEEEEECC
GPRILTKQQGQ
CCEECCCCCCC
>Mature Secondary Structure
MIIIKNKDEIEKMDISGNVISGMHEALREYVKPGLTTMQVNDFCEKFIRSKGAIPAQIGY
CEEECCCCCHHEECCCCCHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHCCCCCCCCCCC
EGFPYATCCCVNDEICHGYPSDYVLKSGDLLKVDTVVELNGWMSDSCWSYAVGEVDEETK
CCCCCEEEEEECCHHHCCCCCCEEECCCCEEEEEEEEEECCCCCCCCHHHHCCCCCHHHH
KLMEVTRECMYEGIKLAVIGNRLGDIGARIQSIAEANGYSVVREFTGHGIGRGMHEDPMV
HHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCEE
LHYGKEHRGLRLQEGMVLTIEPMINMGTHKLKIDKNGWTARTIDGKKSCQYEHTLAITKD
EEECCCCCCEEECCCEEEEEECCCCCCCEEEEEECCCCEEEEECCCCCCCEEEEEEEECC
GPRILTKQQGQ
CCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11792842; 7559358 [H]