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The map label for this gene is fmt

Identifier: 169824359

GI number: 169824359

Start: 726060

End: 726992

Strand: Direct

Name: fmt

Synonym: FMG_0662

Alternate gene names: 169824359

Gene position: 726060-726992 (Clockwise)

Preceding gene: 169824358

Following gene: 169824360

Centisome position: 40.39

GC content: 27.65

Gene sequence:

>933_bases
ATGAAAAATAAAATTGTATTTACAGGTTCGCCTGATTTTGCAGTTGAGAGTTTGCAAAGATTATATGATAATCCAAATAA
CGAAATTCAATTAGTAATATCACAAGAAGATAAAAAACGAAATAGAAACAAATTTTCACCTACAGCTGTAAAAAAAAGAG
CTATGGAATTGGGGATTGATGTTATCACTCCAAAAAATATCAATGATGAAGAAGTTTTCGATTTACTAGATAAACTTAAT
CCTGATTTTATTGTGGTAGTAGCTTATGGTCAATTAATCAAAAAAAGAATTCTTGATAGATTTAAAAACAAGATTTTGAA
TGTTCACGCATCAATTTTACCAAAATACAGAGGAGCTTCTCCAATTAATTATTCACTATTAAATGGCGATAAGGAGTCTG
GAGTAAGTATAATGTTAGTTGAACAAGGCCTTGATACGGGAGATGTATTAGCAGTAGATAAAATTAAGCTTGACAATGAA
ATTATGCTTGAAGAATTACACGATAAATTAATGATAATGGGTGCTGATTTAATTAATAAAGTAATTGATGATTACCAAAA
ATATTTTGATTCAAGAAAAGAACAAAATGAAAATGAGGCCTCCATAGTAGGAAAAATTCATAAATCTATGGGCCAAATTA
ATTTTAATGAGAAATCAGATGTTATTTACAATAAATTTAGAGGATTAACTCCTTGGCCGGGGTTGTTTTTCAAATTAGAA
GATAAAATAATAAAAGTTCACAATATCAACATAATAAAACAATATAATGATAATAAGAATGGTGAAGTTGTAAAGGTAGA
TAAAAATGGTATAAAAGTTGCTTGCGAAGATGGATTTATCATTATCACAAGATTACAACTTCCTAATAAAAAACCTCTAA
ATATAAGCGAATATTTAAATGGAAATTCATTTGAAGAGGGAATAATTTTGTAG

Upstream 100 bases:

>100_bases
AAAGCACATTGTTTTTGTCATGAATTAGATCACTTGGATGGCGTATTGTACACTGATAAAGTATTGAATCTTTCTGAAGA
AGAAGTTGAGAGATTGAATA

Downstream 100 bases:

>100_bases
GAGGAATCATTGTTTAATTTTTATTATGATAGGACTATGCTGCTTTTAATTCCAGCTTTGATATTGGCGTTTTACTCACA
ATACAAGGTTAGTCATACTT

Product: methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MKNKIVFTGSPDFAVESLQRLYDNPNNEIQLVISQEDKKRNRNKFSPTAVKKRAMELGIDVITPKNINDEEVFDLLDKLN
PDFIVVVAYGQLIKKRILDRFKNKILNVHASILPKYRGASPINYSLLNGDKESGVSIMLVEQGLDTGDVLAVDKIKLDNE
IMLEELHDKLMIMGADLINKVIDDYQKYFDSRKEQNENEASIVGKIHKSMGQINFNEKSDVIYNKFRGLTPWPGLFFKLE
DKIIKVHNINIIKQYNDNKNGEVVKVDKNGIKVACEDGFIIITRLQLPNKKPLNISEYLNGNSFEEGIIL

Sequences:

>Translated_310_residues
MKNKIVFTGSPDFAVESLQRLYDNPNNEIQLVISQEDKKRNRNKFSPTAVKKRAMELGIDVITPKNINDEEVFDLLDKLN
PDFIVVVAYGQLIKKRILDRFKNKILNVHASILPKYRGASPINYSLLNGDKESGVSIMLVEQGLDTGDVLAVDKIKLDNE
IMLEELHDKLMIMGADLINKVIDDYQKYFDSRKEQNENEASIVGKIHKSMGQINFNEKSDVIYNKFRGLTPWPGLFFKLE
DKIIKVHNINIIKQYNDNKNGEVVKVDKNGIKVACEDGFIIITRLQLPNKKPLNISEYLNGNSFEEGIIL
>Mature_310_residues
MKNKIVFTGSPDFAVESLQRLYDNPNNEIQLVISQEDKKRNRNKFSPTAVKKRAMELGIDVITPKNINDEEVFDLLDKLN
PDFIVVVAYGQLIKKRILDRFKNKILNVHASILPKYRGASPINYSLLNGDKESGVSIMLVEQGLDTGDVLAVDKIKLDNE
IMLEELHDKLMIMGADLINKVIDDYQKYFDSRKEQNENEASIVGKIHKSMGQINFNEKSDVIYNKFRGLTPWPGLFFKLE
DKIIKVHNINIIKQYNDNKNGEVVKVDKNGIKVACEDGFIIITRLQLPNKKPLNISEYLNGNSFEEGIIL

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family

Homologues:

Organism=Homo sapiens, GI164663775, Length=315, Percent_Identity=25.3968253968254, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI238814322, Length=244, Percent_Identity=25.4098360655738, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI21614513, Length=150, Percent_Identity=30, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1789683, Length=298, Percent_Identity=31.8791946308725, Blast_Score=169, Evalue=2e-43,
Organism=Escherichia coli, GI1788589, Length=260, Percent_Identity=27.3076923076923, Blast_Score=114, Evalue=6e-27,
Organism=Escherichia coli, GI1787483, Length=102, Percent_Identity=31.3725490196078, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788846, Length=113, Percent_Identity=29.2035398230088, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI133930964, Length=247, Percent_Identity=27.1255060728745, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI45550868, Length=303, Percent_Identity=27.7227722772277, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI28571984, Length=225, Percent_Identity=29.3333333333333, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24585660, Length=236, Percent_Identity=25.4237288135593, Blast_Score=79, Evalue=5e-15,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): FMT_FINM2 (B0S140)

Other databases:

- EMBL:   AP008971
- RefSeq:   YP_001691970.1
- ProteinModelPortal:   B0S140
- SMR:   B0S140
- GeneID:   6019712
- GenomeReviews:   AP008971_GR
- KEGG:   fma:FMG_0662
- HOGENOM:   HBG571560
- OMA:   VVAYGAI
- BioCyc:   FMAG334413:FMG_0662-MONOMER
- HAMAP:   MF_00182
- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR015518
- Gene3D:   G3DSA:3.10.25.10
- Gene3D:   G3DSA:3.40.50.170
- PANTHER:   PTHR11138
- TIGRFAMs:   TIGR00460

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N; SSF50486 FMT_C_like; SSF53328 formyl_transf

EC number: =2.1.2.9

Molecular weight: Translated: 35411; Mature: 35411

Theoretical pI: Translated: 7.64; Mature: 7.64

Prosite motif: PS00373 GART

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNKIVFTGSPDFAVESLQRLYDNPNNEIQLVISQEDKKRNRNKFSPTAVKKRAMELGID
CCCCEEEECCCCHHHHHHHHHHCCCCCEEEEEEECCHHHHCCCCCCHHHHHHHHHHHCCE
VITPKNINDEEVFDLLDKLNPDFIVVVAYGQLIKKRILDRFKNKILNVHASILPKYRGAS
EECCCCCCHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
PINYSLLNGDKESGVSIMLVEQGLDTGDVLAVDKIKLDNEIMLEELHDKLMIMGADLINK
CCEEEEECCCCCCCCEEEEEECCCCCCCEEEEEEEECCHHHHHHHHHHHHEEHHHHHHHH
VIDDYQKYFDSRKEQNENEASIVGKIHKSMGQINFNEKSDVIYNKFRGLTPWPGLFFKLE
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCEEEEEE
DKIIKVHNINIIKQYNDNKNGEVVKVDKNGIKVACEDGFIIITRLQLPNKKPLNISEYLN
CEEEEEEEEEEEEECCCCCCCCEEEEECCCEEEEECCCEEEEEEEECCCCCCCCHHHHCC
GNSFEEGIIL
CCCCCCCCCC
>Mature Secondary Structure
MKNKIVFTGSPDFAVESLQRLYDNPNNEIQLVISQEDKKRNRNKFSPTAVKKRAMELGID
CCCCEEEECCCCHHHHHHHHHHCCCCCEEEEEEECCHHHHCCCCCCHHHHHHHHHHHCCE
VITPKNINDEEVFDLLDKLNPDFIVVVAYGQLIKKRILDRFKNKILNVHASILPKYRGAS
EECCCCCCHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
PINYSLLNGDKESGVSIMLVEQGLDTGDVLAVDKIKLDNEIMLEELHDKLMIMGADLINK
CCEEEEECCCCCCCCEEEEEECCCCCCCEEEEEEEECCHHHHHHHHHHHHEEHHHHHHHH
VIDDYQKYFDSRKEQNENEASIVGKIHKSMGQINFNEKSDVIYNKFRGLTPWPGLFFKLE
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCEEEEEE
DKIIKVHNINIIKQYNDNKNGEVVKVDKNGIKVACEDGFIIITRLQLPNKKPLNISEYLN
CEEEEEEEEEEEEECCCCCCCCEEEEECCCEEEEECCCEEEEEEEECCCCCCCCHHHHCC
GNSFEEGIIL
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA