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The map label for this gene is gltT [H]

Identifier: 169823957

GI number: 169823957

Start: 307901

End: 309166

Strand: Direct

Name: gltT [H]

Synonym: FMG_0260

Alternate gene names: 169823957

Gene position: 307901-309166 (Clockwise)

Preceding gene: 169823956

Following gene: 169823958

Centisome position: 17.13

GC content: 36.33

Gene sequence:

>1266_bases
ATGAAACAAAAGAAAAAAATGGGACTTACAACTCAAATTTTCATAGGATTATTTTTAGGGTTGTTTGTCGGAATAGTTTT
TAATCTATTTGTTCCTTCATCATATATAAAAGATACAATTTTGGTAAATGGCGTATTTGATGTATTGGGACAAGGATTTA
TTAGATTAATGCAAATGCTCGTGGTTCCATTGGTGTTCTTCTCACTTGTAACTGGCGCTATGAGCATGGGGGATACTAAA
AAACTAGGGAAAATAGGAGTTAAAACACTTGTGTTTTATTTGTTCACAACTGCCTTGGCGATAACGTTGGCGCTATTATT
GGCATCATTTATCAAGCCTGGAGTTGGAATTGATCTTACCAAAGTAAGTCAAGCAGCAGAGGCCAATCCTGCACAAGCTG
TTTCACTAAAAGATACTGTATTGAATTTAATTCCTACAAATCCAATTCGAGCGATGTCTGAAGGAAATATGTTGCAAATA
ATTTTCTTTGCACTCTTAGTTGGAATTATTTTGGCAAATTTGGGAGAAAAAGCACACAACGTTGCAAATATTTGCGAAGA
GTTCAACGACATCATGATGGATATGACTATGATTGTAATGAAGTTTGCACCAATTGGTGTATTTGCACTTATCACAAAGA
CATTCGCAACTTTAGGATTATCAGCTATATTCTCTATGTTAAAGTACATGCTCACAGTAGTTTTAGGATTGGGACTTCAA
CTTTTATTAGTGTACATGGTTTTATTGACGATTTTTGCGAAAGTAAATCCATTCAAATTCTTGAAGAAATTCTTCCCGGT
TTTGGGATTCGCATTCTCCACATCATCTTCAAATGCAACAGTGCCAATGAACATAAACAAATTGGAAGAGCTTGGAGTTA
GTAGGAAAATTTCTTCATTCACAATTCCACTTGGAGCGACAATCAACATGGACGGAACTGCAATCATGCAGGGAGTTGCA
GTTGTATTTGCAGCGAACGCTTACGGAATGCAATTGACTCCACAAAATTTCTTGACAGTAATTGCTGCAGCGACACTTGC
ATCGGTAGGTACTGCGGGAATTCCTTCAGTTGGGTTGATAACTTTATCCATGGTATTTAATTCAATTGGACTTCCGATTT
CTGCGATTGCAATGATAATGGGAATAGACAGAATTTTGGATATGATTAGAACAGCGATAAATATCACAGGAGATGCTGTG
TGTACAGTCATCGTCGCTAATAGCTCTGGTGAAGAATATTTCGACAAAGAAAAATTTAATTCGTAA

Upstream 100 bases:

>100_bases
AAATTTACAAATTCACTGATTGGCAAACTTCTTTGCAAAAATATATCGAAAAAAACAATTTGTAATGCAAAATGAATTTT
AAGAAAAAGGAAAGATATTT

Downstream 100 bases:

>100_bases
ATTATAATAAATGATAAACACTTATAGAATATTTCAATAAGTGTTTATTTTTTTATTTGATATAATGAATATAAGGAGGG
GTAATTTTGAAATTAGAAAA

Product: proton/sodium-glutamate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MKQKKKMGLTTQIFIGLFLGLFVGIVFNLFVPSSYIKDTILVNGVFDVLGQGFIRLMQMLVVPLVFFSLVTGAMSMGDTK
KLGKIGVKTLVFYLFTTALAITLALLLASFIKPGVGIDLTKVSQAAEANPAQAVSLKDTVLNLIPTNPIRAMSEGNMLQI
IFFALLVGIILANLGEKAHNVANICEEFNDIMMDMTMIVMKFAPIGVFALITKTFATLGLSAIFSMLKYMLTVVLGLGLQ
LLLVYMVLLTIFAKVNPFKFLKKFFPVLGFAFSTSSSNATVPMNINKLEELGVSRKISSFTIPLGATINMDGTAIMQGVA
VVFAANAYGMQLTPQNFLTVIAAATLASVGTAGIPSVGLITLSMVFNSIGLPISAIAMIMGIDRILDMIRTAINITGDAV
CTVIVANSSGEEYFDKEKFNS

Sequences:

>Translated_421_residues
MKQKKKMGLTTQIFIGLFLGLFVGIVFNLFVPSSYIKDTILVNGVFDVLGQGFIRLMQMLVVPLVFFSLVTGAMSMGDTK
KLGKIGVKTLVFYLFTTALAITLALLLASFIKPGVGIDLTKVSQAAEANPAQAVSLKDTVLNLIPTNPIRAMSEGNMLQI
IFFALLVGIILANLGEKAHNVANICEEFNDIMMDMTMIVMKFAPIGVFALITKTFATLGLSAIFSMLKYMLTVVLGLGLQ
LLLVYMVLLTIFAKVNPFKFLKKFFPVLGFAFSTSSSNATVPMNINKLEELGVSRKISSFTIPLGATINMDGTAIMQGVA
VVFAANAYGMQLTPQNFLTVIAAATLASVGTAGIPSVGLITLSMVFNSIGLPISAIAMIMGIDRILDMIRTAINITGDAV
CTVIVANSSGEEYFDKEKFNS
>Mature_421_residues
MKQKKKMGLTTQIFIGLFLGLFVGIVFNLFVPSSYIKDTILVNGVFDVLGQGFIRLMQMLVVPLVFFSLVTGAMSMGDTK
KLGKIGVKTLVFYLFTTALAITLALLLASFIKPGVGIDLTKVSQAAEANPAQAVSLKDTVLNLIPTNPIRAMSEGNMLQI
IFFALLVGIILANLGEKAHNVANICEEFNDIMMDMTMIVMKFAPIGVFALITKTFATLGLSAIFSMLKYMLTVVLGLGLQ
LLLVYMVLLTIFAKVNPFKFLKKFFPVLGFAFSTSSSNATVPMNINKLEELGVSRKISSFTIPLGATINMDGTAIMQGVA
VVFAANAYGMQLTPQNFLTVIAAATLASVGTAGIPSVGLITLSMVFNSIGLPISAIAMIMGIDRILDMIRTAINITGDAV
CTVIVANSSGEEYFDKEKFNS

Specific function: This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI169790839, Length=427, Percent_Identity=29.2740046838407, Blast_Score=185, Evalue=6e-47,
Organism=Homo sapiens, GI21314632, Length=396, Percent_Identity=32.5757575757576, Blast_Score=181, Evalue=9e-46,
Organism=Homo sapiens, GI194239697, Length=460, Percent_Identity=29.1304347826087, Blast_Score=181, Evalue=2e-45,
Organism=Homo sapiens, GI66773030, Length=418, Percent_Identity=30.8612440191388, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI40254478, Length=468, Percent_Identity=30.7692307692308, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI5032093, Length=394, Percent_Identity=32.994923857868, Blast_Score=173, Evalue=3e-43,
Organism=Homo sapiens, GI223468566, Length=278, Percent_Identity=34.5323741007194, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI4827012, Length=293, Percent_Identity=32.7645051194539, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI223468564, Length=269, Percent_Identity=34.5724907063197, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI262359914, Length=427, Percent_Identity=25.0585480093677, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI301601644, Length=124, Percent_Identity=41.1290322580645, Blast_Score=103, Evalue=2e-22,
Organism=Escherichia coli, GI1790514, Length=425, Percent_Identity=33.6470588235294, Blast_Score=244, Evalue=1e-65,
Organism=Escherichia coli, GI1789947, Length=382, Percent_Identity=30.1047120418848, Blast_Score=192, Evalue=5e-50,
Organism=Escherichia coli, GI1788024, Length=385, Percent_Identity=30.3896103896104, Blast_Score=147, Evalue=9e-37,
Organism=Escherichia coli, GI1789473, Length=370, Percent_Identity=27.5675675675676, Blast_Score=117, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI71983106, Length=419, Percent_Identity=32.2195704057279, Blast_Score=214, Evalue=9e-56,
Organism=Caenorhabditis elegans, GI71983099, Length=419, Percent_Identity=32.2195704057279, Blast_Score=214, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI17537407, Length=448, Percent_Identity=31.6964285714286, Blast_Score=201, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI193206505, Length=397, Percent_Identity=33.2493702770781, Blast_Score=199, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI71996953, Length=447, Percent_Identity=29.082774049217, Blast_Score=184, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17541374, Length=392, Percent_Identity=29.3367346938776, Blast_Score=169, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI193206654, Length=403, Percent_Identity=27.2952853598015, Blast_Score=152, Evalue=4e-37,
Organism=Drosophila melanogaster, GI24583025, Length=449, Percent_Identity=28.7305122494432, Blast_Score=187, Evalue=2e-47,
Organism=Drosophila melanogaster, GI17137668, Length=449, Percent_Identity=28.7305122494432, Blast_Score=187, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24583023, Length=449, Percent_Identity=28.7305122494432, Blast_Score=187, Evalue=2e-47,
Organism=Drosophila melanogaster, GI281360481, Length=460, Percent_Identity=28.0434782608696, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI281360483, Length=460, Percent_Identity=28.0434782608696, Blast_Score=118, Evalue=7e-27,
Organism=Drosophila melanogaster, GI17137666, Length=460, Percent_Identity=28.0434782608696, Blast_Score=118, Evalue=7e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 45193; Mature: 45193

Theoretical pI: Translated: 9.79; Mature: 9.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
5.7 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
5.7 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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C
>Mature Secondary Structure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C

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]