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The map label for this gene is yeiG [H]

Identifier: 167625937

GI number: 167625937

Start: 4912818

End: 4913657

Strand: Reverse

Name: yeiG [H]

Synonym: Shal_4032

Alternate gene names: 167625937

Gene position: 4913657-4912818 (Counterclockwise)

Preceding gene: 167625938

Following gene: 167625936

Centisome position: 94.01

GC content: 47.86

Gene sequence:

>840_bases
ATGACCGTTGAAAATATCAGTGTAAATAAGAGCTTTGGTGGCTGGCATAAACAATATAGCCATCATTCGAAGACACTTAA
TTGCGCCATGCGATTTGCCATTTACTTACCGCCTCAAGCGTCAAATGGTGAAAAGGTGCCGGTGCTTTATTGGCTATCTG
GCTTAACCTGTACCGACGAAAACTTTATGCAAAAAGCTGGCGCTCAGCGCATGGCTGCAGAACTTGGCATCGCGATTGTT
GCGCCTGATACCAGCCCTCGAGGCGACGATGTTGCCGATGATACTGGCTACGATCTCGGTAAGGGTGCAGGTTTCTATGT
TAACGCCACTCAAGCACCTTGGAATCGTCATTATAGAATGTATGACTATGTGGTAAATGAATTGCCGCGGCTGATAGAGT
CGATGTTCCCCGTCAGCGATAAGCGCTCAATTGCGGGTCACTCTATGGGCGGGCATGGCGCACTCGTTATTGCGATGCGT
AACCCACAGGTGTATCAGTCAGTGTCGGCATTTAGTCCGATTACTAATCCAGTCAACTGCCCTTGGGGTAAAAAGGCATT
CACCGCTTATTTAGGCCGTGATACCACTACATGGACTGACTACGATGCTAGCCTGTTGATGCGTCAAGCGACTGAGTTTG
TGCCAGCGCTAGTAGATCAGGGAGAGGCTGATGACTTCCTTGTTGAGCAATTAAAGCCAGAGGTGTTAGAAGCTGCTGCC
AAGTTAAGTGGCTATCCACTGACGCTCAATATGCAAGAAGGCTTCGATCATAGCTATTACTTCATCTCTAGCTTTATTGA
AAGCCACCTGCGCTTTCATGCAGAGCACTTGGCTAAATAA

Upstream 100 bases:

>100_bases
TTTTTAAAGATTGAACATCTATTGGTTTAGCTTTTAAAGATTGGGCTTTAAAGATTAACCTTTCAAAATTAAGTAAAAAA
TTTATAGGAGTCGGTATTAA

Downstream 100 bases:

>100_bases
AGTGATCAGCCGTTTTTTAAATGAGTGAAGTCATTCGTTAGATTACTTCGTTTGATGACTCTCAGTTTGCCAAATAGCCG
CCATGTAGGGCGGCTTTTTG

Product: S-formylglutathione hydrolase

Products: NA

Alternate protein names: FGH [H]

Number of amino acids: Translated: 279; Mature: 278

Protein sequence:

>279_residues
MTVENISVNKSFGGWHKQYSHHSKTLNCAMRFAIYLPPQASNGEKVPVLYWLSGLTCTDENFMQKAGAQRMAAELGIAIV
APDTSPRGDDVADDTGYDLGKGAGFYVNATQAPWNRHYRMYDYVVNELPRLIESMFPVSDKRSIAGHSMGGHGALVIAMR
NPQVYQSVSAFSPITNPVNCPWGKKAFTAYLGRDTTTWTDYDASLLMRQATEFVPALVDQGEADDFLVEQLKPEVLEAAA
KLSGYPLTLNMQEGFDHSYYFISSFIESHLRFHAEHLAK

Sequences:

>Translated_279_residues
MTVENISVNKSFGGWHKQYSHHSKTLNCAMRFAIYLPPQASNGEKVPVLYWLSGLTCTDENFMQKAGAQRMAAELGIAIV
APDTSPRGDDVADDTGYDLGKGAGFYVNATQAPWNRHYRMYDYVVNELPRLIESMFPVSDKRSIAGHSMGGHGALVIAMR
NPQVYQSVSAFSPITNPVNCPWGKKAFTAYLGRDTTTWTDYDASLLMRQATEFVPALVDQGEADDFLVEQLKPEVLEAAA
KLSGYPLTLNMQEGFDHSYYFISSFIESHLRFHAEHLAK
>Mature_278_residues
TVENISVNKSFGGWHKQYSHHSKTLNCAMRFAIYLPPQASNGEKVPVLYWLSGLTCTDENFMQKAGAQRMAAELGIAIVA
PDTSPRGDDVADDTGYDLGKGAGFYVNATQAPWNRHYRMYDYVVNELPRLIESMFPVSDKRSIAGHSMGGHGALVIAMRN
PQVYQSVSAFSPITNPVNCPWGKKAFTAYLGRDTTTWTDYDASLLMRQATEFVPALVDQGEADDFLVEQLKPEVLEAAAK
LSGYPLTLNMQEGFDHSYYFISSFIESHLRFHAEHLAK

Specific function: Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate [H]

COG id: COG0627

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the esterase D family [H]

Homologues:

Organism=Homo sapiens, GI33413400, Length=281, Percent_Identity=53.7366548042705, Blast_Score=318, Evalue=5e-87,
Organism=Escherichia coli, GI1788477, Length=279, Percent_Identity=58.4229390681004, Blast_Score=349, Evalue=9e-98,
Organism=Escherichia coli, GI1786551, Length=275, Percent_Identity=55.6363636363636, Blast_Score=328, Evalue=3e-91,
Organism=Caenorhabditis elegans, GI17510185, Length=284, Percent_Identity=49.2957746478873, Blast_Score=266, Evalue=1e-71,
Organism=Saccharomyces cerevisiae, GI6322393, Length=287, Percent_Identity=42.8571428571429, Blast_Score=229, Evalue=5e-61,
Organism=Drosophila melanogaster, GI45551932, Length=283, Percent_Identity=51.5901060070671, Blast_Score=291, Evalue=3e-79,
Organism=Drosophila melanogaster, GI24648347, Length=283, Percent_Identity=51.5901060070671, Blast_Score=291, Evalue=4e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000801
- InterPro:   IPR014186 [H]

Pfam domain/function: PF00756 Esterase [H]

EC number: =3.1.2.12 [H]

Molecular weight: Translated: 31075; Mature: 30944

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVENISVNKSFGGWHKQYSHHSKTLNCAMRFAIYLPPQASNGEKVPVLYWLSGLTCTDE
CCCCCEECCCCCCCHHHHHHHHHHHHHEEEEEEEEECCCCCCCCCCEEEEEECCCEECCH
NFMQKAGAQRMAAELGIAIVAPDTSPRGDDVADDTGYDLGKGAGFYVNATQAPWNRHYRM
HHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHCHHH
YDYVVNELPRLIESMFPVSDKRSIAGHSMGGHGALVIAMRNPQVYQSVSAFSPITNPVNC
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHCCCCCCCCC
PWGKKAFTAYLGRDTTTWTDYDASLLMRQATEFVPALVDQGEADDFLVEQLKPEVLEAAA
CCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCHHHHHHHH
KLSGYPLTLNMQEGFDHSYYFISSFIESHLRFHAEHLAK
HHCCCCEEEEHHCCCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TVENISVNKSFGGWHKQYSHHSKTLNCAMRFAIYLPPQASNGEKVPVLYWLSGLTCTDE
CCCCEECCCCCCCHHHHHHHHHHHHHEEEEEEEEECCCCCCCCCCEEEEEECCCEECCH
NFMQKAGAQRMAAELGIAIVAPDTSPRGDDVADDTGYDLGKGAGFYVNATQAPWNRHYRM
HHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHCHHH
YDYVVNELPRLIESMFPVSDKRSIAGHSMGGHGALVIAMRNPQVYQSVSAFSPITNPVNC
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHCCCCCCCCC
PWGKKAFTAYLGRDTTTWTDYDASLLMRQATEFVPALVDQGEADDFLVEQLKPEVLEAAA
CCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCHHHHHHHH
KLSGYPLTLNMQEGFDHSYYFISSFIESHLRFHAEHLAK
HHCCCCEEEEHHCCCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA