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The map label for this gene is ilvA [H]

Identifier: 167625845

GI number: 167625845

Start: 4803346

End: 4804899

Strand: Reverse

Name: ilvA [H]

Synonym: Shal_3940

Alternate gene names: 167625845

Gene position: 4804899-4803346 (Counterclockwise)

Preceding gene: 167625846

Following gene: 167625844

Centisome position: 91.93

GC content: 50.64

Gene sequence:

>1554_bases
ATGTTGGCTTTAGCATCACAATCGCAACTGGATTTAGCCCATTATTATTTGCAGAAAATTTTGCTGTCATCGGTTTATGA
TGTGGCTAAAGTCACACCGCTGTCGAGCCTTAATAAGCTGTCGGCACGCTTGGGCTGTCAGGTCTTTTTAAAGCGTGAAG
ATCTGCAGCCAGTGCACTCTTTTAAGCTTCGCGGTGCTTACAATAAAATTGCCGAGTTAACCAAAGATGAGTGCGAGTGC
GGTGTGGTTTGTGCCTCTGCCGGTAATCATGCTCAAGGCGTGGCGATGTCGGCAGTGGCCCGTGGTATTAGTGCGGTTAT
CGTGATGCCAGAAACCACCCCAGATATTAAGGTCGATGCGGTTAGGCGTTTAGGCGGTGAAGTGGTGCTCCATGGTCAAG
CATTCGATCAAGCCAATGCTTATGCGCAGAGCCTAGCTAAGAGTGAGGGCCGAGTCTATGTCGCGCCTTTTGATGATGAA
GCGGTCATTGCTGGCCAAGGCACCGTTGCGCAAGAGATGTTACAGCAGCAGCGCGATCTCGAAGTGGTGTTTGTGCCTGT
TGGTGGTGGCGGCCTGATTGCAGGGGTTGCGGCTTACTATAAGGCCGTGATGCCACAGGTGAAGATTATTGGTGTAGAGC
CTGAAGATTCTGCCTGTTTAAAAGCGGCACTTGAGGCCGATGAGCGGGTAATATTACCGCAAGTTGGCCTATTTGCCGAT
GGGGTGGCAGTTAAGCAGATTGGCGCCGAGCCCTTTAGATTGGCCCGTGAGTATGTCGATGATGTGATCACCGTGAATTC
AGATGAGATCTGCTCTGCGGTCAAAGATATCTTTGAAGACACGCGCGCGATTGCCGAGCCGTCGGGAGCACTGTCACTGG
CTGGGCTGAAAAAGTATATCGGCACCAATGGTAAGGGCGAGAAAGTCGGTGCGATTTTAAGTGGCGCTAACGTGAACTTT
CATAGCCTACGTTATGTGTCGGAGCGCTGTGAACTCGGTGAGCAGAAAGAGGCTATTTTGGCGGTTAAAGTGCCGGAGCG
CCCCGGTGTGTTTCTGCGTTTTTGTGAGCTGTTAGGTAAGCGAGCAATGACCGAGTTTAACTACCGCTTTAGCAGCCGTG
ACAAGGCCGTGGTGTTTGCGGGGATTAGGCTTACTCAAGGGCAAACTGAGCTAGATGAGATAGTCACTAACCTTGAGTCT
GAAGGCTTTGATGTCCAGGACTTGTCTCAGGATGAAACCGCTAAATTGCATGTGCGCTATATGGTGGGAGGTCATCCACC
AGAGCCGTTAGAGGAGCGTTTGTTTAGCTTTGAATTTCCTGAGCATCCGGGGGCGCTGTTTAAGTTTTTAACCACCTTGC
AGAGCAAGTGGAATATCAGTCTGTTCCATTACCGTAATCATGGCGCGGCCTACGGCCGAGTGCTCGCGGGGTTCGAGGTG
CCGGAAAGTGATGCTTTGGCTTTTCAGCAGTTCTTAACAGAGTTAGGTTTTGTTTATCAGGAAGAGACAGATAGTCCGGC
TTATCGACTGTTTTTAGATAACCGCAGCCGATAG

Upstream 100 bases:

>100_bases
CTCAAAGCCTACGCGTTACTCGCAACCAGTGCCGATAAAGGCGCAGTGCGCGATACCAGTAAGTTGGTCTAATCAGTTTT
CCGGGATTAAGAGGTAGTTT

Downstream 100 bases:

>100_bases
TTGCCGCTATATAAGTTACAGAGGCAGTAGCGTTTTTCGATGCTGCCTTTTTATTGAAGATAAACAACAGTAAGACTGGA
TACAATCTTTATCAGCTATC

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 517; Mature: 517

Protein sequence:

>517_residues
MLALASQSQLDLAHYYLQKILLSSVYDVAKVTPLSSLNKLSARLGCQVFLKREDLQPVHSFKLRGAYNKIAELTKDECEC
GVVCASAGNHAQGVAMSAVARGISAVIVMPETTPDIKVDAVRRLGGEVVLHGQAFDQANAYAQSLAKSEGRVYVAPFDDE
AVIAGQGTVAQEMLQQQRDLEVVFVPVGGGGLIAGVAAYYKAVMPQVKIIGVEPEDSACLKAALEADERVILPQVGLFAD
GVAVKQIGAEPFRLAREYVDDVITVNSDEICSAVKDIFEDTRAIAEPSGALSLAGLKKYIGTNGKGEKVGAILSGANVNF
HSLRYVSERCELGEQKEAILAVKVPERPGVFLRFCELLGKRAMTEFNYRFSSRDKAVVFAGIRLTQGQTELDEIVTNLES
EGFDVQDLSQDETAKLHVRYMVGGHPPEPLEERLFSFEFPEHPGALFKFLTTLQSKWNISLFHYRNHGAAYGRVLAGFEV
PESDALAFQQFLTELGFVYQEETDSPAYRLFLDNRSR

Sequences:

>Translated_517_residues
MLALASQSQLDLAHYYLQKILLSSVYDVAKVTPLSSLNKLSARLGCQVFLKREDLQPVHSFKLRGAYNKIAELTKDECEC
GVVCASAGNHAQGVAMSAVARGISAVIVMPETTPDIKVDAVRRLGGEVVLHGQAFDQANAYAQSLAKSEGRVYVAPFDDE
AVIAGQGTVAQEMLQQQRDLEVVFVPVGGGGLIAGVAAYYKAVMPQVKIIGVEPEDSACLKAALEADERVILPQVGLFAD
GVAVKQIGAEPFRLAREYVDDVITVNSDEICSAVKDIFEDTRAIAEPSGALSLAGLKKYIGTNGKGEKVGAILSGANVNF
HSLRYVSERCELGEQKEAILAVKVPERPGVFLRFCELLGKRAMTEFNYRFSSRDKAVVFAGIRLTQGQTELDEIVTNLES
EGFDVQDLSQDETAKLHVRYMVGGHPPEPLEERLFSFEFPEHPGALFKFLTTLQSKWNISLFHYRNHGAAYGRVLAGFEV
PESDALAFQQFLTELGFVYQEETDSPAYRLFLDNRSR
>Mature_517_residues
MLALASQSQLDLAHYYLQKILLSSVYDVAKVTPLSSLNKLSARLGCQVFLKREDLQPVHSFKLRGAYNKIAELTKDECEC
GVVCASAGNHAQGVAMSAVARGISAVIVMPETTPDIKVDAVRRLGGEVVLHGQAFDQANAYAQSLAKSEGRVYVAPFDDE
AVIAGQGTVAQEMLQQQRDLEVVFVPVGGGGLIAGVAAYYKAVMPQVKIIGVEPEDSACLKAALEADERVILPQVGLFAD
GVAVKQIGAEPFRLAREYVDDVITVNSDEICSAVKDIFEDTRAIAEPSGALSLAGLKKYIGTNGKGEKVGAILSGANVNF
HSLRYVSERCELGEQKEAILAVKVPERPGVFLRFCELLGKRAMTEFNYRFSSRDKAVVFAGIRLTQGQTELDEIVTNLES
EGFDVQDLSQDETAKLHVRYMVGGHPPEPLEERLFSFEFPEHPGALFKFLTTLQSKWNISLFHYRNHGAAYGRVLAGFEV
PESDALAFQQFLTELGFVYQEETDSPAYRLFLDNRSR

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=337, Percent_Identity=32.6409495548961, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI19923959, Length=271, Percent_Identity=34.6863468634686, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI33469958, Length=310, Percent_Identity=27.741935483871, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI295821202, Length=329, Percent_Identity=27.0516717325228, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI295821200, Length=329, Percent_Identity=27.0516717325228, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI4557415, Length=329, Percent_Identity=27.0516717325228, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1790207, Length=498, Percent_Identity=61.6465863453815, Blast_Score=599, Evalue=1e-172,
Organism=Escherichia coli, GI1789505, Length=301, Percent_Identity=37.5415282392027, Blast_Score=177, Evalue=2e-45,
Organism=Escherichia coli, GI1789235, Length=332, Percent_Identity=25, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI2367138, Length=206, Percent_Identity=27.6699029126214, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71991565, Length=320, Percent_Identity=35, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17537387, Length=355, Percent_Identity=30.4225352112676, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17508781, Length=278, Percent_Identity=31.294964028777, Blast_Score=113, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6320930, Length=521, Percent_Identity=51.2476007677543, Blast_Score=482, Evalue=1e-137,
Organism=Saccharomyces cerevisiae, GI6322631, Length=298, Percent_Identity=36.5771812080537, Blast_Score=169, Evalue=8e-43,
Organism=Saccharomyces cerevisiae, GI6319788, Length=286, Percent_Identity=26.9230769230769, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6321594, Length=210, Percent_Identity=26.1904761904762, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI21355833, Length=314, Percent_Identity=34.0764331210191, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI24645328, Length=250, Percent_Identity=33.2, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24643623, Length=223, Percent_Identity=28.2511210762332, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI20129101, Length=223, Percent_Identity=28.2511210762332, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005787
- InterPro:   IPR001721 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 56582; Mature: 56582

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLALASQSQLDLAHYYLQKILLSSVYDVAKVTPLSSLNKLSARLGCQVFLKREDLQPVHS
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEEECCCCCHHHH
FKLRGAYNKIAELTKDECECGVVCASAGNHAQGVAMSAVARGISAVIVMPETTPDIKVDA
HHHCCHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHCCCEEEEEECCCCCCCHHHH
VRRLGGEVVLHGQAFDQANAYAQSLAKSEGRVYVAPFDDEAVIAGQGTVAQEMLQQQRDL
HHHCCCEEEEECCCHHHHHHHHHHHHHCCCEEEEEECCCCEEEECCCHHHHHHHHHCCCC
EVVFVPVGGGGLIAGVAAYYKAVMPQVKIIGVEPEDSACLKAALEADERVILPQVGLFAD
EEEEEEECCCHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHCCCCEEECCCCCCHHC
GVAVKQIGAEPFRLAREYVDDVITVNSDEICSAVKDIFEDTRAIAEPSGALSLAGLKKYI
CHHHHHHCCCHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHH
GTNGKGEKVGAILSGANVNFHSLRYVSERCELGEQKEAILAVKVPERPGVFLRFCELLGK
CCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHH
RAMTEFNYRFSSRDKAVVFAGIRLTQGQTELDEIVTNLESEGFDVQDLSQDETAKLHVRY
HHHHHHCCEECCCCCEEEEEEEEEECCCHHHHHHHHHHCCCCCCHHCCCCCCCEEEEEEE
MVGGHPPEPLEERLFSFEFPEHPGALFKFLTTLQSKWNISLFHYRNHGAAYGRVLAGFEV
EECCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHEECCCC
PESDALAFQQFLTELGFVYQEETDSPAYRLFLDNRSR
CCHHHHHHHHHHHHHCCEEECCCCCCEEEEEECCCCC
>Mature Secondary Structure
MLALASQSQLDLAHYYLQKILLSSVYDVAKVTPLSSLNKLSARLGCQVFLKREDLQPVHS
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEEECCCCCHHHH
FKLRGAYNKIAELTKDECECGVVCASAGNHAQGVAMSAVARGISAVIVMPETTPDIKVDA
HHHCCHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHCCCEEEEEECCCCCCCHHHH
VRRLGGEVVLHGQAFDQANAYAQSLAKSEGRVYVAPFDDEAVIAGQGTVAQEMLQQQRDL
HHHCCCEEEEECCCHHHHHHHHHHHHHCCCEEEEEECCCCEEEECCCHHHHHHHHHCCCC
EVVFVPVGGGGLIAGVAAYYKAVMPQVKIIGVEPEDSACLKAALEADERVILPQVGLFAD
EEEEEEECCCHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHCCCCEEECCCCCCHHC
GVAVKQIGAEPFRLAREYVDDVITVNSDEICSAVKDIFEDTRAIAEPSGALSLAGLKKYI
CHHHHHHCCCHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHH
GTNGKGEKVGAILSGANVNFHSLRYVSERCELGEQKEAILAVKVPERPGVFLRFCELLGK
CCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHH
RAMTEFNYRFSSRDKAVVFAGIRLTQGQTELDEIVTNLESEGFDVQDLSQDETAKLHVRY
HHHHHHCCEECCCCCEEEEEEEEEECCCHHHHHHHHHHCCCCCCHHCCCCCCCEEEEEEE
MVGGHPPEPLEERLFSFEFPEHPGALFKFLTTLQSKWNISLFHYRNHGAAYGRVLAGFEV
EECCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHEECCCC
PESDALAFQQFLTELGFVYQEETDSPAYRLFLDNRSR
CCHHHHHHHHHHHHHCCEEECCCCCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11248100 [H]