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The map label for this gene is ilvD [H]

Identifier: 167625846

GI number: 167625846

Start: 4804928

End: 4806775

Strand: Reverse

Name: ilvD [H]

Synonym: Shal_3941

Alternate gene names: 167625846

Gene position: 4806775-4804928 (Counterclockwise)

Preceding gene: 167625847

Following gene: 167625845

Centisome position: 91.96

GC content: 52.0

Gene sequence:

>1848_bases
ATGCCAAAACTACGCTCAGCAACCAGTACCGAAGGCCGTAACATGGCGGGAGCCCGTGCATTATGGCGTGCAACAGGTGT
TAAAGATAACGACTTCGGTAAGCCGATCATTGCTATCGCCAACTCTTTTACCCAGTTTGTGCCGGGTCATGTGCACTTAA
AAGATATGGGCTCATTAGTGGCGGGAGCGATTGAGGAAGCAGGCGGTATTGCTAAAGAATTTAATACCATCGCCGTCGAT
GACGGTATTGCGATGGGGCACGGCGGCATGCTGTATAGCCTACCTTCGCGTGAGCTGATCGCCGATAGCGTGGAATATAT
GGTAAATGCCCACTGCGCCGATGCATTAGTGTGTATCTCCAACTGCGACAAGATCACCCCTGGCATGCTGATGGCATCTT
TAAGACTGAATATCCCAGTGATATTTGTCTCTGGCGGACCGATGGAGGCCGGTAAAACTAAGCTGTCAGATCAGCTGATT
AAGCTGGATCTGGTCGATGCCATGGTTGCTGGCGCCGACTCCCGCGTTTCAGATGCCGATAGCGAGCAGATTGAGCGCAG
CGCTTGCCCAACTTGTGGGTCATGCTCGGGCATGTTTACCGCTAACTCTATGAACTGCTTAACCGAAGCGCTGGGTTTAT
CATTGCCGGGCAATGGTTCAATGTTGGCTACCCACGCCGATCGCCGCGAGTTATTCCTTGAGGCGGGTCGCCGCATTATG
GATCTTGCTACTCGCTATTATCAACATGACGATGAATCCGCACTGCCGCGCAACATCGCTAACTTTAAGGCGTTTGAAAA
TGCCATGACACTCGATATTGCCATGGGCGGTTCGAGCAATACTGTGCTGCATCTACTGGCTTCTGCGCAAGAAGGCGAAG
TTGACTTCACCATGGATGATATCGATCGTCTGTCTCGCCTAGTGCCTCACCTTTGCAAAGTGGCGCCATCAACCCCTAAA
TACCATATGGAAGATGTACACCGCGCGGGTGGGGTAATGGGGATTTTAGGTGAGTTAGACCGAGCTAACTTGCTCCATAA
CGATGTGTACCATGTCGCGGGTAGCAATCTTGCCGATGTATTAGCACGATTTGATATTGTGCAGACCGACGACGCCGCGG
TGCATAAATTCTTCTCGGCAGGCCCCGCAGGCATCCCCACCACTAAAGCCTTCAGCCAAGATTGCCGCTGGGACAGTGTT
GATAACGACCGCAAAGAGGGTTGTATCCGTAGCCGTGAGTTTGCCTTTAGCCAAGAGGGGGGGCTTGCGGTGTTATCGGG
TAACGTTGCCCTAGATGGCTGTATTGTTAAGACCGCTGGCGTAGAAGTTGAAAACCATACCTTTATCGGCAGTGCTCGCG
TTTTTGAGAGTCAAGATGATGCGGTGGCTGGGATCTTGGGTGGTGAAGTGGTTGCTGGCGATGTTGTGGTTATTCGTTAC
GAAGGCCCTAAAGGTGGCCCAGGTATGCAAGAGATGTTGTACCCAACCAGTTACCTTAAGTCGCGCGGTTTAGGCACAAA
GTGCGCACTGATCACCGATGGTCGTTTCTCGGGAGGCACCTCGGGCTTGTCTATTGGTCATGTTTCACCAGAAGCAGCTG
CTGGTGGCACTATCGGTCTAGTGCAAACGGGCGATCGAATTGAGATTGATATTCCAGCTCGTTCAATCAAACTTGCGATT
AGCGATATTGAATTAGCGGCGCGCCGCACGGCGATGGAAGCACTTGGCAAAGATGCATGGAAACCACTTGGCCGTGTAAG
ACAAGTATCGATGGCGCTCAAAGCCTACGCGTTACTCGCAACCAGTGCCGATAAAGGCGCAGTGCGCGATACCAGTAAGT
TGGTCTAA

Upstream 100 bases:

>100_bases
AGAACCTAGAACCTAGAACCTAGAACCTAGAACCTAGAACCTAGAACCTAGAACCTAGAACCTAGAACCTAGAACCTTCT
TTTAAACAAAGGATAAAGCA

Downstream 100 bases:

>100_bases
TCAGTTTTCCGGGATTAAGAGGTAGTTTATGTTGGCTTTAGCATCACAATCGCAACTGGATTTAGCCCATTATTATTTGC
AGAAAATTTTGCTGTCATCG

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 615; Mature: 614

Protein sequence:

>615_residues
MPKLRSATSTEGRNMAGARALWRATGVKDNDFGKPIIAIANSFTQFVPGHVHLKDMGSLVAGAIEEAGGIAKEFNTIAVD
DGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADALVCISNCDKITPGMLMASLRLNIPVIFVSGGPMEAGKTKLSDQLI
KLDLVDAMVAGADSRVSDADSEQIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSMLATHADRRELFLEAGRRIM
DLATRYYQHDDESALPRNIANFKAFENAMTLDIAMGGSSNTVLHLLASAQEGEVDFTMDDIDRLSRLVPHLCKVAPSTPK
YHMEDVHRAGGVMGILGELDRANLLHNDVYHVAGSNLADVLARFDIVQTDDAAVHKFFSAGPAGIPTTKAFSQDCRWDSV
DNDRKEGCIRSREFAFSQEGGLAVLSGNVALDGCIVKTAGVEVENHTFIGSARVFESQDDAVAGILGGEVVAGDVVVIRY
EGPKGGPGMQEMLYPTSYLKSRGLGTKCALITDGRFSGGTSGLSIGHVSPEAAAGGTIGLVQTGDRIEIDIPARSIKLAI
SDIELAARRTAMEALGKDAWKPLGRVRQVSMALKAYALLATSADKGAVRDTSKLV

Sequences:

>Translated_615_residues
MPKLRSATSTEGRNMAGARALWRATGVKDNDFGKPIIAIANSFTQFVPGHVHLKDMGSLVAGAIEEAGGIAKEFNTIAVD
DGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADALVCISNCDKITPGMLMASLRLNIPVIFVSGGPMEAGKTKLSDQLI
KLDLVDAMVAGADSRVSDADSEQIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSMLATHADRRELFLEAGRRIM
DLATRYYQHDDESALPRNIANFKAFENAMTLDIAMGGSSNTVLHLLASAQEGEVDFTMDDIDRLSRLVPHLCKVAPSTPK
YHMEDVHRAGGVMGILGELDRANLLHNDVYHVAGSNLADVLARFDIVQTDDAAVHKFFSAGPAGIPTTKAFSQDCRWDSV
DNDRKEGCIRSREFAFSQEGGLAVLSGNVALDGCIVKTAGVEVENHTFIGSARVFESQDDAVAGILGGEVVAGDVVVIRY
EGPKGGPGMQEMLYPTSYLKSRGLGTKCALITDGRFSGGTSGLSIGHVSPEAAAGGTIGLVQTGDRIEIDIPARSIKLAI
SDIELAARRTAMEALGKDAWKPLGRVRQVSMALKAYALLATSADKGAVRDTSKLV
>Mature_614_residues
PKLRSATSTEGRNMAGARALWRATGVKDNDFGKPIIAIANSFTQFVPGHVHLKDMGSLVAGAIEEAGGIAKEFNTIAVDD
GIAMGHGGMLYSLPSRELIADSVEYMVNAHCADALVCISNCDKITPGMLMASLRLNIPVIFVSGGPMEAGKTKLSDQLIK
LDLVDAMVAGADSRVSDADSEQIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSMLATHADRRELFLEAGRRIMD
LATRYYQHDDESALPRNIANFKAFENAMTLDIAMGGSSNTVLHLLASAQEGEVDFTMDDIDRLSRLVPHLCKVAPSTPKY
HMEDVHRAGGVMGILGELDRANLLHNDVYHVAGSNLADVLARFDIVQTDDAAVHKFFSAGPAGIPTTKAFSQDCRWDSVD
NDRKEGCIRSREFAFSQEGGLAVLSGNVALDGCIVKTAGVEVENHTFIGSARVFESQDDAVAGILGGEVVAGDVVVIRYE
GPKGGPGMQEMLYPTSYLKSRGLGTKCALITDGRFSGGTSGLSIGHVSPEAAAGGTIGLVQTGDRIEIDIPARSIKLAIS
DIELAARRTAMEALGKDAWKPLGRVRQVSMALKAYALLATSADKGAVRDTSKLV

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=614, Percent_Identity=78.1758957654723, Blast_Score=994, Evalue=0.0,
Organism=Escherichia coli, GI1788157, Length=537, Percent_Identity=31.098696461825, Blast_Score=201, Evalue=8e-53,
Organism=Escherichia coli, GI2367371, Length=490, Percent_Identity=30.6122448979592, Blast_Score=178, Evalue=7e-46,
Organism=Escherichia coli, GI1786464, Length=539, Percent_Identity=30.2411873840445, Blast_Score=162, Evalue=6e-41,
Organism=Saccharomyces cerevisiae, GI6322476, Length=612, Percent_Identity=36.7647058823529, Blast_Score=334, Evalue=2e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 65142; Mature: 65011

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKLRSATSTEGRNMAGARALWRATGVKDNDFGKPIIAIANSFTQFVPGHVHLKDMGSLV
CCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AGAIEEAGGIAKEFNTIAVDDGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADALVCIS
HHHHHHHCCHHHHCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMASLRLNIPVIFVSGGPMEAGKTKLSDQLIKLDLVDAMVAGADSRVSDAD
CCCCCCHHHHHHHEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCC
SEQIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSMLATHADRRELFLEAGRRIM
HHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHHHHHH
DLATRYYQHDDESALPRNIANFKAFENAMTLDIAMGGSSNTVLHLLASAQEGEVDFTMDD
HHHHHHHCCCCCCCCCCHHHHHHHHCCCEEEEEEECCCCCCEEEEEECCCCCCEEEEHHH
IDRLSRLVPHLCKVAPSTPKYHMEDVHRAGGVMGILGELDRANLLHNDVYHVAGSNLADV
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEHHHCCHHHHHHHHHHHHHCCCCHHHH
LARFDIVQTDDAAVHKFFSAGPAGIPTTKAFSQDCRWDSVDNDRKEGCIRSREFAFSQEG
HHHHCCCCCCHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCC
GLAVLSGNVALDGCIVKTAGVEVENHTFIGSARVFESQDDAVAGILGGEVVAGDVVVIRY
CEEEEECCEEEEEEEEEECCCEEECCEEEECEEEECCCCCCEEEEECCCEEECCEEEEEE
EGPKGGPGMQEMLYPTSYLKSRGLGTKCALITDGRFSGGTSGLSIGHVSPEAAAGGTIGL
CCCCCCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCCEEECCCCCCCCCCCCEEE
VQTGDRIEIDIPARSIKLAISDIELAARRTAMEALGKDAWKPLGRVRQVSMALKAYALLA
EECCCEEEEEECCCEEEEEEHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHE
TSADKGAVRDTSKLV
ECCCCCCCCHHHCCC
>Mature Secondary Structure 
PKLRSATSTEGRNMAGARALWRATGVKDNDFGKPIIAIANSFTQFVPGHVHLKDMGSLV
CCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AGAIEEAGGIAKEFNTIAVDDGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADALVCIS
HHHHHHHCCHHHHCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMASLRLNIPVIFVSGGPMEAGKTKLSDQLIKLDLVDAMVAGADSRVSDAD
CCCCCCHHHHHHHEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCC
SEQIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSMLATHADRRELFLEAGRRIM
HHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHHHHHH
DLATRYYQHDDESALPRNIANFKAFENAMTLDIAMGGSSNTVLHLLASAQEGEVDFTMDD
HHHHHHHCCCCCCCCCCHHHHHHHHCCCEEEEEEECCCCCCEEEEEECCCCCCEEEEHHH
IDRLSRLVPHLCKVAPSTPKYHMEDVHRAGGVMGILGELDRANLLHNDVYHVAGSNLADV
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEHHHCCHHHHHHHHHHHHHCCCCHHHH
LARFDIVQTDDAAVHKFFSAGPAGIPTTKAFSQDCRWDSVDNDRKEGCIRSREFAFSQEG
HHHHCCCCCCHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCC
GLAVLSGNVALDGCIVKTAGVEVENHTFIGSARVFESQDDAVAGILGGEVVAGDVVVIRY
CEEEEECCEEEEEEEEEECCCEEECCEEEECEEEECCCCCCEEEEECCCEEECCEEEEEE
EGPKGGPGMQEMLYPTSYLKSRGLGTKCALITDGRFSGGTSGLSIGHVSPEAAAGGTIGL
CCCCCCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCCEEECCCCCCCCCCCCEEE
VQTGDRIEIDIPARSIKLAISDIELAARRTAMEALGKDAWKPLGRVRQVSMALKAYALLA
EECCCEEEEEECCCEEEEEEHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHE
TSADKGAVRDTSKLV
ECCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA