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The map label for this gene is mdh [H]

Identifier: 167625778

GI number: 167625778

Start: 4696141

End: 4697310

Strand: Reverse

Name: mdh [H]

Synonym: Shal_3873

Alternate gene names: 167625778

Gene position: 4697310-4696141 (Counterclockwise)

Preceding gene: 167625779

Following gene: 167625777

Centisome position: 89.87

GC content: 50.26

Gene sequence:

>1170_bases
ATGGAATTACAGGCAAATTGGCATTTCCCCACTGCTATTACCGTCGGTGATGGTTGCCTAAACCTGCTTGGCGAGCGTTG
TAAGGCGCTGCAGATGACGAAGGTATTGCTGGTAAGCGATCCCTGTTTGGCGACTATGCCTATGGTGAGTGAGGCGATGC
AATACTGCACTCTGGCAGGATTAAGCGTTGAGTTATTTTGTGATATTCGGACTAACCCGACAGATGAAGATGTTCTTGCT
GGAGTGCAGGTCTTTAACCAAGGCCGCTTTGATGGTGTCGTAGCTTTAGGTGGTGGCTCGAGTATCGATGCCGCAAAAGC
CATTGCCATGATAGCGAAGCAATCTATTTCACTGTGGGAGGCCGAAGACTGTGGCAATAACTGGACTCGCATCGATGCAA
GTTTAATAATCCCTGTTGTTGCAGTGCCGACCACCGCAGGTACTGGCTCTGAAGTTGGGCGGGCCGCGGTGATCACCGAT
ACTAAGGGCGCCCATGCTATTAAGCGGATTATATTTCACCCGCAAATGCTGCCCGCAAGTGTGCTGCTCGACCCTCGATT
GACCACTGGTTTGCCGGCAAATATGACTGCTGCCACGGGTTTCGATGCTTTATCGCATAATCTCGAAGCCTACTGCGCGC
CATCTTATCATCCGATGGCGGAGGGCATTGCGCTGGAGGGGATCCGCTTGATTCAAACCTATCTGCCTTTGGCTGTTGCC
AAAGGTGACGATATTGAGGCTAGAACTCAGATGTTGGTGGCCTCTACGATGGGGGCGACCAGTTTTCAGCGTGGACTCGG
TGGCATGCATGCTATCGCGCATACATTAGGTGCGCTGTATAACCAACATCACGGCTTACTCAATGCCATATTAATGCCCT
ATGTTTTACAGCGAAATCGTCACGCGATTGAGGCGCGGATCATCCGCCTAGCCCGTTATTTAGCACTTGAAGACTCAAGC
TTTGATGGTTTTTTAAATTGGATATTGCAGCTGCGAGAGCAGTTGGTGATACCGCACTCCTTGGCGGAAATTGGGCTAGA
TTTGCGGGATAAACGTCTTATCGGTGAGATGTCGGCAAAAGATGCTGCGGCCAAGGGAAATCCGATAGCCTTGACTCAAG
CTCAGTATTCACAACTGTTTGAGCAAGCGGTTTTAGGTGAGTTGAATTAA

Upstream 100 bases:

>100_bases
TTAGGTTTTGAGCAGCTGACTCGGCCCAAGTCATTTCATATCAAACATAATTAAATTCACTGCCGTTGGGTGCATTGCGG
CAATACCTTAGGAGCCATCA

Downstream 100 bases:

>100_bases
GTTTGTTGCTGTTTGAACTTAAGTTATAAAACTCAGACGGATTCGATTCTAGCTTACTGCAGGAGAGGCGAATGATATTG
GGTATATTACAATGTGATGA

Product: iron-containing alcohol dehydrogenase

Products: NA

Alternate protein names: MEDH [H]

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MELQANWHFPTAITVGDGCLNLLGERCKALQMTKVLLVSDPCLATMPMVSEAMQYCTLAGLSVELFCDIRTNPTDEDVLA
GVQVFNQGRFDGVVALGGGSSIDAAKAIAMIAKQSISLWEAEDCGNNWTRIDASLIIPVVAVPTTAGTGSEVGRAAVITD
TKGAHAIKRIIFHPQMLPASVLLDPRLTTGLPANMTAATGFDALSHNLEAYCAPSYHPMAEGIALEGIRLIQTYLPLAVA
KGDDIEARTQMLVASTMGATSFQRGLGGMHAIAHTLGALYNQHHGLLNAILMPYVLQRNRHAIEARIIRLARYLALEDSS
FDGFLNWILQLREQLVIPHSLAEIGLDLRDKRLIGEMSAKDAAAKGNPIALTQAQYSQLFEQAVLGELN

Sequences:

>Translated_389_residues
MELQANWHFPTAITVGDGCLNLLGERCKALQMTKVLLVSDPCLATMPMVSEAMQYCTLAGLSVELFCDIRTNPTDEDVLA
GVQVFNQGRFDGVVALGGGSSIDAAKAIAMIAKQSISLWEAEDCGNNWTRIDASLIIPVVAVPTTAGTGSEVGRAAVITD
TKGAHAIKRIIFHPQMLPASVLLDPRLTTGLPANMTAATGFDALSHNLEAYCAPSYHPMAEGIALEGIRLIQTYLPLAVA
KGDDIEARTQMLVASTMGATSFQRGLGGMHAIAHTLGALYNQHHGLLNAILMPYVLQRNRHAIEARIIRLARYLALEDSS
FDGFLNWILQLREQLVIPHSLAEIGLDLRDKRLIGEMSAKDAAAKGNPIALTQAQYSQLFEQAVLGELN
>Mature_389_residues
MELQANWHFPTAITVGDGCLNLLGERCKALQMTKVLLVSDPCLATMPMVSEAMQYCTLAGLSVELFCDIRTNPTDEDVLA
GVQVFNQGRFDGVVALGGGSSIDAAKAIAMIAKQSISLWEAEDCGNNWTRIDASLIIPVVAVPTTAGTGSEVGRAAVITD
TKGAHAIKRIIFHPQMLPASVLLDPRLTTGLPANMTAATGFDALSHNLEAYCAPSYHPMAEGIALEGIRLIQTYLPLAVA
KGDDIEARTQMLVASTMGATSFQRGLGGMHAIAHTLGALYNQHHGLLNAILMPYVLQRNRHAIEARIIRLARYLALEDSS
FDGFLNWILQLREQLVIPHSLAEIGLDLRDKRLIGEMSAKDAAAKGNPIALTQAQYSQLFEQAVLGELN

Specific function: May Act On The Acetaldehyde Produced From The Degradation Of Ethanolamine. [C]

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Integral Membrane Protein [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=304, Percent_Identity=28.6184210526316, Blast_Score=99, Evalue=9e-21,
Organism=Escherichia coli, GI87082107, Length=380, Percent_Identity=31.3157894736842, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI48994951, Length=360, Percent_Identity=31.3888888888889, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI1789163, Length=379, Percent_Identity=28.2321899736148, Blast_Score=149, Evalue=4e-37,
Organism=Escherichia coli, GI1787493, Length=374, Percent_Identity=28.0748663101604, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1789386, Length=359, Percent_Identity=25.6267409470752, Blast_Score=86, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17537053, Length=284, Percent_Identity=28.5211267605634, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6321181, Length=380, Percent_Identity=31.8421052631579, Blast_Score=190, Evalue=3e-49,
Organism=Drosophila melanogaster, GI24657991, Length=418, Percent_Identity=26.555023923445, Blast_Score=100, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.244 [H]

Molecular weight: Translated: 41854; Mature: 41854

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: PS00913 ADH_IRON_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELQANWHFPTAITVGDGCLNLLGERCKALQMTKVLLVSDPCLATMPMVSEAMQYCTLAG
CCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHCC
LSVELFCDIRTNPTDEDVLAGVQVFNQGRFDGVVALGGGSSIDAAKAIAMIAKQSISLWE
CEEEEEEEECCCCCHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCEE
AEDCGNNWTRIDASLIIPVVAVPTTAGTGSEVGRAAVITDTKGAHAIKRIIFHPQMLPAS
HHHCCCCCEEECCEEEEEEEEECCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCHH
VLLDPRLTTGLPANMTAATGFDALSHNLEAYCAPSYHPMAEGIALEGIRLIQTYLPLAVA
HEECCCCCCCCCCCCCHHHCHHHHHCCCCEEECCCCCCHHCCHHHHHHHHHHHHHHHHEE
KGDDIEARTQMLVASTMGATSFQRGLGGMHAIAHTLGALYNQHHGLLNAILMPYVLQRNR
CCCCHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
HAIEARIIRLARYLALEDSSFDGFLNWILQLREQLVIPHSLAEIGLDLRDKRLIGEMSAK
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHH
DAAAKGNPIALTQAQYSQLFEQAVLGELN
HHCCCCCCEEEEHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MELQANWHFPTAITVGDGCLNLLGERCKALQMTKVLLVSDPCLATMPMVSEAMQYCTLAG
CCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHCC
LSVELFCDIRTNPTDEDVLAGVQVFNQGRFDGVVALGGGSSIDAAKAIAMIAKQSISLWE
CEEEEEEEECCCCCHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCEE
AEDCGNNWTRIDASLIIPVVAVPTTAGTGSEVGRAAVITDTKGAHAIKRIIFHPQMLPAS
HHHCCCCCEEECCEEEEEEEEECCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCHH
VLLDPRLTTGLPANMTAATGFDALSHNLEAYCAPSYHPMAEGIALEGIRLIQTYLPLAVA
HEECCCCCCCCCCCCCHHHCHHHHHCCCCEEECCCCCCHHCCHHHHHHHHHHHHHHHHEE
KGDDIEARTQMLVASTMGATSFQRGLGGMHAIAHTLGALYNQHHGLLNAILMPYVLQRNR
CCCCHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
HAIEARIIRLARYLALEDSSFDGFLNWILQLREQLVIPHSLAEIGLDLRDKRLIGEMSAK
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHH
DAAAKGNPIALTQAQYSQLFEQAVLGELN
HHCCCCCCEEEEHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1644761; 1995642 [H]