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The map label for this gene is guaA [C]

Identifier: 167625777

GI number: 167625777

Start: 4695347

End: 4696069

Strand: Reverse

Name: guaA [C]

Synonym: Shal_3872

Alternate gene names: 167625777

Gene position: 4696069-4695347 (Counterclockwise)

Preceding gene: 167625778

Following gene: 167625776

Centisome position: 89.84

GC content: 46.2

Gene sequence:

>723_bases
ATGATATTGGGTATATTACAATGTGATGATGTCAGGCCTGAATTGCAGGCTAAGTATGGCAACTATCCGCAGATGTTTAT
CTCTTTATTCGAGTCCGTGGGCGTTACGATCCAGTTCAAGGTTTATAGGGTCATTGATGGGCAATACCCAGAATCAATCG
ATAGATGTGATGCCTATATCACGACTGGCAGCCGTTTTGGGGTGAACGATGATGCGGACTGGATACGGCGGTTTGAACAG
TTTGTCGTTGAGCTATATCTGGCGAATAAAAGATTTATCGGGATCTGTTTTGGGCACCAAATGATGGCAAAGGCCTTGGG
CGGACAGATTAAGCCGTCTGAAAAAGGGTGGGGGATAGGTGTCAATAAGGCGCAAATCGTCCTGCCGCAAGCTTGGATGA
GTGCTGATCTTAATGAAATATCGCTAGTGGTCAGCCATCAAGAGCAAGTGGTTAAATTACCCGAAGATGCAGTCATACTG
GCCGGGAGTGAGTTTTGTCCCTTTTATATGATGCAAATCAAGCAACATTTCCTTGGCATTCAAGGTCACCCTGAGTTTAG
CAAAGAGTATGTGCGTGCATTAATGGATGCCCGGCGAGATTGCATTCCAGCTCAGCAAATTACAGCAGGAATAGAATCGC
TGTCGATGCCAGTTGACGCAGCCTTAGTGTCGCGTTGGTTGGTTAATTTTCTCATTCAAACTCGCGCAGGAGGCCATTTG
TGA

Upstream 100 bases:

>100_bases
AGCAAGCGGTTTTAGGTGAGTTGAATTAAGTTTGTTGCTGTTTGAACTTAAGTTATAAAACTCAGACGGATTCGATTCTA
GCTTACTGCAGGAGAGGCGA

Downstream 100 bases:

>100_bases
ATAAGGTCCCAGCCATTACCTATGACAGTAAAAAGCGTATAATCAATCTAAATTAAAGCCTCAATCTAAATCGATAACAC
TATGCAGCTAAAACCACTCG

Product: GMP synthase glutamine amidotransferase subunit

Products: AMP; L-Glutamate; GMP; H+; Diphosphate [C]

Alternate protein names: Glutamine Amidotransferase Class I; Glutamine Amidotransferase; Amidotransferase; GMP Synthase; Class I Glutamine Amidotransferase; GMP Synthase Glutamine Amidotransferase Subunit; Class I Glutamine Amidotransferase Family Protein; Glutamine Amidotransferase Class-I Family Protein; Glutamine Amidotransferase Class-I Family; Glutamine Amidotransferase Protein; Guanosine Monophosphate Synthetase; GMP Synthase Subunit A

Number of amino acids: Translated: 240; Mature: 240

Protein sequence:

>240_residues
MILGILQCDDVRPELQAKYGNYPQMFISLFESVGVTIQFKVYRVIDGQYPESIDRCDAYITTGSRFGVNDDADWIRRFEQ
FVVELYLANKRFIGICFGHQMMAKALGGQIKPSEKGWGIGVNKAQIVLPQAWMSADLNEISLVVSHQEQVVKLPEDAVIL
AGSEFCPFYMMQIKQHFLGIQGHPEFSKEYVRALMDARRDCIPAQQITAGIESLSMPVDAALVSRWLVNFLIQTRAGGHL

Sequences:

>Translated_240_residues
MILGILQCDDVRPELQAKYGNYPQMFISLFESVGVTIQFKVYRVIDGQYPESIDRCDAYITTGSRFGVNDDADWIRRFEQ
FVVELYLANKRFIGICFGHQMMAKALGGQIKPSEKGWGIGVNKAQIVLPQAWMSADLNEISLVVSHQEQVVKLPEDAVIL
AGSEFCPFYMMQIKQHFLGIQGHPEFSKEYVRALMDARRDCIPAQQITAGIESLSMPVDAALVSRWLVNFLIQTRAGGHL
>Mature_240_residues
MILGILQCDDVRPELQAKYGNYPQMFISLFESVGVTIQFKVYRVIDGQYPESIDRCDAYITTGSRFGVNDDADWIRRFEQ
FVVELYLANKRFIGICFGHQMMAKALGGQIKPSEKGWGIGVNKAQIVLPQAWMSADLNEISLVVSHQEQVVKLPEDAVIL
AGSEFCPFYMMQIKQHFLGIQGHPEFSKEYVRALMDARRDCIPAQQITAGIESLSMPVDAALVSRWLVNFLIQTRAGGHL

Specific function: Catalyzes The Synthesis Of Gmp From Xmp. [C]

COG id: COG0518

COG function: function code F; GMP synthase - Glutamine amidotransferase domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Saccharomyces cerevisiae, GI6323155, Length=214, Percent_Identity=26.1682242990654, Blast_Score=73, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 6.3.5.2 [C]

Molecular weight: Translated: 27068; Mature: 27068

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILGILQCDDVRPELQAKYGNYPQMFISLFESVGVTIQFKVYRVIDGQYPESIDRCDAYI
CEEEEEECCCCCHHHHHHCCCCHHHHHHHHHHCCCEEEEEEEEEECCCCCHHHHHHHHEE
TTGSRFGVNDDADWIRRFEQFVVELYLANKRFIGICFGHQMMAKALGGQIKPSEKGWGIG
ECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHCCCCCCCCCCCCCC
VNKAQIVLPQAWMSADLNEISLVVSHQEQVVKLPEDAVILAGSEFCPFYMMQIKQHFLGI
CCCCEEEECHHHHHCCHHHHHEEEECCHHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCC
QGHPEFSKEYVRALMDARRDCIPAQQITAGIESLSMPVDAALVSRWLVNFLIQTRAGGHL
CCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MILGILQCDDVRPELQAKYGNYPQMFISLFESVGVTIQFKVYRVIDGQYPESIDRCDAYI
CEEEEEECCCCCHHHHHHCCCCHHHHHHHHHHCCCEEEEEEEEEECCCCCHHHHHHHHEE
TTGSRFGVNDDADWIRRFEQFVVELYLANKRFIGICFGHQMMAKALGGQIKPSEKGWGIG
ECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHCCCCCCCCCCCCCC
VNKAQIVLPQAWMSADLNEISLVVSHQEQVVKLPEDAVILAGSEFCPFYMMQIKQHFLGI
CCCCEEEECHHHHHCCHHHHHEEEECCHHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCC
QGHPEFSKEYVRALMDARRDCIPAQQITAGIESLSMPVDAALVSRWLVNFLIQTRAGGHL
CCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.35 {8-azaXMP}} 1 {NH4+}} 0.42 {6-thioXMP}} 0.53 {ATP}} 2 {1-ribosyl-4,6-dihydroxypyrazolo[3,4-d]-pyrimidine} 0.058 {XMP}} 0.029 {XMP}} [C]

Substrates: ATP; L-Glutamine; H2O; Xanthosine 5'-phosphate [C]

Specific reaction: ATP + L-Glutamine + H2O + Xanthosine 5'-phosphate --> AMP + L-Glutamate + GMP + (2) H+ + Diphosphate [C]

General reaction: Amination [C]

Inhibitor: 1, N6-Ethenoadenosine; 1-Methyl adenosine 5'-phosphate 5'-phosphate; 2', 3'-Dihydroadenosine; 2'-Deoxyadenosine; 2, 6-Diaminopurine ribonucleoside; 2-Amino-6-methyl thiopurine ribonucleoside; 2-Fluoroadenosine; 3'-Deoxyadenosine; 5'-Azido-5'-deoxyadenosin

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA