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The map label for this gene is purP [H]

Identifier: 167625227

GI number: 167625227

Start: 4044020

End: 4045405

Strand: Reverse

Name: purP [H]

Synonym: Shal_3315

Alternate gene names: 167625227

Gene position: 4045405-4044020 (Counterclockwise)

Preceding gene: 167625229

Following gene: 167625225

Centisome position: 77.4

GC content: 48.27

Gene sequence:

>1386_bases
ATGAGTACGCCAAGCAATAAACAACATGCTGCAACTAATGAAGAGCCTGCAGAAGCTTGTGCTTCTGCCCAACCTGCAAG
TGGTGGGTTGTTAGAGCGCTTTTTTAAATTATCAGCCCACAACACCACTGTATCTACCGAAGTTATAGCGGGCATTACCA
CCTTCATGACCATGGTGTATATCGTGTTCGTGAATCCACAAATTCTATCGGCTGCTGGTATGGATGCCAGTGCGGTATTT
GTGGTCACCTGTTTGATCAGCGCTATCGGCTGTATCGCCATGGGCTTAATTGCCAATCTGCCAATTGCACTAGCGCCTGC
AATGGGTCTAAATGCGTTTTTTGCCTTCTCTGTAGTAGTGGGGATGGGCGTAAGCTGGCAAATCGGTATGGGCACCATTT
TTTGGGGCGCAGTTTGTTTTGCTATTGTGTCCTTACTTGGGATCCGTTCTTGGATCTTAACCAATATCCCAAAATGTTTA
CGTATTGGTATTCCTAGCGGTATCGGTTTGCTGATAGCCATGGTTGGCTTTAGTAATGCCGGCATTGTGGTCGCAAGTCC
AGCGACTATGATCACCGTTGGCGACTTAAGCTCACTGCAGTGTGTTTTAGGTGCGCTAGGTTTCTTTATTATCGTAATTC
TAGCCTCTCGTGGTATTCATTCCGCTGTGCTGGTCTCGATTGCCGTTGTGACTGCCATAGCGGCCCTGATGGGGGATATT
GAGTACACTGGCATCGTGTCTATGCCGCCTAGTATCGCTAATACCTTTGGTCAGCTCGATCTTGCAGGTTCATTAGATGT
GGCGTTGATGGGCGTTATTTTCTCATTTGCCTTAGTAAGCCTTTTCGATAGTTCTGGCACCATGATTGGCGTCACTGAAA
AGTGCGGTTTCACTGATGAGCGCGGCCGTTTCCCACGTATGAAACAAGCCTTGATGACAGACTCTGCAACTTCTGTTGTT
GGCGCTTACATGGGCACATCAACGGTAACGGCTTACATTGAAAGCTCGGCAGGTGTCGCTGCGGGTGGCCGTACCGGTTT
AACCGCAATCGTTGCCGGTCTACTGTTTGTTTTGGTGATTTTCTTCTCGCCATTGGCGGCTATGGTACCGGGTTACGCGG
TTGCTGGCGCGCTGGTTTATGTCGGTATTTTGATGTCATCAGAACTGGCTAAAATTGATGGTAAAGACTTAACCGAGTCG
GCTCCAGCCTTTATCACCGCAGTGATGATGCCATTTACCTTCTCAATCACCGAAGGCGTAGCAGCAGGTTTTATTACTTA
CTGCGTATTGAAAGCGGGCACCAATCGCTGGCGTGAAATCCACCCTGGTGTGGCGCTAGTGGCACTGCTATTTATTATCA
AGTTTGCCTTTGTTGATGGGCATTAA

Upstream 100 bases:

>100_bases
TTTCAGGGGATCAAGTGTGTGCGTCGTAAATTTAATATTGATGTTGCACAGCTGTTTGGGACGCGGGTTGAGTGAAGTTA
AAAGTGGAAATAATCTATTT

Downstream 100 bases:

>100_bases
TTCTACTCGCTTAAATGAGTAGCTTGTAAAAGTGATAAACAAATAAAAGGCTCAGAAGGATTACCTTCTGAGCCTTTTTT
ATATGACTAGATTTACAAAG

Product: xanthine/uracil/vitamin C permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MSTPSNKQHAATNEEPAEACASAQPASGGLLERFFKLSAHNTTVSTEVIAGITTFMTMVYIVFVNPQILSAAGMDASAVF
VVTCLISAIGCIAMGLIANLPIALAPAMGLNAFFAFSVVVGMGVSWQIGMGTIFWGAVCFAIVSLLGIRSWILTNIPKCL
RIGIPSGIGLLIAMVGFSNAGIVVASPATMITVGDLSSLQCVLGALGFFIIVILASRGIHSAVLVSIAVVTAIAALMGDI
EYTGIVSMPPSIANTFGQLDLAGSLDVALMGVIFSFALVSLFDSSGTMIGVTEKCGFTDERGRFPRMKQALMTDSATSVV
GAYMGTSTVTAYIESSAGVAAGGRTGLTAIVAGLLFVLVIFFSPLAAMVPGYAVAGALVYVGILMSSELAKIDGKDLTES
APAFITAVMMPFTFSITEGVAAGFITYCVLKAGTNRWREIHPGVALVALLFIIKFAFVDGH

Sequences:

>Translated_461_residues
MSTPSNKQHAATNEEPAEACASAQPASGGLLERFFKLSAHNTTVSTEVIAGITTFMTMVYIVFVNPQILSAAGMDASAVF
VVTCLISAIGCIAMGLIANLPIALAPAMGLNAFFAFSVVVGMGVSWQIGMGTIFWGAVCFAIVSLLGIRSWILTNIPKCL
RIGIPSGIGLLIAMVGFSNAGIVVASPATMITVGDLSSLQCVLGALGFFIIVILASRGIHSAVLVSIAVVTAIAALMGDI
EYTGIVSMPPSIANTFGQLDLAGSLDVALMGVIFSFALVSLFDSSGTMIGVTEKCGFTDERGRFPRMKQALMTDSATSVV
GAYMGTSTVTAYIESSAGVAAGGRTGLTAIVAGLLFVLVIFFSPLAAMVPGYAVAGALVYVGILMSSELAKIDGKDLTES
APAFITAVMMPFTFSITEGVAAGFITYCVLKAGTNRWREIHPGVALVALLFIIKFAFVDGH
>Mature_460_residues
STPSNKQHAATNEEPAEACASAQPASGGLLERFFKLSAHNTTVSTEVIAGITTFMTMVYIVFVNPQILSAAGMDASAVFV
VTCLISAIGCIAMGLIANLPIALAPAMGLNAFFAFSVVVGMGVSWQIGMGTIFWGAVCFAIVSLLGIRSWILTNIPKCLR
IGIPSGIGLLIAMVGFSNAGIVVASPATMITVGDLSSLQCVLGALGFFIIVILASRGIHSAVLVSIAVVTAIAALMGDIE
YTGIVSMPPSIANTFGQLDLAGSLDVALMGVIFSFALVSLFDSSGTMIGVTEKCGFTDERGRFPRMKQALMTDSATSVVG
AYMGTSTVTAYIESSAGVAAGGRTGLTAIVAGLLFVLVIFFSPLAAMVPGYAVAGALVYVGILMSSELAKIDGKDLTESA
PAFITAVMMPFTFSITEGVAAGFITYCVLKAGTNRWREIHPGVALVALLFIIKFAFVDGH

Specific function: High-affinity uptake of adenine [H]

COG id: COG2252

COG function: function code R; Permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. AzgA purine transporter (TC 2.A.1.40) subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790150, Length=440, Percent_Identity=65, Blast_Score=574, Evalue=1e-165,
Organism=Escherichia coli, GI87082309, Length=431, Percent_Identity=60.7888631090487, Blast_Score=536, Evalue=1e-153,
Organism=Escherichia coli, GI1790499, Length=438, Percent_Identity=36.986301369863, Blast_Score=284, Evalue=1e-77,
Organism=Escherichia coli, GI48994909, Length=431, Percent_Identity=35.9628770301624, Blast_Score=261, Evalue=8e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 47600; Mature: 47469

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTPSNKQHAATNEEPAEACASAQPASGGLLERFFKLSAHNTTVSTEVIAGITTFMTMVY
CCCCCCCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
IVFVNPQILSAAGMDASAVFVVTCLISAIGCIAMGLIANLPIALAPAMGLNAFFAFSVVV
HHHCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
GMGVSWQIGMGTIFWGAVCFAIVSLLGIRSWILTNIPKCLRIGIPSGIGLLIAMVGFSNA
HCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHCCCCC
GIVVASPATMITVGDLSSLQCVLGALGFFIIVILASRGIHSAVLVSIAVVTAIAALMGDI
CEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCC
EYTGIVSMPPSIANTFGQLDLAGSLDVALMGVIFSFALVSLFDSSGTMIGVTEKCGFTDE
CCCEEECCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCC
RGRFPRMKQALMTDSATSVVGAYMGTSTVTAYIESSAGVAAGGRTGLTAIVAGLLFVLVI
CCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCHHHHHHHHHHHHHH
FFSPLAAMVPGYAVAGALVYVGILMSSELAKIDGKDLTESAPAFITAVMMPFTFSITEGV
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
AAGFITYCVLKAGTNRWREIHPGVALVALLFIIKFAFVDGH
HHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
STPSNKQHAATNEEPAEACASAQPASGGLLERFFKLSAHNTTVSTEVIAGITTFMTMVY
CCCCCCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
IVFVNPQILSAAGMDASAVFVVTCLISAIGCIAMGLIANLPIALAPAMGLNAFFAFSVVV
HHHCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
GMGVSWQIGMGTIFWGAVCFAIVSLLGIRSWILTNIPKCLRIGIPSGIGLLIAMVGFSNA
HCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHCCCCC
GIVVASPATMITVGDLSSLQCVLGALGFFIIVILASRGIHSAVLVSIAVVTAIAALMGDI
CEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCC
EYTGIVSMPPSIANTFGQLDLAGSLDVALMGVIFSFALVSLFDSSGTMIGVTEKCGFTDE
CCCEEECCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCC
RGRFPRMKQALMTDSATSVVGAYMGTSTVTAYIESSAGVAAGGRTGLTAIVAGLLFVLVI
CCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCHHHHHHHHHHHHHH
FFSPLAAMVPGYAVAGALVYVGILMSSELAKIDGKDLTESAPAFITAVMMPFTFSITEGV
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
AAGFITYCVLKAGTNRWREIHPGVALVALLFIIKFAFVDGH
HHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7686882; 9278503 [H]