Click here to switch to the map view.

The map label for this gene is lpxB

Identifier: 167624882

GI number: 167624882

Start: 3611722

End: 3612873

Strand: Reverse

Name: lpxB

Synonym: Shal_2968

Alternate gene names: 167624882

Gene position: 3612873-3611722 (Counterclockwise)

Preceding gene: 167624883

Following gene: 167624881

Centisome position: 69.12

GC content: 46.35

Gene sequence:

>1152_bases
ATGAGTTCAAACAATCCTCATGTATTTGCAATGGTTGCCGGAGAGATCTCGGGCGACATACTCGGTGCAGGCTTAATTAA
AGCACTAAAGACTCGATATCCAGATGCTAAATTTGTCGGAATAGGTGGGCCCCGTATGGAAGCCCTAGGTTTTGAGTCTA
TCTTCTCTTATGAAGAGCTCGCTGTGATGGGCATCGTTGAGGTCCTATCGCGCTTACCTAGGTTGCTAAAAGTGCGGGCA
ACATTAATCGATGAGTTGGTTAAGATAAATCCGGACTGTTTTATTGGTATCGATGCACCGGATTTTAATATCGGTTTAGA
GTTAAAGCTTAAGAACCGTGGCATTAAAACGGTGCATTACGTTAGCCCATCAGTATGGGCATGGCGACCAAAGCGTATTT
TCAAAATAGCCAAGGCTACCGATATGGTGCTGTCACTGCTACCTTTTGAAAAAGCGTTTTATGATAAACATCAAGTGCCT
TGCACCTTTGTAGGCCATACCTTGGCCGATGATATTGAACTTGAAAGCGATAAAGCGCAGGCCCGTGAATTACTCGGGCT
AGATAAAGAAGCTGAGTACTTGGCGATATTACCGGGTTCTCGAGGGGGGGAGCTTAAGATGTTGGCCGAGCCGTTTGTTA
AGGCGGCGAGCCTAATCAAACAGCGCTATCCAGATATCAAATTTGTTACGCCCTTGGTTAATCAAAAGCGTCGCGACCAA
TTTGAGCAAGCTCTACGCGAGCATGCGCCGGATCTAGAGATCGATTTAGTTGAAGGTCAGTCCCGAGAGGTAATGGCTGC
CGCTGACTGCATACTGCTAGCTTCAGGTACTGCAACGCTTGAAGCCATGCTGGTTAAGCGTCCCATGGTAGTGGCTTATC
GCGTTAGCCCAATAACGTATCGTATCGCTAAAGGCATGATGCTCACTAAGCGATATTCATTACCAAACCTCCTTGCAGAT
GATGATGTGGTTGAGGAGCTAATTCAGGCCGACTGTACGCCAGAGAAAATAGCGACAGCCGTTGCAACTCAGCTAGATAA
TGACTTTAGCCCAATGTATGATCGCTTTATGCAGATGCATAAGAGCCTTCGTTGTGATGCCAGTGCACGTGCTGCAGATG
CTGTGATTAAGTTAGTAGAGGATAAAGTCTAA

Upstream 100 bases:

>100_bases
GTTGCTTCCTCGCAACGAGGCATCATTCGCTAGTCAAGTTATAGAGCCCGTGTAAAAGCGGGTTCTTTCTTTCCACCTCA
TCAATGACAGACGCCATTCT

Downstream 100 bases:

>100_bases
TGGCGGTGATTAAAGGTATTACACCAGAGCAGGTGGCTCAAATTTGTATTGGTCACTATGCCGGTGTCGATGAGGTTGGC
CGCGGACCTTTGATTGGCAA

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 383; Mature: 382

Protein sequence:

>383_residues
MSSNNPHVFAMVAGEISGDILGAGLIKALKTRYPDAKFVGIGGPRMEALGFESIFSYEELAVMGIVEVLSRLPRLLKVRA
TLIDELVKINPDCFIGIDAPDFNIGLELKLKNRGIKTVHYVSPSVWAWRPKRIFKIAKATDMVLSLLPFEKAFYDKHQVP
CTFVGHTLADDIELESDKAQARELLGLDKEAEYLAILPGSRGGELKMLAEPFVKAASLIKQRYPDIKFVTPLVNQKRRDQ
FEQALREHAPDLEIDLVEGQSREVMAAADCILLASGTATLEAMLVKRPMVVAYRVSPITYRIAKGMMLTKRYSLPNLLAD
DDVVEELIQADCTPEKIATAVATQLDNDFSPMYDRFMQMHKSLRCDASARAADAVIKLVEDKV

Sequences:

>Translated_383_residues
MSSNNPHVFAMVAGEISGDILGAGLIKALKTRYPDAKFVGIGGPRMEALGFESIFSYEELAVMGIVEVLSRLPRLLKVRA
TLIDELVKINPDCFIGIDAPDFNIGLELKLKNRGIKTVHYVSPSVWAWRPKRIFKIAKATDMVLSLLPFEKAFYDKHQVP
CTFVGHTLADDIELESDKAQARELLGLDKEAEYLAILPGSRGGELKMLAEPFVKAASLIKQRYPDIKFVTPLVNQKRRDQ
FEQALREHAPDLEIDLVEGQSREVMAAADCILLASGTATLEAMLVKRPMVVAYRVSPITYRIAKGMMLTKRYSLPNLLAD
DDVVEELIQADCTPEKIATAVATQLDNDFSPMYDRFMQMHKSLRCDASARAADAVIKLVEDKV
>Mature_382_residues
SSNNPHVFAMVAGEISGDILGAGLIKALKTRYPDAKFVGIGGPRMEALGFESIFSYEELAVMGIVEVLSRLPRLLKVRAT
LIDELVKINPDCFIGIDAPDFNIGLELKLKNRGIKTVHYVSPSVWAWRPKRIFKIAKATDMVLSLLPFEKAFYDKHQVPC
TFVGHTLADDIELESDKAQARELLGLDKEAEYLAILPGSRGGELKMLAEPFVKAASLIKQRYPDIKFVTPLVNQKRRDQF
EQALREHAPDLEIDLVEGQSREVMAAADCILLASGTATLEAMLVKRPMVVAYRVSPITYRIAKGMMLTKRYSLPNLLADD
DVVEELIQADCTPEKIATAVATQLDNDFSPMYDRFMQMHKSLRCDASARAADAVIKLVEDKV

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family

Homologues:

Organism=Escherichia coli, GI1786379, Length=382, Percent_Identity=56.282722513089, Blast_Score=440, Evalue=1e-125,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXB_SHEHH (B0TP70)

Other databases:

- EMBL:   CP000931
- RefSeq:   YP_001675176.1
- ProteinModelPortal:   B0TP70
- GeneID:   5906834
- GenomeReviews:   CP000931_GR
- KEGG:   shl:Shal_2968
- HOGENOM:   HBG584837
- OMA:   DFTHRVA
- ProtClustDB:   PRK00025
- BioCyc:   SHAL458817:SHAL_2968-MONOMER
- HAMAP:   MF_00392
- InterPro:   IPR003835
- TIGRFAMs:   TIGR00215

Pfam domain/function: PF02684 LpxB

EC number: =2.4.1.182

Molecular weight: Translated: 42598; Mature: 42467

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSNNPHVFAMVAGEISGDILGAGLIKALKTRYPDAKFVGIGGPRMEALGFESIFSYEEL
CCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHH
AVMGIVEVLSRLPRLLKVRATLIDELVKINPDCFIGIDAPDFNIGLELKLKNRGIKTVHY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEECCCCCEEEEE
VSPSVWAWRPKRIFKIAKATDMVLSLLPFEKAFYDKHQVPCTFVGHTLADDIELESDKAQ
ECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHCCCCCCCHHHH
ARELLGLDKEAEYLAILPGSRGGELKMLAEPFVKAASLIKQRYPDIKFVTPLVNQKRRDQ
HHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEECHHHCHHHHHH
FEQALREHAPDLEIDLVEGQSREVMAAADCILLASGTATLEAMLVKRPMVVAYRVSPITY
HHHHHHHCCCCCEEEEECCCCCCHHHHHCEEEEECCHHHHHHHHHCCCEEEEEEECCHHH
RIAKGMMLTKRYSLPNLLADDDVVEELIQADCTPEKIATAVATQLDNDFSPMYDRFMQMH
HHHCCCCEEECCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHH
KSLRCDASARAADAVIKLVEDKV
HHHCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SSNNPHVFAMVAGEISGDILGAGLIKALKTRYPDAKFVGIGGPRMEALGFESIFSYEEL
CCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHH
AVMGIVEVLSRLPRLLKVRATLIDELVKINPDCFIGIDAPDFNIGLELKLKNRGIKTVHY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEECCCCCEEEEE
VSPSVWAWRPKRIFKIAKATDMVLSLLPFEKAFYDKHQVPCTFVGHTLADDIELESDKAQ
ECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHCCCCCCCHHHH
ARELLGLDKEAEYLAILPGSRGGELKMLAEPFVKAASLIKQRYPDIKFVTPLVNQKRRDQ
HHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEECHHHCHHHHHH
FEQALREHAPDLEIDLVEGQSREVMAAADCILLASGTATLEAMLVKRPMVVAYRVSPITY
HHHHHHHCCCCCEEEEECCCCCCHHHHHCEEEEECCHHHHHHHHHCCCEEEEEEECCHHH
RIAKGMMLTKRYSLPNLLADDDVVEELIQADCTPEKIATAVATQLDNDFSPMYDRFMQMH
HHHCCCCEEECCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHH
KSLRCDASARAADAVIKLVEDKV
HHHCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA