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The map label for this gene is dmsA [H]

Identifier: 167624840

GI number: 167624840

Start: 3555901

End: 3558423

Strand: Reverse

Name: dmsA [H]

Synonym: Shal_2926

Alternate gene names: 167624840

Gene position: 3558423-3555901 (Counterclockwise)

Preceding gene: 167624841

Following gene: 167624839

Centisome position: 68.08

GC content: 47.48

Gene sequence:

>2523_bases
ATGGAACGTAGAAGTTTCTTAAAAATGAGTGCTGCGCTGGGCTGCGCAGCAACAGTTACCGGCTGTAATTCTAGCTCTGA
CGATGCCAACGTGATCCCACCACAACCGCCTGTTAAAGACGAAGTGGTGAACTGGTCATCTTGCCTAGTTAACTGTGGTT
CTAACTGTCCAATTAAAGTCTTTACTAAAGACGGTATCGTGACGCGCGTTGAAACCGATCACGAAGTAGAAGACAACTAT
GGTCTACACCAAGTTCGTGCTTGTGCTCGTGGCCGTTCACTACGTCAAAGAAACTACGCCGTTGACCGCCTAAAGACACC
AATGAAGCGTGTTGGTGAGCGCGGTAAAGCAGAATTTGTACCCATTAGCTGGGACGAAGCAACTAGCATTATTGCTGAAA
AGCTATCTGCTGTTTATGCACAAGAGAACGGTGCTAAGTCAGTATTCCGTAGCTATGGTTCAGGTGCTTACTATGGTTTT
GCATCAAATGCCTGTTTCAACCGTCTATTTAACCTAAACGGTGGCTGCCTAAATGCTTATGGTAACTACTCTTGGGCGCA
GCAGATGGAAGCGGCGAAGCACACCTTCGGTACCGGTAGTACCATGGGTTCTTCAACCATTACTATCGAAGACAGTGATT
TCTTCCTAGGCGTGGCGTACAACCCAAGCGAAATCCGCCAGTCAGGTTCGGGCGAAGGTTACGATTACCTACAGGCTCTG
CAAAAAAATAACGGCCTAGAAGTGGTGATGATCGATCCTCGCTACACAGACTCTATGCTAGGTAAAGAGTCAAGCTGGTT
ACCAATCCGTCCAGGCACCGATGCGGCATTTGCTGAAGCGGTAGCTTACCAGATGATCAATCACGCAAACTTTGCGGGAC
AATCATTACCATTTGTACTTGAGAACTCTGTTGGTTTCACTAAGCAATCAATTGAAGATCAAATTGCTATTTTCGCAGCG
AGTGGCGATGCGACTAAGCAAGAATACGCTAAGGTGATGAACTCAGATGAAAACTACCAAGACTACATTCTAGGTCAAGG
TATTTACTCTGATGCGAAAACACCTGAGTGGGCAGAGAAAATCTGTGGTATTTCTGCTGACAAAATTCGTTATATCGCCG
GCAAGCTAATGACCGCCAAAGCGCCATACATAGTGATTGGCGCAGGTGTTAACCGTCAAGCTAACGGCGAGCAAAGCATG
CGTGCGCTTTACATGCTATCAGTGTTAACGGGTAAGTTAGGTACACGCGGCGCATCAAACGGTGAGTTGCCATACATGAG
CAGCATGTCTCGCGCAGGTATTCCTACAGGTAGCAACCCAGTTAAAGAAAGCATCTCTTTCTTCACTTGGTCTGAAGCGA
TTCTAAATGGCGAAACCATGACAGCTCGTAGCCACGGTATTCGCGGTACAGACGGTTTGGATACGCCACTTGGTGCGAAT
ATTAAGTTCATCTTGTCTGCATCAGATAGCTCGCTATTGAATCAGCACGCCGAAATCAACAATACGGCTGAAATCTTCCG
CACCGCAGAAGATCTATTCATCGTGTCTTGTGACTGCTGGATGACGCCGGGTGCTAAGTTCGCCGATATCATCCTGCCTG
ATACTAGCTGGTTAGAATCAAACGATTTAGTTAACGACTCTTATGCTTCAGGCTCTCTAGGTTACCTAACTGCAATGTCT
TCGTCTGTTGAGACAATGTGGGATTGTAAGTCTATGTATGAAGCCGCTGCTATGATCGCTGACAAGATGGGCGTTGGCGC
TGGCTTTAGAGCAGGCAAGAACGAAGATGAGTGGTTAGAAGAGCTTTATCAAAGTACTAAAGCTAACAGCAACAACATCG
ATGTGACACCAGCGTTCCCAGCGACTTACAAAGAAGCGCAAGAGATAGGCTTCTTCCGTAAGAACATGAACGACAACCAC
GTTGCACTGCAAAGTTTTGTTAAAGAAGGTAAAGCCCTTTCGACCCCAAGTGGCAAGATTGAGATTTATTCGGCTGAACT
TGCATGGCGCGCGGCTAACTGGGATCAAGAAAGCAGTGCTCAAAACCCAACGGGCGTAAAAGGCGACACCATCACAGCCA
TTCCACAGTACACTGTAACGTGGCACGGTTATGAAGATGAAGACGCTAAAGCGGAATACCCAATTCAGCTTGCGGGTTAC
CACACTAAAGGCCGTACTCATTCGAGCTACCACAACGTTCCATGGTTACGTGAAGCGGTAGAAGATGCCGTTTGGGTTAA
CCCAATGGACGGTGCTAAGCACGGCTTAAGCTCTGGCGACAAGATTGAGATGTACAACGAGTACGGTTCAGTTGAAGTCA
CTGTACGGATCACGCCACGTGTTGCACCAGGTGTATTTGCACTAGGACAAGGCGCTTGGTACAAGCCTGGTAACAAGCAA
GGCAGTACTGGTCACATTGTTGACGAAGGCGGCGCGATTAACTCGCTAACACGCTACCAGCCAAGCCCTGTCGCTAAAGG
TAACCCACAGCACACTATTCGTGTTGCCATTAAAAAGATTTAA

Upstream 100 bases:

>100_bases
CCTGAACCACAATTACAACGCCCATCAACTGATGTTGACCTTCAGCTACAAGCTGAAATAGGTCGAGTCAGTCACTAATA
AGTTTGAGGAAAACAAGATT

Downstream 100 bases:

>100_bases
GAGAGTAGTTAATTATGACTGAAGCAACTCAATACGGTTTTTACGTCGACAGCACTAAGTGTACTGGCTGTAAGGCGTGT
CATGTATCTTGTAAAGACCG

Product: anaerobic dimethyl sulfoxide reductase subunit A

Products: Reduced form of N-Oxide compounds [C]

Alternate protein names: DMSO reductase [H]

Number of amino acids: Translated: 840; Mature: 840

Protein sequence:

>840_residues
MERRSFLKMSAALGCAATVTGCNSSSDDANVIPPQPPVKDEVVNWSSCLVNCGSNCPIKVFTKDGIVTRVETDHEVEDNY
GLHQVRACARGRSLRQRNYAVDRLKTPMKRVGERGKAEFVPISWDEATSIIAEKLSAVYAQENGAKSVFRSYGSGAYYGF
ASNACFNRLFNLNGGCLNAYGNYSWAQQMEAAKHTFGTGSTMGSSTITIEDSDFFLGVAYNPSEIRQSGSGEGYDYLQAL
QKNNGLEVVMIDPRYTDSMLGKESSWLPIRPGTDAAFAEAVAYQMINHANFAGQSLPFVLENSVGFTKQSIEDQIAIFAA
SGDATKQEYAKVMNSDENYQDYILGQGIYSDAKTPEWAEKICGISADKIRYIAGKLMTAKAPYIVIGAGVNRQANGEQSM
RALYMLSVLTGKLGTRGASNGELPYMSSMSRAGIPTGSNPVKESISFFTWSEAILNGETMTARSHGIRGTDGLDTPLGAN
IKFILSASDSSLLNQHAEINNTAEIFRTAEDLFIVSCDCWMTPGAKFADIILPDTSWLESNDLVNDSYASGSLGYLTAMS
SSVETMWDCKSMYEAAAMIADKMGVGAGFRAGKNEDEWLEELYQSTKANSNNIDVTPAFPATYKEAQEIGFFRKNMNDNH
VALQSFVKEGKALSTPSGKIEIYSAELAWRAANWDQESSAQNPTGVKGDTITAIPQYTVTWHGYEDEDAKAEYPIQLAGY
HTKGRTHSSYHNVPWLREAVEDAVWVNPMDGAKHGLSSGDKIEMYNEYGSVEVTVRITPRVAPGVFALGQGAWYKPGNKQ
GSTGHIVDEGGAINSLTRYQPSPVAKGNPQHTIRVAIKKI

Sequences:

>Translated_840_residues
MERRSFLKMSAALGCAATVTGCNSSSDDANVIPPQPPVKDEVVNWSSCLVNCGSNCPIKVFTKDGIVTRVETDHEVEDNY
GLHQVRACARGRSLRQRNYAVDRLKTPMKRVGERGKAEFVPISWDEATSIIAEKLSAVYAQENGAKSVFRSYGSGAYYGF
ASNACFNRLFNLNGGCLNAYGNYSWAQQMEAAKHTFGTGSTMGSSTITIEDSDFFLGVAYNPSEIRQSGSGEGYDYLQAL
QKNNGLEVVMIDPRYTDSMLGKESSWLPIRPGTDAAFAEAVAYQMINHANFAGQSLPFVLENSVGFTKQSIEDQIAIFAA
SGDATKQEYAKVMNSDENYQDYILGQGIYSDAKTPEWAEKICGISADKIRYIAGKLMTAKAPYIVIGAGVNRQANGEQSM
RALYMLSVLTGKLGTRGASNGELPYMSSMSRAGIPTGSNPVKESISFFTWSEAILNGETMTARSHGIRGTDGLDTPLGAN
IKFILSASDSSLLNQHAEINNTAEIFRTAEDLFIVSCDCWMTPGAKFADIILPDTSWLESNDLVNDSYASGSLGYLTAMS
SSVETMWDCKSMYEAAAMIADKMGVGAGFRAGKNEDEWLEELYQSTKANSNNIDVTPAFPATYKEAQEIGFFRKNMNDNH
VALQSFVKEGKALSTPSGKIEIYSAELAWRAANWDQESSAQNPTGVKGDTITAIPQYTVTWHGYEDEDAKAEYPIQLAGY
HTKGRTHSSYHNVPWLREAVEDAVWVNPMDGAKHGLSSGDKIEMYNEYGSVEVTVRITPRVAPGVFALGQGAWYKPGNKQ
GSTGHIVDEGGAINSLTRYQPSPVAKGNPQHTIRVAIKKI
>Mature_840_residues
MERRSFLKMSAALGCAATVTGCNSSSDDANVIPPQPPVKDEVVNWSSCLVNCGSNCPIKVFTKDGIVTRVETDHEVEDNY
GLHQVRACARGRSLRQRNYAVDRLKTPMKRVGERGKAEFVPISWDEATSIIAEKLSAVYAQENGAKSVFRSYGSGAYYGF
ASNACFNRLFNLNGGCLNAYGNYSWAQQMEAAKHTFGTGSTMGSSTITIEDSDFFLGVAYNPSEIRQSGSGEGYDYLQAL
QKNNGLEVVMIDPRYTDSMLGKESSWLPIRPGTDAAFAEAVAYQMINHANFAGQSLPFVLENSVGFTKQSIEDQIAIFAA
SGDATKQEYAKVMNSDENYQDYILGQGIYSDAKTPEWAEKICGISADKIRYIAGKLMTAKAPYIVIGAGVNRQANGEQSM
RALYMLSVLTGKLGTRGASNGELPYMSSMSRAGIPTGSNPVKESISFFTWSEAILNGETMTARSHGIRGTDGLDTPLGAN
IKFILSASDSSLLNQHAEINNTAEIFRTAEDLFIVSCDCWMTPGAKFADIILPDTSWLESNDLVNDSYASGSLGYLTAMS
SSVETMWDCKSMYEAAAMIADKMGVGAGFRAGKNEDEWLEELYQSTKANSNNIDVTPAFPATYKEAQEIGFFRKNMNDNH
VALQSFVKEGKALSTPSGKIEIYSAELAWRAANWDQESSAQNPTGVKGDTITAIPQYTVTWHGYEDEDAKAEYPIQLAGY
HTKGRTHSSYHNVPWLREAVEDAVWVNPMDGAKHGLSSGDKIEMYNEYGSVEVTVRITPRVAPGVFALGQGAWYKPGNKQ
GSTGHIVDEGGAINSLTRYQPSPVAKGNPQHTIRVAIKKI

Specific function: Terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds. Allows E.coli to grow anaerobically on Me(2)SO as respiratory oxidant [H]

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI87081797, Length=853, Percent_Identity=40.6799531066823, Blast_Score=587, Evalue=1e-168,
Organism=Escherichia coli, GI1787870, Length=851, Percent_Identity=39.7179788484136, Blast_Score=572, Evalue=1e-164,
Organism=Escherichia coli, GI171474008, Length=847, Percent_Identity=39.1971664698937, Blast_Score=544, Evalue=1e-156,
Organism=Escherichia coli, GI145693196, Length=778, Percent_Identity=25.706940874036, Blast_Score=183, Evalue=3e-47,
Organism=Escherichia coli, GI87081994, Length=837, Percent_Identity=24.0143369175627, Blast_Score=166, Evalue=4e-42,
Organism=Escherichia coli, GI1787231, Length=786, Percent_Identity=24.3002544529262, Blast_Score=155, Evalue=1e-38,
Organism=Escherichia coli, GI3868721, Length=630, Percent_Identity=24.1269841269841, Blast_Score=112, Evalue=1e-25,
Organism=Escherichia coli, GI1788534, Length=533, Percent_Identity=23.2645403377111, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI3868720, Length=464, Percent_Identity=24.5689655172414, Blast_Score=66, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011888
- InterPro:   IPR009010
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655
- InterPro:   IPR006311 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: 1.8.99.- [C]

Molecular weight: Translated: 91529; Mature: 91529

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00551 MOLYBDOPTERIN_PROK_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERRSFLKMSAALGCAATVTGCNSSSDDANVIPPQPPVKDEVVNWSSCLVNCGSNCPIKV
CCHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCHHHHCCHHHHHHCCCCCCCEEE
FTKDGIVTRVETDHEVEDNYGLHQVRACARGRSLRQRNYAVDRLKTPMKRVGERGKAEFV
EECCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEE
PISWDEATSIIAEKLSAVYAQENGAKSVFRSYGSGAYYGFASNACFNRLFNLNGGCLNAY
ECCHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCEEEECHHHHHHHHHHCCCCCEEECC
GNYSWAQQMEAAKHTFGTGSTMGSSTITIEDSDFFLGVAYNPSEIRQSGSGEGYDYLQAL
CCCHHHHHHHHHHHCCCCCCCCCCCEEEEECCCEEEEEEECHHHHHHCCCCCCHHHHHHH
QKNNGLEVVMIDPRYTDSMLGKESSWLPIRPGTDAAFAEAVAYQMINHANFAGQSLPFVL
HCCCCCEEEEECCCCCHHHHCCCCCEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEE
ENSVGFTKQSIEDQIAIFAASGDATKQEYAKVMNSDENYQDYILGQGIYSDAKTPEWAEK
ECCCCCCHHHCCCEEEEEEECCCCCHHHHHHHHCCCCCCHHHEECCCCCCCCCCHHHHHH
ICGISADKIRYIAGKLMTAKAPYIVIGAGVNRQANGEQSMRALYMLSVLTGKLGTRGASN
HHCCCHHHHHHHHHHHEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
GELPYMSSMSRAGIPTGSNPVKESISFFTWSEAILNGETMTARSHGIRGTDGLDTPLGAN
CCCCCHHHHHHCCCCCCCCHHHHHHHHEEHHHHHHCCCEEEHHCCCCCCCCCCCCCCCCC
IKFILSASDSSLLNQHAEINNTAEIFRTAEDLFIVSCDCWMTPGAKFADIILPDTSWLES
EEEEEECCCHHHHHHHHCCCCHHHHHHHHCCEEEEEECCEECCCCCEEEEEECCCCCCCC
NDLVNDSYASGSLGYLTAMSSSVETMWDCKSMYEAAAMIADKMGVGAGFRAGKNEDEWLE
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
ELYQSTKANSNNIDVTPAFPATYKEAQEIGFFRKNMNDNHVALQSFVKEGKALSTPSGKI
HHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEECCCCCCE
EIYSAELAWRAANWDQESSAQNPTGVKGDTITAIPQYTVTWHGYEDEDAKAEYPIQLAGY
EEEEEEEEEEECCCCCCCCCCCCCCCCCCEEEECCCEEEEECCCCCCCCCCCCCEEEEEE
HTKGRTHSSYHNVPWLREAVEDAVWVNPMDGAKHGLSSGDKIEMYNEYGSVEVTVRITPR
ECCCCCCCCCCCCHHHHHHHHHHEECCCCCCHHHCCCCCCEEEEEECCCCEEEEEEECCC
VAPGVFALGQGAWYKPGNKQGSTGHIVDEGGAINSLTRYQPSPVAKGNPQHTIRVAIKKI
CCCCEEEECCCCEECCCCCCCCCCCEEECCCCCCHHHCCCCCCCCCCCCCCEEEEEEECC
>Mature Secondary Structure
MERRSFLKMSAALGCAATVTGCNSSSDDANVIPPQPPVKDEVVNWSSCLVNCGSNCPIKV
CCHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCHHHHCCHHHHHHCCCCCCCEEE
FTKDGIVTRVETDHEVEDNYGLHQVRACARGRSLRQRNYAVDRLKTPMKRVGERGKAEFV
EECCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEE
PISWDEATSIIAEKLSAVYAQENGAKSVFRSYGSGAYYGFASNACFNRLFNLNGGCLNAY
ECCHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCEEEECHHHHHHHHHHCCCCCEEECC
GNYSWAQQMEAAKHTFGTGSTMGSSTITIEDSDFFLGVAYNPSEIRQSGSGEGYDYLQAL
CCCHHHHHHHHHHHCCCCCCCCCCCEEEEECCCEEEEEEECHHHHHHCCCCCCHHHHHHH
QKNNGLEVVMIDPRYTDSMLGKESSWLPIRPGTDAAFAEAVAYQMINHANFAGQSLPFVL
HCCCCCEEEEECCCCCHHHHCCCCCEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEE
ENSVGFTKQSIEDQIAIFAASGDATKQEYAKVMNSDENYQDYILGQGIYSDAKTPEWAEK
ECCCCCCHHHCCCEEEEEEECCCCCHHHHHHHHCCCCCCHHHEECCCCCCCCCCHHHHHH
ICGISADKIRYIAGKLMTAKAPYIVIGAGVNRQANGEQSMRALYMLSVLTGKLGTRGASN
HHCCCHHHHHHHHHHHEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
GELPYMSSMSRAGIPTGSNPVKESISFFTWSEAILNGETMTARSHGIRGTDGLDTPLGAN
CCCCCHHHHHHCCCCCCCCHHHHHHHHEEHHHHHHCCCEEEHHCCCCCCCCCCCCCCCCC
IKFILSASDSSLLNQHAEINNTAEIFRTAEDLFIVSCDCWMTPGAKFADIILPDTSWLES
EEEEEECCCHHHHHHHHCCCCHHHHHHHHCCEEEEEECCEECCCCCEEEEEECCCCCCCC
NDLVNDSYASGSLGYLTAMSSSVETMWDCKSMYEAAAMIADKMGVGAGFRAGKNEDEWLE
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
ELYQSTKANSNNIDVTPAFPATYKEAQEIGFFRKNMNDNHVALQSFVKEGKALSTPSGKI
HHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEECCCCCCE
EIYSAELAWRAANWDQESSAQNPTGVKGDTITAIPQYTVTWHGYEDEDAKAEYPIQLAGY
EEEEEEEEEEECCCCCCCCCCCCCCCCCCEEEECCCEEEEECCCCCCCCCCCCCEEEEEE
HTKGRTHSSYHNVPWLREAVEDAVWVNPMDGAKHGLSSGDKIEMYNEYGSVEVTVRITPR
ECCCCCCCCCCCCHHHHHHHHHHEECCCCCCHHHCCCCCCEEEEEECCCCEEEEEEECCC
VAPGVFALGQGAWYKPGNKQGSTGHIVDEGGAINSLTRYQPSPVAKGNPQHTIRVAIKKI
CCCCEEEECCCCEECCCCCCCCCCCEEECCCCCCHHHCCCCCCCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: May Bind 4Fe-4S Cluster. [C]

Metal ions: Fe; Mo [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N-Oxide; Sulfoxide Compounds Including Trimethylamine N-Oxide. [C]

Specific reaction: Reduces Various N-Oxide And Sulfoxide Compounds Including Trimethylamine N-Oxide. [C]

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3062312; 8905232; 9278503; 2170332; 8125918; 10801884 [H]