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The map label for this gene is acdA [H]

Identifier: 167624790

GI number: 167624790

Start: 3496217

End: 3497374

Strand: Reverse

Name: acdA [H]

Synonym: Shal_2876

Alternate gene names: 167624790

Gene position: 3497374-3496217 (Counterclockwise)

Preceding gene: 167624791

Following gene: 167624789

Centisome position: 66.91

GC content: 51.9

Gene sequence:

>1158_bases
ATGGATTTCAACCTGAATGAAGACCAACGTCAATTTAGCGATCTTGCGCAGCAGTTTGCTGCAGAAGAGTTAGCGCCGTT
TGCCGCCAAGTGGGATGAAGAGCACCACTTCCCAAAAGATGTGATCCAAAAGGCGGGAGAGCTAGGTTTTTGCTCGCTGT
ATTCGCCAGAGTCAGAAGGGGGAATGGGACTGTCGCGTTTAGATTCATCGATTATTTTTGAGCAGCTGTCTATGGGCTGC
ACTGCGACCACTGCCATGCTCACAATTCATAATATGGCGACTTGGATGGTGACCAGTTTTGGCGCTGAAACGCTGCGCCA
AGAGTGGTCTGAGTCACTGACCACAGGTGAAAAGTTAGCATCATATTGCTTAACAGAACCTGGGGCGGGCAGTGATGCAG
CTGCGCTGCAGACCAAGGCGGTACGTGATGGTGATGAGTATGTGATTTCAGGCTCAAAAGTCTTTATCTCTGGAGCGGGA
GCCACCGAGTTGTTAGTGGTGATGTGCCGCACCGGAGGCGCTGGACCTAAAGGCATTTCTGCGATTGCGGTTCCTGCCGA
TGCAGCAGGCATTATCTACGGCAAGGCGGAAGATAAGATGGGCTGGAACGCTCAGCCAACCCGTGAAATCACCTTTGAAA
ATGTGCGTGTTCCCGCCTCTTACTTATTAGGTGAAGAAGGCCAAGGCTTTACCTTCGCCATGAAGGGACTCGATGGCGGG
CGCATCAATATTGCCACCTGTTCAATTGGTACCGCTCAAGCGGCGCTTGAGCGAGCGACGCAATATATGAATGAGCGTAA
GCAGTTCGGTAAGCCTTTGGCGGCATTTCAGGCGCTGCAGTTTAAGCTGGCCGATATGGCGACCGAGCTGGTAGCTGCCC
GCCAGTTAGTGCGTCTAGCCGCTTTTAAACTCGATCAACAAGATCCAGAAGCCACCGCATACTGCGCCATGGCAAAACGC
TTTGCCACCGATATCGGATTCCAGGTATGTGACGCGGCGCTGCAAATTCATGGCGGCTATGGTTACATTCGAGAGTACCC
ACTAGAGCGCCATGTGCGTGATGTGCGAGTACACCAAATATTAGAGGGAACCAACGAAATCATGCGATTGATTATCTCTC
GCCGTTTATTGGATGAAAACGCGGGCGCGATTCTCTAG

Upstream 100 bases:

>100_bases
TGCTTAAGACCCATAGCCTCATCGCTTGATGGTGCAGACCTAGGACCTAGGACCTAGGACCTAGAGCAGAGGCAATAGAC
AGGACAACAGGAGTACTCAG

Downstream 100 bases:

>100_bases
GCCGCCTAGCATCAGCTTTAAATTGATTTCAGTTTTATAAAAGGAGTTATCTATGTCTCAGGAGAATGCCAGCACGTTAG
CGACAGAGAAATCGCTATTA

Product: acyl-CoA dehydrogenase domain-containing protein

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MDFNLNEDQRQFSDLAQQFAAEELAPFAAKWDEEHHFPKDVIQKAGELGFCSLYSPESEGGMGLSRLDSSIIFEQLSMGC
TATTAMLTIHNMATWMVTSFGAETLRQEWSESLTTGEKLASYCLTEPGAGSDAAALQTKAVRDGDEYVISGSKVFISGAG
ATELLVVMCRTGGAGPKGISAIAVPADAAGIIYGKAEDKMGWNAQPTREITFENVRVPASYLLGEEGQGFTFAMKGLDGG
RINIATCSIGTAQAALERATQYMNERKQFGKPLAAFQALQFKLADMATELVAARQLVRLAAFKLDQQDPEATAYCAMAKR
FATDIGFQVCDAALQIHGGYGYIREYPLERHVRDVRVHQILEGTNEIMRLIISRRLLDENAGAIL

Sequences:

>Translated_385_residues
MDFNLNEDQRQFSDLAQQFAAEELAPFAAKWDEEHHFPKDVIQKAGELGFCSLYSPESEGGMGLSRLDSSIIFEQLSMGC
TATTAMLTIHNMATWMVTSFGAETLRQEWSESLTTGEKLASYCLTEPGAGSDAAALQTKAVRDGDEYVISGSKVFISGAG
ATELLVVMCRTGGAGPKGISAIAVPADAAGIIYGKAEDKMGWNAQPTREITFENVRVPASYLLGEEGQGFTFAMKGLDGG
RINIATCSIGTAQAALERATQYMNERKQFGKPLAAFQALQFKLADMATELVAARQLVRLAAFKLDQQDPEATAYCAMAKR
FATDIGFQVCDAALQIHGGYGYIREYPLERHVRDVRVHQILEGTNEIMRLIISRRLLDENAGAIL
>Mature_385_residues
MDFNLNEDQRQFSDLAQQFAAEELAPFAAKWDEEHHFPKDVIQKAGELGFCSLYSPESEGGMGLSRLDSSIIFEQLSMGC
TATTAMLTIHNMATWMVTSFGAETLRQEWSESLTTGEKLASYCLTEPGAGSDAAALQTKAVRDGDEYVISGSKVFISGAG
ATELLVVMCRTGGAGPKGISAIAVPADAAGIIYGKAEDKMGWNAQPTREITFENVRVPASYLLGEEGQGFTFAMKGLDGG
RINIATCSIGTAQAALERATQYMNERKQFGKPLAAFQALQFKLADMATELVAARQLVRLAAFKLDQQDPEATAYCAMAKR
FATDIGFQVCDAALQIHGGYGYIREYPLERHVRDVRVHQILEGTNEIMRLIISRRLLDENAGAIL

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI7656849, Length=375, Percent_Identity=56.8, Blast_Score=455, Evalue=1e-128,
Organism=Homo sapiens, GI4557233, Length=375, Percent_Identity=41.3333333333333, Blast_Score=276, Evalue=2e-74,
Organism=Homo sapiens, GI187960098, Length=381, Percent_Identity=37.7952755905512, Blast_Score=266, Evalue=2e-71,
Organism=Homo sapiens, GI4557231, Length=381, Percent_Identity=37.7952755905512, Blast_Score=266, Evalue=3e-71,
Organism=Homo sapiens, GI21361497, Length=389, Percent_Identity=35.73264781491, Blast_Score=226, Evalue=3e-59,
Organism=Homo sapiens, GI4501859, Length=374, Percent_Identity=35.5614973262032, Blast_Score=226, Evalue=3e-59,
Organism=Homo sapiens, GI4501857, Length=371, Percent_Identity=33.9622641509434, Blast_Score=219, Evalue=3e-57,
Organism=Homo sapiens, GI226958412, Length=376, Percent_Identity=31.9148936170213, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI76496475, Length=382, Percent_Identity=32.9842931937173, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI4557235, Length=382, Percent_Identity=32.9842931937173, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI226958414, Length=336, Percent_Identity=31.8452380952381, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI4503943, Length=384, Percent_Identity=27.34375, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI38505218, Length=355, Percent_Identity=29.5774647887324, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI7669494, Length=365, Percent_Identity=26.8493150684932, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI211971008, Length=369, Percent_Identity=28.4552845528455, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI48976061, Length=369, Percent_Identity=28.4552845528455, Blast_Score=110, Evalue=2e-24,
Organism=Escherichia coli, GI1786223, Length=384, Percent_Identity=29.9479166666667, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI87081958, Length=387, Percent_Identity=32.0413436692506, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI87082384, Length=292, Percent_Identity=28.7671232876712, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17533517, Length=379, Percent_Identity=51.9788918205805, Blast_Score=416, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI17534899, Length=383, Percent_Identity=39.686684073107, Blast_Score=269, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI17569725, Length=382, Percent_Identity=39.2670157068063, Blast_Score=269, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI17570075, Length=381, Percent_Identity=36.4829396325459, Blast_Score=258, Evalue=5e-69,
Organism=Caenorhabditis elegans, GI17506239, Length=380, Percent_Identity=35, Blast_Score=224, Evalue=6e-59,
Organism=Caenorhabditis elegans, GI17508101, Length=376, Percent_Identity=33.2446808510638, Blast_Score=214, Evalue=5e-56,
Organism=Caenorhabditis elegans, GI17538396, Length=381, Percent_Identity=32.0209973753281, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI71985184, Length=353, Percent_Identity=33.1444759206799, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17505929, Length=367, Percent_Identity=32.1525885558583, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17551932, Length=362, Percent_Identity=30.939226519337, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI71990804, Length=285, Percent_Identity=35.7894736842105, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI32563615, Length=232, Percent_Identity=38.3620689655172, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI71982178, Length=275, Percent_Identity=29.0909090909091, Blast_Score=145, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17534353, Length=383, Percent_Identity=27.9373368146214, Blast_Score=144, Evalue=9e-35,
Organism=Caenorhabditis elegans, GI71985192, Length=301, Percent_Identity=30.5647840531561, Blast_Score=141, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI17562446, Length=337, Percent_Identity=31.1572700296736, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17531909, Length=245, Percent_Identity=27.3469387755102, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24660351, Length=384, Percent_Identity=38.28125, Blast_Score=264, Evalue=9e-71,
Organism=Drosophila melanogaster, GI21356377, Length=379, Percent_Identity=39.5778364116095, Blast_Score=263, Evalue=2e-70,
Organism=Drosophila melanogaster, GI24646207, Length=376, Percent_Identity=39.0957446808511, Blast_Score=233, Evalue=1e-61,
Organism=Drosophila melanogaster, GI24666513, Length=372, Percent_Identity=33.8709677419355, Blast_Score=215, Evalue=5e-56,
Organism=Drosophila melanogaster, GI21355753, Length=383, Percent_Identity=34.4647519582245, Blast_Score=214, Evalue=1e-55,
Organism=Drosophila melanogaster, GI281363737, Length=341, Percent_Identity=33.1378299120235, Blast_Score=189, Evalue=4e-48,
Organism=Drosophila melanogaster, GI19920834, Length=379, Percent_Identity=28.2321899736148, Blast_Score=141, Evalue=9e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 41870; Mature: 41870

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFNLNEDQRQFSDLAQQFAAEELAPFAAKWDEEHHFPKDVIQKAGELGFCSLYSPESEG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCEEEECCCCCCC
GMGLSRLDSSIIFEQLSMGCTATTAMLTIHNMATWMVTSFGAETLRQEWSESLTTGEKLA
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
SYCLTEPGAGSDAAALQTKAVRDGDEYVISGSKVFISGAGATELLVVMCRTGGAGPKGIS
HHHCCCCCCCCCHHHHHHHHHCCCCCEEEECCEEEEECCCHHHHHHHHCCCCCCCCCCCE
AIAVPADAAGIIYGKAEDKMGWNAQPTREITFENVRVPASYLLGEEGQGFTFAMKGLDGG
EEEECCCCCEEEEECCCCCCCCCCCCCCCEECCCCCCCHHHHCCCCCCCEEEEEECCCCC
RINIATCSIGTAQAALERATQYMNERKQFGKPLAAFQALQFKLADMATELVAARQLVRLA
EEEEEEECCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AFKLDQQDPEATAYCAMAKRFATDIGFQVCDAALQIHGGYGYIREYPLERHVRDVRVHQI
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHCCCHHHHHHHHHHHHH
LEGTNEIMRLIISRRLLDENAGAIL
HHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MDFNLNEDQRQFSDLAQQFAAEELAPFAAKWDEEHHFPKDVIQKAGELGFCSLYSPESEG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCEEEECCCCCCC
GMGLSRLDSSIIFEQLSMGCTATTAMLTIHNMATWMVTSFGAETLRQEWSESLTTGEKLA
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
SYCLTEPGAGSDAAALQTKAVRDGDEYVISGSKVFISGAGATELLVVMCRTGGAGPKGIS
HHHCCCCCCCCCHHHHHHHHHCCCCCEEEECCEEEEECCCHHHHHHHHCCCCCCCCCCCE
AIAVPADAAGIIYGKAEDKMGWNAQPTREITFENVRVPASYLLGEEGQGFTFAMKGLDGG
EEEECCCCCEEEEECCCCCCCCCCCCCCCEECCCCCCCHHHHCCCCCCCEEEEEECCCCC
RINIATCSIGTAQAALERATQYMNERKQFGKPLAAFQALQFKLADMATELVAARQLVRLA
EEEEEEECCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AFKLDQQDPEATAYCAMAKRFATDIGFQVCDAALQIHGGYGYIREYPLERHVRDVRVHQI
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHCCCHHHHHHHHHHHHH
LEGTNEIMRLIISRRLLDENAGAIL
HHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]