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The map label for this gene is polC [H]

Identifier: 167624226

GI number: 167624226

Start: 2787445

End: 2788086

Strand: Direct

Name: polC [H]

Synonym: Shal_2302

Alternate gene names: 167624226

Gene position: 2787445-2788086 (Clockwise)

Preceding gene: 167624224

Following gene: 167624228

Centisome position: 53.33

GC content: 44.7

Gene sequence:

>642_bases
TTGACCAATACAACCCACTCACGCCCAATTCAGCCTGCCGACACCGTAATAGTGCTCGACTTTGAAACCACGGGTCTATC
TCCCAATCAAGGTGATCGAGCAATTGAAATCGGTGCTGTCATGCTTAAAGATGGCAAGGTCATTGATAGGTTTCAACAAC
TAATGAACCCAGGTTTTAGAGTTAGTGGCTTTATCGAGAACTACACGGGGATCAGTAATGAGATGTTGAGTGACGCGAAG
TCATGTGAAACGGTGATGACTCAATTTGCAGACTTCATCGGTGATTACAACCTCGTCGCCCACAATGCCTCATTCGACCA
ACGCTTTTTGGATGCCGAACTCAGTCGAGTTAACTGCAATTATCCTGGGCAATTTGCCTGCTCTATGTTAATTGCACGCA
GGTTATATCAAGACGCGCCGAATCATAAACTCGGCAGTTTAATCCATTATAAAAATATCCAACATGATGGTGTGTTTCAC
CGAGCCTTAGCCGATAGTGAAATGACCGCCGATCTTTGGCTAGTCATGCTTGAAGATTTAAACGCAGATTACCAGATCAA
GCGAGCTGACTTTTCCTTATTACAAGCCATTGCCAAACAAAGCAAAGCTAGCGTTAGCCAATATTTAGCACGCCAGCGCT
AA

Upstream 100 bases:

>100_bases
GGACTAATCAGCCTAAAGCTTCAAATGGGGCAATAACTTGATTGACTGTCTATTAAGGATCAATACAATATCGAACAAAC
TTTATTGATGATGATTCAAC

Downstream 100 bases:

>100_bases
CAAACAGCACTGTTTAATCGTAAGATTAGACAGTGCTGTATTTTTAATGCCTGTGTTAAACCAAGTGTTAAAAACTGATA
ATCTAACATGATGCTAACCG

Product: DNA polymerase III subunit epsilon

Products: NA

Alternate protein names: PolIII [H]

Number of amino acids: Translated: 213; Mature: 212

Protein sequence:

>213_residues
MTNTTHSRPIQPADTVIVLDFETTGLSPNQGDRAIEIGAVMLKDGKVIDRFQQLMNPGFRVSGFIENYTGISNEMLSDAK
SCETVMTQFADFIGDYNLVAHNASFDQRFLDAELSRVNCNYPGQFACSMLIARRLYQDAPNHKLGSLIHYKNIQHDGVFH
RALADSEMTADLWLVMLEDLNADYQIKRADFSLLQAIAKQSKASVSQYLARQR

Sequences:

>Translated_213_residues
MTNTTHSRPIQPADTVIVLDFETTGLSPNQGDRAIEIGAVMLKDGKVIDRFQQLMNPGFRVSGFIENYTGISNEMLSDAK
SCETVMTQFADFIGDYNLVAHNASFDQRFLDAELSRVNCNYPGQFACSMLIARRLYQDAPNHKLGSLIHYKNIQHDGVFH
RALADSEMTADLWLVMLEDLNADYQIKRADFSLLQAIAKQSKASVSQYLARQR
>Mature_212_residues
TNTTHSRPIQPADTVIVLDFETTGLSPNQGDRAIEIGAVMLKDGKVIDRFQQLMNPGFRVSGFIENYTGISNEMLSDAKS
CETVMTQFADFIGDYNLVAHNASFDQRFLDAELSRVNCNYPGQFACSMLIARRLYQDAPNHKLGSLIHYKNIQHDGVFHR
ALADSEMTADLWLVMLEDLNADYQIKRADFSLLQAIAKQSKASVSQYLARQR

Specific function: Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG2176

COG function: function code L; DNA polymerase III, alpha subunit (gram-positive type)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 exonuclease domain [H]

Homologues:

Organism=Escherichia coli, GI1788149, Length=161, Percent_Identity=33.5403726708075, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1786409, Length=170, Percent_Identity=30, Blast_Score=69, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011708
- InterPro:   IPR006054
- InterPro:   IPR006055
- InterPro:   IPR013520
- InterPro:   IPR023223
- InterPro:   IPR016027
- InterPro:   IPR004013
- InterPro:   IPR003141
- InterPro:   IPR006308
- InterPro:   IPR012337 [H]

Pfam domain/function: PF07733 DNA_pol3_alpha; PF00929 Exonuc_X-T; PF02811 PHP [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 23973; Mature: 23842

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNTTHSRPIQPADTVIVLDFETTGLSPNQGDRAIEIGAVMLKDGKVIDRFQQLMNPGFR
CCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCEEEEEEEEECCCHHHHHHHHHHCCCCE
VSGFIENYTGISNEMLSDAKSCETVMTQFADFIGDYNLVAHNASFDQRFLDAELSRVNCN
EEHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHCCCC
YPGQFACSMLIARRLYQDAPNHKLGSLIHYKNIQHDGVFHRALADSEMTADLWLVMLEDL
CCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCHHHHHHCCCCHHHHHHHHHHHHC
NADYQIKRADFSLLQAIAKQSKASVSQYLARQR
CCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TNTTHSRPIQPADTVIVLDFETTGLSPNQGDRAIEIGAVMLKDGKVIDRFQQLMNPGFR
CCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCEEEEEEEEECCCHHHHHHHHHHCCCCE
VSGFIENYTGISNEMLSDAKSCETVMTQFADFIGDYNLVAHNASFDQRFLDAELSRVNCN
EEHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHCCCC
YPGQFACSMLIARRLYQDAPNHKLGSLIHYKNIQHDGVFHRALADSEMTADLWLVMLEDL
CCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCHHHHHHCCCCHHHHHHHHHHHHC
NADYQIKRADFSLLQAIAKQSKASVSQYLARQR
CCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]