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The map label for this gene is aceA [C]

Identifier: 167624177

GI number: 167624177

Start: 2731863

End: 2733446

Strand: Direct

Name: aceA [C]

Synonym: Shal_2253

Alternate gene names: 167624177

Gene position: 2731863-2733446 (Clockwise)

Preceding gene: 167624174

Following gene: 167624178

Centisome position: 52.27

GC content: 45.33

Gene sequence:

>1584_bases
ATGACAAATTACAGATCAAACATCGATGAAGCTGCTACCTTGATTAATGCTGAAGGTAGTGCATGGAATGCAATTAACCC
TGAGTCTGTAGCCCGTATGCGTCTACAAAATCGTTTCAAAACCGGATTAGATATTGCGAAATACACCGCCAAAATTATGC
GTGAAGACATGGATAACTACGACAAGGACTCATCGCAGTACACTCAGTCGTTAGGTTGTTGGCATGGCTTTATTGGTCAG
CAGAAGATGATCTCGATTAAAAAGCATCTACTGACCACAAAGCGTCGTTATCTTTACCTTTCTGGCTGGATGGTTGCGGC
GCTTCGTAGTGAGTTTGGTCCATTGCCAGATCAATCTATGCACGAAAAGACCTCTGTCGCATCGTTAATCAAAGAGCTAT
ACACTTTCCTTCGTCAAGCCGATGCTCGTGAGCTAGGTGGCCTATTCCGTCAGTTAGACGCTGCTAACCCAAGTGATAAA
GCGGTAATTCAAGCTAAAATTGATAATTTTGAAACTCATGTTGTCCCTATCATTGCCGATATCGATGCGGGTTTTGGTAA
TGAAGAAGCCACCTACCTGATGGCAAAGCAGATGATTGAAGCGGGTGCCTGCTGTATTCAGTTAGAAAACCAAGTATCTG
ATGTTAAGCAATGTGGTCACCAAGATGGCAAGGTGACAGTTCCTCATGTTGAGTTTCTCGCTAAAATTAATGCCGTTCGT
TATGCATTCTTAGAGTTAGGGATCGATGATGGCGTTATCGTTGCTCGTACCGACTCACTAGGTGCTGGCCTAACCCAGAA
GATTGCAGTAACCAGCGAGGCGGGAGATTTAGGAGACAAGTACAACTCTTTCCTAGAAGTTGAAGCGGTTGATGCTGCCA
AGCTTGCTAACGGTGATGTGGTATTCCAGCAAAATGGCGAACTTGTTAAACCAGCACGCCTTCCTAACGGATTATTTAAG
TTCCGCGCAGGGACCGGTGAAGAGCGCTGTGTGCTTGATTGTATTACCTCGCTACAAAATGGTGCCGACCTGCTTTGGAT
TGAAACAGAGAAGCCTCACGTAGCCCAAATCGGTGCAATGGTTAATAAGATCCGTGAAACCGTTCCCAATGCAAAACTCG
TCTATAACAACTCACCTTCGTTTAACTGGACACTAAACTTCCGCCAGCAGGTATTCGATACAATGGTTGAAGCAGGCCAA
GATGTTTCGGCATATGAGCGCGAGAAGTTAATGGCCATTGAATACGATGCAACAGAACTTGCTATTCAAGCTGATGAAAA
GATCCGTACCTTCCAAGCCGATGCTGCTCGTGAAGCGGGTATTTTCCACCACTTGATTACCCTACCGACTTACCACACCG
CTGCGCTTTCAACAGATAACTTAGCGAAAGAGTATTTTGGCGACCAAGGAATGCTTGGTTATGTGGCTAACGTTCAGCGT
AAGGAGATCCGTCAAGGTATCGCCTGTGTTAAGCACCAAAACATGGCTGGATCTGATATGGGTGATGATCACAAAGAGTA
CTTCTCTGGTGACCAAGCACTGAAGGCATCGGGTAAAGACAACACCATGAACCAATTTAGCTAA

Upstream 100 bases:

>100_bases
CCGGATATAGAAACTATCAATTAGACTTATTTAAACAAATCCTACTAATATTTTCAACGTAATCAATCGCCGCTAATCAT
ATTGTTAAAGGAATAGACAC

Downstream 100 bases:

>100_bases
GTCGTCATTATGGCAATCGGTTTTTGAAGTGGACTAGATTGTTAATAATGAGCTAATTATGAAAGGCCTGCTAAAGAGCA
GGCTTTTTTATATCGAGTAG

Product: isocitrate lyase

Products: NA

Alternate protein names: ICL; Isocitrase; Isocitratase [H]

Number of amino acids: Translated: 527; Mature: 526

Protein sequence:

>527_residues
MTNYRSNIDEAATLINAEGSAWNAINPESVARMRLQNRFKTGLDIAKYTAKIMREDMDNYDKDSSQYTQSLGCWHGFIGQ
QKMISIKKHLLTTKRRYLYLSGWMVAALRSEFGPLPDQSMHEKTSVASLIKELYTFLRQADARELGGLFRQLDAANPSDK
AVIQAKIDNFETHVVPIIADIDAGFGNEEATYLMAKQMIEAGACCIQLENQVSDVKQCGHQDGKVTVPHVEFLAKINAVR
YAFLELGIDDGVIVARTDSLGAGLTQKIAVTSEAGDLGDKYNSFLEVEAVDAAKLANGDVVFQQNGELVKPARLPNGLFK
FRAGTGEERCVLDCITSLQNGADLLWIETEKPHVAQIGAMVNKIRETVPNAKLVYNNSPSFNWTLNFRQQVFDTMVEAGQ
DVSAYEREKLMAIEYDATELAIQADEKIRTFQADAAREAGIFHHLITLPTYHTAALSTDNLAKEYFGDQGMLGYVANVQR
KEIRQGIACVKHQNMAGSDMGDDHKEYFSGDQALKASGKDNTMNQFS

Sequences:

>Translated_527_residues
MTNYRSNIDEAATLINAEGSAWNAINPESVARMRLQNRFKTGLDIAKYTAKIMREDMDNYDKDSSQYTQSLGCWHGFIGQ
QKMISIKKHLLTTKRRYLYLSGWMVAALRSEFGPLPDQSMHEKTSVASLIKELYTFLRQADARELGGLFRQLDAANPSDK
AVIQAKIDNFETHVVPIIADIDAGFGNEEATYLMAKQMIEAGACCIQLENQVSDVKQCGHQDGKVTVPHVEFLAKINAVR
YAFLELGIDDGVIVARTDSLGAGLTQKIAVTSEAGDLGDKYNSFLEVEAVDAAKLANGDVVFQQNGELVKPARLPNGLFK
FRAGTGEERCVLDCITSLQNGADLLWIETEKPHVAQIGAMVNKIRETVPNAKLVYNNSPSFNWTLNFRQQVFDTMVEAGQ
DVSAYEREKLMAIEYDATELAIQADEKIRTFQADAAREAGIFHHLITLPTYHTAALSTDNLAKEYFGDQGMLGYVANVQR
KEIRQGIACVKHQNMAGSDMGDDHKEYFSGDQALKASGKDNTMNQFS
>Mature_526_residues
TNYRSNIDEAATLINAEGSAWNAINPESVARMRLQNRFKTGLDIAKYTAKIMREDMDNYDKDSSQYTQSLGCWHGFIGQQ
KMISIKKHLLTTKRRYLYLSGWMVAALRSEFGPLPDQSMHEKTSVASLIKELYTFLRQADARELGGLFRQLDAANPSDKA
VIQAKIDNFETHVVPIIADIDAGFGNEEATYLMAKQMIEAGACCIQLENQVSDVKQCGHQDGKVTVPHVEFLAKINAVRY
AFLELGIDDGVIVARTDSLGAGLTQKIAVTSEAGDLGDKYNSFLEVEAVDAAKLANGDVVFQQNGELVKPARLPNGLFKF
RAGTGEERCVLDCITSLQNGADLLWIETEKPHVAQIGAMVNKIRETVPNAKLVYNNSPSFNWTLNFRQQVFDTMVEAGQD
VSAYEREKLMAIEYDATELAIQADEKIRTFQADAAREAGIFHHLITLPTYHTAALSTDNLAKEYFGDQGMLGYVANVQRK
EIRQGIACVKHQNMAGSDMGDDHKEYFSGDQALKASGKDNTMNQFS

Specific function: Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase- positive serine pathway [H]

COG id: COG2224

COG function: function code C; Isocitrate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family [H]

Homologues:

Organism=Escherichia coli, GI1790445, Length=409, Percent_Identity=28.1173594132029, Blast_Score=130, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17561814, Length=409, Percent_Identity=28.1173594132029, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI71982926, Length=409, Percent_Identity=28.1173594132029, Blast_Score=130, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6320908, Length=171, Percent_Identity=29.8245614035088, Blast_Score=77, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006254
- InterPro:   IPR000918
- InterPro:   IPR015813 [H]

Pfam domain/function: PF00463 ICL [H]

EC number: =4.1.3.1 [H]

Molecular weight: Translated: 58488; Mature: 58357

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNYRSNIDEAATLINAEGSAWNAINPESVARMRLQNRFKTGLDIAKYTAKIMREDMDNY
CCCCCCCHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCC
DKDSSQYTQSLGCWHGFIGQQKMISIKKHLLTTKRRYLYLSGWMVAALRSEFGPLPDQSM
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHCCCCCCCHH
HEKTSVASLIKELYTFLRQADARELGGLFRQLDAANPSDKAVIQAKIDNFETHVVPIIAD
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEEEEEEEE
IDAGFGNEEATYLMAKQMIEAGACCIQLENQVSDVKQCGHQDGKVTVPHVEFLAKINAVR
CCCCCCCCHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHCCCCCCEECHHHHHHHHHHHHH
YAFLELGIDDGVIVARTDSLGAGLTQKIAVTSEAGDLGDKYNSFLEVEAVDAAKLANGDV
HHHHHCCCCCCEEEEECCCCCCCCCCEEEEECCCCCCHHHHHCEEEEEECCHHHHCCCCE
VFQQNGELVKPARLPNGLFKFRAGTGEERCVLDCITSLQNGADLLWIETEKPHVAQIGAM
EEECCCCEECCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHH
VNKIRETVPNAKLVYNNSPSFNWTLNFRQQVFDTMVEAGQDVSAYEREKLMAIEYDATEL
HHHHHHHCCCCEEEECCCCCEEEEECHHHHHHHHHHHCCCCCHHHHHCCEEEEEECCHHE
AIQADEKIRTFQADAAREAGIFHHLITLPTYHTAALSTDNLAKEYFGDQGMLGYVANVQR
EEECCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHCCCCCCCHHHHHHHH
KEIRQGIACVKHQNMAGSDMGDDHKEYFSGDQALKASGKDNTMNQFS
HHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCHHEECCCCCCCCCCCC
>Mature Secondary Structure 
TNYRSNIDEAATLINAEGSAWNAINPESVARMRLQNRFKTGLDIAKYTAKIMREDMDNY
CCCCCCHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCC
DKDSSQYTQSLGCWHGFIGQQKMISIKKHLLTTKRRYLYLSGWMVAALRSEFGPLPDQSM
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHCCCCCCCHH
HEKTSVASLIKELYTFLRQADARELGGLFRQLDAANPSDKAVIQAKIDNFETHVVPIIAD
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEEEEEEEE
IDAGFGNEEATYLMAKQMIEAGACCIQLENQVSDVKQCGHQDGKVTVPHVEFLAKINAVR
CCCCCCCCHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHCCCCCCEECHHHHHHHHHHHHH
YAFLELGIDDGVIVARTDSLGAGLTQKIAVTSEAGDLGDKYNSFLEVEAVDAAKLANGDV
HHHHHCCCCCCEEEEECCCCCCCCCCEEEEECCCCCCHHHHHCEEEEEECCHHHHCCCCE
VFQQNGELVKPARLPNGLFKFRAGTGEERCVLDCITSLQNGADLLWIETEKPHVAQIGAM
EEECCCCEECCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHH
VNKIRETVPNAKLVYNNSPSFNWTLNFRQQVFDTMVEAGQDVSAYEREKLMAIEYDATEL
HHHHHHHCCCCEEEECCCCCEEEEECHHHHHHHHHHHCCCCCHHHHHCCEEEEEECCHHE
AIQADEKIRTFQADAAREAGIFHHLITLPTYHTAALSTDNLAKEYFGDQGMLGYVANVQR
EEECCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHCCCCCCCHHHHHHHH
KEIRQGIACVKHQNMAGSDMGDDHKEYFSGDQALKASGKDNTMNQFS
HHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCHHEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]