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The map label for this gene is codB [H]

Identifier: 167624085

GI number: 167624085

Start: 2610053

End: 2611318

Strand: Reverse

Name: codB [H]

Synonym: Shal_2161

Alternate gene names: 167624085

Gene position: 2611318-2610053 (Counterclockwise)

Preceding gene: 167624087

Following gene: 167624084

Centisome position: 49.96

GC content: 45.02

Gene sequence:

>1266_bases
ATGGCAAGCGATAATAATTACAGTCTAACCCCAGTACCGAACTCGGCACGTAAAGGGGTTCTCTCTCTAACAATGGTGAT
GTTAGGGTTAACCTTTTTTTCAGCGAGTATGTGGACCGGAGGAACGCTCGGCACCGGCCTCTCTTTTAATGATTTTGTTC
TTGCCGTTCTTATTGGTAATTTAATTCTCGGTATTTACACTTCATTTCTTGGTTACATCGGTGCTCAATCTGGCCTTTCT
ACTCATCTCCTCGCTCGTTACTCATTCGGTTTAAAAGGTTCTTGGTTACCCTCGCTACTTCTCGGTGGCACTCAAGTTGG
TTGGTTTGGTGTTGGCGTGGCGATGTTTGCTATCCCAGTACAAAAAGCCACAGGCATCGACACTAATCTTCTTATTATTA
TCTCAGGCCTGCTTATGACCTTTACCGTCTATTTCGGTATTGGTGCGATTATGATTTTGTCAGCCATCGCAGTCCCTGCC
ATTGCTCTGTTTGGTGGTTTCTCTGTGCTACAGGCGGTTGATACCATGGGCGGCATGCAAGGCTTAATGGCCGTTGAGCC
AGAAAACCCCATTGATTTTAATACAGCGTTGGTCTTGGTTGTTGGCTCATTCATTTCAGCCGGTACTCTGACAGCTGATT
TTGTTCGCTTTGGTAAGAATCCAAAAACCGCCGTGTTTGTCACCATGTTCGCCTTCTTCGTCGGTAATTCGTTGATGTTT
ATCTTCGGTGCAGCGGGCGCGGCGGCGACAGGCCAAGCCGATATTTCAGAGGTAATGATTGCACAAGGGCTATTGATCCC
AGCGATTATCATCTTAGGTTTAAATATTTGGACCACCAACGATAACGCTCTGTATGCTTCAGGCTTAGGCTTTTCGAACA
TTACCGGCTTACCGAGTAAATATTTATCCATTTTTAATGGCGTGATTGGTACCCTGTGTGCACTTTGGCTATATAATAAC
TTTGTCGGTTGGCTGACCTTTCTGTCTGCCGCAATCCCACCGATTGGTGGCATTATCATCGCCGATTACCTTCGAAACCG
CGAAAAATATAAAGACTTTGCCAATGCCAAGTTTTCGACTGTCAACTGGGCTGCAATTAGCGGCGTGATGATAGGCGTGC
TTGCAGGCCACTTATTACCAGGCATAGTGCCAATTAATGCCGTGCTTGCTGGCGCCTTCAGCTATCTCTTGATAGATGAA
ATTCAAGTTCGTATCAAAAAACAAAATTTAGTTAAATCAGATTGTAAAGATGCAACCAATGCATAA

Upstream 100 bases:

>100_bases
GCCGTTTGCCCGACGTGTAGCTCTACAGCCCTTGCTTGATCGCAGGTTTAAGCACTTTAGGTAAGCCGTGTATTTTCTTT
ATTCTATCCAAGGACAATAA

Downstream 100 bases:

>100_bases
GGAAAACTCCATGTCATCAGCAAATATGTTGATCAAAAACGTGACGCTAAACGGCAAAAAAGGCCTTCATCAACTACTCA
TTGAAGACGGTCAGTTTAAG

Product: cytosine permease

Products: Proton [Cytoplasm]; cytosine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 421; Mature: 420

Protein sequence:

>421_residues
MASDNNYSLTPVPNSARKGVLSLTMVMLGLTFFSASMWTGGTLGTGLSFNDFVLAVLIGNLILGIYTSFLGYIGAQSGLS
THLLARYSFGLKGSWLPSLLLGGTQVGWFGVGVAMFAIPVQKATGIDTNLLIIISGLLMTFTVYFGIGAIMILSAIAVPA
IALFGGFSVLQAVDTMGGMQGLMAVEPENPIDFNTALVLVVGSFISAGTLTADFVRFGKNPKTAVFVTMFAFFVGNSLMF
IFGAAGAAATGQADISEVMIAQGLLIPAIIILGLNIWTTNDNALYASGLGFSNITGLPSKYLSIFNGVIGTLCALWLYNN
FVGWLTFLSAAIPPIGGIIIADYLRNREKYKDFANAKFSTVNWAAISGVMIGVLAGHLLPGIVPINAVLAGAFSYLLIDE
IQVRIKKQNLVKSDCKDATNA

Sequences:

>Translated_421_residues
MASDNNYSLTPVPNSARKGVLSLTMVMLGLTFFSASMWTGGTLGTGLSFNDFVLAVLIGNLILGIYTSFLGYIGAQSGLS
THLLARYSFGLKGSWLPSLLLGGTQVGWFGVGVAMFAIPVQKATGIDTNLLIIISGLLMTFTVYFGIGAIMILSAIAVPA
IALFGGFSVLQAVDTMGGMQGLMAVEPENPIDFNTALVLVVGSFISAGTLTADFVRFGKNPKTAVFVTMFAFFVGNSLMF
IFGAAGAAATGQADISEVMIAQGLLIPAIIILGLNIWTTNDNALYASGLGFSNITGLPSKYLSIFNGVIGTLCALWLYNN
FVGWLTFLSAAIPPIGGIIIADYLRNREKYKDFANAKFSTVNWAAISGVMIGVLAGHLLPGIVPINAVLAGAFSYLLIDE
IQVRIKKQNLVKSDCKDATNA
>Mature_420_residues
ASDNNYSLTPVPNSARKGVLSLTMVMLGLTFFSASMWTGGTLGTGLSFNDFVLAVLIGNLILGIYTSFLGYIGAQSGLST
HLLARYSFGLKGSWLPSLLLGGTQVGWFGVGVAMFAIPVQKATGIDTNLLIIISGLLMTFTVYFGIGAIMILSAIAVPAI
ALFGGFSVLQAVDTMGGMQGLMAVEPENPIDFNTALVLVVGSFISAGTLTADFVRFGKNPKTAVFVTMFAFFVGNSLMFI
FGAAGAAATGQADISEVMIAQGLLIPAIIILGLNIWTTNDNALYASGLGFSNITGLPSKYLSIFNGVIGTLCALWLYNNF
VGWLTFLSAAIPPIGGIIIADYLRNREKYKDFANAKFSTVNWAAISGVMIGVLAGHLLPGIVPINAVLAGAFSYLLIDEI
QVRIKKQNLVKSDCKDATNA

Specific function: Required for cytosine transport into the cell [H]

COG id: COG1457

COG function: function code F; Purine-cytosine permease and related proteins

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine-cytosine permease family [H]

Homologues:

Organism=Escherichia coli, GI1786530, Length=417, Percent_Identity=73.621103117506, Blast_Score=596, Evalue=1e-171,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001248
- InterPro:   IPR012681 [H]

Pfam domain/function: PF02133 Transp_cyt_pur [H]

EC number: NA

Molecular weight: Translated: 44318; Mature: 44186

Theoretical pI: Translated: 8.16; Mature: 8.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASDNNYSLTPVPNSARKGVLSLTMVMLGLTFFSASMWTGGTLGTGLSFNDFVLAVLIGN
CCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
LILGIYTSFLGYIGAQSGLSTHLLARYSFGLKGSWLPSLLLGGTQVGWFGVGVAMFAIPV
HHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHH
QKATGIDTNLLIIISGLLMTFTVYFGIGAIMILSAIAVPAIALFGGFSVLQAVDTMGGMQ
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GLMAVEPENPIDFNTALVLVVGSFISAGTLTADFVRFGKNPKTAVFVTMFAFFVGNSLMF
CCEEECCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEE
IFGAAGAAATGQADISEVMIAQGLLIPAIIILGLNIWTTNDNALYASGLGFSNITGLPSK
EEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEECCCCEEEECCCCCCCCCCCHHH
YLSIFNGVIGTLCALWLYNNFVGWLTFLSAAIPPIGGIIIADYLRNREKYKDFANAKFST
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCHHHHHHHHCCCCCC
VNWAAISGVMIGVLAGHLLPGIVPINAVLAGAFSYLLIDEIQVRIKKQNLVKSDCKDATN
CHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
A
C
>Mature Secondary Structure 
ASDNNYSLTPVPNSARKGVLSLTMVMLGLTFFSASMWTGGTLGTGLSFNDFVLAVLIGN
CCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
LILGIYTSFLGYIGAQSGLSTHLLARYSFGLKGSWLPSLLLGGTQVGWFGVGVAMFAIPV
HHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHH
QKATGIDTNLLIIISGLLMTFTVYFGIGAIMILSAIAVPAIALFGGFSVLQAVDTMGGMQ
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GLMAVEPENPIDFNTALVLVVGSFISAGTLTADFVRFGKNPKTAVFVTMFAFFVGNSLMF
CCEEECCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEE
IFGAAGAAATGQADISEVMIAQGLLIPAIIILGLNIWTTNDNALYASGLGFSNITGLPSK
EEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEECCCCEEEECCCCCCCCCCCHHH
YLSIFNGVIGTLCALWLYNNFVGWLTFLSAAIPPIGGIIIADYLRNREKYKDFANAKFST
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCHHHHHHHHCCCCCC
VNWAAISGVMIGVLAGHLLPGIVPINAVLAGAFSYLLIDEIQVRIKKQNLVKSDCKDATN
CHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
A
C

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; cytosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + cytosine [Periplasm] = Proton [Cytoplasm] + cytosine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]