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The map label for this gene is norM [H]

Identifier: 167623942

GI number: 167623942

Start: 2433859

End: 2435217

Strand: Reverse

Name: norM [H]

Synonym: Shal_2016

Alternate gene names: 167623942

Gene position: 2435217-2433859 (Counterclockwise)

Preceding gene: 167623944

Following gene: 167623939

Centisome position: 46.59

GC content: 44.59

Gene sequence:

>1359_bases
ATGAACCATTCTGGCTTTCAAGCCAAACGCTTAATTCAATTAGCACTGCCAGTGCTAATCGCTCAAGTAACACAAACTAT
GATGGGCTTTATTGACACCGTCATGGCCGGTCGCGTCAGTGCCGTCGATATGGCAGCCGTTGCTATCAGTGCTAGCTTGT
GGCTACCTGCCTTGCTGTTTGTTCAAGGTTTATTAATGGCCTTTACACCAGTATTTGCTCACCATCATGGTGCAGACAAT
CAAAAGGCGATTCAACCATTAGCTTACCAAGCTGCTTATATTGCCATAATTGGCAGTGTGGGTGTGGTGCTTATCCTCTC
ATTTGCAGAGAATATTTTCACCATGATGGAGCTTGAGCCCGAAATGGCCAGGCTCGGTATTGGATATTTAAATGGCTTCA
TGTGGGGCGTACCTGCATTCGTGCTTTATCAAGTATTAAGAGGTTGTAGCGAAGGGATCTCATATACCTTGCCCACTATG
GTCATAGGTTTTGTCGGCTTAGCCGTTAACATCCCAGCTAACTACATCTTTATCTATGGTCACTTTGGTATGCCTGCTAT
GGGCGGCGCGGGTTGTGGTGTTGCTACTGCATTAGTGTTCTGGGCAATGCTTATCGCCATGATTATCTATATGCAATTCC
ATAAGAAGTTTAAAGAGCTTGCTCCGTTCAAATCTTTTCACATGCCAGACTTTAAAGTCATGTTCGATATGACAAAACAT
GGCTTTCCGATAGCTATGGCGTTGTTTTTTGAAGTGAGTTTATTTGCAATCATCGCACTATTACTTGCACCTTTAGGCGC
AACTGTTGTCGCTGGACATCAGATAGCACTTAACTTTTCATCGATTGTATTTATGTTGCCATTGTCACTCGGTATCGCAG
TATCAATTCGTGTCGGCTATTACCTAGGACAAGACAAGCCTGAAATTGCAGCCTTAGTGACCAAGCTAGCACTGATGATC
TCGTTTTCGTTAGCAGCCTGTACCGCGATCATTACTGTGCTATTTAGAAATGAAATCGCACTACTTTATAATGACAACCC
AGAAGTAGTAGCGCTGGCAGGTAGCTTAATGTTCTATGCTGCTTTCTATCAGTTATCAGATTCAGTTCAAGTCGTTACCG
CTGGTGCTCTGCGTGGATATAAAGATACCCGCAGCGCGTTTTACATCACCTTAGTTTCGTACTGGGGTGTGGGGATGACC
TTAGGTTATACATTGGCCCGTACCGATATCATCGTGCCACATATGGGCGCTCAAGGATTCTGGATAGGGCTAATTGCCGG
TCTTACGAGCGCTGCGATAATGTTTGCCGCACGCTTGAGATACGTTCAAAAAAGGGGTGTTATTCACTCTGCAATCTAA

Upstream 100 bases:

>100_bases
GTGTTTAAGCCTAATTTCTTATCTATCGCCAACACTTCACATGTTGCTTGAACTATACCTGTAAACATTTTATCTCTCGT
TAGTATTAAGGGCTGTATTC

Downstream 100 bases:

>100_bases
TTAGCTGCGGCCTAATTAACAGCTATCTAGCTCAGCGCTAGTTACAAACAAAAGGCCAACTCTACCGGAGTTGGCCTTTT
TATTTACCAGTCTTATCCTA

Product: MATE efflux family protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 452; Mature: 452

Protein sequence:

>452_residues
MNHSGFQAKRLIQLALPVLIAQVTQTMMGFIDTVMAGRVSAVDMAAVAISASLWLPALLFVQGLLMAFTPVFAHHHGADN
QKAIQPLAYQAAYIAIIGSVGVVLILSFAENIFTMMELEPEMARLGIGYLNGFMWGVPAFVLYQVLRGCSEGISYTLPTM
VIGFVGLAVNIPANYIFIYGHFGMPAMGGAGCGVATALVFWAMLIAMIIYMQFHKKFKELAPFKSFHMPDFKVMFDMTKH
GFPIAMALFFEVSLFAIIALLLAPLGATVVAGHQIALNFSSIVFMLPLSLGIAVSIRVGYYLGQDKPEIAALVTKLALMI
SFSLAACTAIITVLFRNEIALLYNDNPEVVALAGSLMFYAAFYQLSDSVQVVTAGALRGYKDTRSAFYITLVSYWGVGMT
LGYTLARTDIIVPHMGAQGFWIGLIAGLTSAAIMFAARLRYVQKRGVIHSAI

Sequences:

>Translated_452_residues
MNHSGFQAKRLIQLALPVLIAQVTQTMMGFIDTVMAGRVSAVDMAAVAISASLWLPALLFVQGLLMAFTPVFAHHHGADN
QKAIQPLAYQAAYIAIIGSVGVVLILSFAENIFTMMELEPEMARLGIGYLNGFMWGVPAFVLYQVLRGCSEGISYTLPTM
VIGFVGLAVNIPANYIFIYGHFGMPAMGGAGCGVATALVFWAMLIAMIIYMQFHKKFKELAPFKSFHMPDFKVMFDMTKH
GFPIAMALFFEVSLFAIIALLLAPLGATVVAGHQIALNFSSIVFMLPLSLGIAVSIRVGYYLGQDKPEIAALVTKLALMI
SFSLAACTAIITVLFRNEIALLYNDNPEVVALAGSLMFYAAFYQLSDSVQVVTAGALRGYKDTRSAFYITLVSYWGVGMT
LGYTLARTDIIVPHMGAQGFWIGLIAGLTSAAIMFAARLRYVQKRGVIHSAI
>Mature_452_residues
MNHSGFQAKRLIQLALPVLIAQVTQTMMGFIDTVMAGRVSAVDMAAVAISASLWLPALLFVQGLLMAFTPVFAHHHGADN
QKAIQPLAYQAAYIAIIGSVGVVLILSFAENIFTMMELEPEMARLGIGYLNGFMWGVPAFVLYQVLRGCSEGISYTLPTM
VIGFVGLAVNIPANYIFIYGHFGMPAMGGAGCGVATALVFWAMLIAMIIYMQFHKKFKELAPFKSFHMPDFKVMFDMTKH
GFPIAMALFFEVSLFAIIALLLAPLGATVVAGHQIALNFSSIVFMLPLSLGIAVSIRVGYYLGQDKPEIAALVTKLALMI
SFSLAACTAIITVLFRNEIALLYNDNPEVVALAGSLMFYAAFYQLSDSVQVVTAGALRGYKDTRSAFYITLVSYWGVGMT
LGYTLARTDIIVPHMGAQGFWIGLIAGLTSAAIMFAARLRYVQKRGVIHSAI

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Homo sapiens, GI153792564, Length=451, Percent_Identity=22.6164079822616, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI22907060, Length=433, Percent_Identity=21.4780600461894, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI38261960, Length=487, Percent_Identity=21.7659137577002, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI48994890, Length=439, Percent_Identity=53.7585421412301, Blast_Score=453, Evalue=1e-129,
Organism=Escherichia coli, GI226510954, Length=448, Percent_Identity=24.5535714285714, Blast_Score=101, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6321821, Length=393, Percent_Identity=22.64631043257, Blast_Score=97, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6320545, Length=419, Percent_Identity=18.3770883054893, Blast_Score=67, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 49002; Mature: 49002

Theoretical pI: Translated: 8.90; Mature: 8.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
5.8 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
5.8 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCC
>Mature Secondary Structure
MNHSGFQAKRLIQLALPVLIAQVTQTMMGFIDTVMAGRVSAVDMAAVAISASLWLPALLF
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
VQGLLMAFTPVFAHHHGADNQKAIQPLAYQAAYIAIIGSVGVVLILSFAENIFTMMELEP
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
EMARLGIGYLNGFMWGVPAFVLYQVLRGCSEGISYTLPTMVIGFVGLAVNIPANYIFIYG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEECCCCEEEEEE
HFGMPAMGGAGCGVATALVFWAMLIAMIIYMQFHKKFKELAPFKSFHMPDFKVMFDMTKH
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCHHHHHHHHCC
GFPIAMALFFEVSLFAIIALLLAPLGATVVAGHQIALNFSSIVFMLPLSLGIAVSIRVGY
CCHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCEEEEEHHHHHHHHHHHHCEEEEEEEEE
YLGQDKPEIAALVTKLALMISFSLAACTAIITVLFRNEIALLYNDNPEVVALAGSLMFYA
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCEEEHHHHHHHHH
AFYQLSDSVQVVTAGALRGYKDTRSAFYITLVSYWGVGMTLGYTLARTDIIVPHMGAQGF
HHHHHCCCHHEEEHHHHCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHEEEEECCCCCHH
WIGLIAGLTSAAIMFAARLRYVQKRGVIHSAI
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]