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The map label for this gene is 167623431

Identifier: 167623431

GI number: 167623431

Start: 1803807

End: 1805300

Strand: Reverse

Name: 167623431

Synonym: Shal_1500

Alternate gene names: NA

Gene position: 1805300-1803807 (Counterclockwise)

Preceding gene: 167623435

Following gene: 167623412

Centisome position: 34.54

GC content: 44.98

Gene sequence:

>1494_bases
ATGCAAATCATCCATCATGGTGCGGTCAATGGTGTAACAGGCTCATGCCACCAACTAGATATCAATCCGCAATCCAGCAT
TCTAATAGATTGTGGGCTGTTTCAAGGAGCCGAAACAGCGGATAAAACCGCCGCAGATCAGCTCCAAATAGAATTTGACT
TAACCCATATCACTGCACTCATTGTTACTCACTGCCACATCGACCATGTGGGCCGGATCCCATATTTACTTGCCGCAGGG
TTTAATGGCCCCATATACGCAACAACGGCATCAGCCGCATTACTGCCGTTAGTCATAGAGGATGCGCTAAAGGTCGGCGT
CACCAGAAACCAGCGATTAATTAATTTATATTTAAAGCGCTTACAACAATTAATTCAGCCTATTGATTATGAGCAATGGT
TTACCCTGGAGGTTAAAAACAGTGACAGTGGATACCAACAAGCCAAAGCGCAGTTTAACGTAGCAGGACACATACTAGGC
TCTGCCTATGTTGAAATAGAACTGAGTGGCTCATCGCTAAATCATAACTGTACTCACAAAAATTCTCACAAGAACACAGA
TATTCACAACAGTAACAGCGGCAACAGGCATGACGATGACATTAAGAATGAAAAGGACAGCCATCTTGTTGTCTTTTCAG
GCGACCTAGGCGCGAGTAACACCCCGTTACTGCCAAGTCCGAAAAGCCCATTTCGAGCCGACACGTTAGTGATTGAGTCC
ACCTATGGTGATAAAAATCACCATAACCGCGAACATAGAGCAGAAAGCTTACGCCATGTAATAGAGAGAGCAGTCAGCGA
CAACGGCGTAGTACTCATTCCGGCCTTTAGCATTGGACGAACGCAGGAACTACTGTATGAGTTAGAGCAAATTATCTTTA
GCCAACAACACAACCCTATATGGCAAAGCATAGAGATAATTATAGACTCCCCCATGGCCGCCAACTTTACCGAACAATAT
ATAGAATATAAAAACCTGTGGGATTCAGAGGCCAAAGCCGTATTAGCGCAGCAACGCCACCCTCTCGATTTTAGCCAGCT
TTACACCATAGATAGCCACCAAGACCACCTAGCGGTAGTCAACTACCTTTCAAGCAGGCAAAAACCCGCTATCGTTATTG
CAGCAAGCGGAATGTGTACAGGTGGGAGAATCATTAACTATCTACAGCGATTTTTAGCCGAACCGACTGCAGATATTCTA
TTTGTGGGTTACCAAGCCAAAGGAACTATCGGACGAGATATTCAAGAATACGGACCAACTGGAGGCTACGTGTATATTGA
GGGAGAAAAAATCGATATCAAGGCAGGAATACACACCATAAGCGGCTATTCCGCCCATGCAGACCAACAAAACCTGATTG
ATTTTGTCAAAGGCATTGAGCACAAACCCAAACACATCCGCATCGTCCACGGTGATACCGAGGCCAAACAAGCACTAGCA
GATAAATACCGACAGCTTTTACCTAACGCTGAGATTAAAATAGGAACAGGCTAG

Upstream 100 bases:

>100_bases
GGCCGTTCCATCTTTGCTTACCCCGTCTTTGCTTATCCGGCTTTTATCGTCTTAGCTTTTCCCTTATCCTTAAGCGTAAA
GCAACGATAAGGAAATCGAC

Downstream 100 bases:

>100_bases
AGCTATTAAGGCCAACTAAAAATAGAACTAATATTTTGCTCTGTGCACTTCTCCGTGCCCTCTGTGAAAGCGAAGCGCTT
CGTATTCCGTAAGCTAAGCG

Product: beta-lactamase domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 497; Mature: 497

Protein sequence:

>497_residues
MQIIHHGAVNGVTGSCHQLDINPQSSILIDCGLFQGAETADKTAADQLQIEFDLTHITALIVTHCHIDHVGRIPYLLAAG
FNGPIYATTASAALLPLVIEDALKVGVTRNQRLINLYLKRLQQLIQPIDYEQWFTLEVKNSDSGYQQAKAQFNVAGHILG
SAYVEIELSGSSLNHNCTHKNSHKNTDIHNSNSGNRHDDDIKNEKDSHLVVFSGDLGASNTPLLPSPKSPFRADTLVIES
TYGDKNHHNREHRAESLRHVIERAVSDNGVVLIPAFSIGRTQELLYELEQIIFSQQHNPIWQSIEIIIDSPMAANFTEQY
IEYKNLWDSEAKAVLAQQRHPLDFSQLYTIDSHQDHLAVVNYLSSRQKPAIVIAASGMCTGGRIINYLQRFLAEPTADIL
FVGYQAKGTIGRDIQEYGPTGGYVYIEGEKIDIKAGIHTISGYSAHADQQNLIDFVKGIEHKPKHIRIVHGDTEAKQALA
DKYRQLLPNAEIKIGTG

Sequences:

>Translated_497_residues
MQIIHHGAVNGVTGSCHQLDINPQSSILIDCGLFQGAETADKTAADQLQIEFDLTHITALIVTHCHIDHVGRIPYLLAAG
FNGPIYATTASAALLPLVIEDALKVGVTRNQRLINLYLKRLQQLIQPIDYEQWFTLEVKNSDSGYQQAKAQFNVAGHILG
SAYVEIELSGSSLNHNCTHKNSHKNTDIHNSNSGNRHDDDIKNEKDSHLVVFSGDLGASNTPLLPSPKSPFRADTLVIES
TYGDKNHHNREHRAESLRHVIERAVSDNGVVLIPAFSIGRTQELLYELEQIIFSQQHNPIWQSIEIIIDSPMAANFTEQY
IEYKNLWDSEAKAVLAQQRHPLDFSQLYTIDSHQDHLAVVNYLSSRQKPAIVIAASGMCTGGRIINYLQRFLAEPTADIL
FVGYQAKGTIGRDIQEYGPTGGYVYIEGEKIDIKAGIHTISGYSAHADQQNLIDFVKGIEHKPKHIRIVHGDTEAKQALA
DKYRQLLPNAEIKIGTG
>Mature_497_residues
MQIIHHGAVNGVTGSCHQLDINPQSSILIDCGLFQGAETADKTAADQLQIEFDLTHITALIVTHCHIDHVGRIPYLLAAG
FNGPIYATTASAALLPLVIEDALKVGVTRNQRLINLYLKRLQQLIQPIDYEQWFTLEVKNSDSGYQQAKAQFNVAGHILG
SAYVEIELSGSSLNHNCTHKNSHKNTDIHNSNSGNRHDDDIKNEKDSHLVVFSGDLGASNTPLLPSPKSPFRADTLVIES
TYGDKNHHNREHRAESLRHVIERAVSDNGVVLIPAFSIGRTQELLYELEQIIFSQQHNPIWQSIEIIIDSPMAANFTEQY
IEYKNLWDSEAKAVLAQQRHPLDFSQLYTIDSHQDHLAVVNYLSSRQKPAIVIAASGMCTGGRIINYLQRFLAEPTADIL
FVGYQAKGTIGRDIQEYGPTGGYVYIEGEKIDIKAGIHTISGYSAHADQQNLIDFVKGIEHKPKHIRIVHGDTEAKQALA
DKYRQLLPNAEIKIGTG

Specific function: Has endoribonuclease activity towards 23S and 16S rRNA (in vitro) [H]

COG id: COG1236

COG function: function code J; Predicted exonuclease of the beta-lactamase fold involved in RNA processing

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family [H]

Homologues:

Organism=Homo sapiens, GI7706427, Length=493, Percent_Identity=25.9634888438134, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI33300633, Length=499, Percent_Identity=23.0460921843687, Blast_Score=115, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI32566029, Length=475, Percent_Identity=25.8947368421053, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI32564696, Length=503, Percent_Identity=23.4592445328032, Blast_Score=117, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6323307, Length=510, Percent_Identity=24.1176470588235, Blast_Score=117, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24648013, Length=493, Percent_Identity=25.5578093306288, Blast_Score=140, Evalue=3e-33,
Organism=Drosophila melanogaster, GI21358523, Length=497, Percent_Identity=23.943661971831, Blast_Score=124, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022712
- InterPro:   IPR001279
- InterPro:   IPR011108 [H]

Pfam domain/function: PF10996 Beta-Casp; PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 55162; Mature: 55162

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIIHHGAVNGVTGSCHQLDINPQSSILIDCGLFQGAETADKTAADQLQIEFDLTHITAL
CCEEECCCCCCCCCCCEEEECCCCCCEEEEECCCCCCCCCCCCCCCEEEEEEEHHHHHHH
IVTHCHIDHVGRIPYLLAAGFNGPIYATTASAALLPLVIEDALKVGVTRNQRLINLYLKR
HHHHHHHHCCCCCCEEEEECCCCCEEEECHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
LQQLIQPIDYEQWFTLEVKNSDSGYQQAKAQFNVAGHILGSAYVEIELSGSSLNHNCTHK
HHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHEEEEEEEEEEEEECCCCCCCCCCCC
NSHKNTDIHNSNSGNRHDDDIKNEKDSHLVVFSGDLGASNTPLLPSPKSPFRADTLVIES
CCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEE
TYGDKNHHNREHRAESLRHVIERAVSDNGVVLIPAFSIGRTQELLYELEQIIFSQQHNPI
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCH
WQSIEIIIDSPMAANFTEQYIEYKNLWDSEAKAVLAQQRHPLDFSQLYTIDSHQDHLAVV
HHEEEEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHEEEECCCCCHHHHH
NYLSSRQKPAIVIAASGMCTGGRIINYLQRFLAEPTADILFVGYQAKGTIGRDIQEYGPT
HHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCHHHHCCC
GGYVYIEGEKIDIKAGIHTISGYSAHADQQNLIDFVKGIEHKPKHIRIVHGDTEAKQALA
CCEEEEECCEEEEEECEEEECCCCCCCCHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHH
DKYRQLLPNAEIKIGTG
HHHHHHCCCCCEEECCC
>Mature Secondary Structure
MQIIHHGAVNGVTGSCHQLDINPQSSILIDCGLFQGAETADKTAADQLQIEFDLTHITAL
CCEEECCCCCCCCCCCEEEECCCCCCEEEEECCCCCCCCCCCCCCCEEEEEEEHHHHHHH
IVTHCHIDHVGRIPYLLAAGFNGPIYATTASAALLPLVIEDALKVGVTRNQRLINLYLKR
HHHHHHHHCCCCCCEEEEECCCCCEEEECHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
LQQLIQPIDYEQWFTLEVKNSDSGYQQAKAQFNVAGHILGSAYVEIELSGSSLNHNCTHK
HHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHEEEEEEEEEEEEECCCCCCCCCCCC
NSHKNTDIHNSNSGNRHDDDIKNEKDSHLVVFSGDLGASNTPLLPSPKSPFRADTLVIES
CCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEE
TYGDKNHHNREHRAESLRHVIERAVSDNGVVLIPAFSIGRTQELLYELEQIIFSQQHNPI
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCH
WQSIEIIIDSPMAANFTEQYIEYKNLWDSEAKAVLAQQRHPLDFSQLYTIDSHQDHLAVV
HHEEEEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHEEEECCCCCHHHHH
NYLSSRQKPAIVIAASGMCTGGRIINYLQRFLAEPTADILFVGYQAKGTIGRDIQEYGPT
HHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCHHHHCCC
GGYVYIEGEKIDIKAGIHTISGYSAHADQQNLIDFVKGIEHKPKHIRIVHGDTEAKQALA
CCEEEEECCEEEEEECEEEECCCCCCCCHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHH
DKYRQLLPNAEIKIGTG
HHHHHHCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA