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The map label for this gene is gltP [H]

Identifier: 167623336

GI number: 167623336

Start: 1697441

End: 1698706

Strand: Direct

Name: gltP [H]

Synonym: Shal_1405

Alternate gene names: 167623336

Gene position: 1697441-1698706 (Clockwise)

Preceding gene: 167623335

Following gene: 167623339

Centisome position: 32.47

GC content: 50.0

Gene sequence:

>1266_bases
ATGTGGAATAAAGTTCGCGGCTCTCTGCCACTGCAGTTGGTTTTGGCTGCAGGCGCTGCCTGGCTATTCGCAACCTCGCT
AACCTCTCTTGCTCACCCTAGCGTGATAGCCGAAGTTGAACGGCAAGCTTGGTATCAATTTTTAATGTTGGGTAAAACGG
TCTATATCGGTTTACTGAAGATGGTCGTCGGTATCATGGTGATGCTGTCGTTAATCGAAGGGATCAGCAACATAGGCGCG
ATAGCTAAGCTTAAAACCTTAGGCGGGCGTACGTTAGCGTTTTACACCTTTACCACCATGATTGCGGTAAGTCTTGGCTT
AGGGGCATCCTTACTGCTGCCAGCTTGGCAACCGCTGACCCAGGCTGTGCCTTTAGCTGAGGGGGCTACGTTAATTGGTG
AGCAGGCAGCGAGCGGCGGGGCGATTGCGACTAAGCTGCTGAATATGGCCTTAGTTAACCCTGTTGCGGCCATTGCTAGT
GGCAATCTGCTTGCAGTGGTGGTGTTCTCTTTCATGTTTGGGATATCACTATTAACAGCATTACCGGAAAAGCATCCGCT
ATTCGAGGTGATATCAGGCCTTAACAAAGGCATTAACACCATGGTGGGCGGTATTATTCGCCTGTCTCCACTGGCCATCT
TCGCTATCGTTCTGGAGTTTTCCCTTAAAGGAAGTACGGCTCTATTTAGTCAATTAGCGCTGTTTGCACTTTTGGTTTTT
GCACTAACCATGTTCCACGGGCTGGTGGTGTTACCTAGCTTGGCAAAGCTGCTGACTGGGATCAAAATATCCACGCTGTT
TAAAGGTATTAGCGCCCCTTTAGCGATGGCCTTTGCGACCTCATCGAGTGCTGCAACCCTGCCTTTGTCGATGCGAAGTG
CCCAGGAGCTTGGCGTATCACCCACCACTAGCAGTATGGTGTTACCGTTAGGGTCAGTGATGAATATGGACGGTACTGCG
CTATTTGAAGGTGTCGCCGCGGTTTTTCTCGCGCAGCTATTTGGCGTCGATCTGACAACATCAGGCATAGTGATGATCTT
TATCATGGCGATGGTGTCTTCTATTGGTGCCCCTGGAATGCCATCGGGGTCAATGTCGGGCATGCAGTTGGTGTTGCTTG
CAGCAGGGATCCCCTTAGAAGCGATCGCAATCTTGCTGATCATTGAAAAGCCGTTAGATACCTTCCGCACTGCTGTGAAT
GTTGAAGGCGATATCATCGCGGCCCTAGTCATTGATAAGTGGCAACGAAGCGAAGGTAATAACTAA

Upstream 100 bases:

>100_bases
CCGCGATTGACTACCTATTCGTCAGTTGTTAAATACTAACTCTTTGCTATAGAGCATTAGCTCCTAGCTCGAAATCAATT
AAGTTAATTTGGAATACCCC

Downstream 100 bases:

>100_bases
TACCAAAGCCATGTTCAAAGTATTAAGGTCATCTAAGACGTTAATTTAGCCATCTTGAGGTTGAACCACAAAAGGGCTGC
TTAGGTGACCAGCTGGTTAC

Product: sodium:dicarboxylate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MWNKVRGSLPLQLVLAAGAAWLFATSLTSLAHPSVIAEVERQAWYQFLMLGKTVYIGLLKMVVGIMVMLSLIEGISNIGA
IAKLKTLGGRTLAFYTFTTMIAVSLGLGASLLLPAWQPLTQAVPLAEGATLIGEQAASGGAIATKLLNMALVNPVAAIAS
GNLLAVVVFSFMFGISLLTALPEKHPLFEVISGLNKGINTMVGGIIRLSPLAIFAIVLEFSLKGSTALFSQLALFALLVF
ALTMFHGLVVLPSLAKLLTGIKISTLFKGISAPLAMAFATSSSAATLPLSMRSAQELGVSPTTSSMVLPLGSVMNMDGTA
LFEGVAAVFLAQLFGVDLTTSGIVMIFIMAMVSSIGAPGMPSGSMSGMQLVLLAAGIPLEAIAILLIIEKPLDTFRTAVN
VEGDIIAALVIDKWQRSEGNN

Sequences:

>Translated_421_residues
MWNKVRGSLPLQLVLAAGAAWLFATSLTSLAHPSVIAEVERQAWYQFLMLGKTVYIGLLKMVVGIMVMLSLIEGISNIGA
IAKLKTLGGRTLAFYTFTTMIAVSLGLGASLLLPAWQPLTQAVPLAEGATLIGEQAASGGAIATKLLNMALVNPVAAIAS
GNLLAVVVFSFMFGISLLTALPEKHPLFEVISGLNKGINTMVGGIIRLSPLAIFAIVLEFSLKGSTALFSQLALFALLVF
ALTMFHGLVVLPSLAKLLTGIKISTLFKGISAPLAMAFATSSSAATLPLSMRSAQELGVSPTTSSMVLPLGSVMNMDGTA
LFEGVAAVFLAQLFGVDLTTSGIVMIFIMAMVSSIGAPGMPSGSMSGMQLVLLAAGIPLEAIAILLIIEKPLDTFRTAVN
VEGDIIAALVIDKWQRSEGNN
>Mature_421_residues
MWNKVRGSLPLQLVLAAGAAWLFATSLTSLAHPSVIAEVERQAWYQFLMLGKTVYIGLLKMVVGIMVMLSLIEGISNIGA
IAKLKTLGGRTLAFYTFTTMIAVSLGLGASLLLPAWQPLTQAVPLAEGATLIGEQAASGGAIATKLLNMALVNPVAAIAS
GNLLAVVVFSFMFGISLLTALPEKHPLFEVISGLNKGINTMVGGIIRLSPLAIFAIVLEFSLKGSTALFSQLALFALLVF
ALTMFHGLVVLPSLAKLLTGIKISTLFKGISAPLAMAFATSSSAATLPLSMRSAQELGVSPTTSSMVLPLGSVMNMDGTA
LFEGVAAVFLAQLFGVDLTTSGIVMIFIMAMVSSIGAPGMPSGSMSGMQLVLLAAGIPLEAIAILLIIEKPLDTFRTAVN
VEGDIIAALVIDKWQRSEGNN

Specific function: This carrier protein is part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI223468566, Length=273, Percent_Identity=35.5311355311355, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI223468564, Length=264, Percent_Identity=35.6060606060606, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI5032093, Length=270, Percent_Identity=35.9259259259259, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI4827012, Length=278, Percent_Identity=34.8920863309352, Blast_Score=138, Evalue=9e-33,
Organism=Homo sapiens, GI169790839, Length=315, Percent_Identity=31.4285714285714, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI21314632, Length=296, Percent_Identity=31.0810810810811, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI66773030, Length=259, Percent_Identity=33.976833976834, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI194239697, Length=262, Percent_Identity=34.3511450381679, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI40254478, Length=260, Percent_Identity=33.8461538461538, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI301601644, Length=127, Percent_Identity=40.9448818897638, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI262359914, Length=240, Percent_Identity=31.25, Blast_Score=92, Evalue=9e-19,
Organism=Escherichia coli, GI1790514, Length=383, Percent_Identity=30.5483028720627, Blast_Score=165, Evalue=4e-42,
Organism=Escherichia coli, GI1789947, Length=370, Percent_Identity=25.4054054054054, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1788024, Length=400, Percent_Identity=26, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1789473, Length=264, Percent_Identity=25.3787878787879, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71983106, Length=408, Percent_Identity=29.656862745098, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI71983099, Length=408, Percent_Identity=29.656862745098, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI71996953, Length=302, Percent_Identity=32.1192052980132, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17537407, Length=382, Percent_Identity=29.0575916230367, Blast_Score=138, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI193206505, Length=253, Percent_Identity=35.5731225296443, Blast_Score=120, Evalue=9e-28,
Organism=Caenorhabditis elegans, GI193206654, Length=261, Percent_Identity=30.6513409961686, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17541374, Length=259, Percent_Identity=33.5907335907336, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24583025, Length=259, Percent_Identity=28.957528957529, Blast_Score=114, Evalue=9e-26,
Organism=Drosophila melanogaster, GI17137668, Length=259, Percent_Identity=28.957528957529, Blast_Score=114, Evalue=9e-26,
Organism=Drosophila melanogaster, GI24583023, Length=259, Percent_Identity=28.957528957529, Blast_Score=114, Evalue=9e-26,
Organism=Drosophila melanogaster, GI281360481, Length=274, Percent_Identity=27.3722627737226, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI281360483, Length=274, Percent_Identity=27.3722627737226, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI17137666, Length=274, Percent_Identity=27.3722627737226, Blast_Score=72, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 43850; Mature: 43850

Theoretical pI: Translated: 9.44; Mature: 9.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWNKVRGSLPLQLVLAAGAAWLFATSLTSLAHPSVIAEVERQAWYQFLMLGKTVYIGLLK
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MVVGIMVMLSLIEGISNIGAIAKLKTLGGRTLAFYTFTTMIAVSLGLGASLLLPAWQPLT
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHCCCHHHH
QAVPLAEGATLIGEQAASGGAIATKLLNMALVNPVAAIASGNLLAVVVFSFMFGISLLTA
HHCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
LPEKHPLFEVISGLNKGINTMVGGIIRLSPLAIFAIVLEFSLKGSTALFSQLALFALLVF
CCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
ALTMFHGLVVLPSLAKLLTGIKISTLFKGISAPLAMAFATSSSAATLPLSMRSAQELGVS
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCC
PTTSSMVLPLGSVMNMDGTALFEGVAAVFLAQLFGVDLTTSGIVMIFIMAMVSSIGAPGM
CCCCCHHHCHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCC
PSGSMSGMQLVLLAAGIPLEAIAILLIIEKPLDTFRTAVNVEGDIIAALVIDKWQRSEGN
CCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCC
N
C
>Mature Secondary Structure
MWNKVRGSLPLQLVLAAGAAWLFATSLTSLAHPSVIAEVERQAWYQFLMLGKTVYIGLLK
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MVVGIMVMLSLIEGISNIGAIAKLKTLGGRTLAFYTFTTMIAVSLGLGASLLLPAWQPLT
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHCCCHHHH
QAVPLAEGATLIGEQAASGGAIATKLLNMALVNPVAAIASGNLLAVVVFSFMFGISLLTA
HHCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
LPEKHPLFEVISGLNKGINTMVGGIIRLSPLAIFAIVLEFSLKGSTALFSQLALFALLVF
CCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
ALTMFHGLVVLPSLAKLLTGIKISTLFKGISAPLAMAFATSSSAATLPLSMRSAQELGVS
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCC
PTTSSMVLPLGSVMNMDGTALFEGVAAVFLAQLFGVDLTTSGIVMIFIMAMVSSIGAPGM
CCCCCHHHCHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCC
PSGSMSGMQLVLLAAGIPLEAIAILLIIEKPLDTFRTAVNVEGDIIAALVIDKWQRSEGN
CCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCC
N
C

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1971622; 1551855; 8265357; 9278503 [H]