Click here to switch to the map view.

The map label for this gene is xseA

Identifier: 167623307

GI number: 167623307

Start: 1653551

End: 1654888

Strand: Reverse

Name: xseA

Synonym: Shal_1375

Alternate gene names: 167623307

Gene position: 1654888-1653551 (Counterclockwise)

Preceding gene: 167623311

Following gene: 167623306

Centisome position: 31.66

GC content: 50.75

Gene sequence:

>1338_bases
ATGAAAACCCCAAAAAACGATGTTTATACCGTCTCTCGCCTCAATGGTGAAGTTAGACAACTTTTAGAGGGTCAGCTTGG
CCGTATATGGCTAAATGCTGAAATTTCAAACTTTGCCGCACCGGGATCTGGCCATTGGTATTTAACGCTCAAGGACAATT
TCTCCCAAATTCGTTGTGCCATGTTTAAGGGCCGTAACCAAGCCGTCACCTTTCGTCCTGCCAACGGCCAGCAAGTATTA
GTTAAGGGCAATATCAGCGTTTACGAGCCCCGTGGTGACTACCAGCTGCTTATTGAGTCGATGCTGCCAGCAGGAGACGG
TCTGCTAGCTCAGCAGTATGAAGCATTAAAGATGAAACTTGCCGCAGAAGGATTGTTTGCCAGCGACACTAAGCGGTCCC
TGCCCGCAAATATCCAAAGAATTGGTGTGGTCACCTCACCCACTGGCGCGGCCATTCGCGACATCTTGCATGTACTGGCG
CGCCGTGACGCCTCCATTGAAGTCATCATCTACCCGACTCCTGTGCAAGGCACAGACGCCGCAAAAAGTATTTGTGATGC
CATCAACCTGGCTAACTCTCGTCGCGAGGTGGATGTATTACTGGTCACCCGTGGCGGCGGCTCATTAGAGGACTTATGGA
GTTTTAACGACGAAGGCTTAGCGCATACCCTCTATAACAGCGGTATTCCTGTAGTATCGGCCGTCGGCCACGAAGTGGAC
ATGACCATTAGTGATTATGTTGCCGACCTTCGCGCCCCGACCCCCTCTGCTGGCGCAGAGCTATTATCGAAAGATGCCGA
CAACAAGGCACAAAAGCTGTTATCGCAGTTATCGCGCCTAAAACAGAGCTGGCAGCATTATCAGTTAAAGAAGCAAAATC
AACTGCAAGCTTGTGAACATCGCCTGCAAAAACAAGATCCGCAGCGCCGTCTGCAGATGTACGAGCAAAGCTTTGATGAG
ATGCAGCTGCGCCTACAACAAGCAATGCAAACCAAGTTACATGCTTATACCTTAAAGCAACAGAACCTAAGTAGCCGACT
AGCCAGTCAGTCGCCGCAGCATAGGCTCGACCTTGAAGCCCAGCGTTTGAGTTATCTCAGTGCCAAGCTCAATGGTGCCA
TGATTGATAAGTTAAAGATGAGTGAGCAGCGCCTCGCCCACCGTGCGCAGCAGTTAGATACTGTGAGTCCGTTAGCCACA
CTCAGTCGCGGCTACAGCATCACCTTAACGGGTGAGGGAAAAGTGGTGCAATCACCGAGTGATACGTGTGTGGGGGATAC
GCTTACCACACGGTTACGTGATGGGAGTGTGACTTCCACTGTGGTTGAAGTGGGTTAA

Upstream 100 bases:

>100_bases
TTAGGAATTAGAGGTGAAATATTGCGGCGAGATTATACCTTGCATATATGGGTTGGTAAATGGAAAATAGACATTAATTC
GCATTTGTGTGTAAAAAATT

Downstream 100 bases:

>100_bases
CTTTACTTTGAAGTTAGATTCAAACTTCATTCGAAAATTTTTGTTCAAACGAAATTTTTGTTCAAACTTCGTTTGATAAA
AGTTTGATAAAAAGTCGTGG

Product: exodeoxyribonuclease VII large subunit

Products: NA

Alternate protein names: Exodeoxyribonuclease VII large subunit; Exonuclease VII large subunit

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
MKTPKNDVYTVSRLNGEVRQLLEGQLGRIWLNAEISNFAAPGSGHWYLTLKDNFSQIRCAMFKGRNQAVTFRPANGQQVL
VKGNISVYEPRGDYQLLIESMLPAGDGLLAQQYEALKMKLAAEGLFASDTKRSLPANIQRIGVVTSPTGAAIRDILHVLA
RRDASIEVIIYPTPVQGTDAAKSICDAINLANSRREVDVLLVTRGGGSLEDLWSFNDEGLAHTLYNSGIPVVSAVGHEVD
MTISDYVADLRAPTPSAGAELLSKDADNKAQKLLSQLSRLKQSWQHYQLKKQNQLQACEHRLQKQDPQRRLQMYEQSFDE
MQLRLQQAMQTKLHAYTLKQQNLSSRLASQSPQHRLDLEAQRLSYLSAKLNGAMIDKLKMSEQRLAHRAQQLDTVSPLAT
LSRGYSITLTGEGKVVQSPSDTCVGDTLTTRLRDGSVTSTVVEVG

Sequences:

>Translated_445_residues
MKTPKNDVYTVSRLNGEVRQLLEGQLGRIWLNAEISNFAAPGSGHWYLTLKDNFSQIRCAMFKGRNQAVTFRPANGQQVL
VKGNISVYEPRGDYQLLIESMLPAGDGLLAQQYEALKMKLAAEGLFASDTKRSLPANIQRIGVVTSPTGAAIRDILHVLA
RRDASIEVIIYPTPVQGTDAAKSICDAINLANSRREVDVLLVTRGGGSLEDLWSFNDEGLAHTLYNSGIPVVSAVGHEVD
MTISDYVADLRAPTPSAGAELLSKDADNKAQKLLSQLSRLKQSWQHYQLKKQNQLQACEHRLQKQDPQRRLQMYEQSFDE
MQLRLQQAMQTKLHAYTLKQQNLSSRLASQSPQHRLDLEAQRLSYLSAKLNGAMIDKLKMSEQRLAHRAQQLDTVSPLAT
LSRGYSITLTGEGKVVQSPSDTCVGDTLTTRLRDGSVTSTVVEVG
>Mature_445_residues
MKTPKNDVYTVSRLNGEVRQLLEGQLGRIWLNAEISNFAAPGSGHWYLTLKDNFSQIRCAMFKGRNQAVTFRPANGQQVL
VKGNISVYEPRGDYQLLIESMLPAGDGLLAQQYEALKMKLAAEGLFASDTKRSLPANIQRIGVVTSPTGAAIRDILHVLA
RRDASIEVIIYPTPVQGTDAAKSICDAINLANSRREVDVLLVTRGGGSLEDLWSFNDEGLAHTLYNSGIPVVSAVGHEVD
MTISDYVADLRAPTPSAGAELLSKDADNKAQKLLSQLSRLKQSWQHYQLKKQNQLQACEHRLQKQDPQRRLQMYEQSFDE
MQLRLQQAMQTKLHAYTLKQQNLSSRLASQSPQHRLDLEAQRLSYLSAKLNGAMIDKLKMSEQRLAHRAQQLDTVSPLAT
LSRGYSITLTGEGKVVQSPSDTCVGDTLTTRLRDGSVTSTVVEVG

Specific function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides

COG id: COG1570

COG function: function code L; Exonuclease VII, large subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xseA family

Homologues:

Organism=Escherichia coli, GI1788856, Length=437, Percent_Identity=50.1144164759725, Blast_Score=439, Evalue=1e-124,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): EX7L_SHEHH (B0TLJ2)

Other databases:

- EMBL:   CP000931
- RefSeq:   YP_001673601.1
- GeneID:   5906575
- GenomeReviews:   CP000931_GR
- KEGG:   shl:Shal_1375
- HOGENOM:   HBG634411
- OMA:   EQRASIG
- ProtClustDB:   PRK00286
- BioCyc:   SHAL458817:SHAL_1375-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00378
- InterPro:   IPR003753
- InterPro:   IPR020579
- InterPro:   IPR004365
- TIGRFAMs:   TIGR00237

Pfam domain/function: PF02601 Exonuc_VII_L; PF01336 tRNA_anti

EC number: =3.1.11.6

Molecular weight: Translated: 49243; Mature: 49243

Theoretical pI: Translated: 9.18; Mature: 9.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTPKNDVYTVSRLNGEVRQLLEGQLGRIWLNAEISNFAAPGSGHWYLTLKDNFSQIRCA
CCCCCCCCEEHHHCCHHHHHHHCCCCCEEEEEEEHHHCCCCCCCEEEEEECCCHHHHHHH
MFKGRNQAVTFRPANGQQVLVKGNISVYEPRGDYQLLIESMLPAGDGLLAQQYEALKMKL
HHCCCCCEEEEECCCCCEEEEECCEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHH
AAEGLFASDTKRSLPANIQRIGVVTSPTGAAIRDILHVLARRDASIEVIIYPTPVQGTDA
HHCCCCCCCCCCCCCCCHHHEEEEECCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCHH
AKSICDAINLANSRREVDVLLVTRGGGSLEDLWSFNDEGLAHTLYNSGIPVVSAVGHEVD
HHHHHHHHHHCCCCCEEEEEEEECCCCCHHHHHCCCCCCCHHHHHCCCCCEEECCCCCCC
MTISDYVADLRAPTPSAGAELLSKDADNKAQKLLSQLSRLKQSWQHYQLKKQNQLQACEH
CCHHHHHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLQKQDPQRRLQMYEQSFDEMQLRLQQAMQTKLHAYTLKQQNLSSRLASQSPQHRLDLEA
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCHH
QRLSYLSAKLNGAMIDKLKMSEQRLAHRAQQLDTVSPLATLSRGYSITLTGEGKVVQSPS
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCEEEECCC
DTCVGDTLTTRLRDGSVTSTVVEVG
CCCCCCHHHHHCCCCCCEEEEEECC
>Mature Secondary Structure
MKTPKNDVYTVSRLNGEVRQLLEGQLGRIWLNAEISNFAAPGSGHWYLTLKDNFSQIRCA
CCCCCCCCEEHHHCCHHHHHHHCCCCCEEEEEEEHHHCCCCCCCEEEEEECCCHHHHHHH
MFKGRNQAVTFRPANGQQVLVKGNISVYEPRGDYQLLIESMLPAGDGLLAQQYEALKMKL
HHCCCCCEEEEECCCCCEEEEECCEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHH
AAEGLFASDTKRSLPANIQRIGVVTSPTGAAIRDILHVLARRDASIEVIIYPTPVQGTDA
HHCCCCCCCCCCCCCCCHHHEEEEECCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCHH
AKSICDAINLANSRREVDVLLVTRGGGSLEDLWSFNDEGLAHTLYNSGIPVVSAVGHEVD
HHHHHHHHHHCCCCCEEEEEEEECCCCCHHHHHCCCCCCCHHHHHCCCCCEEECCCCCCC
MTISDYVADLRAPTPSAGAELLSKDADNKAQKLLSQLSRLKQSWQHYQLKKQNQLQACEH
CCHHHHHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLQKQDPQRRLQMYEQSFDEMQLRLQQAMQTKLHAYTLKQQNLSSRLASQSPQHRLDLEA
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCHH
QRLSYLSAKLNGAMIDKLKMSEQRLAHRAQQLDTVSPLATLSRGYSITLTGEGKVVQSPS
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCEEEECCC
DTCVGDTLTTRLRDGSVTSTVVEVG
CCCCCCHHHHHCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA