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The map label for this gene is pyrG

Identifier: 167623155

GI number: 167623155

Start: 1485035

End: 1486675

Strand: Direct

Name: pyrG

Synonym: Shal_1221

Alternate gene names: 167623155

Gene position: 1485035-1486675 (Clockwise)

Preceding gene: 167623154

Following gene: 167623156

Centisome position: 28.41

GC content: 44.79

Gene sequence:

>1641_bases
ATGACTACAAGGTATATCTTCGTTACTGGTGGCGTTGTTTCATCACTAGGTAAAGGCATTGCAGCAGCATCATTGGCTGC
AATATTAGAGGCTCGCGGCCTAAACGTAACCATTATGAAGCTGGATCCATACATTAACGTCGATCCAGGTACCATGAGTC
CGACACAGCACGGTGAAGTGTTTGTGACAGAAGACGGCGCTGAAACTGATCTAGATTTAGGTCACTATGAGCGTTTCATC
CGTACCAAGATGAATCGTCGTAATAACTTTACTACGGGTCGTATTTACGAAGAAGTTCTACGTAAAGAGCGTCGTGGTGA
CTACTTAGGTGCAACCATTCAGGTTATTCCGCACATCACTAACGCTATCAAAGAGAAAGTACTTGCTGGTGGCGAAGGTC
ATGATGTAGCGATTGTTGAGATCGGTGGCACGGTGGGTGATATTGAATCACTGCCATTCCTAGAGTCTATCCGTCAGCTA
GGCGTTGAGCTTGGCCGTGATAGAACCCTATTTATGCATTTGACTCTTGTACCTTTCTTAGGTGCAGCAGGTGAAGTGAA
AACTAAACCGACACAGCATTCAGTTAAAGAGCTACGTTCAATCGGTATTGCTCCTGATGTCTTGGTTTGTCGTGGTGATC
GCGCTATTCCTGCAAATGAAAAAGCAAAGATTTCTTTATTCTGTAACGTTGAAGAACGTGCAGTTATCTCGCTAAAAGAC
GTAGATAGTATCTATAAGATCCCTGCGTTATTAAAAGCACAAGGTCTAGACCAACTTGTGACAAAGCGTTTCGGCATCGA
TTGTAAAGAAGCTGATTTAGCCGAGTGGGAAAAGGTTGTTTACCAAGAAGCTAACCCTGTGGGTGAAGTGACTATTGGTA
TGGTAGGCAAGTACATTGAACTACCAGATGCATATAAGTCAGTTAACGAAGCACTAAAGCATGCAGGTTTATTTAACCGC
GTGTCAGTTAACATCAAGTATATTGATTCACAAAACGTAGAAGCTAAGGGCGATGAAGTCTTACAAGGCTTAGACGGTAT
CTTGGTTCCTGGTGGATTCGGTGAGCGCGGTGTTGAAGGTAAGATCATGGCGGCTCAGTTCGCTCGTGAAAATAACCTAC
CTTACTTCGGTATCTGTTTAGGTATGCAGGTTGCGTTGATTGAGTTTGCACGCCATGTTGCAGGTCTTGAGGGTGCACAC
TCAACTGAGTTTGACAAAAACACGCCGCACCCAGTTGTTGGTTTGATCACTGAGTGGATCAACGAAGATGGTCAAGTTGA
AGAGCGTCATGAAGAGTCAGACTTAGGCGGCACAATGCGTCTTGGTGCTCAGCTATGTCACCTTGAAGAAGGCACTAAAG
CGGCTGCAGCTTATAAGTCTACTACTTGTGTTGAACGTCACCGTCACCGTTACGAAGTGAACAACAACTATAAAGAGCGT
CTTGAAAAAGCAGGCCTGATCTTTAGTGGTCTTTCATCAGATCGCTCACTGGTTGAGATGATTGAGCTACCGAATCACCC
ATGGTTCGTAGCAGGTCAGTTCCATCCTGAATTCACATCGACTCCTCGTGATGGCCAACCGTTATTTGAAGGGTTTGTAG
CTGCCGCTTATACCTACCAAAAACGTGATTTAGAAGACTAA

Upstream 100 bases:

>100_bases
AATTGTAGTTTGTCGAATCGCAGTTGCTTTGGTATAATATTGCCCCGTCCTAGTGCTTTCTTACAAGCACGTATTTCCAA
CTCATTTTCTCAGGTTCAGC

Downstream 100 bases:

>100_bases
ATAAAACGAAACCGCTTCCATTGCATGGAAGCGGTTTTTTTGTTTATGGCGATTTTTTTGTGACGACGTAATATCAATCG
GTATAAATGTGTGGTTTTTT

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase

Number of amino acids: Translated: 546; Mature: 545

Protein sequence:

>546_residues
MTTRYIFVTGGVVSSLGKGIAAASLAAILEARGLNVTIMKLDPYINVDPGTMSPTQHGEVFVTEDGAETDLDLGHYERFI
RTKMNRRNNFTTGRIYEEVLRKERRGDYLGATIQVIPHITNAIKEKVLAGGEGHDVAIVEIGGTVGDIESLPFLESIRQL
GVELGRDRTLFMHLTLVPFLGAAGEVKTKPTQHSVKELRSIGIAPDVLVCRGDRAIPANEKAKISLFCNVEERAVISLKD
VDSIYKIPALLKAQGLDQLVTKRFGIDCKEADLAEWEKVVYQEANPVGEVTIGMVGKYIELPDAYKSVNEALKHAGLFNR
VSVNIKYIDSQNVEAKGDEVLQGLDGILVPGGFGERGVEGKIMAAQFARENNLPYFGICLGMQVALIEFARHVAGLEGAH
STEFDKNTPHPVVGLITEWINEDGQVEERHEESDLGGTMRLGAQLCHLEEGTKAAAAYKSTTCVERHRHRYEVNNNYKER
LEKAGLIFSGLSSDRSLVEMIELPNHPWFVAGQFHPEFTSTPRDGQPLFEGFVAAAYTYQKRDLED

Sequences:

>Translated_546_residues
MTTRYIFVTGGVVSSLGKGIAAASLAAILEARGLNVTIMKLDPYINVDPGTMSPTQHGEVFVTEDGAETDLDLGHYERFI
RTKMNRRNNFTTGRIYEEVLRKERRGDYLGATIQVIPHITNAIKEKVLAGGEGHDVAIVEIGGTVGDIESLPFLESIRQL
GVELGRDRTLFMHLTLVPFLGAAGEVKTKPTQHSVKELRSIGIAPDVLVCRGDRAIPANEKAKISLFCNVEERAVISLKD
VDSIYKIPALLKAQGLDQLVTKRFGIDCKEADLAEWEKVVYQEANPVGEVTIGMVGKYIELPDAYKSVNEALKHAGLFNR
VSVNIKYIDSQNVEAKGDEVLQGLDGILVPGGFGERGVEGKIMAAQFARENNLPYFGICLGMQVALIEFARHVAGLEGAH
STEFDKNTPHPVVGLITEWINEDGQVEERHEESDLGGTMRLGAQLCHLEEGTKAAAAYKSTTCVERHRHRYEVNNNYKER
LEKAGLIFSGLSSDRSLVEMIELPNHPWFVAGQFHPEFTSTPRDGQPLFEGFVAAAYTYQKRDLED
>Mature_545_residues
TTRYIFVTGGVVSSLGKGIAAASLAAILEARGLNVTIMKLDPYINVDPGTMSPTQHGEVFVTEDGAETDLDLGHYERFIR
TKMNRRNNFTTGRIYEEVLRKERRGDYLGATIQVIPHITNAIKEKVLAGGEGHDVAIVEIGGTVGDIESLPFLESIRQLG
VELGRDRTLFMHLTLVPFLGAAGEVKTKPTQHSVKELRSIGIAPDVLVCRGDRAIPANEKAKISLFCNVEERAVISLKDV
DSIYKIPALLKAQGLDQLVTKRFGIDCKEADLAEWEKVVYQEANPVGEVTIGMVGKYIELPDAYKSVNEALKHAGLFNRV
SVNIKYIDSQNVEAKGDEVLQGLDGILVPGGFGERGVEGKIMAAQFARENNLPYFGICLGMQVALIEFARHVAGLEGAHS
TEFDKNTPHPVVGLITEWINEDGQVEERHEESDLGGTMRLGAQLCHLEEGTKAAAAYKSTTCVERHRHRYEVNNNYKERL
EKAGLIFSGLSSDRSLVEMIELPNHPWFVAGQFHPEFTSTPRDGQPLFEGFVAAAYTYQKRDLED

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Homo sapiens, GI148491070, Length=559, Percent_Identity=44.5438282647585, Blast_Score=473, Evalue=1e-133,
Organism=Homo sapiens, GI28559085, Length=557, Percent_Identity=44.7037701974865, Blast_Score=467, Evalue=1e-131,
Organism=Homo sapiens, GI28559083, Length=557, Percent_Identity=44.7037701974865, Blast_Score=467, Evalue=1e-131,
Organism=Homo sapiens, GI221316689, Length=557, Percent_Identity=44.7037701974865, Blast_Score=467, Evalue=1e-131,
Organism=Escherichia coli, GI1789142, Length=542, Percent_Identity=77.3062730627306, Blast_Score=853, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25148299, Length=612, Percent_Identity=37.4183006535948, Blast_Score=414, Evalue=1e-116,
Organism=Saccharomyces cerevisiae, GI6319432, Length=568, Percent_Identity=40.3169014084507, Blast_Score=437, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6322563, Length=566, Percent_Identity=41.696113074205, Blast_Score=435, Evalue=1e-122,
Organism=Drosophila melanogaster, GI24664469, Length=557, Percent_Identity=44.8833034111311, Blast_Score=468, Evalue=1e-132,
Organism=Drosophila melanogaster, GI21357815, Length=503, Percent_Identity=43.5387673956262, Blast_Score=399, Evalue=1e-111,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PYRG_SHEHH (B0TK03)

Other databases:

- EMBL:   CP000931
- RefSeq:   YP_001673449.1
- ProteinModelPortal:   B0TK03
- SMR:   B0TK03
- GeneID:   5903957
- GenomeReviews:   CP000931_GR
- KEGG:   shl:Shal_1221
- HOGENOM:   HBG597806
- OMA:   RVTMQKL
- ProtClustDB:   PRK05380
- BioCyc:   SHAL458817:SHAL_1221-MONOMER
- HAMAP:   MF_01227
- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991
- TIGRFAMs:   TIGR00337

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase

EC number: =6.3.4.2

Molecular weight: Translated: 60207; Mature: 60076

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 379-379 ACT_SITE 515-515 ACT_SITE 517-517

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTRYIFVTGGVVSSLGKGIAAASLAAILEARGLNVTIMKLDPYINVDPGTMSPTQHGEV
CCEEEEEEECHHHHHHCCHHHHHHHHHHHHHCCCEEEEEEECCEEECCCCCCCCCCCCEE
FVTEDGAETDLDLGHYERFIRTKMNRRNNFTTGRIYEEVLRKERRGDYLGATIQVIPHIT
EEECCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
NAIKEKVLAGGEGHDVAIVEIGGTVGDIESLPFLESIRQLGVELGRDRTLFMHLTLVPFL
HHHHHHHHCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEHHHHC
GAAGEVKTKPTQHSVKELRSIGIAPDVLVCRGDRAIPANEKAKISLFCNVEERAVISLKD
CCCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCEEEEEEEECCCCEEEEEHH
VDSIYKIPALLKAQGLDQLVTKRFGIDCKEADLAEWEKVVYQEANPVGEVTIGMVGKYIE
HHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHCCCCC
LPDAYKSVNEALKHAGLFNRVSVNIKYIDSQNVEAKGDEVLQGLDGILVPGGFGERGVEG
CCHHHHHHHHHHHHCCCEEEEEEEEEEECCCCCCCCHHHHHHCCCCEEECCCCCCCCCCC
KIMAAQFARENNLPYFGICLGMQVALIEFARHVAGLEGAHSTEFDKNTPHPVVGLITEWI
CCHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHH
NEDGQVEERHEESDLGGTMRLGAQLCHLEEGTKAAAAYKSTTCVERHRHRYEVNNNYKER
CCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHH
LEKAGLIFSGLSSDRSLVEMIELPNHPWFVAGQFHPEFTSTPRDGQPLFEGFVAAAYTYQ
HHHCCCEEECCCCCHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHH
KRDLED
HCCCCC
>Mature Secondary Structure 
TTRYIFVTGGVVSSLGKGIAAASLAAILEARGLNVTIMKLDPYINVDPGTMSPTQHGEV
CEEEEEEECHHHHHHCCHHHHHHHHHHHHHCCCEEEEEEECCEEECCCCCCCCCCCCEE
FVTEDGAETDLDLGHYERFIRTKMNRRNNFTTGRIYEEVLRKERRGDYLGATIQVIPHIT
EEECCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
NAIKEKVLAGGEGHDVAIVEIGGTVGDIESLPFLESIRQLGVELGRDRTLFMHLTLVPFL
HHHHHHHHCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEHHHHC
GAAGEVKTKPTQHSVKELRSIGIAPDVLVCRGDRAIPANEKAKISLFCNVEERAVISLKD
CCCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCEEEEEEEECCCCEEEEEHH
VDSIYKIPALLKAQGLDQLVTKRFGIDCKEADLAEWEKVVYQEANPVGEVTIGMVGKYIE
HHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHCCCCC
LPDAYKSVNEALKHAGLFNRVSVNIKYIDSQNVEAKGDEVLQGLDGILVPGGFGERGVEG
CCHHHHHHHHHHHHCCCEEEEEEEEEEECCCCCCCCHHHHHHCCCCEEECCCCCCCCCCC
KIMAAQFARENNLPYFGICLGMQVALIEFARHVAGLEGAHSTEFDKNTPHPVVGLITEWI
CCHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHH
NEDGQVEERHEESDLGGTMRLGAQLCHLEEGTKAAAAYKSTTCVERHRHRYEVNNNYKER
CCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHH
LEKAGLIFSGLSSDRSLVEMIELPNHPWFVAGQFHPEFTSTPRDGQPLFEGFVAAAYTYQ
HHHCCCEEECCCCCHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHH
KRDLED
HCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA