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The map label for this gene is hemH2 [H]

Identifier: 167623109

GI number: 167623109

Start: 1427710

End: 1428723

Strand: Direct

Name: hemH2 [H]

Synonym: Shal_1175

Alternate gene names: 167623109

Gene position: 1427710-1428723 (Clockwise)

Preceding gene: 167623108

Following gene: 167623114

Centisome position: 27.31

GC content: 47.44

Gene sequence:

>1014_bases
TTGGCTAAGTATTTAGGGCTGACCAAAGACGTTGGACATAAAAATCGCGGTAAAACAGGCGTATTGTTAGTTAATTTAGG
CACTCCCGATGAGCCGACTCCATCGGCTGTTAGGCGCTATCTAGCGGAGTTCCTCGCCGACCCACGTGTCATTGAGATCC
CAAAGCTAGTTTGGATGTGTATTTTACACGGCATCATCTTACGTGTGCGCCCTGCAAAATCGGCTGCGCTTTATCGGCAA
GTGTGGACTGAGCAGGGCTCTCCCTTGATGGATATCACCCGCCGCCAAAGCCAAAAGTTGGCTGAGTATTTTGCAAAAGA
GGGCGATGAGCTGTCGGTAGATTTTTGCATGCGTTACGGTAAACCGTCGGTATCATCGACGCTACAAAGAATGCATCAAG
AGGGAGTCGATAAGCTGGTGGTGTTGCCGCTTTACCCGCAATATTCGGCACCTACAACGGCCTCAGCTTTCGATGCTATT
GCCAAAGAGCTTATGAGCTGGCGTTATCTGCCTGCGCTGCATTTCATCAATACTTATCATGATCATCCTGACTTTATTGA
TGCGTTAGCGGCATCGATTGCTAAAGACTTTGAGATTAATGGTCGGCCACAAAAGTTAGTGCTCTCATACCATGGTATGC
CGGAGCGTAATTTGCATTTGGGCGACCCCTATTACTGTTTTTGTATGAAGACCACTAAGCTGGTGGTTGAAAAGCTTGGT
TTGAGTGAAGAGCAATATATTACGACATTCCAATCTCGTTTCGGTAAAGCCAAGTGGCTAACACCTTATACCGATGCCAC
CATGGAAGCCTTACCTGGGCAAGGCATAAAAGACATTGCGGTTGTATGCCCAGCCTTTAGTGCCGACTGCCTAGAAACGT
TAGAGGAGATCGCCGGTGAGAACCGCCATATCTTTGAGGAGGCGGGAGGTGATAAGTATCGTTATATTGCCGCGCTTAAT
GACGATGATGCCCATATTAAGATGATGGCGAACATTGTTAGGCCACATATTTAA

Upstream 100 bases:

>100_bases
GATTATTAGAAGACTGGCAATACCTTGTATTGCCAGTTTTTTTTGAGTCATAAAGAGCGTTGATTGTATCAACAGATTTT
CTATGAGTTAAGGAGTTATC

Downstream 100 bases:

>100_bases
GTCATATAGCTAAGTCTTATGTTTAGGCTGTCTACTTAGTGAGAAAAGGGAGCCACTATGCAAATAGTGGCTCCCTTAAT
TATTAAGTCTTTAGGGGCGC

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase 2; Protoheme ferro-lyase 2 [H]

Number of amino acids: Translated: 337; Mature: 336

Protein sequence:

>337_residues
MAKYLGLTKDVGHKNRGKTGVLLVNLGTPDEPTPSAVRRYLAEFLADPRVIEIPKLVWMCILHGIILRVRPAKSAALYRQ
VWTEQGSPLMDITRRQSQKLAEYFAKEGDELSVDFCMRYGKPSVSSTLQRMHQEGVDKLVVLPLYPQYSAPTTASAFDAI
AKELMSWRYLPALHFINTYHDHPDFIDALAASIAKDFEINGRPQKLVLSYHGMPERNLHLGDPYYCFCMKTTKLVVEKLG
LSEEQYITTFQSRFGKAKWLTPYTDATMEALPGQGIKDIAVVCPAFSADCLETLEEIAGENRHIFEEAGGDKYRYIAALN
DDDAHIKMMANIVRPHI

Sequences:

>Translated_337_residues
MAKYLGLTKDVGHKNRGKTGVLLVNLGTPDEPTPSAVRRYLAEFLADPRVIEIPKLVWMCILHGIILRVRPAKSAALYRQ
VWTEQGSPLMDITRRQSQKLAEYFAKEGDELSVDFCMRYGKPSVSSTLQRMHQEGVDKLVVLPLYPQYSAPTTASAFDAI
AKELMSWRYLPALHFINTYHDHPDFIDALAASIAKDFEINGRPQKLVLSYHGMPERNLHLGDPYYCFCMKTTKLVVEKLG
LSEEQYITTFQSRFGKAKWLTPYTDATMEALPGQGIKDIAVVCPAFSADCLETLEEIAGENRHIFEEAGGDKYRYIAALN
DDDAHIKMMANIVRPHI
>Mature_336_residues
AKYLGLTKDVGHKNRGKTGVLLVNLGTPDEPTPSAVRRYLAEFLADPRVIEIPKLVWMCILHGIILRVRPAKSAALYRQV
WTEQGSPLMDITRRQSQKLAEYFAKEGDELSVDFCMRYGKPSVSSTLQRMHQEGVDKLVVLPLYPQYSAPTTASAFDAIA
KELMSWRYLPALHFINTYHDHPDFIDALAASIAKDFEINGRPQKLVLSYHGMPERNLHLGDPYYCFCMKTTKLVVEKLGL
SEEQYITTFQSRFGKAKWLTPYTDATMEALPGQGIKDIAVVCPAFSADCLETLEEIAGENRHIFEEAGGDKYRYIAALND
DDAHIKMMANIVRPHI

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499021, Length=339, Percent_Identity=28.3185840707965, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI60499025, Length=334, Percent_Identity=28.4431137724551, Blast_Score=108, Evalue=6e-24,
Organism=Escherichia coli, GI1786681, Length=316, Percent_Identity=48.1012658227848, Blast_Score=300, Evalue=1e-82,
Organism=Saccharomyces cerevisiae, GI6324750, Length=339, Percent_Identity=25.9587020648968, Blast_Score=99, Evalue=7e-22,
Organism=Drosophila melanogaster, GI17864156, Length=333, Percent_Identity=27.3273273273273, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24651774, Length=265, Percent_Identity=26.4150943396226, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI45552018, Length=168, Percent_Identity=27.9761904761905, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 38043; Mature: 37912

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKYLGLTKDVGHKNRGKTGVLLVNLGTPDEPTPSAVRRYLAEFLADPRVIEIPKLVWMC
CCCCCCCCHHCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHHH
ILHGIILRVRPAKSAALYRQVWTEQGSPLMDITRRQSQKLAEYFAKEGDELSVDFCMRYG
HHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHCC
KPSVSSTLQRMHQEGVDKLVVLPLYPQYSAPTTASAFDAIAKELMSWRYLPALHFINTYH
CCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DHPDFIDALAASIAKDFEINGRPQKLVLSYHGMPERNLHLGDPYYCFCMKTTKLVVEKLG
CCHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEEEEHHHHHHHHHHC
LSEEQYITTFQSRFGKAKWLTPYTDATMEALPGQGIKDIAVVCPAFSADCLETLEEIAGE
CCHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCHHHHHHCCCCCHHHHHHHHHHCCC
NRHIFEEAGGDKYRYIAALNDDDAHIKMMANIVRPHI
CCEEHHHCCCCCEEEEEEECCCCHHHHHHHHHHCCCC
>Mature Secondary Structure 
AKYLGLTKDVGHKNRGKTGVLLVNLGTPDEPTPSAVRRYLAEFLADPRVIEIPKLVWMC
CCCCCCCHHCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHHH
ILHGIILRVRPAKSAALYRQVWTEQGSPLMDITRRQSQKLAEYFAKEGDELSVDFCMRYG
HHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHCC
KPSVSSTLQRMHQEGVDKLVVLPLYPQYSAPTTASAFDAIAKELMSWRYLPALHFINTYH
CCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DHPDFIDALAASIAKDFEINGRPQKLVLSYHGMPERNLHLGDPYYCFCMKTTKLVVEKLG
CCHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEEEEHHHHHHHHHHC
LSEEQYITTFQSRFGKAKWLTPYTDATMEALPGQGIKDIAVVCPAFSADCLETLEEIAGE
CCHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCHHHHHHCCCCCHHHHHHHHHHCCC
NRHIFEEAGGDKYRYIAALNDDDAHIKMMANIVRPHI
CCEEHHHCCCCCEEEEEEECCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]