Click here to switch to the map view.

The map label for this gene is proC [H]

Identifier: 167623105

GI number: 167623105

Start: 1423705

End: 1424523

Strand: Reverse

Name: proC [H]

Synonym: Shal_1171

Alternate gene names: 167623105

Gene position: 1424523-1423705 (Counterclockwise)

Preceding gene: 167623106

Following gene: 167623104

Centisome position: 27.25

GC content: 46.76

Gene sequence:

>819_bases
ATGACACAAAATAAAGTATGCTTTATTGGCGCAGGTAATATGACTCGCAGCATCGTCAGCGGCCTAGTTAAAAGCGGTTA
CAGCTCTGAACTGATCGAAGCTACCAACCCAAGTCAGCCTAAGCTAGATGCTATGGTGGCAGACTTTGGCATTAAGGTAT
CGAACAACAACCTTGAGGCAGCACAGGCTGCCGACGTTATCGTGCTAGGTGTTAAACCCCATCTGATGCAAGTTGTAGGT
GAAGAGCTAAGCGGCTTAGATCTATCCAACAAACTGATTATCACCATAGCCGCAGGTGTTACCGCTAAACGTTATAGCGA
TTATTTTAAGCAAGAGATCAAACTAATACGTACTATGCCTAATACTCCCACGCAAATCGGTGTAGGCTTAACAGGGCTTT
TTGCTGGTGATGATATATCTACTGAGCAAAAAGCTATCGCAGAAACATTAATGGCCACTGGCGGTGAAGTTGTTTGGGTC
AACAAAGAAGATGATTTAAACCAAGTGATCGCACTCGCAGGTAGCTCTCCGGCTTACTTCTTCCTGTTTTTAGAAGCTAT
GGTAGAAAGTGCTGTTAAAGGCGGAATGTCGGAATTAGCCGCAAGAGAGATGGCGCAGCAAGCAGCTCTTGGTGCAGCCT
TAATGGTTAAGCAAAACCCTGACGTTAGCCTTGCCCAACTTAGAGCAAACGTCACATCAAAAGGCGGCACGACAGCGCAA
GCGGTTGCCACTTTTGAAGAAGGTAACCTACGAGGCTTGGTCGATAGCGCAATGAACAATTGCATCGCCCGCGCCGAAGA
GATGGCGAAGCAGTACTAG

Upstream 100 bases:

>100_bases
ATTGCTCTTATCCGCCCAGATATTAACAGGTAAAATAGTCTTTATTTACTCTGTGCGGCTAAGATTTAGTGCAGCTAACT
AATAACAACAAGAGATCTTC

Downstream 100 bases:

>100_bases
TTTTTTAATTTAACTTGAACAAGTAGAGTAAACAGATGAATGCATTTAGTTTTCTGATAAGCACGGTATTCGATCTATAC
CTGATGGTCGTGGTATTGCG

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 272; Mature: 271

Protein sequence:

>272_residues
MTQNKVCFIGAGNMTRSIVSGLVKSGYSSELIEATNPSQPKLDAMVADFGIKVSNNNLEAAQAADVIVLGVKPHLMQVVG
EELSGLDLSNKLIITIAAGVTAKRYSDYFKQEIKLIRTMPNTPTQIGVGLTGLFAGDDISTEQKAIAETLMATGGEVVWV
NKEDDLNQVIALAGSSPAYFFLFLEAMVESAVKGGMSELAAREMAQQAALGAALMVKQNPDVSLAQLRANVTSKGGTTAQ
AVATFEEGNLRGLVDSAMNNCIARAEEMAKQY

Sequences:

>Translated_272_residues
MTQNKVCFIGAGNMTRSIVSGLVKSGYSSELIEATNPSQPKLDAMVADFGIKVSNNNLEAAQAADVIVLGVKPHLMQVVG
EELSGLDLSNKLIITIAAGVTAKRYSDYFKQEIKLIRTMPNTPTQIGVGLTGLFAGDDISTEQKAIAETLMATGGEVVWV
NKEDDLNQVIALAGSSPAYFFLFLEAMVESAVKGGMSELAAREMAQQAALGAALMVKQNPDVSLAQLRANVTSKGGTTAQ
AVATFEEGNLRGLVDSAMNNCIARAEEMAKQY
>Mature_271_residues
TQNKVCFIGAGNMTRSIVSGLVKSGYSSELIEATNPSQPKLDAMVADFGIKVSNNNLEAAQAADVIVLGVKPHLMQVVGE
ELSGLDLSNKLIITIAAGVTAKRYSDYFKQEIKLIRTMPNTPTQIGVGLTGLFAGDDISTEQKAIAETLMATGGEVVWVN
KEDDLNQVIALAGSSPAYFFLFLEAMVESAVKGGMSELAAREMAQQAALGAALMVKQNPDVSLAQLRANVTSKGGTTAQA
VATFEEGNLRGLVDSAMNNCIARAEEMAKQY

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI24797097, Length=276, Percent_Identity=32.9710144927536, Blast_Score=124, Evalue=7e-29,
Organism=Homo sapiens, GI21361454, Length=272, Percent_Identity=32.3529411764706, Blast_Score=124, Evalue=8e-29,
Organism=Homo sapiens, GI24797095, Length=275, Percent_Identity=32.3636363636364, Blast_Score=124, Evalue=8e-29,
Organism=Homo sapiens, GI198041662, Length=274, Percent_Identity=28.4671532846715, Blast_Score=120, Evalue=2e-27,
Organism=Escherichia coli, GI1786585, Length=270, Percent_Identity=37.4074074074074, Blast_Score=157, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI17569021, Length=268, Percent_Identity=30.5970149253731, Blast_Score=120, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI17540664, Length=281, Percent_Identity=29.5373665480427, Blast_Score=87, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6320861, Length=289, Percent_Identity=30.1038062283737, Blast_Score=100, Evalue=3e-22,
Organism=Drosophila melanogaster, GI21358587, Length=268, Percent_Identity=29.4776119402985, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24648116, Length=281, Percent_Identity=30.6049822064057, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24647700, Length=171, Percent_Identity=30.9941520467836, Blast_Score=82, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 28769; Mature: 28638

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQNKVCFIGAGNMTRSIVSGLVKSGYSSELIEATNPSQPKLDAMVADFGIKVSNNNLEA
CCCCCEEEEECCHHHHHHHHHHHHCCCCCHHHHCCCCCCCHHHHHHHHCCEEEECCCCCH
AQAADVIVLGVKPHLMQVVGEELSGLDLSNKLIITIAAGVTAKRYSDYFKQEIKLIRTMP
HHHCCEEEECCCHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHCCC
NTPTQIGVGLTGLFAGDDISTEQKAIAETLMATGGEVVWVNKEDDLNQVIALAGSSPAYF
CCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHEECCCCCHHH
FLFLEAMVESAVKGGMSELAAREMAQQAALGAALMVKQNPDVSLAQLRANVTSKGGTTAQ
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHCCCCCCHHH
AVATFEEGNLRGLVDSAMNNCIARAEEMAKQY
HEEEECCCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TQNKVCFIGAGNMTRSIVSGLVKSGYSSELIEATNPSQPKLDAMVADFGIKVSNNNLEA
CCCCEEEEECCHHHHHHHHHHHHCCCCCHHHHCCCCCCCHHHHHHHHCCEEEECCCCCH
AQAADVIVLGVKPHLMQVVGEELSGLDLSNKLIITIAAGVTAKRYSDYFKQEIKLIRTMP
HHHCCEEEECCCHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHCCC
NTPTQIGVGLTGLFAGDDISTEQKAIAETLMATGGEVVWVNKEDDLNQVIALAGSSPAYF
CCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHEECCCCCHHH
FLFLEAMVESAVKGGMSELAAREMAQQAALGAALMVKQNPDVSLAQLRANVTSKGGTTAQ
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHCCCCCCHHH
AVATFEEGNLRGLVDSAMNNCIARAEEMAKQY
HEEEECCCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8982386 [H]