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The map label for this gene is hlyU [H]

Identifier: 167623061

GI number: 167623061

Start: 1370298

End: 1370612

Strand: Direct

Name: hlyU [H]

Synonym: Shal_1127

Alternate gene names: 167623061

Gene position: 1370298-1370612 (Clockwise)

Preceding gene: 167623060

Following gene: 167623063

Centisome position: 26.22

GC content: 37.14

Gene sequence:

>315_bases
ATGAATATAGAATTAATGCAGCAACGAGCAGACCATGCCGTTGTATTGTTGAAAGCGTTAGCCAATGAACGTCGTTTATT
TATCTTGTGTTATCTTCTTAATGAAGGCGAGATGTGTGTTGGTGAAATGAATAAGAAGTTGGGGTTAAGCCAATCGGCTC
TGTCTCAGCACTTAGCTTGGTTACGTAAAGATAATTTAGTCGAAACACGCAAAGAAGCTCAAACGGTTTACTATTCGTTA
AAGAGTGAAGAAGTTGCAGAGATCATTAAATTACTGAATAACATCTATTGTGAAAGCTTAAAGACTGTTGCTTAG

Upstream 100 bases:

>100_bases
TTTAAAACAATCTAGCAAAAAGTGTGCTTTATGTCCCGACTATATCTGTAAGGCAACGCTATATTAGGGCGTCGGTTTGT
TTTAGGAGAAATGGCTCGTA

Downstream 100 bases:

>100_bases
TCAATCTAAAGTCAGTTGTTAGCAAGTTAAAGTTTAATTTGTTACGGTTGGTTTTTATTGACTCTACAAAAGCTATATAA
TGGATGACTAATGGAGAGGC

Product: ArsR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 104; Mature: 104

Protein sequence:

>104_residues
MNIELMQQRADHAVVLLKALANERRLFILCYLLNEGEMCVGEMNKKLGLSQSALSQHLAWLRKDNLVETRKEAQTVYYSL
KSEEVAEIIKLLNNIYCESLKTVA

Sequences:

>Translated_104_residues
MNIELMQQRADHAVVLLKALANERRLFILCYLLNEGEMCVGEMNKKLGLSQSALSQHLAWLRKDNLVETRKEAQTVYYSL
KSEEVAEIIKLLNNIYCESLKTVA
>Mature_104_residues
MNIELMQQRADHAVVLLKALANERRLFILCYLLNEGEMCVGEMNKKLGLSQSALSQHLAWLRKDNLVETRKEAQTVYYSL
KSEEVAEIIKLLNNIYCESLKTVA

Specific function: Up-regulates the expression of the hemolysin gene, hlyA, and may promote expression of other virulence determinants in vivo. It may have both positive and negative regulator activities [H]

COG id: COG0640

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH arsR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789021, Length=93, Percent_Identity=43.010752688172, Blast_Score=88, Evalue=1e-19,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001845
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01022 HTH_5 [H]

EC number: NA

Molecular weight: Translated: 11942; Mature: 11942

Theoretical pI: Translated: 7.34; Mature: 7.34

Prosite motif: PS50987 HTH_ARSR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIELMQQRADHAVVLLKALANERRLFILCYLLNEGEMCVGEMNKKLGLSQSALSQHLAW
CCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCHHHHHHHHCCCCHHHHHHHHHH
LRKDNLVETRKEAQTVYYSLKSEEVAEIIKLLNNIYCESLKTVA
HHHCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNIELMQQRADHAVVLLKALANERRLFILCYLLNEGEMCVGEMNKKLGLSQSALSQHLAW
CCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCHHHHHHHHCCCCHHHHHHHHHH
LRKDNLVETRKEAQTVYYSLKSEEVAEIIKLLNNIYCESLKTVA
HHHCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8231807; 9457888; 10952301 [H]