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The map label for this gene is thrB [H]

Identifier: 167623049

GI number: 167623049

Start: 1355134

End: 1356069

Strand: Direct

Name: thrB [H]

Synonym: Shal_1115

Alternate gene names: 167623049

Gene position: 1355134-1356069 (Clockwise)

Preceding gene: 167623048

Following gene: 167623050

Centisome position: 25.93

GC content: 46.79

Gene sequence:

>936_bases
ATGAGTGTAACCATTTATGCCCCAGCATCGATGGGCAACGTAGGCGTGGGTTTTGACCTACTGGGGGCGGCGTTAGCCCC
TATTGATGGCAGTTTGCTTGGCGATAGGGTTAAGGTTGAATCTGCTGAGCAGGGACTTTCACTCATTCTTGAAGGCCATT
GGGCAAGTAAGTTACCGCAAAATGAGCAAGAGAATATTGTCTATCAATGTGCAGCGTTTTTCCTCTGCCATCTAGGTAAA
GACACAGGGCTTAAATTAACGTTAGAGAAGAACTTGCCTGTAGGCAGCGGACTTGGCTCGAGTGCCAGCTCGGTTGTAGC
CGCGCTAATGGCATTAAATGAATTTTTTGAGCAGCCATTTAACGAGCAAGAACTGCTGCGCTTAATGGGGGAGTTCGAAG
GCAAGATCAGTGGCTCAATACATTATGATAATGTTGCCCCTTGTTACTTAGGCGGAATGCAATTGATGCTCGATACGCCT
AAGACTGTTTGTGAAGCGATCCCTGAGTTTAAGCAATGGTATTGGGTGGTGGCTTACCCTGGTATTTCGCTATCAACCTC
AAGAATGCGCCAATTGATGCCCAATGAATTCGATAAGCAGACGACGATCGATTTTGGTCGCTACTTAAGTGCCTTTGTAC
ACGCATCCTATAAGCAAGATGCAGATCTAGCTATTTCGGTATTAAAGGATGTGTTGGCCGAGCCATATCGCGCGCCTGAA
ATCCCTAATTATCAAAATGCTAAAACGGCTTTAGCCGAGTTAGGTATGTTCACGACAGGGATTTCAGGTAGTGGTCCGAC
CCTGTTTAGCATTACCGATGATCTTGATGTGGCTAAGCAAGCACAGCAATGGCTGGACGCGAACTATGTTGAGCCTAGTA
AAGGCTTCTCTCATATCTGCAGAATCGATAGCCAAGGGGCTCGTAGAGTCGACTAA

Upstream 100 bases:

>100_bases
CATTTGTACTTCGAGGATATGGTGCGGGTACCGATGTTACTGCTGCGGGCGCATTTGCCGATATTTTACGTACACTAAAT
TGGACTCGTGAGGTGGGGGT

Downstream 100 bases:

>100_bases
GCGTCTTAACTAGACCCAATGAACAGAATTTTAAGGAAGTCATTATGGAGTTATATAACCTAAAGCACCCGTCACAGGTG
GTGAGCTTTACTGAAGCGGT

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK [H]

Number of amino acids: Translated: 311; Mature: 310

Protein sequence:

>311_residues
MSVTIYAPASMGNVGVGFDLLGAALAPIDGSLLGDRVKVESAEQGLSLILEGHWASKLPQNEQENIVYQCAAFFLCHLGK
DTGLKLTLEKNLPVGSGLGSSASSVVAALMALNEFFEQPFNEQELLRLMGEFEGKISGSIHYDNVAPCYLGGMQLMLDTP
KTVCEAIPEFKQWYWVVAYPGISLSTSRMRQLMPNEFDKQTTIDFGRYLSAFVHASYKQDADLAISVLKDVLAEPYRAPE
IPNYQNAKTALAELGMFTTGISGSGPTLFSITDDLDVAKQAQQWLDANYVEPSKGFSHICRIDSQGARRVD

Sequences:

>Translated_311_residues
MSVTIYAPASMGNVGVGFDLLGAALAPIDGSLLGDRVKVESAEQGLSLILEGHWASKLPQNEQENIVYQCAAFFLCHLGK
DTGLKLTLEKNLPVGSGLGSSASSVVAALMALNEFFEQPFNEQELLRLMGEFEGKISGSIHYDNVAPCYLGGMQLMLDTP
KTVCEAIPEFKQWYWVVAYPGISLSTSRMRQLMPNEFDKQTTIDFGRYLSAFVHASYKQDADLAISVLKDVLAEPYRAPE
IPNYQNAKTALAELGMFTTGISGSGPTLFSITDDLDVAKQAQQWLDANYVEPSKGFSHICRIDSQGARRVD
>Mature_310_residues
SVTIYAPASMGNVGVGFDLLGAALAPIDGSLLGDRVKVESAEQGLSLILEGHWASKLPQNEQENIVYQCAAFFLCHLGKD
TGLKLTLEKNLPVGSGLGSSASSVVAALMALNEFFEQPFNEQELLRLMGEFEGKISGSIHYDNVAPCYLGGMQLMLDTPK
TVCEAIPEFKQWYWVVAYPGISLSTSRMRQLMPNEFDKQTTIDFGRYLSAFVHASYKQDADLAISVLKDVLAEPYRAPEI
PNYQNAKTALAELGMFTTGISGSGPTLFSITDDLDVAKQAQQWLDANYVEPSKGFSHICRIDSQGARRVD

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate [H]

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786184, Length=306, Percent_Identity=53.5947712418301, Blast_Score=352, Evalue=1e-98,
Organism=Saccharomyces cerevisiae, GI6321814, Length=321, Percent_Identity=24.6105919003115, Blast_Score=73, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.39 [H]

Molecular weight: Translated: 33950; Mature: 33819

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVTIYAPASMGNVGVGFDLLGAALAPIDGSLLGDRVKVESAEQGLSLILEGHWASKLPQ
CEEEEEECCCCCCCCCCHHHHHHHHCCCCCCCCCCEEECCCHHCCCEEEEECCHHHCCCC
NEQENIVYQCAAFFLCHLGKDTGLKLTLEKNLPVGSGLGSSASSVVAALMALNEFFEQPF
CCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
NEQELLRLMGEFEGKISGSIHYDNVAPCYLGGMQLMLDTPKTVCEAIPEFKQWYWVVAYP
CHHHHHHHHHHHCCCCCCEEEECCCCCHHHCCCCEEECCHHHHHHHHHHHHHEEEEEEEC
GISLSTSRMRQLMPNEFDKQTTIDFGRYLSAFVHASYKQDADLAISVLKDVLAEPYRAPE
CCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCC
IPNYQNAKTALAELGMFTTGISGSGPTLFSITDDLDVAKQAQQWLDANYVEPSKGFSHIC
CCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCHHHHH
RIDSQGARRVD
HCCCCCCCCCC
>Mature Secondary Structure 
SVTIYAPASMGNVGVGFDLLGAALAPIDGSLLGDRVKVESAEQGLSLILEGHWASKLPQ
EEEEEECCCCCCCCCCHHHHHHHHCCCCCCCCCCEEECCCHHCCCEEEEECCHHHCCCC
NEQENIVYQCAAFFLCHLGKDTGLKLTLEKNLPVGSGLGSSASSVVAALMALNEFFEQPF
CCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
NEQELLRLMGEFEGKISGSIHYDNVAPCYLGGMQLMLDTPKTVCEAIPEFKQWYWVVAYP
CHHHHHHHHHHHCCCCCCEEEECCCCCHHHCCCCEEECCHHHHHHHHHHHHHEEEEEEEC
GISLSTSRMRQLMPNEFDKQTTIDFGRYLSAFVHASYKQDADLAISVLKDVLAEPYRAPE
CCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCC
IPNYQNAKTALAELGMFTTGISGSGPTLFSITDDLDVAKQAQQWLDANYVEPSKGFSHIC
CCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCHHHHH
RIDSQGARRVD
HCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]