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The map label for this gene is thrC [H]

Identifier: 167623050

GI number: 167623050

Start: 1356114

End: 1357400

Strand: Direct

Name: thrC [H]

Synonym: Shal_1116

Alternate gene names: 167623050

Gene position: 1356114-1357400 (Clockwise)

Preceding gene: 167623049

Following gene: 167623051

Centisome position: 25.94

GC content: 45.38

Gene sequence:

>1287_bases
ATGGAGTTATATAACCTAAAGCACCCGTCACAGGTGGTGAGCTTTACTGAAGCGGTCAAGTTAGGCCTTGGAAAGGACAG
AGGTCTATTTTTCCCAAAACAGATCCCACAGTTGCAAGATGTCGATAGCTTATTGGCGCTGCCATTTGTAGAGAGAAGTA
AGAAAGTCATTGGTGCTTGGTTGGCCTCTGAGCTTGGCCAAGATACTGTTGATAGATTGGTAGAGCGTGCCTTTAACTTT
GAGCTGCCATTAGTGAAGGCTGATAGCAATCTGTATAGTTTGGAGTTGTTTCATGGTCCAACGCTTGCGTTTAAAGATTT
TGGCGCCCGCTTTATGGCCCAGTGTTTAAATGAACTAGCTAAATCAGAAAAGATTAACATTCTCACAGCCACCTCTGGCG
ACACTGGGGCTGCGGTAGCAGATGCATTCTATGGCTTAGATAATATTAATGTGGTGGTGCTGTATCCAAAAGGCAAAATC
AGCGTACTACAGGAGAAGATGTTTACCACATTAGGAAACAATATCCATACGGTTGCGGTAGAGTCAGACTTTGATGCGTG
CCAAACTTTGGTAAAGCAATCATTTGAAGATCTCGATATTAGGGAGGGTTTGCATCTTAACTCGGCAAACTCAATTAATA
TCAGCCGTTTGCTTGCTCAAATTTGCTATTACTTCGAAGCGGTTGCACAGTTTAAGCAACATAATGAAAGCGATCCCGTG
ATTGCCGTACCCAGTGGTAACTTTGGTAACCTAACGGCTGGCTTATTTGCTAAAGCCATGGGGCTACCTATCAAGCGATT
TATTGCTGCCACAAACAGTAATGATACCGTACCTCGCTATTTAGATAGTGGCAAATGGCAGCCAGAAACCACCGTCGCGA
CGATGTCCAATGCGATGGATGTGGCCGAGCCGAGTAACTGGCCACGTGTCGAAGCGATTGTAGAGGTTATGGATTGGTCT
TTGGAGGATATTGTTGGCTTGGGGATCACTGAGACGCAAACAGCGGCTTCGGTGCAAGCGCTGAATAGCGCTGGGTACCT
TTCAGAGCCTCACGCTGCCATTGCTGCTTTGGCACTTAAGCAAACTATGTCTGCAGATGAGAAGGGAATATTCTTAGCAA
CGGCTCATCCGGCTAAATTTAATGAGGTTGTGGAAGAGATCCTCAATATTGAGCTAGCCTTACCTGAGCCATTAGCTCGT
GTCGTCCCGAAAGCTATTTGGTCTGCAGAGTTACCAGCAGATTTTGCGCTGTTAAAACAACATCTTTTCAAGGTGTTGCT
AGATTAA

Upstream 100 bases:

>100_bases
AAGGCTTCTCTCATATCTGCAGAATCGATAGCCAAGGGGCTCGTAGAGTCGACTAAGCGTCTTAACTAGACCCAATGAAC
AGAATTTTAAGGAAGTCATT

Downstream 100 bases:

>100_bases
CTGGGCTGGTTAAATAGGATAAAACATAAATGTTACTTAAATAAGGAAGCTGTTAAGGCTTCCTTTTTTTGTTGATAAAT
TGTGGGTAGCAATTTAAATA

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MELYNLKHPSQVVSFTEAVKLGLGKDRGLFFPKQIPQLQDVDSLLALPFVERSKKVIGAWLASELGQDTVDRLVERAFNF
ELPLVKADSNLYSLELFHGPTLAFKDFGARFMAQCLNELAKSEKINILTATSGDTGAAVADAFYGLDNINVVVLYPKGKI
SVLQEKMFTTLGNNIHTVAVESDFDACQTLVKQSFEDLDIREGLHLNSANSINISRLLAQICYYFEAVAQFKQHNESDPV
IAVPSGNFGNLTAGLFAKAMGLPIKRFIAATNSNDTVPRYLDSGKWQPETTVATMSNAMDVAEPSNWPRVEAIVEVMDWS
LEDIVGLGITETQTAASVQALNSAGYLSEPHAAIAALALKQTMSADEKGIFLATAHPAKFNEVVEEILNIELALPEPLAR
VVPKAIWSAELPADFALLKQHLFKVLLD

Sequences:

>Translated_428_residues
MELYNLKHPSQVVSFTEAVKLGLGKDRGLFFPKQIPQLQDVDSLLALPFVERSKKVIGAWLASELGQDTVDRLVERAFNF
ELPLVKADSNLYSLELFHGPTLAFKDFGARFMAQCLNELAKSEKINILTATSGDTGAAVADAFYGLDNINVVVLYPKGKI
SVLQEKMFTTLGNNIHTVAVESDFDACQTLVKQSFEDLDIREGLHLNSANSINISRLLAQICYYFEAVAQFKQHNESDPV
IAVPSGNFGNLTAGLFAKAMGLPIKRFIAATNSNDTVPRYLDSGKWQPETTVATMSNAMDVAEPSNWPRVEAIVEVMDWS
LEDIVGLGITETQTAASVQALNSAGYLSEPHAAIAALALKQTMSADEKGIFLATAHPAKFNEVVEEILNIELALPEPLAR
VVPKAIWSAELPADFALLKQHLFKVLLD
>Mature_428_residues
MELYNLKHPSQVVSFTEAVKLGLGKDRGLFFPKQIPQLQDVDSLLALPFVERSKKVIGAWLASELGQDTVDRLVERAFNF
ELPLVKADSNLYSLELFHGPTLAFKDFGARFMAQCLNELAKSEKINILTATSGDTGAAVADAFYGLDNINVVVLYPKGKI
SVLQEKMFTTLGNNIHTVAVESDFDACQTLVKQSFEDLDIREGLHLNSANSINISRLLAQICYYFEAVAQFKQHNESDPV
IAVPSGNFGNLTAGLFAKAMGLPIKRFIAATNSNDTVPRYLDSGKWQPETTVATMSNAMDVAEPSNWPRVEAIVEVMDWS
LEDIVGLGITETQTAASVQALNSAGYLSEPHAAIAALALKQTMSADEKGIFLATAHPAKFNEVVEEILNIELALPEPLAR
VVPKAIWSAELPADFALLKQHLFKVLLD

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=440, Percent_Identity=31.8181818181818, Blast_Score=182, Evalue=5e-46,
Organism=Homo sapiens, GI149193323, Length=436, Percent_Identity=31.1926605504587, Blast_Score=165, Evalue=6e-41,
Organism=Escherichia coli, GI1786185, Length=422, Percent_Identity=56.3981042654028, Blast_Score=476, Evalue=1e-135,
Organism=Saccharomyces cerevisiae, GI6319901, Length=448, Percent_Identity=33.2589285714286, Blast_Score=211, Evalue=2e-55,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 46841; Mature: 46841

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELYNLKHPSQVVSFTEAVKLGLGKDRGLFFPKQIPQLQDVDSLLALPFVERSKKVIGAW
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
LASELGQDTVDRLVERAFNFELPLVKADSNLYSLELFHGPTLAFKDFGARFMAQCLNELA
HHHHHCHHHHHHHHHHHHCCCCCEEEECCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHH
KSEKINILTATSGDTGAAVADAFYGLDNINVVVLYPKGKISVLQEKMFTTLGNNIHTVAV
CCCCEEEEEECCCCCCHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHCCCEEEEEE
ESDFDACQTLVKQSFEDLDIREGLHLNSANSINISRLLAQICYYFEAVAQFKQHNESDPV
ECCHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCE
IAVPSGNFGNLTAGLFAKAMGLPIKRFIAATNSNDTVPRYLDSGKWQPETTVATMSNAMD
EEECCCCCCCHHHHHHHHHHCCCHHHHHEECCCCCCCHHHHHCCCCCCCHHHHHHHHHHH
VAEPSNWPRVEAIVEVMDWSLEDIVGLGITETQTAASVQALNSAGYLSEPHAAIAALALK
CCCCCCCHHHHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
QTMSADEKGIFLATAHPAKFNEVVEEILNIELALPEPLARVVPKAIWSAELPADFALLKQ
HHHCCCCCCEEEEECCCHHHHHHHHHHHCCEECCCCHHHHHHHHHHHCCCCCHHHHHHHH
HLFKVLLD
HHHHHHCC
>Mature Secondary Structure
MELYNLKHPSQVVSFTEAVKLGLGKDRGLFFPKQIPQLQDVDSLLALPFVERSKKVIGAW
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
LASELGQDTVDRLVERAFNFELPLVKADSNLYSLELFHGPTLAFKDFGARFMAQCLNELA
HHHHHCHHHHHHHHHHHHCCCCCEEEECCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHH
KSEKINILTATSGDTGAAVADAFYGLDNINVVVLYPKGKISVLQEKMFTTLGNNIHTVAV
CCCCEEEEEECCCCCCHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHCCCEEEEEE
ESDFDACQTLVKQSFEDLDIREGLHLNSANSINISRLLAQICYYFEAVAQFKQHNESDPV
ECCHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCE
IAVPSGNFGNLTAGLFAKAMGLPIKRFIAATNSNDTVPRYLDSGKWQPETTVATMSNAMD
EEECCCCCCCHHHHHHHHHHCCCHHHHHEECCCCCCCHHHHHCCCCCCCHHHHHHHHHHH
VAEPSNWPRVEAIVEVMDWSLEDIVGLGITETQTAASVQALNSAGYLSEPHAAIAALALK
CCCCCCCHHHHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
QTMSADEKGIFLATAHPAKFNEVVEEILNIELALPEPLARVVPKAIWSAELPADFALLKQ
HHHCCCCCCEEEEECCCHHHHHHHHHHHCCEECCCCHHHHHHHHHHHCCCCCHHHHHHHH
HLFKVLLD
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]