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The map label for this gene is folK [H]

Identifier: 167622951

GI number: 167622951

Start: 1242698

End: 1243189

Strand: Direct

Name: folK [H]

Synonym: Shal_1012

Alternate gene names: 167622951

Gene position: 1242698-1243189 (Clockwise)

Preceding gene: 167622950

Following gene: 167622952

Centisome position: 23.77

GC content: 42.28

Gene sequence:

>492_bases
ATGGCGAAGATTTTTATAAGCCTTGGCAGTAATATTGAACCAGAACGTTACCTTAAGGCCGCGCTAACTGATCTTGATTA
CTATTTTGAAACTCTCGAACTGTCATCGGTATTTGAAAGTGAAGCTGTGGGTTTTGAAGGCACTAATTTTCTCAATATGG
TGGTTGCAGCCCAAACTGAACTACCGATAGCTGACGTGGTTAACAGGTTTAAACAGATTGAACAAAGCCACGGCCGAGTG
AAAGGTGCCAAGAAGTTTGCCCCAAGAACCTTAGATTTAGATCTGTTGTTGTATGACGATACAGTTAGTACTCAGCCAAT
AGAGCTTCCTAGAGCGGAGATCCTTTATAATGCCTTTGTTTTATGGCCATTAGCTGAAATCGCCCCCTCTTTAACCCACC
CTGTTGTCAAACAGTCGTATCAAACCCTTTGGGATAGCTACGACAAGAGTCAGCAATCATTATGGCCAGTTGAATTTAGC
TGGTCTAAGTAA

Upstream 100 bases:

>100_bases
TGAATTCAATGTGCCATGGGTAAAAGTTAAGGTGATGAAACCCGGCGCTGTACCTACAGCGTCTGCAGTGGGTGTTGAGA
TTGAAAGAGGTTATGCATAG

Downstream 100 bases:

>100_bases
AACCTTTTTTGATTTAGGATAGTTATGGATACCTTTCAGGTGATTATATTGGCTCTTATTCAGGGCCTCACCGAGTTTTT
GCCGATCTCAAGTTCCGCTC

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 163; Mature: 162

Protein sequence:

>163_residues
MAKIFISLGSNIEPERYLKAALTDLDYYFETLELSSVFESEAVGFEGTNFLNMVVAAQTELPIADVVNRFKQIEQSHGRV
KGAKKFAPRTLDLDLLLYDDTVSTQPIELPRAEILYNAFVLWPLAEIAPSLTHPVVKQSYQTLWDSYDKSQQSLWPVEFS
WSK

Sequences:

>Translated_163_residues
MAKIFISLGSNIEPERYLKAALTDLDYYFETLELSSVFESEAVGFEGTNFLNMVVAAQTELPIADVVNRFKQIEQSHGRV
KGAKKFAPRTLDLDLLLYDDTVSTQPIELPRAEILYNAFVLWPLAEIAPSLTHPVVKQSYQTLWDSYDKSQQSLWPVEFS
WSK
>Mature_162_residues
AKIFISLGSNIEPERYLKAALTDLDYYFETLELSSVFESEAVGFEGTNFLNMVVAAQTELPIADVVNRFKQIEQSHGRVK
GAKKFAPRTLDLDLLLYDDTVSTQPIELPRAEILYNAFVLWPLAEIAPSLTHPVVKQSYQTLWDSYDKSQQSLWPVEFSW
SK

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=155, Percent_Identity=34.1935483870968, Blast_Score=83, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6324073, Length=169, Percent_Identity=31.3609467455621, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 18581; Mature: 18450

Theoretical pI: Translated: 4.46; Mature: 4.46

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIFISLGSNIEPERYLKAALTDLDYYFETLELSSVFESEAVGFEGTNFLNMVVAAQTE
CEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCC
LPIADVVNRFKQIEQSHGRVKGAKKFAPRTLDLDLLLYDDTVSTQPIELPRAEILYNAFV
CCHHHHHHHHHHHHHHCCCCCCHHHCCCCEECEEEEEECCCCCCCCCCCCHHHHHHHHHH
LWPLAEIAPSLTHPVVKQSYQTLWDSYDKSQQSLWPVEFSWSK
HHHHHHHCHHHCCHHHHHHHHHHHHHHCCHHHCCCCEEECCCC
>Mature Secondary Structure 
AKIFISLGSNIEPERYLKAALTDLDYYFETLELSSVFESEAVGFEGTNFLNMVVAAQTE
EEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCC
LPIADVVNRFKQIEQSHGRVKGAKKFAPRTLDLDLLLYDDTVSTQPIELPRAEILYNAFV
CCHHHHHHHHHHHHHHCCCCCCHHHCCCCEECEEEEEECCCCCCCCCCCCHHHHHHHHHH
LWPLAEIAPSLTHPVVKQSYQTLWDSYDKSQQSLWPVEFSWSK
HHHHHHHCHHHCCHHHHHHHHHHHHHHCCHHHCCCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]