Click here to switch to the map view.

The map label for this gene is pdxA [H]

Identifier: 167622856

GI number: 167622856

Start: 1134757

End: 1135740

Strand: Reverse

Name: pdxA [H]

Synonym: Shal_0916

Alternate gene names: 167622856

Gene position: 1135740-1134757 (Counterclockwise)

Preceding gene: 167622857

Following gene: 167622855

Centisome position: 21.73

GC content: 47.36

Gene sequence:

>984_bases
TTGTCAACTAAACGAATTGCCATCACGCCGGGTGAACCGGCGGGGATAGGCCCCGATTTAGTGATACAACTAGCTCAGCA
GGCTTGGCCTGCTGAGCTAGTCGTTTGTGCTGATCCTGAATTGCTCAAGTCTCGAGCCAAGAAGCTTGGGCTATCGATTA
CGCTACGCCCATACCAACCTAACCAGCCGCCTAAGGCGCAAGAGGCAGGTACACTAACTATCGTGCCTTTTACCCTTGAG
GCCGACGTGCATTGTGGGAAATTGAACGAAGCCAATAGTGCCTACGTTGTTGAAACCCTAAGATTTGCGGGTGAAAAGAA
CATGGTTGGTGAGTTTGATGCTGTAGTGACGGGCCCCGTCCATAAAGGCATCATTAATCAGGCGGGTATTCCGTTTAGTG
GACATACTGAGTTCTTTGCAAACCAAGCAAATTGTCAGGATGTGGTGATGATGCTGGCAGCCCCTGGTTTACAGGTTGCA
CTTGTGACAACCCATATTCCATTAGCTTATGTGTCTAAAGCCATTACTCGCGATAGACTGCATCAGATAGTTAAAATTTT
ACATAACGACTTAGTCGAAAAGTTTGCTATTGAGGCACCGCGGATCTATGTCTGTGGTTTAAATCCTCATGCAGGCGAAG
ACGGCCATTTAGGCAGAGAAGAGATCGATACGATCATCCCTGCACTCAATGAATTAAGAGAACTCGACATGGATATCGTT
GGCCCATTGCCAGCCGATACCCTGTTTCAACCTAAATACCTAGAAGATGCTGACGTTGTACTCGCCATGTACCACGATCA
GGGGCTTCCAGTACTAAAATCTAGAGGATTTGGCAGTTCGGTCAATATCACTCTAGGATTACCCTATATAAGAACGTCGG
TCGACCACGGTACGGCCCTAGAGCTTGCAGGCACGGGTACTGCTGATATTGGCAGTTTTGTTTGCGCATTAAATAAAGCC
ATTGATTTGGCTGCAAAGAATTAG

Upstream 100 bases:

>100_bases
GTCGTAAATTTAATGAAGAGTTACAAAACTGGCTAGATGAGATGCGCGCTGAAGCATTTATCGATATTTTTGAGCCAGAA
ACGAACCGAGGTTAATACTA

Downstream 100 bases:

>100_bases
TGATAAAAGTTACCTCATGAGCAATAAAGTACATTTAGGCCACACGGCCAGAAAACGTTTTGGACAAAACTTCTTAACTG
ACGAGAATGTGATTAATCGC

Product: 4-hydroxythreonine-4-phosphate dehydrogenase

Products: NA

Alternate protein names: 4-(phosphohydroxy)-L-threonine dehydrogenase [H]

Number of amino acids: Translated: 327; Mature: 326

Protein sequence:

>327_residues
MSTKRIAITPGEPAGIGPDLVIQLAQQAWPAELVVCADPELLKSRAKKLGLSITLRPYQPNQPPKAQEAGTLTIVPFTLE
ADVHCGKLNEANSAYVVETLRFAGEKNMVGEFDAVVTGPVHKGIINQAGIPFSGHTEFFANQANCQDVVMMLAAPGLQVA
LVTTHIPLAYVSKAITRDRLHQIVKILHNDLVEKFAIEAPRIYVCGLNPHAGEDGHLGREEIDTIIPALNELRELDMDIV
GPLPADTLFQPKYLEDADVVLAMYHDQGLPVLKSRGFGSSVNITLGLPYIRTSVDHGTALELAGTGTADIGSFVCALNKA
IDLAAKN

Sequences:

>Translated_327_residues
MSTKRIAITPGEPAGIGPDLVIQLAQQAWPAELVVCADPELLKSRAKKLGLSITLRPYQPNQPPKAQEAGTLTIVPFTLE
ADVHCGKLNEANSAYVVETLRFAGEKNMVGEFDAVVTGPVHKGIINQAGIPFSGHTEFFANQANCQDVVMMLAAPGLQVA
LVTTHIPLAYVSKAITRDRLHQIVKILHNDLVEKFAIEAPRIYVCGLNPHAGEDGHLGREEIDTIIPALNELRELDMDIV
GPLPADTLFQPKYLEDADVVLAMYHDQGLPVLKSRGFGSSVNITLGLPYIRTSVDHGTALELAGTGTADIGSFVCALNKA
IDLAAKN
>Mature_326_residues
STKRIAITPGEPAGIGPDLVIQLAQQAWPAELVVCADPELLKSRAKKLGLSITLRPYQPNQPPKAQEAGTLTIVPFTLEA
DVHCGKLNEANSAYVVETLRFAGEKNMVGEFDAVVTGPVHKGIINQAGIPFSGHTEFFANQANCQDVVMMLAAPGLQVAL
VTTHIPLAYVSKAITRDRLHQIVKILHNDLVEKFAIEAPRIYVCGLNPHAGEDGHLGREEIDTIIPALNELRELDMDIVG
PLPADTLFQPKYLEDADVVLAMYHDQGLPVLKSRGFGSSVNITLGLPYIRTSVDHGTALELAGTGTADIGSFVCALNKAI
DLAAKN

Specific function: Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) [H]

COG id: COG1995

COG function: function code H; Pyridoxal phosphate biosynthesis protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pdxA family [H]

Homologues:

Organism=Escherichia coli, GI1786237, Length=323, Percent_Identity=65.9442724458204, Blast_Score=435, Evalue=1e-123,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005255 [H]

Pfam domain/function: PF04166 PdxA [H]

EC number: =1.1.1.262 [H]

Molecular weight: Translated: 35119; Mature: 34988

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTKRIAITPGEPAGIGPDLVIQLAQQAWPAELVVCADPELLKSRAKKLGLSITLRPYQP
CCCCEEEECCCCCCCCCHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHCCCEEEEECCCC
NQPPKAQEAGTLTIVPFTLEADVHCGKLNEANSAYVVETLRFAGEKNMVGEFDAVVTGPV
CCCCCCHHCCEEEEEEEEEECCCEECCCCCCCCHHHHHHHHHCCCCCCCCCCCEEEECCH
HKGIINQAGIPFSGHTEFFANQANCQDVVMMLAAPGLQVALVTTHIPLAYVSKAITRDRL
HHHHHHCCCCCCCCCHHHHCCCCCHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHH
HQIVKILHNDLVEKFAIEAPRIYVCGLNPHAGEDGHLGREEIDTIIPALNELRELDMDIV
HHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHC
GPLPADTLFQPKYLEDADVVLAMYHDQGLPVLKSRGFGSSVNITLGLPYIRTSVDHGTAL
CCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEECCCCCCEEEEEEECCHHEECCCCCCEE
ELAGTGTADIGSFVCALNKAIDLAAKN
EEECCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
STKRIAITPGEPAGIGPDLVIQLAQQAWPAELVVCADPELLKSRAKKLGLSITLRPYQP
CCCEEEECCCCCCCCCHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHCCCEEEEECCCC
NQPPKAQEAGTLTIVPFTLEADVHCGKLNEANSAYVVETLRFAGEKNMVGEFDAVVTGPV
CCCCCCHHCCEEEEEEEEEECCCEECCCCCCCCHHHHHHHHHCCCCCCCCCCCEEEECCH
HKGIINQAGIPFSGHTEFFANQANCQDVVMMLAAPGLQVALVTTHIPLAYVSKAITRDRL
HHHHHHCCCCCCCCCHHHHCCCCCHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHH
HQIVKILHNDLVEKFAIEAPRIYVCGLNPHAGEDGHLGREEIDTIIPALNELRELDMDIV
HHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHC
GPLPADTLFQPKYLEDADVVLAMYHDQGLPVLKSRGFGSSVNITLGLPYIRTSVDHGTAL
CCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEECCCCCCEEEEEEECCHHEECCCCCCEE
ELAGTGTADIGSFVCALNKAIDLAAKN
EEECCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]