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The map label for this gene is epd

Identifier: 167622785

GI number: 167622785

Start: 1051215

End: 1052234

Strand: Direct

Name: epd

Synonym: Shal_0845

Alternate gene names: 167622785

Gene position: 1051215-1052234 (Clockwise)

Preceding gene: 167622784

Following gene: 167622786

Centisome position: 20.11

GC content: 47.65

Gene sequence:

>1020_bases
ATGATTAGAGTCGCTATTAATGGCTACGGCCGTATTGGTCGATCAATTCTTCGTGCACTGTATGAGTCTGCAAAACGCGA
TCGCATCCAGATTGTCGCGATTAACGAGTTGGCAAAACCAGAAGCGATGCTTCATTTGACTCAGTACGATACCACCCACG
GCCGCTTCCACACTCAAGTTAAGCTAGATAATCAGCATATGATTATTGGTGATGATGCCATTAAACTGCTGCATGAACCT
AACCCTGCCAACCTGCCTTGGAAAGAGCTGGATATCGATATCGTTTATGAAGCTACAGGCGTAATTAACGATAGGCAAGA
GTGCGAAGCACACCTTAAAGCTGGGGCTAAGCAGGTACTTATTAGTCATCCATCATCAAATGATGTCGATGCCACCATCG
TCTATGGTGTGAACCAAGATTTATTAAGAGCCGAACATACCGTTGTGTCGAATGCCTCGTGCACCACCAACTGTATCGTG
CCGGTGATCGATGTGCTCGATAGACACTTCGAAGTTAAAAGTGGTGCCATCACCACGATCCACTCTGCGATGAACGATCA
GCAGGTGATTGACGCATATCATGACGACCTTCGTCGTACTCGCGCCGCAGGGCAGTCTATAATTCCTGTTGATACTAAGC
TTGCCCGTGGTATTGAGCGCATTCTGCCGCATATGAAAAACAAATTTGAGGCAATCTCAGTTCGGGTGCCAACCATCAAT
GTTACTGCAATCGATCTTTCCGTGACGCTAAATAAGCGCGTCGATATCGAGTTGGTGAACCGGGTACTTAAACAGGCAAC
CGAGGGCTCGTTCTCAGGTGTTGTCGGCTTTACCAATGAGCCGTTAGTATCGTGCGACTTTAACCACGACCCGCGCTCAA
GCATTGTCGATGGCACCCAAACCCGAGTCAGCGATGGTCACTTGGTGAAACTCCTTTTATGGTGCGATAACGAGTGGGGC
TTTGCTAACCGTATGTTAGACACTAGCTTAGAGATGATAAAGGCGAAAAGAAGCTCCTAG

Upstream 100 bases:

>100_bases
TAATCAACAGCTGTGTTAAGGCTATGATACAACGGCTTACCTAATGAGGTAGGCCGTTGTCGTATCAATAAATGGGCTGT
GAAAGGAATAGAAAGCTTAC

Downstream 100 bases:

>100_bases
TTTTTTGTAGGTCGGCATTTATGCCGTCGTTGATAGCTTCATTAATATTGTTAGTGATGCTGTTATTGATAGCGTTGCTG
TCGTTATTAATAGCGCAGTT

Product: erythrose 4-phosphate dehydrogenase

Products: NA

Alternate protein names: E4PDH

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MIRVAINGYGRIGRSILRALYESAKRDRIQIVAINELAKPEAMLHLTQYDTTHGRFHTQVKLDNQHMIIGDDAIKLLHEP
NPANLPWKELDIDIVYEATGVINDRQECEAHLKAGAKQVLISHPSSNDVDATIVYGVNQDLLRAEHTVVSNASCTTNCIV
PVIDVLDRHFEVKSGAITTIHSAMNDQQVIDAYHDDLRRTRAAGQSIIPVDTKLARGIERILPHMKNKFEAISVRVPTIN
VTAIDLSVTLNKRVDIELVNRVLKQATEGSFSGVVGFTNEPLVSCDFNHDPRSSIVDGTQTRVSDGHLVKLLLWCDNEWG
FANRMLDTSLEMIKAKRSS

Sequences:

>Translated_339_residues
MIRVAINGYGRIGRSILRALYESAKRDRIQIVAINELAKPEAMLHLTQYDTTHGRFHTQVKLDNQHMIIGDDAIKLLHEP
NPANLPWKELDIDIVYEATGVINDRQECEAHLKAGAKQVLISHPSSNDVDATIVYGVNQDLLRAEHTVVSNASCTTNCIV
PVIDVLDRHFEVKSGAITTIHSAMNDQQVIDAYHDDLRRTRAAGQSIIPVDTKLARGIERILPHMKNKFEAISVRVPTIN
VTAIDLSVTLNKRVDIELVNRVLKQATEGSFSGVVGFTNEPLVSCDFNHDPRSSIVDGTQTRVSDGHLVKLLLWCDNEWG
FANRMLDTSLEMIKAKRSS
>Mature_339_residues
MIRVAINGYGRIGRSILRALYESAKRDRIQIVAINELAKPEAMLHLTQYDTTHGRFHTQVKLDNQHMIIGDDAIKLLHEP
NPANLPWKELDIDIVYEATGVINDRQECEAHLKAGAKQVLISHPSSNDVDATIVYGVNQDLLRAEHTVVSNASCTTNCIV
PVIDVLDRHFEVKSGAITTIHSAMNDQQVIDAYHDDLRRTRAAGQSIIPVDTKLARGIERILPHMKNKFEAISVRVPTIN
VTAIDLSVTLNKRVDIELVNRVLKQATEGSFSGVVGFTNEPLVSCDFNHDPRSSIVDGTQTRVSDGHLVKLLLWCDNEWG
FANRMLDTSLEMIKAKRSS

Specific function: Catalyzes the NAD-dependent conversion of D-erythrose 4- phosphate to 4-phosphoerythronate

COG id: COG0057

COG function: function code G; Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. Epd subfamily

Homologues:

Organism=Homo sapiens, GI7669492, Length=333, Percent_Identity=37.8378378378378, Blast_Score=253, Evalue=1e-67,
Organism=Homo sapiens, GI7657116, Length=329, Percent_Identity=34.9544072948328, Blast_Score=223, Evalue=2e-58,
Organism=Escherichia coli, GI1789295, Length=331, Percent_Identity=65.2567975830816, Blast_Score=465, Evalue=1e-132,
Organism=Escherichia coli, GI1788079, Length=327, Percent_Identity=39.7553516819572, Blast_Score=259, Evalue=2e-70,
Organism=Caenorhabditis elegans, GI17534677, Length=333, Percent_Identity=38.7387387387387, Blast_Score=248, Evalue=3e-66,
Organism=Caenorhabditis elegans, GI17534679, Length=333, Percent_Identity=38.4384384384384, Blast_Score=247, Evalue=7e-66,
Organism=Caenorhabditis elegans, GI32566163, Length=332, Percent_Identity=37.0481927710843, Blast_Score=238, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI17568413, Length=332, Percent_Identity=37.0481927710843, Blast_Score=238, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6322468, Length=337, Percent_Identity=38.5756676557863, Blast_Score=263, Evalue=4e-71,
Organism=Saccharomyces cerevisiae, GI6321631, Length=337, Percent_Identity=37.9821958456973, Blast_Score=258, Evalue=7e-70,
Organism=Saccharomyces cerevisiae, GI6322409, Length=329, Percent_Identity=38.6018237082067, Blast_Score=255, Evalue=8e-69,
Organism=Drosophila melanogaster, GI85725000, Length=329, Percent_Identity=36.4741641337386, Blast_Score=239, Evalue=2e-63,
Organism=Drosophila melanogaster, GI22023983, Length=329, Percent_Identity=36.4741641337386, Blast_Score=239, Evalue=2e-63,
Organism=Drosophila melanogaster, GI17933600, Length=329, Percent_Identity=36.1702127659575, Blast_Score=239, Evalue=2e-63,
Organism=Drosophila melanogaster, GI18110149, Length=329, Percent_Identity=36.1702127659575, Blast_Score=239, Evalue=2e-63,
Organism=Drosophila melanogaster, GI19922412, Length=332, Percent_Identity=33.7349397590361, Blast_Score=226, Evalue=2e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): E4PD_SHEHH (B0TUC0)

Other databases:

- EMBL:   CP000931
- RefSeq:   YP_001673079.1
- ProteinModelPortal:   B0TUC0
- SMR:   B0TUC0
- GeneID:   5902965
- GenomeReviews:   CP000931_GR
- KEGG:   shl:Shal_0845
- HOGENOM:   HBG571736
- OMA:   IQAKAVR
- ProtClustDB:   PRK13535
- BioCyc:   SHAL458817:SHAL_0845-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01640
- InterPro:   IPR006422
- InterPro:   IPR020831
- InterPro:   IPR020830
- InterPro:   IPR020829
- InterPro:   IPR020828
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR10836
- PIRSF:   PIRSF000149
- PRINTS:   PR00078
- SMART:   SM00846
- TIGRFAMs:   TIGR01532

Pfam domain/function: PF02800 Gp_dh_C; PF00044 Gp_dh_N

EC number: =1.2.1.72

Molecular weight: Translated: 37809; Mature: 37809

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: PS00071 GAPDH

Important sites: ACT_SITE 154-154 BINDING 199-199 BINDING 235-235 BINDING 317-317

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRVAINGYGRIGRSILRALYESAKRDRIQIVAINELAKPEAMLHLTQYDTTHGRFHTQV
CEEEEEECCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEEECCCCCCEEEEEE
KLDNQHMIIGDDAIKLLHEPNPANLPWKELDIDIVYEATGVINDRQECEAHLKAGAKQVL
EECCCEEEECHHHHHHHCCCCCCCCCHHHCCEEEEEEECCCCCCHHHHHHHHHCCCEEEE
ISHPSSNDVDATIVYGVNQDLLRAEHTVVSNASCTTNCIVPVIDVLDRHFEVKSGAITTI
EECCCCCCCCEEEEEECCHHHHHHHHHEECCCCCCCCHHHHHHHHHHHCEECCCCCEEEH
HSAMNDQQVIDAYHDDLRRTRAAGQSIIPVDTKLARGIERILPHMKNKFEAISVRVPTIN
HHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECEEE
VTAIDLSVTLNKRVDIELVNRVLKQATEGSFSGVVGFTNEPLVSCDFNHDPRSSIVDGTQ
EEEEEEEEEECCCCCHHHHHHHHHHHCCCCCCEEEECCCCCEEEEECCCCCCHHHCCCCC
TRVSDGHLVKLLLWCDNEWGFANRMLDTSLEMIKAKRSS
CCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIRVAINGYGRIGRSILRALYESAKRDRIQIVAINELAKPEAMLHLTQYDTTHGRFHTQV
CEEEEEECCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEEECCCCCCEEEEEE
KLDNQHMIIGDDAIKLLHEPNPANLPWKELDIDIVYEATGVINDRQECEAHLKAGAKQVL
EECCCEEEECHHHHHHHCCCCCCCCCHHHCCEEEEEEECCCCCCHHHHHHHHHCCCEEEE
ISHPSSNDVDATIVYGVNQDLLRAEHTVVSNASCTTNCIVPVIDVLDRHFEVKSGAITTI
EECCCCCCCCEEEEEECCHHHHHHHHHEECCCCCCCCHHHHHHHHHHHCEECCCCCEEEH
HSAMNDQQVIDAYHDDLRRTRAAGQSIIPVDTKLARGIERILPHMKNKFEAISVRVPTIN
HHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECEEE
VTAIDLSVTLNKRVDIELVNRVLKQATEGSFSGVVGFTNEPLVSCDFNHDPRSSIVDGTQ
EEEEEEEEEECCCCCHHHHHHHHHHHCCCCCCEEEECCCCCEEEEECCCCCCHHHCCCCC
TRVSDGHLVKLLLWCDNEWGFANRMLDTSLEMIKAKRSS
CCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA