Click here to switch to the map view.

The map label for this gene is tkt1 [H]

Identifier: 167622784

GI number: 167622784

Start: 1049126

End: 1051117

Strand: Direct

Name: tkt1 [H]

Synonym: Shal_0844

Alternate gene names: 167622784

Gene position: 1049126-1051117 (Clockwise)

Preceding gene: 167622782

Following gene: 167622785

Centisome position: 20.07

GC content: 48.29

Gene sequence:

>1992_bases
ATGTCATCTCGTAAAGAACTCGCAAACGCAATCCGCGCATTGACCATGGATGCTGTTCAAAAAGCCAATTCAGGTCACCC
AGGTGCACCTATGGGGATGGCTGATATTGCTGAAGTGCTCTGGAACGATTTCCTAAAGCACAACCCAAACAACCCTGACT
GGGTTGATCGTGACCGCTTTATCCTTTCTAACGGCCACGGCTCTATGCTTATCTACTCTTTGCTGCACCTAACAGGTTAC
GCATTACCTATCGAAGAGTTAAAAAACTTCCGCCAGCTTCACTCTAAAACACCTGGTCACCCAGAATACGGTTACACACC
AGGTGTTGAAACGACAACAGGTCCGTTAGGTGCTGGTATCAGTAACGCTGTTGGTATGGCGATTGCTGAAAAGACATTGG
CTGCACAGTTTAACAAGCCAGGTCACGATATTGTTGATCACTTCACATACTGCTTCCTAGGCGATGGCTGTTTGATGGAA
GGTATCTCTCACGAAGCCTGTTCTCTAGCGGGTACCCTAGGTCTGGGTAAGCTAGTTGCGTTCTGGGATGACAACGGTAT
CTCTATCGACGGTCACGTTGAAGGTTGGTTCACTGACGATACGCCTAAGCGTTTTGAATCTTACGGCTGGCATGTTATCG
CTAACGTAGATGGTCACGACAGCGACGCTATTCGTGCGGCAATCGAAGCAGCTAAGTCTGTTACAGATAAGCCTACAATG
ATCTGCTGTAAAACCACGATCGGTTTTGGTTCGCCAAACAAGTCTGGTAGCCACGACTGTCACGGTGCACCACTAGGTGA
TGCTGAGATTGCTGCTGCACGTGAATTCCTTGGCTGGAACCACGCTGCATTTGAAATCCCTGAAAATGTTTACGCGGGTT
GGGATGCTAAAGAAACTGGCGCAGCGCGTGAGTCAAGCTGGAACGATAAGTTCGCAGCTTATGAAGTAGCATTCCCAGAA
CTAGCTGCTGAATACAAGCGCCGTGTTATCACTGGCGAACTACCTGCTGAGTTTGAAGAGAAAGCACAAGCTTTCGTTCA
AGAGTGCCAAGATAAAGCAGAAGGTATTGCTAGCCGTAAAGCATCACAAAATGCGATTGGTGCATTTGGTGCTATCCTAC
CAGAAATGCTAGGTGGCTCTGCAGATCTAGCCGGTTCTAACCTAACGCTTTGGTCTGGTTCTAAAGGTATTCAAGACGAT
CCTGCTGGTAACTACATCTATTACGGTGTACGTGAATTCGGCATGAGCGGTATCATGAACGGTGCATCACTGCACGGTGG
TTTCATCAACTACGGCGCAACTTTCATGATGTTTATGGAATACGCTCGTAACGCAGTACGTATGTCTGCACTGATGGGCA
TTCAGAACATCTTCGTTTATACCCATGACTCTATCGGTCAAGGTGAAGATGGTCCGACTCACCAGCCAGTTGAGCAACTT
GCAAACCTTCGTATGACACCAAACATGACGGTATGGCGTCCATGTGATGCGGCTGAAACTGCCGTTTCTTGGAAGAATGC
GATTGAACGTCGCAATGCGCCAACATCATTGATCTTTAGCCGTCAAAACCTACCTGCACAAGCACGTACTGCAGAGCAGT
TAGCTAACGTGGTTAAAGGTGGTTATGTATTAAGTGATTGTGCTGGCACGCCAGACCTAATCCTTATCGCTACTGGCTCT
GAAGTTCAGCTAGCCCTTGATTCTGCTGCAGCATTGACTGAGCAAGGTCAGAAGGTTCGCGTAGTATCTATGCCGTCAAC
TAACGAGTTCGACAAGCAAGATGCGGCTTATAAAGAGTCTGTACTGCCAAGCTGCGTGACTAAGCGTGTTGCAATCGAAG
CGGCTCACGTCGATTTCTGGCACAAGTATGTTGGCTTTGGCGGCGCGGTTGTCGGTATGACAACCTTCGGTGAGTCTGCT
CCTGGCGGCGACCTGCTGAAGTACTTTGGCTTTACAGTTGAAAACGTTGTAGCAACCGTTAACGGTCTATAA

Upstream 100 bases:

>100_bases
TGGCTCCAAAATTTGCTGTAGGGAAGGGAAAAGCAAATACAAACTTGTGGCCCTTTTCTTTATCTAAGCCTCAATACCTC
AAAACGAAGCAGGAGAGAGC

Downstream 100 bases:

>100_bases
TCAACAGCTGTGTTAAGGCTATGATACAACGGCTTACCTAATGAGGTAGGCCGTTGTCGTATCAATAAATGGGCTGTGAA
AGGAATAGAAAGCTTACATG

Product: transketolase

Products: NA

Alternate protein names: TK 1 [H]

Number of amino acids: Translated: 663; Mature: 662

Protein sequence:

>663_residues
MSSRKELANAIRALTMDAVQKANSGHPGAPMGMADIAEVLWNDFLKHNPNNPDWVDRDRFILSNGHGSMLIYSLLHLTGY
ALPIEELKNFRQLHSKTPGHPEYGYTPGVETTTGPLGAGISNAVGMAIAEKTLAAQFNKPGHDIVDHFTYCFLGDGCLME
GISHEACSLAGTLGLGKLVAFWDDNGISIDGHVEGWFTDDTPKRFESYGWHVIANVDGHDSDAIRAAIEAAKSVTDKPTM
ICCKTTIGFGSPNKSGSHDCHGAPLGDAEIAAAREFLGWNHAAFEIPENVYAGWDAKETGAARESSWNDKFAAYEVAFPE
LAAEYKRRVITGELPAEFEEKAQAFVQECQDKAEGIASRKASQNAIGAFGAILPEMLGGSADLAGSNLTLWSGSKGIQDD
PAGNYIYYGVREFGMSGIMNGASLHGGFINYGATFMMFMEYARNAVRMSALMGIQNIFVYTHDSIGQGEDGPTHQPVEQL
ANLRMTPNMTVWRPCDAAETAVSWKNAIERRNAPTSLIFSRQNLPAQARTAEQLANVVKGGYVLSDCAGTPDLILIATGS
EVQLALDSAAALTEQGQKVRVVSMPSTNEFDKQDAAYKESVLPSCVTKRVAIEAAHVDFWHKYVGFGGAVVGMTTFGESA
PGGDLLKYFGFTVENVVATVNGL

Sequences:

>Translated_663_residues
MSSRKELANAIRALTMDAVQKANSGHPGAPMGMADIAEVLWNDFLKHNPNNPDWVDRDRFILSNGHGSMLIYSLLHLTGY
ALPIEELKNFRQLHSKTPGHPEYGYTPGVETTTGPLGAGISNAVGMAIAEKTLAAQFNKPGHDIVDHFTYCFLGDGCLME
GISHEACSLAGTLGLGKLVAFWDDNGISIDGHVEGWFTDDTPKRFESYGWHVIANVDGHDSDAIRAAIEAAKSVTDKPTM
ICCKTTIGFGSPNKSGSHDCHGAPLGDAEIAAAREFLGWNHAAFEIPENVYAGWDAKETGAARESSWNDKFAAYEVAFPE
LAAEYKRRVITGELPAEFEEKAQAFVQECQDKAEGIASRKASQNAIGAFGAILPEMLGGSADLAGSNLTLWSGSKGIQDD
PAGNYIYYGVREFGMSGIMNGASLHGGFINYGATFMMFMEYARNAVRMSALMGIQNIFVYTHDSIGQGEDGPTHQPVEQL
ANLRMTPNMTVWRPCDAAETAVSWKNAIERRNAPTSLIFSRQNLPAQARTAEQLANVVKGGYVLSDCAGTPDLILIATGS
EVQLALDSAAALTEQGQKVRVVSMPSTNEFDKQDAAYKESVLPSCVTKRVAIEAAHVDFWHKYVGFGGAVVGMTTFGESA
PGGDLLKYFGFTVENVVATVNGL
>Mature_662_residues
SSRKELANAIRALTMDAVQKANSGHPGAPMGMADIAEVLWNDFLKHNPNNPDWVDRDRFILSNGHGSMLIYSLLHLTGYA
LPIEELKNFRQLHSKTPGHPEYGYTPGVETTTGPLGAGISNAVGMAIAEKTLAAQFNKPGHDIVDHFTYCFLGDGCLMEG
ISHEACSLAGTLGLGKLVAFWDDNGISIDGHVEGWFTDDTPKRFESYGWHVIANVDGHDSDAIRAAIEAAKSVTDKPTMI
CCKTTIGFGSPNKSGSHDCHGAPLGDAEIAAAREFLGWNHAAFEIPENVYAGWDAKETGAARESSWNDKFAAYEVAFPEL
AAEYKRRVITGELPAEFEEKAQAFVQECQDKAEGIASRKASQNAIGAFGAILPEMLGGSADLAGSNLTLWSGSKGIQDDP
AGNYIYYGVREFGMSGIMNGASLHGGFINYGATFMMFMEYARNAVRMSALMGIQNIFVYTHDSIGQGEDGPTHQPVEQLA
NLRMTPNMTVWRPCDAAETAVSWKNAIERRNAPTSLIFSRQNLPAQARTAEQLANVVKGGYVLSDCAGTPDLILIATGSE
VQLALDSAAALTEQGQKVRVVSMPSTNEFDKQDAAYKESVLPSCVTKRVAIEAAHVDFWHKYVGFGGAVVGMTTFGESAP
GGDLLKYFGFTVENVVATVNGL

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=681, Percent_Identity=25.4038179148311, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI4507521, Length=681, Percent_Identity=25.4038179148311, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI133778974, Length=579, Percent_Identity=25.73402417962, Blast_Score=143, Evalue=7e-34,
Organism=Homo sapiens, GI225637459, Length=262, Percent_Identity=24.4274809160305, Blast_Score=76, Evalue=1e-13,
Organism=Escherichia coli, GI48994911, Length=663, Percent_Identity=73.0015082956259, Blast_Score=1042, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=659, Percent_Identity=67.2230652503794, Blast_Score=963, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=594, Percent_Identity=26.0942760942761, Blast_Score=155, Evalue=8e-38,
Organism=Saccharomyces cerevisiae, GI6325331, Length=663, Percent_Identity=48.5671191553544, Blast_Score=591, Evalue=1e-169,
Organism=Saccharomyces cerevisiae, GI6319593, Length=667, Percent_Identity=44.9775112443778, Blast_Score=543, Evalue=1e-155,
Organism=Drosophila melanogaster, GI45551847, Length=679, Percent_Identity=26.2150220913108, Blast_Score=168, Evalue=9e-42,
Organism=Drosophila melanogaster, GI45550715, Length=679, Percent_Identity=26.2150220913108, Blast_Score=168, Evalue=9e-42,
Organism=Drosophila melanogaster, GI24666278, Length=667, Percent_Identity=24.287856071964, Blast_Score=148, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24645119, Length=645, Percent_Identity=25.7364341085271, Blast_Score=145, Evalue=9e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 71348; Mature: 71217

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSRKELANAIRALTMDAVQKANSGHPGAPMGMADIAEVLWNDFLKHNPNNPDWVDRDRF
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCE
ILSNGHGSMLIYSLLHLTGYALPIEELKNFRQLHSKTPGHPEYGYTPGVETTTGPLGAGI
EEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCH
SNAVGMAIAEKTLAAQFNKPGHDIVDHFTYCFLGDGCLMEGISHEACSLAGTLGLGKLVA
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHCCCCCEEE
FWDDNGISIDGHVEGWFTDDTPKRFESYGWHVIANVDGHDSDAIRAAIEAAKSVTDKPTM
EECCCCEEECCCCCCEECCCCHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCE
ICCKTTIGFGSPNKSGSHDCHGAPLGDAEIAAAREFLGWNHAAFEIPENVYAGWDAKETG
EEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEECCCHHHCCCCCHHCC
AARESSWNDKFAAYEVAFPELAAEYKRRVITGELPAEFEEKAQAFVQECQDKAEGIASRK
CCCCCCCCCCCEEEEEHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ASQNAIGAFGAILPEMLGGSADLAGSNLTLWSGSKGIQDDPAGNYIYYGVREFGMSGIMN
CCHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCCEEEECHHHHCHHHCCC
GASLHGGFINYGATFMMFMEYARNAVRMSALMGIQNIFVYTHDSIGQGEDGPTHQPVEQL
CCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCHHHHHHH
ANLRMTPNMTVWRPCDAAETAVSWKNAIERRNAPTSLIFSRQNLPAQARTAEQLANVVKG
HCCCCCCCCEEECCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHC
GYVLSDCAGTPDLILIATGSEVQLALDSAAALTEQGQKVRVVSMPSTNEFDKQDAAYKES
CEEEECCCCCCCEEEEEECCCEEEEHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHH
VLPSCVTKRVAIEAAHVDFWHKYVGFGGAVVGMTTFGESAPGGDLLKYFGFTVENVVATV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHCCHHHHHHHHH
NGL
CCC
>Mature Secondary Structure 
SSRKELANAIRALTMDAVQKANSGHPGAPMGMADIAEVLWNDFLKHNPNNPDWVDRDRF
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCE
ILSNGHGSMLIYSLLHLTGYALPIEELKNFRQLHSKTPGHPEYGYTPGVETTTGPLGAGI
EEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCH
SNAVGMAIAEKTLAAQFNKPGHDIVDHFTYCFLGDGCLMEGISHEACSLAGTLGLGKLVA
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHCCCCCEEE
FWDDNGISIDGHVEGWFTDDTPKRFESYGWHVIANVDGHDSDAIRAAIEAAKSVTDKPTM
EECCCCEEECCCCCCEECCCCHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCE
ICCKTTIGFGSPNKSGSHDCHGAPLGDAEIAAAREFLGWNHAAFEIPENVYAGWDAKETG
EEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEECCCHHHCCCCCHHCC
AARESSWNDKFAAYEVAFPELAAEYKRRVITGELPAEFEEKAQAFVQECQDKAEGIASRK
CCCCCCCCCCCEEEEEHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ASQNAIGAFGAILPEMLGGSADLAGSNLTLWSGSKGIQDDPAGNYIYYGVREFGMSGIMN
CCHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCCEEEECHHHHCHHHCCC
GASLHGGFINYGATFMMFMEYARNAVRMSALMGIQNIFVYTHDSIGQGEDGPTHQPVEQL
CCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCHHHHHHH
ANLRMTPNMTVWRPCDAAETAVSWKNAIERRNAPTSLIFSRQNLPAQARTAEQLANVVKG
HCCCCCCCCEEECCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHC
GYVLSDCAGTPDLILIATGSEVQLALDSAAALTEQGQKVRVVSMPSTNEFDKQDAAYKES
CEEEECCCCCCCEEEEEECCCEEEEHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHH
VLPSCVTKRVAIEAAHVDFWHKYVGFGGAVVGMTTFGESAPGGDLLKYFGFTVENVVATV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHCCHHHHHHHHH
NGL
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]