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The map label for this gene is lysC [H]

Identifier: 167622728

GI number: 167622728

Start: 984154

End: 985539

Strand: Direct

Name: lysC [H]

Synonym: Shal_0788

Alternate gene names: 167622728

Gene position: 984154-985539 (Clockwise)

Preceding gene: 167622727

Following gene: 167622729

Centisome position: 18.83

GC content: 51.52

Gene sequence:

>1386_bases
ATGTTTATAGCATCAGAATCTCCAATATCAGTTTCTAAGTTAACGGTTGCTAAGTTCGGCGGCACTTCGGTTGCCGATTA
CGCTGCGATGCAGCGCTGCGCCGATATTATTATTGCTAACCCGCAAACACGGGTTGTGGTGGTGAGTGCATCGAGTGGCG
TGACCAATCAGTTAGTCGCGCTCACTCAGGCTGAAATCAGTAGTGATGAGTCAAAGGCGCTGATCAAGAAGATCGCCTCA
ATTCAATATCAGATCCTCGATAAGCTCGGTAACCCCAGTGATGTGGCCGCAAAGATTGATCGCACTCTCAGCCATATCTC
GGCTCTAGTGGAGCGACTAAAGCTGATCCGCAGCAAGGCTGTAATGGATGAGCTCTTATCTCAAGGTGAGATGTGCTCTT
CAATATTCTTTGCCGCCGTATTGCGAGAGAAGGGGGCTAGCGCATCGGCTTTTGATGTGCGTCAAGTGCTTAGAACCGAT
AGCCATCATGGCCGCGCCGAACCACAAATCGAGCAAATTGCTGAGCTAGTGCAAACTAATCTTAAGCCTTTGCTCGCCGA
TCAGGTGATAGTGACTCAAGGTTTTGTTGGTGCCGATAGTGAAGGTAACACCACAACCCTTGGCCGTGGTGGTAGTGATT
ACTCTGCAGCATTGTTAGCCGAGGCGTTGCAAGCCTATGCCGTTGAGATCTGGACCGATGTGGCGGGTATATATACCACC
GATCCTCGTCTCGCCCCGAATGCGAGTCCGATCGCCGAAATCAGCTTTAACGAAGCCGCCGAGATGGCGACGTTTGGTGC
CAAGGTTCTACACCCGGCAACTATCTTACCTGCGGTGAGGCAAAAGATTCAGGTCTTCGTTGGCTCAAGCTGGGCACCTG
AGCAGGGTGGCACCTGGATCCGCCATAAGGTTGAAAGCGAGCCTGTTTATCGTGCCGTCGCGGTGCGCCGAGATCAAACT
CTACTCAATCTACACAGCTTGCAGATGCTACATGCGCAAGGCTTTCTCGCCGAGACGTTTGCCACGCTTGCACGGCATAA
GATCAGTGTCGATTTGATCACCACCTCCGAGGTTAACGTGGCACTGACATTAGATAAAACCGGGTCAGATTCTAGCGGCC
AAGGATTATTGAGTGAGGCACTGCTGCAAGAGTTATCACAACACTGTCGGGTGCGCGTCGAAGATGGCTTAGCCTTAGTG
GCGGTGATAGGTAACAACATCGCCTCGACCGCTGGCGTGTGCCGAAGAGTGTTTGAAGTACTGGAGACCTATAATGTACG
CATGATCTGTCAAGGCGCGAGCCCACATAATTTGTGTATTCTGGTGGATGAATCAGAGGCGGCCAATGTTATTCGCGCCC
TGCATGAAAACCTGTTTGAAGCCTAG

Upstream 100 bases:

>100_bases
CTCTTCGGACGAAGTTAGTTCGGAGCTTTTTCATGTTAGTTATTCAAAATACCCATTTCTGTCTGTGTCAGTCATCTCTA
TTTTGCATGGAGGCTGTACT

Downstream 100 bases:

>100_bases
ATAACAGATAACAGATAACTGCTAACAGATAGAGATGAAAGGTAACCGAGTCATTGATGAAATTTACCCAATCGAGCCTA
AAGGTAGGTGAGTTGGCTAC

Product: aspartate kinase III

Products: NA

Alternate protein names: Aspartate kinase III; AKIII; Lysine-sensitive aspartokinase III [H]

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MFIASESPISVSKLTVAKFGGTSVADYAAMQRCADIIIANPQTRVVVVSASSGVTNQLVALTQAEISSDESKALIKKIAS
IQYQILDKLGNPSDVAAKIDRTLSHISALVERLKLIRSKAVMDELLSQGEMCSSIFFAAVLREKGASASAFDVRQVLRTD
SHHGRAEPQIEQIAELVQTNLKPLLADQVIVTQGFVGADSEGNTTTLGRGGSDYSAALLAEALQAYAVEIWTDVAGIYTT
DPRLAPNASPIAEISFNEAAEMATFGAKVLHPATILPAVRQKIQVFVGSSWAPEQGGTWIRHKVESEPVYRAVAVRRDQT
LLNLHSLQMLHAQGFLAETFATLARHKISVDLITTSEVNVALTLDKTGSDSSGQGLLSEALLQELSQHCRVRVEDGLALV
AVIGNNIASTAGVCRRVFEVLETYNVRMICQGASPHNLCILVDESEAANVIRALHENLFEA

Sequences:

>Translated_461_residues
MFIASESPISVSKLTVAKFGGTSVADYAAMQRCADIIIANPQTRVVVVSASSGVTNQLVALTQAEISSDESKALIKKIAS
IQYQILDKLGNPSDVAAKIDRTLSHISALVERLKLIRSKAVMDELLSQGEMCSSIFFAAVLREKGASASAFDVRQVLRTD
SHHGRAEPQIEQIAELVQTNLKPLLADQVIVTQGFVGADSEGNTTTLGRGGSDYSAALLAEALQAYAVEIWTDVAGIYTT
DPRLAPNASPIAEISFNEAAEMATFGAKVLHPATILPAVRQKIQVFVGSSWAPEQGGTWIRHKVESEPVYRAVAVRRDQT
LLNLHSLQMLHAQGFLAETFATLARHKISVDLITTSEVNVALTLDKTGSDSSGQGLLSEALLQELSQHCRVRVEDGLALV
AVIGNNIASTAGVCRRVFEVLETYNVRMICQGASPHNLCILVDESEAANVIRALHENLFEA
>Mature_461_residues
MFIASESPISVSKLTVAKFGGTSVADYAAMQRCADIIIANPQTRVVVVSASSGVTNQLVALTQAEISSDESKALIKKIAS
IQYQILDKLGNPSDVAAKIDRTLSHISALVERLKLIRSKAVMDELLSQGEMCSSIFFAAVLREKGASASAFDVRQVLRTD
SHHGRAEPQIEQIAELVQTNLKPLLADQVIVTQGFVGADSEGNTTTLGRGGSDYSAALLAEALQAYAVEIWTDVAGIYTT
DPRLAPNASPIAEISFNEAAEMATFGAKVLHPATILPAVRQKIQVFVGSSWAPEQGGTWIRHKVESEPVYRAVAVRRDQT
LLNLHSLQMLHAQGFLAETFATLARHKISVDLITTSEVNVALTLDKTGSDSSGQGLLSEALLQELSQHCRVRVEDGLALV
AVIGNNIASTAGVCRRVFEVLETYNVRMICQGASPHNLCILVDESEAANVIRALHENLFEA

Specific function: Lysine biosynthesis; first step. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1790455, Length=450, Percent_Identity=57.1111111111111, Blast_Score=474, Evalue=1e-135,
Organism=Escherichia coli, GI1786183, Length=468, Percent_Identity=29.9145299145299, Blast_Score=196, Evalue=3e-51,
Organism=Escherichia coli, GI1790376, Length=456, Percent_Identity=29.1666666666667, Blast_Score=143, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6320893, Length=496, Percent_Identity=27.2177419354839, Blast_Score=167, Evalue=4e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 49513; Mature: 49513

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFIASESPISVSKLTVAKFGGTSVADYAAMQRCADIIIANPQTRVVVVSASSGVTNQLVA
CCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHEEEECCCEEEEEEECCCCCCHHHHH
LTQAEISSDESKALIKKIASIQYQILDKLGNPSDVAAKIDRTLSHISALVERLKLIRSKA
HHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VMDELLSQGEMCSSIFFAAVLREKGASASAFDVRQVLRTDSHHGRAEPQIEQIAELVQTN
HHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHC
LKPLLADQVIVTQGFVGADSEGNTTTLGRGGSDYSAALLAEALQAYAVEIWTDVAGIYTT
CCHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEC
DPRLAPNASPIAEISFNEAAEMATFGAKVLHPATILPAVRQKIQVFVGSSWAPEQGGTWI
CCCCCCCCCCCEEECHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCCCCCE
RHKVESEPVYRAVAVRRDQTLLNLHSLQMLHAQGFLAETFATLARHKISVDLITTSEVNV
EHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHEEEEEEEEECCEEE
ALTLDKTGSDSSGQGLLSEALLQELSQHCRVRVEDGLALVAVIGNNIASTAGVCRRVFEV
EEEEECCCCCCCCCHHHHHHHHHHHHHHCCEEECCCEEEEEECCCCHHHHHHHHHHHHHH
LETYNVRMICQGASPHNLCILVDESEAANVIRALHENLFEA
HHHCCEEEEEECCCCCCEEEEEECHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFIASESPISVSKLTVAKFGGTSVADYAAMQRCADIIIANPQTRVVVVSASSGVTNQLVA
CCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHEEEECCCEEEEEEECCCCCCHHHHH
LTQAEISSDESKALIKKIASIQYQILDKLGNPSDVAAKIDRTLSHISALVERLKLIRSKA
HHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VMDELLSQGEMCSSIFFAAVLREKGASASAFDVRQVLRTDSHHGRAEPQIEQIAELVQTN
HHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHC
LKPLLADQVIVTQGFVGADSEGNTTTLGRGGSDYSAALLAEALQAYAVEIWTDVAGIYTT
CCHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEC
DPRLAPNASPIAEISFNEAAEMATFGAKVLHPATILPAVRQKIQVFVGSSWAPEQGGTWI
CCCCCCCCCCCEEECHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCCCCCE
RHKVESEPVYRAVAVRRDQTLLNLHSLQMLHAQGFLAETFATLARHKISVDLITTSEVNV
EHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHEEEEEEEEECCEEE
ALTLDKTGSDSSGQGLLSEALLQELSQHCRVRVEDGLALVAVIGNNIASTAGVCRRVFEV
EEEEECCCCCCCCCHHHHHHHHHHHHHHCCEEECCCEEEEEECCCCHHHHHHHHHHHHHH
LETYNVRMICQGASPHNLCILVDESEAANVIRALHENLFEA
HHHCCEEEEEECCCCCCEEEEEECHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3003049; 8265357; 9278503; 6312411 [H]