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The map label for this gene is panC

Identifier: 167622689

GI number: 167622689

Start: 929843

End: 930694

Strand: Reverse

Name: panC

Synonym: Shal_0749

Alternate gene names: 167622689

Gene position: 930694-929843 (Counterclockwise)

Preceding gene: 167622690

Following gene: 167622688

Centisome position: 17.81

GC content: 47.3

Gene sequence:

>852_bases
ATGATCACGACTCAATCTATTTCTGATATCCGTGCCCAAGTTAAAGCATGGCGTCAAAAAGGCGAAACCGTTGCATTTGT
GCCGACGATGGGCAACCTGCACTTAGGCCATATCACTCTAGTCAAAGAAGCTAAAACACGTGCCGACCATGTAGTTGCTT
CTATCTTTGTTAATCCGATGCAATTTGGTCAAAACGAAGATCTCGATGCCTACCCAAGAACCTTAGCCGAGGATCAGGCC
GCATTGACTGCTGCGGGCGCCGAACTACTGTTCACCCCAACACCTGAGATCATCTATCCAAAAGGCATGGATGCACAAAC
CTATGTTGAAGTGCCGAGTATTTCAGATCTGCTTTGTGGTGCTAGCCGTCCTGGACACTTTAGAGGAGTGGCAACCGTCG
TCTGTAAACTGTTCAACATAGTACAGCCAGATATTGCGGTATTCGGACAAAAAGACTTTCAGCAATTATTGGTGATACGG
ACCATGGTGGACGACTTGTCTATGCCAATTGAGATTGTCGGTGTTGATACCATACGCGAAGCCTCGGGTCTTGCCATGAG
TTCACGCAATGGTTATCTCAGCGCGGAGCAAAAAGATCAGGCTTCGCAGATAAAGCGCAGTTTAGACAAGATGGCCGAGT
CGCTCAAAGCTGGCTTAGCGTTCAAGGATATTATCACTCAGGCGCAAACAGAGTTAGCCGAGGCAGGCTTTAGAAATGAT
TATCTAGAGATTAGAAATGCCAATAACTTCGCTATCGCAGACGCTGGTGATGTTAAGTTGGTCATTTTAGTTGCCGCCTA
CATGGGCTCGACTCGACTTATCGACAACCAAGTCGTTACGCTCAACGCCTAA

Upstream 100 bases:

>100_bases
AGGTGTTTTCCCAGGCGATGAGCATACCTTCAACTAATGATATGCTCTCGATCCCCTGATTGAGAGCGCACTTTCAAATT
AGTGTTAGAGCAATAAAATC

Downstream 100 bases:

>100_bases
ACGACAACGACTCCACTCGACTCTACTCTACTCTACTCTACTCATAGAAACAAAAAAACGGTATAACCTAGAGTGTTAAG
CCGTTTTTTTATCGCTCCAT

Product: pantoate--beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 283; Mature: 283

Protein sequence:

>283_residues
MITTQSISDIRAQVKAWRQKGETVAFVPTMGNLHLGHITLVKEAKTRADHVVASIFVNPMQFGQNEDLDAYPRTLAEDQA
ALTAAGAELLFTPTPEIIYPKGMDAQTYVEVPSISDLLCGASRPGHFRGVATVVCKLFNIVQPDIAVFGQKDFQQLLVIR
TMVDDLSMPIEIVGVDTIREASGLAMSSRNGYLSAEQKDQASQIKRSLDKMAESLKAGLAFKDIITQAQTELAEAGFRND
YLEIRNANNFAIADAGDVKLVILVAAYMGSTRLIDNQVVTLNA

Sequences:

>Translated_283_residues
MITTQSISDIRAQVKAWRQKGETVAFVPTMGNLHLGHITLVKEAKTRADHVVASIFVNPMQFGQNEDLDAYPRTLAEDQA
ALTAAGAELLFTPTPEIIYPKGMDAQTYVEVPSISDLLCGASRPGHFRGVATVVCKLFNIVQPDIAVFGQKDFQQLLVIR
TMVDDLSMPIEIVGVDTIREASGLAMSSRNGYLSAEQKDQASQIKRSLDKMAESLKAGLAFKDIITQAQTELAEAGFRND
YLEIRNANNFAIADAGDVKLVILVAAYMGSTRLIDNQVVTLNA
>Mature_283_residues
MITTQSISDIRAQVKAWRQKGETVAFVPTMGNLHLGHITLVKEAKTRADHVVASIFVNPMQFGQNEDLDAYPRTLAEDQA
ALTAAGAELLFTPTPEIIYPKGMDAQTYVEVPSISDLLCGASRPGHFRGVATVVCKLFNIVQPDIAVFGQKDFQQLLVIR
TMVDDLSMPIEIVGVDTIREASGLAMSSRNGYLSAEQKDQASQIKRSLDKMAESLKAGLAFKDIITQAQTELAEAGFRND
YLEIRNANNFAIADAGDVKLVILVAAYMGSTRLIDNQVVTLNA

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=282, Percent_Identity=53.5460992907801, Blast_Score=298, Evalue=3e-82,
Organism=Saccharomyces cerevisiae, GI6322046, Length=304, Percent_Identity=37.5, Blast_Score=178, Evalue=1e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_SHEHH (B0TTI1)

Other databases:

- EMBL:   CP000931
- RefSeq:   YP_001672983.1
- ProteinModelPortal:   B0TTI1
- SMR:   B0TTI1
- GeneID:   5905462
- GenomeReviews:   CP000931_GR
- KEGG:   shl:Shal_0749
- HOGENOM:   HBG428839
- OMA:   RLIDNFT
- ProtClustDB:   PRK00380
- BioCyc:   SHAL458817:SHAL_0749-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR004821
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00125
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 30832; Mature: 30832

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: ACT_SITE 37-37 BINDING 61-61 BINDING 61-61 BINDING 155-155 BINDING 178-178

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITTQSISDIRAQVKAWRQKGETVAFVPTMGNLHLGHITLVKEAKTRADHVVASIFVNPM
CCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCEEECEEEEEHHHHHHHHHHHHHHHHHHH
QFGQNEDLDAYPRTLAEDQAALTAAGAELLFTPTPEIIYPKGMDAQTYVEVPSISDLLCG
HCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCEEECCCCCCCEEEECCCHHHHHHC
ASRPGHFRGVATVVCKLFNIVQPDIAVFGQKDFQQLLVIRTMVDDLSMPIEIVGVDTIRE
CCCCCCHHHHHHHHHHHHHHHCCHHHHHCHHHHHHHHHHHHHHHHHCCCEEEEECHHHHH
ASGLAMSSRNGYLSAEQKDQASQIKRSLDKMAESLKAGLAFKDIITQAQTELAEAGFRND
HCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCC
YLEIRNANNFAIADAGDVKLVILVAAYMGSTRLIDNQVVTLNA
CEEEECCCCEEEECCCCEEEEEHHHHHHCCCEEECCEEEEEEC
>Mature Secondary Structure
MITTQSISDIRAQVKAWRQKGETVAFVPTMGNLHLGHITLVKEAKTRADHVVASIFVNPM
CCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCEEECEEEEEHHHHHHHHHHHHHHHHHHH
QFGQNEDLDAYPRTLAEDQAALTAAGAELLFTPTPEIIYPKGMDAQTYVEVPSISDLLCG
HCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCEEECCCCCCCEEEECCCHHHHHHC
ASRPGHFRGVATVVCKLFNIVQPDIAVFGQKDFQQLLVIRTMVDDLSMPIEIVGVDTIRE
CCCCCCHHHHHHHHHHHHHHHCCHHHHHCHHHHHHHHHHHHHHHHHCCCEEEEECHHHHH
ASGLAMSSRNGYLSAEQKDQASQIKRSLDKMAESLKAGLAFKDIITQAQTELAEAGFRND
HCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCC
YLEIRNANNFAIADAGDVKLVILVAAYMGSTRLIDNQVVTLNA
CEEEECCCCEEEECCCCEEEEEHHHHHHCCCEEECCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA