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The map label for this gene is napA [H]

Identifier: 167622647

GI number: 167622647

Start: 873852

End: 875096

Strand: Reverse

Name: napA [H]

Synonym: Shal_0707

Alternate gene names: 167622647

Gene position: 875096-873852 (Counterclockwise)

Preceding gene: 167622648

Following gene: 167622645

Centisome position: 16.74

GC content: 51.49

Gene sequence:

>1245_bases
ATGCGCTTTCTATATTTAGTTCTTGTATTGCTAACAGTTACCCGAGTATTTGCGGTGCTAGCCAAACGGTTAAATTTGCC
GCCAATCGTGGGTGAGCTGGTGTCAGGGATCGCACTGGGGCTGTTTCTTCACCGTTTTCAAGACCTATTCCCCCTGCTAT
GGCAGGTGACTCAAGGTGAAGCGTTTGAGGCGCTGGCCGATCTGGGGATGTTTTTCCTCATGCTATTGGCGGGCGTGAGA
ATGAGCCCACTGGACTTTAAGAAAACATCCAGCTCAGCCCCCGCTGTGGCGGTCGGCGGTATGTTAGTGCCTATTATTGC
AGGCACCCTGATAGGACTGATGCTATTTCCTGAGTCCCCCTTCAAGACAGTCCAAAGTTGGTTCTTAGGCACTGCCCTTG
CGGTTACCGCCGTGCCAGTAACCATTCGAATGCTGATGGAGTTTAACCGCTTAGATACCGAAGAGGGCAAGACCATTGTC
GCCGCGGCGCTTTGGGATGACTTGTTAAGTTTATTTATCCTCGCACTGTTGTTAGCGACCATCTCCAATGGTGGCACCCT
CTCTTTTAGCTTGGGCTTATGGGGCCCGCTGTTAGCCAAGGTGCTGTTGTTCTTCGCGATTACCATCCCTGTCGGTTACT
ACCTGTTTCCTGTGGTCGGCCGTTACCTTAAGTACGTCAATATTCCCGATATCGATTTTAGTATGCTGTTGATCGCCTCT
CTGGCGTACGCGGTGCTGGCGGAATTGCTGGGGCTACATTTCATTATCGGCGCCTTCGTCGCAGGCATGTTTTTTCATCC
TGCCGTGGTGGAAAAAAAAATATATGACCGAGTAGAGAGGCAGACCTCCGGCATCACCTCCGGCTTTCTCGCACCAATCT
TTTTCGTGTCGATAGGGTTCCATCTAAACTTAACCGCTCTGGTCTCTATCCCCTGGTTTGTCGCGTTACTCATTATCGTC
GCCGTGCTCAGTAAGTTAATAGGAGCCGGACTCTGCGCGCGCGCCACAGGCCACAGTACCCAAGAGTCGCTGCGGATCGG
AGTCGCGATGAGTGGCCGAGGAGCTGTCGAGATTGTTTTAGCAGGTGTTGCCTTGCAAGCCGGACTATTCAACCACCCAG
ACCCTACCCCGCCGATTATCTCTGGACTCTTCTCAGCGATTGTGATCATGGCAATTGCCACCAGCATTATTACCCCACTG
TTATTAGCCTTTCTAATTCGCTATCACGGCGTCGATAAACAATAA

Upstream 100 bases:

>100_bases
ACGATTTGTAAGGTGGAGTACCGTGACTAGGTCAAATATTAGACTTAATACAGGCCCACAACTATTCTAATATTAGTCAA
CCAGAGGGTTGGAAATACAG

Downstream 100 bases:

>100_bases
GTTTCAGATACCCCCCTTCCTACGCAATCCCTGCGTTCAGGGATAAGTAGTTCCATGTACAAAAAAATACCCACATTACG
TGGGTATTTTTAGTTGATTA

Product: sodium/hydrogen exchanger

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 414; Mature: 414

Protein sequence:

>414_residues
MRFLYLVLVLLTVTRVFAVLAKRLNLPPIVGELVSGIALGLFLHRFQDLFPLLWQVTQGEAFEALADLGMFFLMLLAGVR
MSPLDFKKTSSSAPAVAVGGMLVPIIAGTLIGLMLFPESPFKTVQSWFLGTALAVTAVPVTIRMLMEFNRLDTEEGKTIV
AAALWDDLLSLFILALLLATISNGGTLSFSLGLWGPLLAKVLLFFAITIPVGYYLFPVVGRYLKYVNIPDIDFSMLLIAS
LAYAVLAELLGLHFIIGAFVAGMFFHPAVVEKKIYDRVERQTSGITSGFLAPIFFVSIGFHLNLTALVSIPWFVALLIIV
AVLSKLIGAGLCARATGHSTQESLRIGVAMSGRGAVEIVLAGVALQAGLFNHPDPTPPIISGLFSAIVIMAIATSIITPL
LLAFLIRYHGVDKQ

Sequences:

>Translated_414_residues
MRFLYLVLVLLTVTRVFAVLAKRLNLPPIVGELVSGIALGLFLHRFQDLFPLLWQVTQGEAFEALADLGMFFLMLLAGVR
MSPLDFKKTSSSAPAVAVGGMLVPIIAGTLIGLMLFPESPFKTVQSWFLGTALAVTAVPVTIRMLMEFNRLDTEEGKTIV
AAALWDDLLSLFILALLLATISNGGTLSFSLGLWGPLLAKVLLFFAITIPVGYYLFPVVGRYLKYVNIPDIDFSMLLIAS
LAYAVLAELLGLHFIIGAFVAGMFFHPAVVEKKIYDRVERQTSGITSGFLAPIFFVSIGFHLNLTALVSIPWFVALLIIV
AVLSKLIGAGLCARATGHSTQESLRIGVAMSGRGAVEIVLAGVALQAGLFNHPDPTPPIISGLFSAIVIMAIATSIITPL
LLAFLIRYHGVDKQ
>Mature_414_residues
MRFLYLVLVLLTVTRVFAVLAKRLNLPPIVGELVSGIALGLFLHRFQDLFPLLWQVTQGEAFEALADLGMFFLMLLAGVR
MSPLDFKKTSSSAPAVAVGGMLVPIIAGTLIGLMLFPESPFKTVQSWFLGTALAVTAVPVTIRMLMEFNRLDTEEGKTIV
AAALWDDLLSLFILALLLATISNGGTLSFSLGLWGPLLAKVLLFFAITIPVGYYLFPVVGRYLKYVNIPDIDFSMLLIAS
LAYAVLAELLGLHFIIGAFVAGMFFHPAVVEKKIYDRVERQTSGITSGFLAPIFFVSIGFHLNLTALVSIPWFVALLIIV
AVLSKLIGAGLCARATGHSTQESLRIGVAMSGRGAVEIVLAGVALQAGLFNHPDPTPPIISGLFSAIVIMAIATSIITPL
LLAFLIRYHGVDKQ

Specific function: This is a Na(+)/H(+) antiporter. It can mediate sodium uptake when a transmembrane pH gradient is applied [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family [H]

Homologues:

Organism=Escherichia coli, GI1786685, Length=402, Percent_Identity=26.3681592039801, Blast_Score=76, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6322367, Length=417, Percent_Identity=25.8992805755396, Blast_Score=88, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 44646; Mature: 44646

Theoretical pI: Translated: 8.91; Mature: 8.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFLYLVLVLLTVTRVFAVLAKRLNLPPIVGELVSGIALGLFLHRFQDLFPLLWQVTQGE
CHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
AFEALADLGMFFLMLLAGVRMSPLDFKKTSSSAPAVAVGGMLVPIIAGTLIGLMLFPESP
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCH
FKTVQSWFLGTALAVTAVPVTIRMLMEFNRLDTEEGKTIVAAALWDDLLSLFILALLLAT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHH
ISNGGTLSFSLGLWGPLLAKVLLFFAITIPVGYYLFPVVGRYLKYVNIPDIDFSMLLIAS
HCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
LAYAVLAELLGLHFIIGAFVAGMFFHPAVVEKKIYDRVERQTSGITSGFLAPIFFVSIGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
HLNLTALVSIPWFVALLIIVAVLSKLIGAGLCARATGHSTQESLRIGVAMSGRGAVEIVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCHHHHEEEEEECCCCHHHHHH
AGVALQAGLFNHPDPTPPIISGLFSAIVIMAIATSIITPLLLAFLIRYHGVDKQ
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MRFLYLVLVLLTVTRVFAVLAKRLNLPPIVGELVSGIALGLFLHRFQDLFPLLWQVTQGE
CHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
AFEALADLGMFFLMLLAGVRMSPLDFKKTSSSAPAVAVGGMLVPIIAGTLIGLMLFPESP
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCH
FKTVQSWFLGTALAVTAVPVTIRMLMEFNRLDTEEGKTIVAAALWDDLLSLFILALLLAT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHH
ISNGGTLSFSLGLWGPLLAKVLLFFAITIPVGYYLFPVVGRYLKYVNIPDIDFSMLLIAS
HCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
LAYAVLAELLGLHFIIGAFVAGMFFHPAVVEKKIYDRVERQTSGITSGFLAPIFFVSIGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
HLNLTALVSIPWFVALLIIVAVLSKLIGAGLCARATGHSTQESLRIGVAMSGRGAVEIVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCHHHHEEEEEECCCCHHHHHH
AGVALQAGLFNHPDPTPPIISGLFSAIVIMAIATSIITPLLLAFLIRYHGVDKQ
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1312090; 1325937 [H]