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The map label for this gene is hyuA [H]

Identifier: 167622578

GI number: 167622578

Start: 771917

End: 773317

Strand: Direct

Name: hyuA [H]

Synonym: Shal_0638

Alternate gene names: 167622578

Gene position: 771917-773317 (Clockwise)

Preceding gene: 167622577

Following gene: 167622579

Centisome position: 14.77

GC content: 44.83

Gene sequence:

>1401_bases
ATGGGGTCAAAATCTACACTCATTATTAACGGCACCCTTGTCGACGCCCAGAAACAGTCACAGCAACAACTGCTCATTAT
TGATGGCAAAATTGCAGCCGTCGACAAGGTGATCACTGATTACCCCGTTGATACCGAGGTTATAGACGCATCAGGTCTTT
ATGTGATGCCTGGTGGTATCGATGTACACACCCATTTTAATATCGATGTGGGCATCGCTCGTAGTGTCGATGATTTTTAT
ACCGGGACTCGCTCTGCGGCCTGCGGTGGCACCACCATGATTATCGATCATATGGGCTTTGGACCGAAAGGTTGCGATCT
TTTTCACCAGCTTAAGGTCTATAAAGGGTTTGCTAAAGACAAGGCGGTAATCGATTACAGCTTTCATGGGGTGATCCAAC
ATATCAATGATGAAGTTATCGAAGATATGCATGCCATGGTACATCGTGAGGGGATCTCAAGTTTTAAACTTTATCTGACT
TATAATTATAAGCTCGATGACACGGGTGCCTTGCAGGCCCTTAATCGCCTCAACCAAGTTCAAGCCTTAACTGCTGTGCA
TCCCGAAAATGATGCGGCTATCGCTTTAAAACGCAGCCAACTAATAAAAGCAGGTAAAACCTCAGCTAAATATCATGCGA
TCAGTCGTCCATTAGAGTGTGAAGCTGAAGCGATTGCTCGGATGATTAATTTGGCAAAACTTGCCGATGATGCGCCGCTT
TATATTGTTCATCTCTCCAATGGTCTAGGGCTGGATTATATCCGCTTGGCAAAGCAGAATCAGCAAGCAGTATGGAGCGA
AACGTGCCCACAATACCTACTTCTTGATGACAAGCTTTATGAAAATGAGGATGGTGCTAAATATTTAATGAGCCCACCAC
TTAGGCCCAAGGCTGAGCTAGAGAAACTCTGGCAAGGCGTCGAAGATGGCAGCATAGATACGGTTGCGACTGACCACTGT
GCTTTTTCCTATAAAGAGCAAAAAGTATCAGGTAATGATGACTTTTCTGTTTGCCCAAATGGCATGCCAGGAGTTGAAAC
CCGTATGCCGCTGCTGTTTTCAGAGGGAGTGATGTCGGGAAGAATTACCCCAGAAAAATTCGTTGAAATAACTAGCTTTA
AACCTGCAAAACTGTTCGGCCTTTATCCACAAAAAGGCTGCCTTCTACCCGGTTCCGATGCGGATATTGTGTTATTCAAT
CCGGAACTTAAGGTCCATATCAGTCATGAAAACCTACATGACAATAGTGACTATACCCCTTATGAATCACACCAAGTGAA
CGGATGGCCCGTCATGACTATCAGTCGTGGAGAAGTCGTGGCATGTAATGGTGAGTTTCTCGGGAAAGCCGGTGCTGGTC
AATTTGTGCATCGTTTGCCATTCGATAAAAACAAAATCTAA

Upstream 100 bases:

>100_bases
CACTTTTTGTTTTATTCATCTTTTTCATAGTTTTACTTACTCTTTAAGTACTTTTTCAACACTATTTATTTAAACATTAT
TTTAGTTTCAGGAGCACATC

Downstream 100 bases:

>100_bases
TTAGTCATTATCTGTCATCTCTATCACTTAGCAAAGAATGAATTAAAGTAGAGCTAAGTGACAGAAAATTAAGGAATATC
TATGAAACCTATTGCTGTTG

Product: phenylhydantoinase

Products: NA

Alternate protein names: Hydantoin-utilizing enzyme hyuA [H]

Number of amino acids: Translated: 466; Mature: 465

Protein sequence:

>466_residues
MGSKSTLIINGTLVDAQKQSQQQLLIIDGKIAAVDKVITDYPVDTEVIDASGLYVMPGGIDVHTHFNIDVGIARSVDDFY
TGTRSAACGGTTMIIDHMGFGPKGCDLFHQLKVYKGFAKDKAVIDYSFHGVIQHINDEVIEDMHAMVHREGISSFKLYLT
YNYKLDDTGALQALNRLNQVQALTAVHPENDAAIALKRSQLIKAGKTSAKYHAISRPLECEAEAIARMINLAKLADDAPL
YIVHLSNGLGLDYIRLAKQNQQAVWSETCPQYLLLDDKLYENEDGAKYLMSPPLRPKAELEKLWQGVEDGSIDTVATDHC
AFSYKEQKVSGNDDFSVCPNGMPGVETRMPLLFSEGVMSGRITPEKFVEITSFKPAKLFGLYPQKGCLLPGSDADIVLFN
PELKVHISHENLHDNSDYTPYESHQVNGWPVMTISRGEVVACNGEFLGKAGAGQFVHRLPFDKNKI

Sequences:

>Translated_466_residues
MGSKSTLIINGTLVDAQKQSQQQLLIIDGKIAAVDKVITDYPVDTEVIDASGLYVMPGGIDVHTHFNIDVGIARSVDDFY
TGTRSAACGGTTMIIDHMGFGPKGCDLFHQLKVYKGFAKDKAVIDYSFHGVIQHINDEVIEDMHAMVHREGISSFKLYLT
YNYKLDDTGALQALNRLNQVQALTAVHPENDAAIALKRSQLIKAGKTSAKYHAISRPLECEAEAIARMINLAKLADDAPL
YIVHLSNGLGLDYIRLAKQNQQAVWSETCPQYLLLDDKLYENEDGAKYLMSPPLRPKAELEKLWQGVEDGSIDTVATDHC
AFSYKEQKVSGNDDFSVCPNGMPGVETRMPLLFSEGVMSGRITPEKFVEITSFKPAKLFGLYPQKGCLLPGSDADIVLFN
PELKVHISHENLHDNSDYTPYESHQVNGWPVMTISRGEVVACNGEFLGKAGAGQFVHRLPFDKNKI
>Mature_465_residues
GSKSTLIINGTLVDAQKQSQQQLLIIDGKIAAVDKVITDYPVDTEVIDASGLYVMPGGIDVHTHFNIDVGIARSVDDFYT
GTRSAACGGTTMIIDHMGFGPKGCDLFHQLKVYKGFAKDKAVIDYSFHGVIQHINDEVIEDMHAMVHREGISSFKLYLTY
NYKLDDTGALQALNRLNQVQALTAVHPENDAAIALKRSQLIKAGKTSAKYHAISRPLECEAEAIARMINLAKLADDAPLY
IVHLSNGLGLDYIRLAKQNQQAVWSETCPQYLLLDDKLYENEDGAKYLMSPPLRPKAELEKLWQGVEDGSIDTVATDHCA
FSYKEQKVSGNDDFSVCPNGMPGVETRMPLLFSEGVMSGRITPEKFVEITSFKPAKLFGLYPQKGCLLPGSDADIVLFNP
ELKVHISHENLHDNSDYTPYESHQVNGWPVMTISRGEVVACNGEFLGKAGAGQFVHRLPFDKNKI

Specific function: Catalyzes the stereospecific hydrolysis of the cyclic amide bond of D-hydantoin derivatives with an aromatic side chains at the 5'-position. Has no activity on dihydropyrimidines. The physiological function is unknown [H]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503375, Length=471, Percent_Identity=36.0934182590234, Blast_Score=281, Evalue=8e-76,
Organism=Homo sapiens, GI19923821, Length=459, Percent_Identity=35.7298474945534, Blast_Score=260, Evalue=2e-69,
Organism=Homo sapiens, GI4503379, Length=466, Percent_Identity=32.618025751073, Blast_Score=258, Evalue=9e-69,
Organism=Homo sapiens, GI4503377, Length=465, Percent_Identity=32.0430107526882, Blast_Score=248, Evalue=1e-65,
Organism=Homo sapiens, GI4503051, Length=465, Percent_Identity=32.4731182795699, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI190194363, Length=465, Percent_Identity=32.4731182795699, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI62422571, Length=465, Percent_Identity=32.4731182795699, Blast_Score=243, Evalue=3e-64,
Organism=Homo sapiens, GI18105007, Length=418, Percent_Identity=24.1626794258373, Blast_Score=91, Evalue=3e-18,
Organism=Escherichia coli, GI87082175, Length=456, Percent_Identity=63.3771929824561, Blast_Score=609, Evalue=1e-175,
Organism=Escherichia coli, GI1786722, Length=463, Percent_Identity=29.3736501079914, Blast_Score=159, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI17539558, Length=463, Percent_Identity=37.7969762419007, Blast_Score=276, Evalue=1e-74,
Organism=Caenorhabditis elegans, GI71989490, Length=470, Percent_Identity=37.0212765957447, Blast_Score=257, Evalue=1e-68,
Organism=Caenorhabditis elegans, GI86575075, Length=466, Percent_Identity=28.1115879828326, Blast_Score=147, Evalue=9e-36,
Organism=Caenorhabditis elegans, GI193204318, Length=419, Percent_Identity=24.8210023866348, Blast_Score=98, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6322218, Length=464, Percent_Identity=26.2931034482759, Blast_Score=120, Evalue=3e-28,
Organism=Drosophila melanogaster, GI221377917, Length=475, Percent_Identity=35.7894736842105, Blast_Score=257, Evalue=1e-68,
Organism=Drosophila melanogaster, GI17137462, Length=462, Percent_Identity=34.6320346320346, Blast_Score=248, Evalue=7e-66,
Organism=Drosophila melanogaster, GI24644287, Length=306, Percent_Identity=34.9673202614379, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24644289, Length=236, Percent_Identity=36.0169491525424, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24642586, Length=415, Percent_Identity=26.9879518072289, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI18859883, Length=461, Percent_Identity=23.4273318872017, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011778
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: 3.-.-.- [C]

Molecular weight: Translated: 51409; Mature: 51278

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSKSTLIINGTLVDAQKQSQQQLLIIDGKIAAVDKVITDYPVDTEVIDASGLYVMPGGI
CCCCCEEEEEEEEECCCCCCCCEEEEECCCHHHHHHHHHCCCCCCEEECCCCCEEECCCE
DVHTHFNIDVGIARSVDDFYTGTRSAACGGTTMIIDHMGFGPKGCDLFHQLKVYKGFAKD
EEEEEEEEEEEEECCCHHHHCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCC
KAVIDYSFHGVIQHINDEVIEDMHAMVHREGISSFKLYLTYNYKLDDTGALQALNRLNQV
CEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEECCCHHHHHHHHHHHH
QALTAVHPENDAAIALKRSQLIKAGKTSAKYHAISRPLECEAEAIARMINLAKLADDAPL
HHHEEECCCCCCEEEEEHHHHHHCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCE
YIVHLSNGLGLDYIRLAKQNQQAVWSETCPQYLLLDDKLYENEDGAKYLMSPPLRPKAEL
EEEECCCCCCCHHHHHHCCCCCHHHHHCCCCEEEECCHHCCCCCCCEEECCCCCCCHHHH
EKLWQGVEDGSIDTVATDHCAFSYKEQKVSGNDDFSVCPNGMPGVETRMPLLFSEGVMSG
HHHHCCCCCCCCCEEEECCCEECCHHCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCC
RITPEKFVEITSFKPAKLFGLYPQKGCLLPGSDADIVLFNPELKVHISHENLHDNSDYTP
CCCHHHHEEECCCCCCCEEECCCCCCEECCCCCCCEEEECCCEEEEEECCCCCCCCCCCC
YESHQVNGWPVMTISRGEVVACNGEFLGKAGAGQFVHRLPFDKNKI
CCCCCCCCEEEEEEECCCEEEECCCCCCCCCCCHHHHHCCCCCCCC
>Mature Secondary Structure 
GSKSTLIINGTLVDAQKQSQQQLLIIDGKIAAVDKVITDYPVDTEVIDASGLYVMPGGI
CCCCEEEEEEEEECCCCCCCCEEEEECCCHHHHHHHHHCCCCCCEEECCCCCEEECCCE
DVHTHFNIDVGIARSVDDFYTGTRSAACGGTTMIIDHMGFGPKGCDLFHQLKVYKGFAKD
EEEEEEEEEEEEECCCHHHHCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCC
KAVIDYSFHGVIQHINDEVIEDMHAMVHREGISSFKLYLTYNYKLDDTGALQALNRLNQV
CEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEECCCHHHHHHHHHHHH
QALTAVHPENDAAIALKRSQLIKAGKTSAKYHAISRPLECEAEAIARMINLAKLADDAPL
HHHEEECCCCCCEEEEEHHHHHHCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCE
YIVHLSNGLGLDYIRLAKQNQQAVWSETCPQYLLLDDKLYENEDGAKYLMSPPLRPKAEL
EEEECCCCCCCHHHHHHCCCCCHHHHHCCCCEEEECCHHCCCCCCCEEECCCCCCCHHHH
EKLWQGVEDGSIDTVATDHCAFSYKEQKVSGNDDFSVCPNGMPGVETRMPLLFSEGVMSG
HHHHCCCCCCCCCEEEECCCEECCHHCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCC
RITPEKFVEITSFKPAKLFGLYPQKGCLLPGSDADIVLFNPELKVHISHENLHDNSDYTP
CCCHHHHEEECCCCCCCEEECCCCCCEECCCCCCCEEEECCCEEEEEECCCCCCCCCCCC
YESHQVNGWPVMTISRGEVVACNGEFLGKAGAGQFVHRLPFDKNKI
CCCCCCCCEEEEEEECCCEEEECCCCCCCCCCCHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA