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The map label for this gene is strL [H]

Identifier: 167622550

GI number: 167622550

Start: 736706

End: 737641

Strand: Direct

Name: strL [H]

Synonym: Shal_0610

Alternate gene names: 167622550

Gene position: 736706-737641 (Clockwise)

Preceding gene: 167622548

Following gene: 167622551

Centisome position: 14.09

GC content: 50.64

Gene sequence:

>936_bases
ATGAAGAAAATGGCGAAGATTATGGTTACAGGCGCAAGCGGGCTGTTAGGGCGGGCGCTGATAAAACAGCTGGGTCAAAA
CTCACAGCAGCAGATAATTGCTTGCGGATACAGTCGGTTTGGCCCAAATATAGAGAGGCTCGACTTAACTCAAGCGGCGC
AGGTGAGTTCTTTTGTCGCTAAGCATAAGCCCGATATTATCTTGCACTGCGCGGCTGAGCGTAGACCGGATGTGTCCGAG
CAAGATCCCCAAGCCGCATTGGCGCTTAACAGCGAGGCCACACAGTTTTTAACTCAGGCTGCCAGTCAACATGGCGCTTG
GCTGTTATATATCTCAACCGATTATGTGTTCGATGGCAGCCAGTCCCCTTATCGAGAAGATGCCGAGACCAATCCCGTTA
ATTTTTACGGTCAATCTAAGCTGAAGGGCGAGCTGGTCGTTAGCGATGCGCAGCAAGGTTTTGCCATTTTGCGCCTGCCG
ATACTCTACGGTGAGGTGGAGTCGTTAAATGAGTCTGCGGTGATGGTGCTACTTAATCACTTGGTCGATACGGCTGAGCA
GTCCATCGATAACTGGGCAATTAGAAGCCCCACCTCTACCGCCGATGTGGCTGCGGCCATCACGAAAATGATAGCTCTTA
AGCAGGCTGGAGAGCCCTTAGCGGGCCATTATCACTTCAGTGCCAAAGAGACGATGACCAAGTATCAGATGTTGCTGGTG
ATGGGGGAGCTGCTGGGGCTAGCCACTGGGCACCTCATTCCTGTGACCTCTCCCACAGATAGTGCAAAACGCCCAAAAGA
CAGTACCTTAAGCTGTGAGCGGCTTGTCAGTTTAGAGATTGAAAGCAAGGTACCTTTTAGGATTGGATTTAAAAGAGCGC
TGCAGGACTCTCCCTGTGCGGCTGCTTACTTAAAAGTTGATAATGTAAGAAGCTAA

Upstream 100 bases:

>100_bases
GATAGGTTCTTCAATGAAAAGTTATCTGTAGCAAGAGTAAACCAGTGGTAACAGGATGAAAACCCCTTAAGATGGATGAC
CAGTTTGAGCAATTCAATGG

Downstream 100 bases:

>100_bases
TTTCACAAGCGGCAAATATCACAAGTAACGAATACCATAAGAACAATAAACGATGAAAAACCTTGGTTTTAAAAACTTAC
CCATACGCAACCTTGGCGCG

Product: dTDP-4-dehydrorhamnose reductase

Products: NA

Alternate protein names: dTDP-4-keto-L-rhamnose reductase; dTDP-6-deoxy-L-lyxo-4-hexulose reductase; dTDP-6-deoxy-L-mannose dehydrogenase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MKKMAKIMVTGASGLLGRALIKQLGQNSQQQIIACGYSRFGPNIERLDLTQAAQVSSFVAKHKPDIILHCAAERRPDVSE
QDPQAALALNSEATQFLTQAASQHGAWLLYISTDYVFDGSQSPYREDAETNPVNFYGQSKLKGELVVSDAQQGFAILRLP
ILYGEVESLNESAVMVLLNHLVDTAEQSIDNWAIRSPTSTADVAAAITKMIALKQAGEPLAGHYHFSAKETMTKYQMLLV
MGELLGLATGHLIPVTSPTDSAKRPKDSTLSCERLVSLEIESKVPFRIGFKRALQDSPCAAAYLKVDNVRS

Sequences:

>Translated_311_residues
MKKMAKIMVTGASGLLGRALIKQLGQNSQQQIIACGYSRFGPNIERLDLTQAAQVSSFVAKHKPDIILHCAAERRPDVSE
QDPQAALALNSEATQFLTQAASQHGAWLLYISTDYVFDGSQSPYREDAETNPVNFYGQSKLKGELVVSDAQQGFAILRLP
ILYGEVESLNESAVMVLLNHLVDTAEQSIDNWAIRSPTSTADVAAAITKMIALKQAGEPLAGHYHFSAKETMTKYQMLLV
MGELLGLATGHLIPVTSPTDSAKRPKDSTLSCERLVSLEIESKVPFRIGFKRALQDSPCAAAYLKVDNVRS
>Mature_311_residues
MKKMAKIMVTGASGLLGRALIKQLGQNSQQQIIACGYSRFGPNIERLDLTQAAQVSSFVAKHKPDIILHCAAERRPDVSE
QDPQAALALNSEATQFLTQAASQHGAWLLYISTDYVFDGSQSPYREDAETNPVNFYGQSKLKGELVVSDAQQGFAILRLP
ILYGEVESLNESAVMVLLNHLVDTAEQSIDNWAIRSPTSTADVAAAITKMIALKQAGEPLAGHYHFSAKETMTKYQMLLV
MGELLGLATGHLIPVTSPTDSAKRPKDSTLSCERLVSLEIESKVPFRIGFKRALQDSPCAAAYLKVDNVRS

Specific function: Involved in the biosynthesis of the streptose moiety of streptomycin. Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose. RmlD uses NADH and NADPH nearly equally well [H]

COG id: COG1091

COG function: function code M; dTDP-4-dehydrorhamnose reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose reductase family [H]

Homologues:

Organism=Homo sapiens, GI33519455, Length=292, Percent_Identity=43.1506849315069, Blast_Score=249, Evalue=3e-66,
Organism=Homo sapiens, GI11034825, Length=292, Percent_Identity=43.1506849315069, Blast_Score=249, Evalue=3e-66,
Organism=Escherichia coli, GI1788352, Length=257, Percent_Identity=28.0155642023346, Blast_Score=94, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005913
- InterPro:   IPR016040 [H]

Pfam domain/function: PF04321 RmlD_sub_bind [H]

EC number: =1.1.1.133 [H]

Molecular weight: Translated: 33895; Mature: 33895

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKMAKIMVTGASGLLGRALIKQLGQNSQQQIIACGYSRFGPNIERLDLTQAAQVSSFVA
CCCCEEEEEECCCHHHHHHHHHHHCCCCCHHEEEECHHHHCCCCHHCCHHHHHHHHHHHH
KHKPDIILHCAAERRPDVSEQDPQAALALNSEATQFLTQAASQHGAWLLYISTDYVFDGS
HCCCCEEEEECCCCCCCCCCCCCCCEEEECHHHHHHHHHHHHCCCCEEEEEEEEEEECCC
QSPYREDAETNPVNFYGQSKLKGELVVSDAQQGFAILRLPILYGEVESLNESAVMVLLNH
CCCCCCCCCCCCEEEEECCCCCCEEEEECCCCCEEEEEEHHHHCCHHHCCHHHHHHHHHH
LVDTAEQSIDNWAIRSPTSTADVAAAITKMIALKQAGEPLAGHYHFSAKETMTKYQMLLV
HHHHHHHHHCCCEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEECHHHHHHHHHHHHH
MGELLGLATGHLIPVTSPTDSAKRPKDSTLSCERLVSLEIESKVPFRIGFKRALQDSPCA
HHHHHHHHCCCEEEECCCCCCCCCCCCCCCCHHHHEEEEECCCCCHHHHHHHHHCCCCCC
AAYLKVDNVRS
EEEEEECCCCC
>Mature Secondary Structure
MKKMAKIMVTGASGLLGRALIKQLGQNSQQQIIACGYSRFGPNIERLDLTQAAQVSSFVA
CCCCEEEEEECCCHHHHHHHHHHHCCCCCHHEEEECHHHHCCCCHHCCHHHHHHHHHHHH
KHKPDIILHCAAERRPDVSEQDPQAALALNSEATQFLTQAASQHGAWLLYISTDYVFDGS
HCCCCEEEEECCCCCCCCCCCCCCCEEEECHHHHHHHHHHHHCCCCEEEEEEEEEEECCC
QSPYREDAETNPVNFYGQSKLKGELVVSDAQQGFAILRLPILYGEVESLNESAVMVLLNH
CCCCCCCCCCCCEEEEECCCCCCEEEEECCCCCEEEEEEHHHHCCHHHCCHHHHHHHHHH
LVDTAEQSIDNWAIRSPTSTADVAAAITKMIALKQAGEPLAGHYHFSAKETMTKYQMLLV
HHHHHHHHHCCCEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEECHHHHHHHHHHHHH
MGELLGLATGHLIPVTSPTDSAKRPKDSTLSCERLVSLEIESKVPFRIGFKRALQDSPCA
HHHHHHHHCCCEEEECCCCCCCCCCCCCCCCHHHHEEEEECCCCCHHHHHHHHHCCCCCC
AAYLKVDNVRS
EEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1661369 [H]