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The map label for this gene is tyrP [H]

Identifier: 167622529

GI number: 167622529

Start: 705955

End: 707157

Strand: Direct

Name: tyrP [H]

Synonym: Shal_0589

Alternate gene names: 167622529

Gene position: 705955-707157 (Clockwise)

Preceding gene: 167622526

Following gene: 167622530

Centisome position: 13.51

GC content: 47.13

Gene sequence:

>1203_bases
ATGAACAAAAGTAAAATCTTCGGCAGTATGCTGATTATTGCGGGTACCACAATCGGTGCCGGTATGTTGGCATTACCTCT
CGCAGCATCGGGTCTTGGCTTTGGCATGGCGAGCATTATCATGCTCTTGATTTGGTCTTTGATGACCTATACCGCACTGC
TTATGATTGAAGTGCATCAACATGCGCCAGTCGATGCCACGCTGCACACGCTGGCACACAAACTATTGGGTCGTAAAGGA
CAAGTCATAGCAAGCTTTGCAATGATGTTTCTCTTCTACGCATTATGTGCTGCTTATATTGCCGGTGGCGGTGAGCAGAT
CCACAGTAAATTAACCAACTGGTTTGGACTCGAGCTGCCGATGCAAGCTGGCGCAATTATCTTTACCTTGCTAATCGGTA
CCGTTGTGGCCATAGGCACTCGTTCGGTCGATATGATTAATCGAAGCCTGTTCTCGCTTAAGCTTATCGCGTTAGTGGTG
ATGTTGTTTCTGTTACTGCCCCATGTTTCTGTCGAGAATTTAGTCGCTTTACCTGTACATCAAGGCTTGGTATTTGCCTC
TCTGCCAGTGATATTCACCTCTTTTGGCTTTCACGGCTCTATTCCATCAGTGGTGCGCTACTTAGGTAAAGATACCAAGG
CGCTGCGCTGGATCATTGTCGTGGGCTCTGCATTGCCGCTAATGATATATGTGTTATGGATGTTAGCCAGCCAAGGGGTA
TTGCCTCAGCAAGATCTAATGGCTAGCCAAAGTCTGAATGGCTTTATTGGTTCTCTGAGCCGAATGCTAGAAAACCCTAT
GATTGCTAATGCGGTATCTATCTTTGCCGATCTAGCGTTAGCGACATCATTCCTTGGGGTGAGTTTAGGCCTGTTCGACT
TTATCGGTGACTTACTAAAGCGTAGCACTAAGGCTAGTCACAGAGTGCAGGTAGGCTTAGTGACTTTCTTACCGCCACTG
GGTTTTGCATTGTTCTACCCTCAAGGTTTTATCACTGCACTGGGCTATGCGGCTTTTGCTTTAGTGATTTTGGCAGTGTT
TTTGCCAGTCGCTATGGTTAGCGCACAGCGTAAGCAAGCAGGCTTGCAAGGGTATCGAGTGAAAGGCGGCAACTTGGGTT
TGATCGCGGCAACATTAGCTGGTGTATTGATCATTAGCGTCCAGCTTATGCAGATTTTTAATCTGTTGCCTGCGGTAGGT
TGA

Upstream 100 bases:

>100_bases
CATGTTTTAAATCACTCCATTGTGGCAATTCCATCTTTCGGAAGCTGGCCACCATCAAAGCCTGTTCCGAGCACTTTATC
GTTAATTTGGAACACCATAA

Downstream 100 bases:

>100_bases
TAGGTTACAAATTTATAAAAGACACTTATCTTGCTGAGTAATTGACTGAAAAATAGCTGATTAAGCAATATTTTGCCTTG
TTGGTTGTTTTTTTAGTCAT

Product: aromatic amino acid transporter

Products: Proton [Cytoplasm]; L-tyrosine [Cytoplasm] [C]

Alternate protein names: Tyrosine permease [H]

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MNKSKIFGSMLIIAGTTIGAGMLALPLAASGLGFGMASIIMLLIWSLMTYTALLMIEVHQHAPVDATLHTLAHKLLGRKG
QVIASFAMMFLFYALCAAYIAGGGEQIHSKLTNWFGLELPMQAGAIIFTLLIGTVVAIGTRSVDMINRSLFSLKLIALVV
MLFLLLPHVSVENLVALPVHQGLVFASLPVIFTSFGFHGSIPSVVRYLGKDTKALRWIIVVGSALPLMIYVLWMLASQGV
LPQQDLMASQSLNGFIGSLSRMLENPMIANAVSIFADLALATSFLGVSLGLFDFIGDLLKRSTKASHRVQVGLVTFLPPL
GFALFYPQGFITALGYAAFALVILAVFLPVAMVSAQRKQAGLQGYRVKGGNLGLIAATLAGVLIISVQLMQIFNLLPAVG

Sequences:

>Translated_400_residues
MNKSKIFGSMLIIAGTTIGAGMLALPLAASGLGFGMASIIMLLIWSLMTYTALLMIEVHQHAPVDATLHTLAHKLLGRKG
QVIASFAMMFLFYALCAAYIAGGGEQIHSKLTNWFGLELPMQAGAIIFTLLIGTVVAIGTRSVDMINRSLFSLKLIALVV
MLFLLLPHVSVENLVALPVHQGLVFASLPVIFTSFGFHGSIPSVVRYLGKDTKALRWIIVVGSALPLMIYVLWMLASQGV
LPQQDLMASQSLNGFIGSLSRMLENPMIANAVSIFADLALATSFLGVSLGLFDFIGDLLKRSTKASHRVQVGLVTFLPPL
GFALFYPQGFITALGYAAFALVILAVFLPVAMVSAQRKQAGLQGYRVKGGNLGLIAATLAGVLIISVQLMQIFNLLPAVG
>Mature_400_residues
MNKSKIFGSMLIIAGTTIGAGMLALPLAASGLGFGMASIIMLLIWSLMTYTALLMIEVHQHAPVDATLHTLAHKLLGRKG
QVIASFAMMFLFYALCAAYIAGGGEQIHSKLTNWFGLELPMQAGAIIFTLLIGTVVAIGTRSVDMINRSLFSLKLIALVV
MLFLLLPHVSVENLVALPVHQGLVFASLPVIFTSFGFHGSIPSVVRYLGKDTKALRWIIVVGSALPLMIYVLWMLASQGV
LPQQDLMASQSLNGFIGSLSRMLENPMIANAVSIFADLALATSFLGVSLGLFDFIGDLLKRSTKASHRVQVGLVTFLPPL
GFALFYPQGFITALGYAAFALVILAVFLPVAMVSAQRKQAGLQGYRVKGGNLGLIAATLAGVLIISVQLMQIFNLLPAVG

Specific function: Involved in transporting tyrosine across the cytoplasmic membrane [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788218, Length=402, Percent_Identity=50.9950248756219, Blast_Score=397, Evalue=1e-112,
Organism=Escherichia coli, GI1790145, Length=409, Percent_Identity=31.2958435207824, Blast_Score=200, Evalue=1e-52,
Organism=Escherichia coli, GI1789552, Length=384, Percent_Identity=30.46875, Blast_Score=191, Evalue=5e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 42661; Mature: 42661

Theoretical pI: Translated: 10.32; Mature: 10.32

Prosite motif: PS00589 PTS_HPR_SER ; PS00594 AROMATIC_AA_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure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CCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-tyrosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3049553; 9097040; 9278503 [H]