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The map label for this gene is nhaC [H]

Identifier: 167622487

GI number: 167622487

Start: 658504

End: 660033

Strand: Direct

Name: nhaC [H]

Synonym: Shal_0547

Alternate gene names: 167622487

Gene position: 658504-660033 (Clockwise)

Preceding gene: 167622484

Following gene: 167622491

Centisome position: 12.6

GC content: 47.71

Gene sequence:

>1530_bases
ATGAGCTCAAATAATGATCTTCAACAGTCAGAGTCTGTGACTATTGACCCTTTAGAAGATAGTCGACATACCGCTCCAAC
ATTACTCGATGCCCTGATCCCGATAATTGCCTTGGTGATGATGCTCACCGCCGCAGTGTATCTGTTTTCATCCGACAGCT
CTTACGGTGCAAACCAGATAGCCTTGATTATGGCTGGCTGTATAGGGCTATTAATTGGTTGGAAGAACGGCTATAGCTGG
GCGGAAATGGAGCAAGGCATTGTCCGCAGTATCGGTGTGGCTACTGGTGCTATATTAATCTTATTTACCGTTGGGTCCTT
GATTGGTACCTGGATCCTTGCAGGCACCGTACCGACCATGATCTATTACGGCATGTTGGTACTCAACCCCGAGTATTTCT
ATGTTGCCTGCTGCTTATTATGTGCTGTGGTTGCTATCAGTATCGGTAGCTCTTGGACGGTTGCAGGTACCTTAGGCATT
GCCTTGGTCGGAGTGGCTTCTGCTATGGGGCTTAATGTGGAAATCACCGCCGGAGCCATTATTAGCGGTGCGTATTTTGG
CGATAAGATGTCGCCATTGTCAGACACCACTAACTTAGCGCCTGCGGTCGCAGGAACCGATATCTTCAGTCATATTAGAC
ACATGCTATGGACTACGGCACCAAGTATTATTATCGCCATGATAGGTTTTTTATTCTTGGGCTTTAACACCCAATCAGGC
ATGGATAACAATAATTTTGAAACCACTCTGTCACTCATTCAAGCCGATTTTAATCCTGGCGTTCATCTACTCTTACCCTT
GCTAGTGGTATTTATTTTGGCCTGGAAAAAAATCCCGGCCTTTCCGACTGTGATTATCGGCACGATTGCCGGTGCTGTCT
GCGCGGCGCTATTCCAATTTGATAATGTGGTCAAATTTGCAGATGACGAAACCTTGATGCCGGTTGTGGCATTGATTAAA
GGGATCTGGGTGGCGATGTTTAATGGCTACACCGCCAGTACGGGGGATGAGGTGTTAGACAATCTACTCAGTCGCGGTGG
TATGAGCACCATGATGAATACGGTTTGGTTAATTCTTTGCGCCATGACCTTCGGTGGCATCATGGAGGTTACAGGTCTGC
TTAAGCGCATTTTGCAGAGTATTCTGAGTCTAGTGAAGTCCAGCGGTAGTTTGATTTTGACGACATTAGCGAGCGGTATC
GGCGCCAATTTGATCACCGCCGATCAGTTTATCGCAATCGTTTTGCCGGGGCGTATGCTTAAAGTGGAATACGCAAAACG
AGGCTTAGCACCGGTTAACTTAAGCCGAGCGTTAGAGGATTCGGCCACGATTACTAGCCCGCTTATTCCGTGGAACACCT
GTGGCGCGTATATGGCCAGCACCTTAGGGGTGGCGACAGTGGCTTATCTACCTTACGCCTTCTTTAACTTAGTGTGTCCA
CTTATTAGCGCAGCCTATGCGAAATACGACTTTAAAATCGAGCGATTGCCAGAGGCTGAAGTACCACAGGCACAAGAGGC
CGTTGCTTAA

Upstream 100 bases:

>100_bases
GGTACGCTAAACCATTGCGGTATGGTGAACAGTTCGTAATTAAATTCGTTTTTAAAGCGAATAGAGCTGAAGGACATAAT
AAAAATAATAAGGATGTTTC

Downstream 100 bases:

>100_bases
GCAGGCGTGAGACATTGGTAGTAGTCAGGACAAAAAAAAGCCTTGTCGGTTAGGAATCGACAAGGCACTTGGCGTAGCTA
TTAATCGAATTATTAATAAG

Product: Na+/H+ antiporter NhaC

Products: NA

Alternate protein names: Sodium/hydrogen antiporter; Sodium/proton antiporter [H]

Number of amino acids: Translated: 509; Mature: 508

Protein sequence:

>509_residues
MSSNNDLQQSESVTIDPLEDSRHTAPTLLDALIPIIALVMMLTAAVYLFSSDSSYGANQIALIMAGCIGLLIGWKNGYSW
AEMEQGIVRSIGVATGAILILFTVGSLIGTWILAGTVPTMIYYGMLVLNPEYFYVACCLLCAVVAISIGSSWTVAGTLGI
ALVGVASAMGLNVEITAGAIISGAYFGDKMSPLSDTTNLAPAVAGTDIFSHIRHMLWTTAPSIIIAMIGFLFLGFNTQSG
MDNNNFETTLSLIQADFNPGVHLLLPLLVVFILAWKKIPAFPTVIIGTIAGAVCAALFQFDNVVKFADDETLMPVVALIK
GIWVAMFNGYTASTGDEVLDNLLSRGGMSTMMNTVWLILCAMTFGGIMEVTGLLKRILQSILSLVKSSGSLILTTLASGI
GANLITADQFIAIVLPGRMLKVEYAKRGLAPVNLSRALEDSATITSPLIPWNTCGAYMASTLGVATVAYLPYAFFNLVCP
LISAAYAKYDFKIERLPEAEVPQAQEAVA

Sequences:

>Translated_509_residues
MSSNNDLQQSESVTIDPLEDSRHTAPTLLDALIPIIALVMMLTAAVYLFSSDSSYGANQIALIMAGCIGLLIGWKNGYSW
AEMEQGIVRSIGVATGAILILFTVGSLIGTWILAGTVPTMIYYGMLVLNPEYFYVACCLLCAVVAISIGSSWTVAGTLGI
ALVGVASAMGLNVEITAGAIISGAYFGDKMSPLSDTTNLAPAVAGTDIFSHIRHMLWTTAPSIIIAMIGFLFLGFNTQSG
MDNNNFETTLSLIQADFNPGVHLLLPLLVVFILAWKKIPAFPTVIIGTIAGAVCAALFQFDNVVKFADDETLMPVVALIK
GIWVAMFNGYTASTGDEVLDNLLSRGGMSTMMNTVWLILCAMTFGGIMEVTGLLKRILQSILSLVKSSGSLILTTLASGI
GANLITADQFIAIVLPGRMLKVEYAKRGLAPVNLSRALEDSATITSPLIPWNTCGAYMASTLGVATVAYLPYAFFNLVCP
LISAAYAKYDFKIERLPEAEVPQAQEAVA
>Mature_508_residues
SSNNDLQQSESVTIDPLEDSRHTAPTLLDALIPIIALVMMLTAAVYLFSSDSSYGANQIALIMAGCIGLLIGWKNGYSWA
EMEQGIVRSIGVATGAILILFTVGSLIGTWILAGTVPTMIYYGMLVLNPEYFYVACCLLCAVVAISIGSSWTVAGTLGIA
LVGVASAMGLNVEITAGAIISGAYFGDKMSPLSDTTNLAPAVAGTDIFSHIRHMLWTTAPSIIIAMIGFLFLGFNTQSGM
DNNNFETTLSLIQADFNPGVHLLLPLLVVFILAWKKIPAFPTVIIGTIAGAVCAALFQFDNVVKFADDETLMPVVALIKG
IWVAMFNGYTASTGDEVLDNLLSRGGMSTMMNTVWLILCAMTFGGIMEVTGLLKRILQSILSLVKSSGSLILTTLASGIG
ANLITADQFIAIVLPGRMLKVEYAKRGLAPVNLSRALEDSATITSPLIPWNTCGAYMASTLGVATVAYLPYAFFNLVCPL
ISAAYAKYDFKIERLPEAEVPQAQEAVA

Specific function: Na(+)/H(+) antiporter. Involved in pH homeostasis and sodium extrusion [H]

COG id: COG1757

COG function: function code C; Na+/H+ antiporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaC Na(+)/H(+) antiporter family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004770
- InterPro:   IPR018461 [H]

Pfam domain/function: PF03553 Na_H_antiporter [H]

EC number: NA

Molecular weight: Translated: 54054; Mature: 53923

Theoretical pI: Translated: 4.45; Mature: 4.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSNNDLQQSESVTIDPLEDSRHTAPTLLDALIPIIALVMMLTAAVYLFSSDSSYGANQI
CCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
ALIMAGCIGLLIGWKNGYSWAEMEQGIVRSIGVATGAILILFTVGSLIGTWILAGTVPTM
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IYYGMLVLNPEYFYVACCLLCAVVAISIGSSWTVAGTLGIALVGVASAMGLNVEITAGAI
HHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCHH
ISGAYFGDKMSPLSDTTNLAPAVAGTDIFSHIRHMLWTTAPSIIIAMIGFLFLGFNTQSG
EECHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
MDNNNFETTLSLIQADFNPGVHLLLPLLVVFILAWKKIPAFPTVIIGTIAGAVCAALFQF
CCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
DNVVKFADDETLMPVVALIKGIWVAMFNGYTASTGDEVLDNLLSRGGMSTMMNTVWLILC
HHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHH
AMTFGGIMEVTGLLKRILQSILSLVKSSGSLILTTLASGIGANLITADQFIAIVLPGRML
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHCCCCCEEHHHEEEEEECCCCE
KVEYAKRGLAPVNLSRALEDSATITSPLIPWNTCGAYMASTLGVATVAYLPYAFFNLVCP
EHHHHHCCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LISAAYAKYDFKIERLPEAEVPQAQEAVA
HHHHHHHHCCCEEECCCCCCCCCHHHCCC
>Mature Secondary Structure 
SSNNDLQQSESVTIDPLEDSRHTAPTLLDALIPIIALVMMLTAAVYLFSSDSSYGANQI
CCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
ALIMAGCIGLLIGWKNGYSWAEMEQGIVRSIGVATGAILILFTVGSLIGTWILAGTVPTM
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IYYGMLVLNPEYFYVACCLLCAVVAISIGSSWTVAGTLGIALVGVASAMGLNVEITAGAI
HHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCHH
ISGAYFGDKMSPLSDTTNLAPAVAGTDIFSHIRHMLWTTAPSIIIAMIGFLFLGFNTQSG
EECHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
MDNNNFETTLSLIQADFNPGVHLLLPLLVVFILAWKKIPAFPTVIIGTIAGAVCAALFQF
CCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
DNVVKFADDETLMPVVALIKGIWVAMFNGYTASTGDEVLDNLLSRGGMSTMMNTVWLILC
HHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHH
AMTFGGIMEVTGLLKRILQSILSLVKSSGSLILTTLASGIGANLITADQFIAIVLPGRML
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHCCCCCEEHHHEEEEEECCCCE
KVEYAKRGLAPVNLSRALEDSATITSPLIPWNTCGAYMASTLGVATVAYLPYAFFNLVCP
EHHHHHCCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LISAAYAKYDFKIERLPEAEVPQAQEAVA
HHHHHHHHCCCEEECCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1660475; 9190799 [H]