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The map label for this gene is hipA [C]

Identifier: 167622359

GI number: 167622359

Start: 494094

End: 495401

Strand: Reverse

Name: hipA [C]

Synonym: Shal_0419

Alternate gene names: 167622359

Gene position: 495401-494094 (Counterclockwise)

Preceding gene: 167622360

Following gene: 167622358

Centisome position: 9.48

GC content: 42.89

Gene sequence:

>1308_bases
ATGAGTGGTTCTAACTTTCACGCCCTAGAGATGCACTTTAGAGGCATGATTATTGGGTCGATTGGTTTTGACATAGACAC
TGAACAATTTTCTATCGAATACACTAAAGCTTGGCAGGAAAATGGTTTTCCTATTTCACCAAAGCTCCCACTTAATGGAC
AAGCTAGCAGTTCGCAAATCTCTATTTACCTCACTAATCTACTACCCGAAAATAAAGGCCTTGATCACCTTATTGAAGCC
CTAGGTATTGCCAAAAGTAATACATTTGGTTTGATCAAAGGCATTGGGTTCGATACCTCTGGTGCAATATTGTATCTGCC
TGAAAACACCAAACCACCAGTAACGTCTTTTACCCCGATTAGCAAAGAAGACCTTATCAAGCGAATCGAAGACCCAGAAC
ATTGGCCGATGGAAATCTGGGACGGAAAACCACGTCTTTCCGTTGCAGGGGTTCAATCAAAAATAAACCTATTCCACACC
GACACAGAATACGGATTTGGTGAAGGTCAGCTCTGTTCAACTCATATCATTAAATTTGAAAAAAACAGTCAGCAGTACCT
CGTACTCAACGAATTTATTACCATGACACTTGCCGGGCTCATTGGTATACAGGTAGCCAAAGTAGAGATAATGCCAATAG
GGAAATACAAAGCGTTATCCGTCACTCGCTTCGATCGCATGTACGATCCTGAGCGCCATATTGTCATGCGTCGTCATCAG
ATCGATGCATGTCAAGCTCTGGGCTTTTCCGTCGCAAGAAAGTATGAACGACATCTTGGTAGTGGTCGTGACGTACGAGA
TATTCGTGAAGGAGTAAGCCTAGAAAAGCTGTTTAGTATCGCAGAGTACTGTGCTAACCCTGCAAAAGCCAAGTTTGACA
TGCTTCGTTGGACAATCTTTAATTTACTCGTTTGCAATGCGGACTCACATGGCAAAAACTATTCATTCTATGTCACTGCT
AATGGGCTTGAACCGACCCCATGGTACGATCTTGTCAACGTGCAGATGTACCCTGATTTTGATCAAGAGCTTGCTATGGC
TATTGGAGGTGAGTTCGAGGCTGACAAGATCCACGCCTACCAATTAATGACATTTGCTGAAGAATGCGGAATTAAGCAAA
ACATACTTGAATTAACCCTCAAACAACTGGCGAAAGCAATTATCGCTAATCTGGATAAAGCGGCAAAACAAGCTGGGGAG
CTTACGGATGCAGAATCCAAGTATGTTGGAACGTACAAAGCAACCATTCAAGCACGATGTGAATACTACCTGGCTCAGGT
TGAAGAAATGAAGCACATTGAGCTATAG

Upstream 100 bases:

>100_bases
GAAGATGTATACTTTTCAACTATCGTCAAAATCCTCAGTGGCCTTGGTATAAAGCTGACCGTCGATACACCTAATAGCAA
AAACAACTTAGGGGGCAGCA

Downstream 100 bases:

>100_bases
CGAAGTAACAACGCTAATATCGATACCATGTAACAGGACATTCAACCCTTCAAATTGATTCTATTAAACATAGAAGTAGC
TTATGGGGGGAATCAAATCT

Product: HipA domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 435; Mature: 434

Protein sequence:

>435_residues
MSGSNFHALEMHFRGMIIGSIGFDIDTEQFSIEYTKAWQENGFPISPKLPLNGQASSSQISIYLTNLLPENKGLDHLIEA
LGIAKSNTFGLIKGIGFDTSGAILYLPENTKPPVTSFTPISKEDLIKRIEDPEHWPMEIWDGKPRLSVAGVQSKINLFHT
DTEYGFGEGQLCSTHIIKFEKNSQQYLVLNEFITMTLAGLIGIQVAKVEIMPIGKYKALSVTRFDRMYDPERHIVMRRHQ
IDACQALGFSVARKYERHLGSGRDVRDIREGVSLEKLFSIAEYCANPAKAKFDMLRWTIFNLLVCNADSHGKNYSFYVTA
NGLEPTPWYDLVNVQMYPDFDQELAMAIGGEFEADKIHAYQLMTFAEECGIKQNILELTLKQLAKAIIANLDKAAKQAGE
LTDAESKYVGTYKATIQARCEYYLAQVEEMKHIEL

Sequences:

>Translated_435_residues
MSGSNFHALEMHFRGMIIGSIGFDIDTEQFSIEYTKAWQENGFPISPKLPLNGQASSSQISIYLTNLLPENKGLDHLIEA
LGIAKSNTFGLIKGIGFDTSGAILYLPENTKPPVTSFTPISKEDLIKRIEDPEHWPMEIWDGKPRLSVAGVQSKINLFHT
DTEYGFGEGQLCSTHIIKFEKNSQQYLVLNEFITMTLAGLIGIQVAKVEIMPIGKYKALSVTRFDRMYDPERHIVMRRHQ
IDACQALGFSVARKYERHLGSGRDVRDIREGVSLEKLFSIAEYCANPAKAKFDMLRWTIFNLLVCNADSHGKNYSFYVTA
NGLEPTPWYDLVNVQMYPDFDQELAMAIGGEFEADKIHAYQLMTFAEECGIKQNILELTLKQLAKAIIANLDKAAKQAGE
LTDAESKYVGTYKATIQARCEYYLAQVEEMKHIEL
>Mature_434_residues
SGSNFHALEMHFRGMIIGSIGFDIDTEQFSIEYTKAWQENGFPISPKLPLNGQASSSQISIYLTNLLPENKGLDHLIEAL
GIAKSNTFGLIKGIGFDTSGAILYLPENTKPPVTSFTPISKEDLIKRIEDPEHWPMEIWDGKPRLSVAGVQSKINLFHTD
TEYGFGEGQLCSTHIIKFEKNSQQYLVLNEFITMTLAGLIGIQVAKVEIMPIGKYKALSVTRFDRMYDPERHIVMRRHQI
DACQALGFSVARKYERHLGSGRDVRDIREGVSLEKLFSIAEYCANPAKAKFDMLRWTIFNLLVCNADSHGKNYSFYVTAN
GLEPTPWYDLVNVQMYPDFDQELAMAIGGEFEADKIHAYQLMTFAEECGIKQNILELTLKQLAKAIIANLDKAAKQAGEL
TDAESKYVGTYKATIQARCEYYLAQVEEMKHIEL

Specific function: Unbalanced Or Excessive Expression Of Hipa Is Toxic To The Cell. [C]

COG id: COG3550

COG function: function code R; Uncharacterized protein related to capsule biosynthesis enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: To E.coli hipA, H.influenzae HI_0665 and y4dM [H]

Homologues:

Organism=Escherichia coli, GI1787785, Length=393, Percent_Identity=26.2086513994911, Blast_Score=128, Evalue=6e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012893
- InterPro:   IPR012894
- InterPro:   IPR017508 [H]

Pfam domain/function: PF07804 HipA_C; PF07805 HipA_N [H]

EC number: NA

Molecular weight: Translated: 49052; Mature: 48921

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGSNFHALEMHFRGMIIGSIGFDIDTEQFSIEYTKAWQENGFPISPKLPLNGQASSSQI
CCCCCEEEEEEEECEEEEEEECCCCCCCCEEEEEEHHHCCCCCCCCCCCCCCCCCCCCEE
SIYLTNLLPENKGLDHLIEALGIAKSNTFGLIKGIGFDTSGAILYLPENTKPPVTSFTPI
EEEEEECCCCCCCHHHHHHHHCCCCCCCCEEEEECCCCCCCEEEEECCCCCCCCCCCCCC
SKEDLIKRIEDPEHWPMEIWDGKPRLSVAGVQSKINLFHTDTEYGFGEGQLCSTHIIKFE
CHHHHHHHCCCCCCCCCEEECCCCCEEEECCCEEEEEEECCCCCCCCCCCEEEEEEEEEE
KNSQQYLVLNEFITMTLAGLIGIQVAKVEIMPIGKYKALSVTRFDRMYDPERHIVMRRHQ
CCCCCEEEHHHHHHHHHHHHHHEEEEEEEEEECCCCEEEEEEHHHHHCCCHHHHHHHHHH
IDACQALGFSVARKYERHLGSGRDVRDIREGVSLEKLFSIAEYCANPAKAKFDMLRWTIF
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHH
NLLVCNADSHGKNYSFYVTANGLEPTPWYDLVNVQMYPDFDQELAMAIGGEFEADKIHAY
HEEEECCCCCCCCEEEEEEECCCCCCCCEEEEEEEECCCHHHHHHHHHCCCCCCCHHHHH
QLMTFAEECGIKQNILELTLKQLAKAIIANLDKAAKQAGELTDAESKYVGTYKATIQARC
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHH
EYYLAQVEEMKHIEL
HHHHHHHHHHHHCCC
>Mature Secondary Structure 
SGSNFHALEMHFRGMIIGSIGFDIDTEQFSIEYTKAWQENGFPISPKLPLNGQASSSQI
CCCCEEEEEEEECEEEEEEECCCCCCCCEEEEEEHHHCCCCCCCCCCCCCCCCCCCCEE
SIYLTNLLPENKGLDHLIEALGIAKSNTFGLIKGIGFDTSGAILYLPENTKPPVTSFTPI
EEEEEECCCCCCCHHHHHHHHCCCCCCCCEEEEECCCCCCCEEEEECCCCCCCCCCCCCC
SKEDLIKRIEDPEHWPMEIWDGKPRLSVAGVQSKINLFHTDTEYGFGEGQLCSTHIIKFE
CHHHHHHHCCCCCCCCCEEECCCCCEEEECCCEEEEEEECCCCCCCCCCCEEEEEEEEEE
KNSQQYLVLNEFITMTLAGLIGIQVAKVEIMPIGKYKALSVTRFDRMYDPERHIVMRRHQ
CCCCCEEEHHHHHHHHHHHHHHEEEEEEEEEECCCCEEEEEEHHHHHCCCHHHHHHHHHH
IDACQALGFSVARKYERHLGSGRDVRDIREGVSLEKLFSIAEYCANPAKAKFDMLRWTIF
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHH
NLLVCNADSHGKNYSFYVTANGLEPTPWYDLVNVQMYPDFDQELAMAIGGEFEADKIHAY
HEEEECCCCCCCCEEEEEEECCCCCCCCEEEEEEEECCCHHHHHHHHHCCCCCCCHHHHH
QLMTFAEECGIKQNILELTLKQLAKAIIANLDKAAKQAGELTDAESKYVGTYKATIQARC
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHH
EYYLAQVEEMKHIEL
HHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]