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The map label for this gene is hutU [H]

Identifier: 167622014

GI number: 167622014

Start: 82702

End: 84366

Strand: Direct

Name: hutU [H]

Synonym: Shal_0073

Alternate gene names: 167622014

Gene position: 82702-84366 (Clockwise)

Preceding gene: 167622013

Following gene: 167622015

Centisome position: 1.58

GC content: 52.43

Gene sequence:

>1665_bases
ATGGATAAGAGACACGATCCAAGCCGCCGCATCATCGCGCCGACAGGAACAAAGCTAAGCTGTAAGAGCTGGTTAACTGA
AGCACCGATGCGGATGTTGATGAACAATCTGCATCCTGATGTTGCTGAGCGTCCTGAAGACCTCGTGGTTTACGGTGGTA
TCGGCCGTGCTGCACGTGACTGGGAATGCTACGACAAAATTGTTGAAGTATTGCAGCGTCTTGAAGATGATGAAACGCTG
ATGGTGCAATCGGGCAAACCAGTTGGAGTATTTAAGACTCACAGCAATGCGCCACGGGTGATTATTGCTAACTCTAATCT
AGTACCACACTGGGCAAACTGGGAACACTTTAACGAACTCGATAAAAAGGGTTTGGCCATGTACGGCCAGATGACGGCAG
GTTCGTGGATCTACATCGGCTCGCAAGGTATCGTGCAGGGCACCTACGAGACTTTTGTGGCGATGGCTAAGCAACACTTT
AATGGTGTATCTGCTGGCAAGTGGATCTTAACCGGCGGTCTTGGCGGTATGGGCGGTGCGCAACCTCTTGCGGGTACCAT
GGCGGGTTACTCGGTACTCACTTGTGAAGTGGACGAAACCCGTATCGATTTCCGTCTTCGTACAAAATATGTTGATAAAA
AAGCGACTTCACTCGATGAAGCCTTGGCAATGATTGAAGAAGCCAACAACAGCGGCAAGCCGGTATCTGTGGGACTATTA
GCCAACGCAGCCGATGTGTTTGCCGAGCTGGTGGAACGAGGTATAACCCCTGATGTGGTGACCGACCAAACCTCTGCTCA
CGATCCGCTAAATGGCTACCTGCCACAGGGCTGGACGCTAGAATATGCAGCCGAGATGCGTAAAAAAGATGAGGCGGCTG
TAGTTAAGGCGGCTAAGCAGTCGATGGCGGTACAGGTTAAGGCGATGCTAGCATTGCAAGCTGCTGGCGCGGCGACCACC
GACTACGGTAACAACATTCGTCAGATGGCATTTGAAGAGGGGGTTGAGAATGCATTCGACTTCCCGGGCTTCGTACCGGC
TTATGTACGCCCACTATTCTGCGAAGGTATTGGCCCTTTCCGCTGGGTAGCACTGTCTGGCGACCCTGAAGATATCTACA
AGACCGATGCCAAGGTAAAAGAGCTTATTCCTGATAACCCGCAGCTACACAACTGGCTCGATATGGCGCGCGAGCGTATC
GCCTTCCAAGGTCTGCCATCACGGATCTGTTGGGTGGGTCTAAAAGACCGTGCGCGTTTGGCATTAGCCTTTAACGAAAT
GGTTAAAAATGGCGAGCTTTCAGCGCCAATCGTGATTGGTCGCGATCACTTAGACTCAGGCTCAGTTGCCAGCCCTAACC
GCGAAACCGAATCAATGCTCGATGGCTCTGATGCGGTATCGGATTGGCCATTGATGAATGCTCTGCTTAACACCGCAAGT
GGCGCAACTTGGGTGTCGTTGCATCACGGCGGTGGTGTTGGTATGGGCTTTAGCCAGCACTCAGGTGTGGTGATTGTGGC
CGATGGCACCGACGACGCGGCAGTGCGCCTCGGTCGCGTACTGTGGAATGATCCGGCTACCGGCGTGATGCGTCACGCTG
ATGCGGGTTACGATATCGCTAAAAATTGTGCAAAAGAGCAGGGTCTAGACCTGCCAATGCTATAA

Upstream 100 bases:

>100_bases
TTTATAAAATGCTCTAAAAAATTAAAAAGACCGTAAATATAAAAGCTTAAAAATAAGCTGATAAGAAAAACACAAAAACA
AATTGAACGAGGTAGTACCG

Downstream 100 bases:

>100_bases
AAAGAATAAGAGGCATTAACATGAGTCATTTAGTATTAACTCCGGGTACGTTAACCCTGGCGCAAATCCGTGAAATTAGC
CGTGGCAAGGTGACATTAGA

Product: urocanate hydratase

Products: NA

Alternate protein names: Urocanase; Imidazolonepropionate hydrolase [H]

Number of amino acids: Translated: 554; Mature: 554

Protein sequence:

>554_residues
MDKRHDPSRRIIAPTGTKLSCKSWLTEAPMRMLMNNLHPDVAERPEDLVVYGGIGRAARDWECYDKIVEVLQRLEDDETL
MVQSGKPVGVFKTHSNAPRVIIANSNLVPHWANWEHFNELDKKGLAMYGQMTAGSWIYIGSQGIVQGTYETFVAMAKQHF
NGVSAGKWILTGGLGGMGGAQPLAGTMAGYSVLTCEVDETRIDFRLRTKYVDKKATSLDEALAMIEEANNSGKPVSVGLL
ANAADVFAELVERGITPDVVTDQTSAHDPLNGYLPQGWTLEYAAEMRKKDEAAVVKAAKQSMAVQVKAMLALQAAGAATT
DYGNNIRQMAFEEGVENAFDFPGFVPAYVRPLFCEGIGPFRWVALSGDPEDIYKTDAKVKELIPDNPQLHNWLDMARERI
AFQGLPSRICWVGLKDRARLALAFNEMVKNGELSAPIVIGRDHLDSGSVASPNRETESMLDGSDAVSDWPLMNALLNTAS
GATWVSLHHGGGVGMGFSQHSGVVIVADGTDDAAVRLGRVLWNDPATGVMRHADAGYDIAKNCAKEQGLDLPML

Sequences:

>Translated_554_residues
MDKRHDPSRRIIAPTGTKLSCKSWLTEAPMRMLMNNLHPDVAERPEDLVVYGGIGRAARDWECYDKIVEVLQRLEDDETL
MVQSGKPVGVFKTHSNAPRVIIANSNLVPHWANWEHFNELDKKGLAMYGQMTAGSWIYIGSQGIVQGTYETFVAMAKQHF
NGVSAGKWILTGGLGGMGGAQPLAGTMAGYSVLTCEVDETRIDFRLRTKYVDKKATSLDEALAMIEEANNSGKPVSVGLL
ANAADVFAELVERGITPDVVTDQTSAHDPLNGYLPQGWTLEYAAEMRKKDEAAVVKAAKQSMAVQVKAMLALQAAGAATT
DYGNNIRQMAFEEGVENAFDFPGFVPAYVRPLFCEGIGPFRWVALSGDPEDIYKTDAKVKELIPDNPQLHNWLDMARERI
AFQGLPSRICWVGLKDRARLALAFNEMVKNGELSAPIVIGRDHLDSGSVASPNRETESMLDGSDAVSDWPLMNALLNTAS
GATWVSLHHGGGVGMGFSQHSGVVIVADGTDDAAVRLGRVLWNDPATGVMRHADAGYDIAKNCAKEQGLDLPML
>Mature_554_residues
MDKRHDPSRRIIAPTGTKLSCKSWLTEAPMRMLMNNLHPDVAERPEDLVVYGGIGRAARDWECYDKIVEVLQRLEDDETL
MVQSGKPVGVFKTHSNAPRVIIANSNLVPHWANWEHFNELDKKGLAMYGQMTAGSWIYIGSQGIVQGTYETFVAMAKQHF
NGVSAGKWILTGGLGGMGGAQPLAGTMAGYSVLTCEVDETRIDFRLRTKYVDKKATSLDEALAMIEEANNSGKPVSVGLL
ANAADVFAELVERGITPDVVTDQTSAHDPLNGYLPQGWTLEYAAEMRKKDEAAVVKAAKQSMAVQVKAMLALQAAGAATT
DYGNNIRQMAFEEGVENAFDFPGFVPAYVRPLFCEGIGPFRWVALSGDPEDIYKTDAKVKELIPDNPQLHNWLDMARERI
AFQGLPSRICWVGLKDRARLALAFNEMVKNGELSAPIVIGRDHLDSGSVASPNRETESMLDGSDAVSDWPLMNALLNTAS
GATWVSLHHGGGVGMGFSQHSGVVIVADGTDDAAVRLGRVLWNDPATGVMRHADAGYDIAKNCAKEQGLDLPML

Specific function: Unknown

COG id: COG2987

COG function: function code E; Urocanate hydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the urocanase family [H]

Homologues:

Organism=Homo sapiens, GI21389467, Length=560, Percent_Identity=33.75, Blast_Score=298, Evalue=1e-80,
Organism=Homo sapiens, GI260306182, Length=229, Percent_Identity=36.2445414847162, Blast_Score=151, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI71997891, Length=560, Percent_Identity=34.1071428571429, Blast_Score=311, Evalue=6e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000193 [H]

Pfam domain/function: PF01175 Urocanase [H]

EC number: =4.2.1.49 [H]

Molecular weight: Translated: 60276; Mature: 60276

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS01233 UROCANASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKRHDPSRRIIAPTGTKLSCKSWLTEAPMRMLMNNLHPDVAERPEDLVVYGGIGRAARD
CCCCCCCCCEEECCCCCCEEHHHHHHHHHHHHHHHHCCCCHHCCCCCEEEECCCCCCCCC
WECYDKIVEVLQRLEDDETLMVQSGKPVGVFKTHSNAPRVIIANSNLVPHWANWEHFNEL
HHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEECCCCCEEEEECCCCCCCCCCCHHHHHH
DKKGLAMYGQMTAGSWIYIGSQGIVQGTYETFVAMAKQHFNGVSAGKWILTGGLGGMGGA
HHCCCEEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCC
QPLAGTMAGYSVLTCEVDETRIDFRLRTKYVDKKATSLDEALAMIEEANNSGKPVSVGLL
CCHHHHHCCCEEEEEEECCCEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEH
ANAADVFAELVERGITPDVVTDQTSAHDPLNGYLPQGWTLEYAAEMRKKDEAAVVKAAKQ
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
SMAVQVKAMLALQAAGAATTDYGNNIRQMAFEEGVENAFDFPGFVPAYVRPLFCEGIGPF
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCE
RWVALSGDPEDIYKTDAKVKELIPDNPQLHNWLDMARERIAFQGLPSRICWVGLKDRARL
EEEEECCCHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHH
ALAFNEMVKNGELSAPIVIGRDHLDSGSVASPNRETESMLDGSDAVSDWPLMNALLNTAS
HHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHCCC
GATWVSLHHGGGVGMGFSQHSGVVIVADGTDDAAVRLGRVLWNDPATGVMRHADAGYDIA
CCEEEEEECCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCHHHHHHCCCCCHHH
KNCAKEQGLDLPML
HHHHHHCCCCCCCC
>Mature Secondary Structure
MDKRHDPSRRIIAPTGTKLSCKSWLTEAPMRMLMNNLHPDVAERPEDLVVYGGIGRAARD
CCCCCCCCCEEECCCCCCEEHHHHHHHHHHHHHHHHCCCCHHCCCCCEEEECCCCCCCCC
WECYDKIVEVLQRLEDDETLMVQSGKPVGVFKTHSNAPRVIIANSNLVPHWANWEHFNEL
HHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEECCCCCEEEEECCCCCCCCCCCHHHHHH
DKKGLAMYGQMTAGSWIYIGSQGIVQGTYETFVAMAKQHFNGVSAGKWILTGGLGGMGGA
HHCCCEEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCC
QPLAGTMAGYSVLTCEVDETRIDFRLRTKYVDKKATSLDEALAMIEEANNSGKPVSVGLL
CCHHHHHCCCEEEEEEECCCEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEH
ANAADVFAELVERGITPDVVTDQTSAHDPLNGYLPQGWTLEYAAEMRKKDEAAVVKAAKQ
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
SMAVQVKAMLALQAAGAATTDYGNNIRQMAFEEGVENAFDFPGFVPAYVRPLFCEGIGPF
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCE
RWVALSGDPEDIYKTDAKVKELIPDNPQLHNWLDMARERIAFQGLPSRICWVGLKDRARL
EEEEECCCHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHH
ALAFNEMVKNGELSAPIVIGRDHLDSGSVASPNRETESMLDGSDAVSDWPLMNALLNTAS
HHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHCCC
GATWVSLHHGGGVGMGFSQHSGVVIVADGTDDAAVRLGRVLWNDPATGVMRHADAGYDIA
CCEEEEEECCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCHHHHHHCCCCCHHH
KNCAKEQGLDLPML
HHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA