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The map label for this gene is hutH [H]

Identifier: 167622015

GI number: 167622015

Start: 84387

End: 85919

Strand: Direct

Name: hutH [H]

Synonym: Shal_0074

Alternate gene names: 167622015

Gene position: 84387-85919 (Clockwise)

Preceding gene: 167622014

Following gene: 167622017

Centisome position: 1.61

GC content: 52.12

Gene sequence:

>1533_bases
ATGAGTCATTTAGTATTAACTCCGGGTACGTTAACCCTGGCGCAAATCCGTGAAATTAGCCGTGGCAAGGTGACATTAGA
GCTGGCTGAGAGTGCGATCGCCGATATCAATACCAGTGCAGGTTTAGTACAGCAGGTATTGGATGAAGGCCGCACGGTTT
ACGGCATCAACACTGGCTTTGGCTTATTAGCCAACACTAAGATTGCCGCCGAGGATTTACAGCTGCTGCAGCGCTCGATT
GTACTGTCCCATGCGGCAGGTACAGGTAAGCACATGAGCGATGAAACCGTGCGCTTGATGATGGTATTGAAGATTAACTC
ACTGAGCCGTGGATTCTCCGGTATTCGTTTAGAGGTGATCAACTTCCTGATTAAGCTGGTTAACGCGGGTGTCTATCCAT
GTGTACCAGAGAAAGGCTCTGTCGGCGCATCGGGCGACTTAGCACCGCTATCACATATGTGTTTGCCACTACTTGGTGAA
GGTGAGATGAGCTACCAAGGTCAGCTGATTAGCGCGGCTGAAGGTCTTGAAATCGCGGGCCTTAAGCCAATCGAATTGGC
GGCGAAAGAAGGCTTAGCACTACTTAACGGTACTCAGGCATCGACGGCTTTAGCACTCGAAGGTTTGTTTAATGCTGAAG
ATCTATTTGCCGCAAGCTCAGTGATTGGTGCCATGAGTGTTGAGGCGGCAATGGGCAGTCGTAGCCCGTTTGATCTTCGT
ATCCATGCGGCTCGTGGTCAGAAAGGTCAGATCGATTCGGCGGCCGTGTTCCGTCATCTGCTCGGGGATGAGTCTGAGAT
CAGTCTCGCTCACCTTAACTGTGAAAAGGTGCAAGATCCTTACTCACTACGTTGTCAGCCACAGGTGCTCGGTGCCTGTT
TAACCCAAATTCGCCATGTGGCCGAGGTATTAGGCACAGAAGCGAATGGCGTCACCGATAACCCATTGGTGTTCCAAGAT
ACGGGCGATATTATCTCTGGCGGTAACTTCCATGCCGAGCCTGTTGCTATGGCGGCGGATAACTTGGCAATTGCTATCGC
AGAACTTGGCTCTATTGCCGAGCGTCGTATAGCGCTATTGATTGACTCGAACCTATCGAAGCTACCCCCATTCTTGGTTG
AGAACGGCGGGGTCAACTCAGGCTTTATGATTGCCCAGGTGACGGCTGCGGCATTGGCATCAGAGAACAAGACCTATGCG
CACCCTGCGTCAGTCGATAGCTTACCAACTTCGGCGAACCAAGAAGACCATGTGTCTATGGCCACCTTTGCGGCGCGCCG
TCTACGTGACATGTCTGAAAACACTCGTGGAGTGCTGGCGGTTGAATTGTTGGCAGCGGCGCAAGGTTTGGATTTCCGTG
CACCACTGCAACCCGCGCTTGCGGTTGCACGGGCTAAGGGCGAGTTGCGTGAGCTGGTGGCCTACTATGATAAGGACCGT
TTCTTCGGCCCAGATATCGAGGCGGCAACGGGCCTTTTGCTTACAGCCAGTTTTAATGCTTACCTGCCAGCAGATATCTT
ACCTAGCCTATAG

Upstream 100 bases:

>100_bases
TGATGCGTCACGCTGATGCGGGTTACGATATCGCTAAAAATTGTGCAAAAGAGCAGGGTCTAGACCTGCCAATGCTATAA
AAAGAATAAGAGGCATTAAC

Downstream 100 bases:

>100_bases
GTAGTATGGGTTAAGTAAGCAGATAGTAAAAAGGGCCCTAAGGCCCTTTTTGTCTTAAAGGGCATATGTTAGCGTTTAAT
GCTCAGTACCTGCGTATATC

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 510; Mature: 509

Protein sequence:

>510_residues
MSHLVLTPGTLTLAQIREISRGKVTLELAESAIADINTSAGLVQQVLDEGRTVYGINTGFGLLANTKIAAEDLQLLQRSI
VLSHAAGTGKHMSDETVRLMMVLKINSLSRGFSGIRLEVINFLIKLVNAGVYPCVPEKGSVGASGDLAPLSHMCLPLLGE
GEMSYQGQLISAAEGLEIAGLKPIELAAKEGLALLNGTQASTALALEGLFNAEDLFAASSVIGAMSVEAAMGSRSPFDLR
IHAARGQKGQIDSAAVFRHLLGDESEISLAHLNCEKVQDPYSLRCQPQVLGACLTQIRHVAEVLGTEANGVTDNPLVFQD
TGDIISGGNFHAEPVAMAADNLAIAIAELGSIAERRIALLIDSNLSKLPPFLVENGGVNSGFMIAQVTAAALASENKTYA
HPASVDSLPTSANQEDHVSMATFAARRLRDMSENTRGVLAVELLAAAQGLDFRAPLQPALAVARAKGELRELVAYYDKDR
FFGPDIEAATGLLLTASFNAYLPADILPSL

Sequences:

>Translated_510_residues
MSHLVLTPGTLTLAQIREISRGKVTLELAESAIADINTSAGLVQQVLDEGRTVYGINTGFGLLANTKIAAEDLQLLQRSI
VLSHAAGTGKHMSDETVRLMMVLKINSLSRGFSGIRLEVINFLIKLVNAGVYPCVPEKGSVGASGDLAPLSHMCLPLLGE
GEMSYQGQLISAAEGLEIAGLKPIELAAKEGLALLNGTQASTALALEGLFNAEDLFAASSVIGAMSVEAAMGSRSPFDLR
IHAARGQKGQIDSAAVFRHLLGDESEISLAHLNCEKVQDPYSLRCQPQVLGACLTQIRHVAEVLGTEANGVTDNPLVFQD
TGDIISGGNFHAEPVAMAADNLAIAIAELGSIAERRIALLIDSNLSKLPPFLVENGGVNSGFMIAQVTAAALASENKTYA
HPASVDSLPTSANQEDHVSMATFAARRLRDMSENTRGVLAVELLAAAQGLDFRAPLQPALAVARAKGELRELVAYYDKDR
FFGPDIEAATGLLLTASFNAYLPADILPSL
>Mature_509_residues
SHLVLTPGTLTLAQIREISRGKVTLELAESAIADINTSAGLVQQVLDEGRTVYGINTGFGLLANTKIAAEDLQLLQRSIV
LSHAAGTGKHMSDETVRLMMVLKINSLSRGFSGIRLEVINFLIKLVNAGVYPCVPEKGSVGASGDLAPLSHMCLPLLGEG
EMSYQGQLISAAEGLEIAGLKPIELAAKEGLALLNGTQASTALALEGLFNAEDLFAASSVIGAMSVEAAMGSRSPFDLRI
HAARGQKGQIDSAAVFRHLLGDESEISLAHLNCEKVQDPYSLRCQPQVLGACLTQIRHVAEVLGTEANGVTDNPLVFQDT
GDIISGGNFHAEPVAMAADNLAIAIAELGSIAERRIALLIDSNLSKLPPFLVENGGVNSGFMIAQVTAAALASENKTYAH
PASVDSLPTSANQEDHVSMATFAARRLRDMSENTRGVLAVELLAAAQGLDFRAPLQPALAVARAKGELRELVAYYDKDRF
FGPDIEAATGLLLTASFNAYLPADILPSL

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=488, Percent_Identity=47.3360655737705, Blast_Score=427, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI17567831, Length=505, Percent_Identity=41.7821782178218, Blast_Score=366, Evalue=1e-101,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 53740; Mature: 53609

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHLVLTPGTLTLAQIREISRGKVTLELAESAIADINTSAGLVQQVLDEGRTVYGINTGF
CCCEEECCCCHHHHHHHHHHCCEEEEEEHHHHHHHCCCHHHHHHHHHHCCCEEEEECCCC
GLLANTKIAAEDLQLLQRSIVLSHAAGTGKHMSDETVRLMMVLKINSLSRGFSGIRLEVI
CEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEHHHHCCCCCHHHHHH
NFLIKLVNAGVYPCVPEKGSVGASGDLAPLSHMCLPLLGEGEMSYQGQLISAAEGLEIAG
HHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEHHCCCCEECC
LKPIELAAKEGLALLNGTQASTALALEGLFNAEDLFAASSVIGAMSVEAAMGSRSPFDLR
CCHHHHHHHCCEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEE
IHAARGQKGQIDSAAVFRHLLGDESEISLAHLNCEKVQDPYSLRCQPQVLGACLTQIRHV
EEECCCCCCCCHHHHHHHHHHCCCCCEEEEECCHHHCCCCCCCCCCHHHHHHHHHHHHHH
AEVLGTEANGVTDNPLVFQDTGDIISGGNFHAEPVAMAADNLAIAIAELGSIAERRIALL
HHHHCCCCCCCCCCCEEEECCCCEECCCCCCCCCHHEECCCCEEEHHHHHHHHHHEEEEE
IDSNLSKLPPFLVENGGVNSGFMIAQVTAAALASENKTYAHPASVDSLPTSANQEDHVSM
EECCHHHCCCCEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHH
ATFAARRLRDMSENTRGVLAVELLAAAQGLDFRAPLQPALAVARAKGELRELVAYYDKDR
HHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
FFGPDIEAATGLLLTASFNAYLPADILPSL
CCCCCHHHHCCEEEEECCCCCCCHHHCCCC
>Mature Secondary Structure 
SHLVLTPGTLTLAQIREISRGKVTLELAESAIADINTSAGLVQQVLDEGRTVYGINTGF
CCEEECCCCHHHHHHHHHHCCEEEEEEHHHHHHHCCCHHHHHHHHHHCCCEEEEECCCC
GLLANTKIAAEDLQLLQRSIVLSHAAGTGKHMSDETVRLMMVLKINSLSRGFSGIRLEVI
CEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEHHHHCCCCCHHHHHH
NFLIKLVNAGVYPCVPEKGSVGASGDLAPLSHMCLPLLGEGEMSYQGQLISAAEGLEIAG
HHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEHHCCCCEECC
LKPIELAAKEGLALLNGTQASTALALEGLFNAEDLFAASSVIGAMSVEAAMGSRSPFDLR
CCHHHHHHHCCEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEE
IHAARGQKGQIDSAAVFRHLLGDESEISLAHLNCEKVQDPYSLRCQPQVLGACLTQIRHV
EEECCCCCCCCHHHHHHHHHHCCCCCEEEEECCHHHCCCCCCCCCCHHHHHHHHHHHHHH
AEVLGTEANGVTDNPLVFQDTGDIISGGNFHAEPVAMAADNLAIAIAELGSIAERRIALL
HHHHCCCCCCCCCCCEEEECCCCEECCCCCCCCCHHEECCCCEEEHHHHHHHHHHEEEEE
IDSNLSKLPPFLVENGGVNSGFMIAQVTAAALASENKTYAHPASVDSLPTSANQEDHVSM
EECCHHHCCCCEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHH
ATFAARRLRDMSENTRGVLAVELLAAAQGLDFRAPLQPALAVARAKGELRELVAYYDKDR
HHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
FFGPDIEAATGLLLTASFNAYLPADILPSL
CCCCCHHHHCCEEEEECCCCCCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA