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The map label for this gene is pepN [H]

Identifier: 167040959

GI number: 167040959

Start: 2388150

End: 2389592

Strand: Reverse

Name: pepN [H]

Synonym: Teth514_2348

Alternate gene names: 167040959

Gene position: 2389592-2388150 (Counterclockwise)

Preceding gene: 167040960

Following gene: 167040956

Centisome position: 97.25

GC content: 31.88

Gene sequence:

>1443_bases
ATGAAAATAAAACAAAAAGCACTACTAGGTTTAGTTATAATTGTAATTATCGGCTTAGTGCTTTATCTTTTGCCTGAAGA
GACTCAACTTACATCTTACACAATTGAAGCAAAATATGATGACCAAAATAAAATAATTTACGCTACTCAAACAGTAAAAT
ACATAAATACCAATGATATCCCCTTAAAAGAAATATACTTTCATCTATATCCAAATGCTTTCAAGACACAAGAGAATTTG
CCTTTTACGAAGGAAGAACTCCCTTTTGCCTATCCTAATGGTTTTCAGCCGGGATTTATAGAGATTGAAAAAGTTACTTT
TGATAAAGACATTCCAGCTACTTACGAATTGGAAGAACCTAATGAGGAAATTTTAAAAATAAATTTGCCTAAAGAATTAA
AAAAAGGAGAAACAATAGAAATCAATATGACCTACAAAGTACAAATTCCACCTTGTAGAAGTAGATTTGGCTATGGGAAC
AATACTGTACAGATAGGAAATTGGTATCCTATACTCTCTGTATATGATAAAAATGGCTGGAATAATGACCCCTACTACAT
TTTTGGAGATCCTTTTTATAGTGATATAGCAAATTACAAAGTGAAATTGTCAGTACCTAAAAAAATGATAGTTGCCTCTA
CTGGAGAGATAAAACAAGAGAAAAACTATGGAGATTCCAAAGAATTAGTTATTGAAGCACAAAAAGTAAGAGATTTTGCT
ATGGTTTTAAGCACGAAATTTAAGATAGCAGAGCAGCAGGTAGATGGCATAAAAGTTAAATCCTATTATTTTACAGAAGG
GTATGGGGATAAAGCTCTTAAATTTGCTGTAGATGCAATTAAGTTTTACAATGATTATATTGGCAAGTATCCTTATAAAC
AATATTCTGTTGTACAGACTGATTTTTACATGGGAGGCATGGAATATCCTAATCTTGTAATGATATCAAAGGATTTGTAT
ACAAAAGCTAATTTGTTTCATTTAGAATATGTAATTGCTCACGAGACTGCTCATCAGTGGTGGTATGGTGTTGTGGGGAA
TAATCAAATAAAAGAATCTTGGCTGGATGAGGGATTGACGGAGTACACTACAATTATGTATATAGAAAGGTATTATGGTA
AGGCAACAGCTGATGAGATTTATAGACTTGTTATAGAGGGAGAATTTAATAAATTTCTAAATACCAATTCAGATATTTCG
TTAGCTAAGACTTTGGCAGATTTTAAAGAGTGGAAGGAGTACACTAATATAGCTTATAACAAAGGAGCAATGGTTTTTTA
TAATCTGAGGAATCTGATAGGTGACGAAGAATTCAAAAAGGTGCTTCAAAATTATTATGATAAATACAAATATAAAATTG
CCACTACGCAAGACCTAATTGACGTAGTGGACAGTGTTACAGGCAAAGATACAGGTGGATTTTTCCAAGAGTGGTTTTAT
TAA

Upstream 100 bases:

>100_bases
TTCTTTTTTAAGGTGCTTTTTATTTTTTAAGTGAAAAAGTTCTATTATTTAAAAATTTGTACTAATATATATTGAAGGAT
AATTTAGGGGAGCTGGTTAT

Downstream 100 bases:

>100_bases
ATTATCATTTTTCGCTTTAGCCTTATATCTTCACCGTAGAAATTGAGCAATTTAAAATGGCCAAATATTCGTGAATAAAT
TCTTTCAGGATAAATTGCCA

Product: peptidase M1, membrane alanine aminopeptidase

Products: NA

Alternate protein names: Alanine aminopeptidase; Lysyl aminopeptidase; Lys-AP [H]

Number of amino acids: Translated: 480; Mature: 480

Protein sequence:

>480_residues
MKIKQKALLGLVIIVIIGLVLYLLPEETQLTSYTIEAKYDDQNKIIYATQTVKYINTNDIPLKEIYFHLYPNAFKTQENL
PFTKEELPFAYPNGFQPGFIEIEKVTFDKDIPATYELEEPNEEILKINLPKELKKGETIEINMTYKVQIPPCRSRFGYGN
NTVQIGNWYPILSVYDKNGWNNDPYYIFGDPFYSDIANYKVKLSVPKKMIVASTGEIKQEKNYGDSKELVIEAQKVRDFA
MVLSTKFKIAEQQVDGIKVKSYYFTEGYGDKALKFAVDAIKFYNDYIGKYPYKQYSVVQTDFYMGGMEYPNLVMISKDLY
TKANLFHLEYVIAHETAHQWWYGVVGNNQIKESWLDEGLTEYTTIMYIERYYGKATADEIYRLVIEGEFNKFLNTNSDIS
LAKTLADFKEWKEYTNIAYNKGAMVFYNLRNLIGDEEFKKVLQNYYDKYKYKIATTQDLIDVVDSVTGKDTGGFFQEWFY

Sequences:

>Translated_480_residues
MKIKQKALLGLVIIVIIGLVLYLLPEETQLTSYTIEAKYDDQNKIIYATQTVKYINTNDIPLKEIYFHLYPNAFKTQENL
PFTKEELPFAYPNGFQPGFIEIEKVTFDKDIPATYELEEPNEEILKINLPKELKKGETIEINMTYKVQIPPCRSRFGYGN
NTVQIGNWYPILSVYDKNGWNNDPYYIFGDPFYSDIANYKVKLSVPKKMIVASTGEIKQEKNYGDSKELVIEAQKVRDFA
MVLSTKFKIAEQQVDGIKVKSYYFTEGYGDKALKFAVDAIKFYNDYIGKYPYKQYSVVQTDFYMGGMEYPNLVMISKDLY
TKANLFHLEYVIAHETAHQWWYGVVGNNQIKESWLDEGLTEYTTIMYIERYYGKATADEIYRLVIEGEFNKFLNTNSDIS
LAKTLADFKEWKEYTNIAYNKGAMVFYNLRNLIGDEEFKKVLQNYYDKYKYKIATTQDLIDVVDSVTGKDTGGFFQEWFY
>Mature_480_residues
MKIKQKALLGLVIIVIIGLVLYLLPEETQLTSYTIEAKYDDQNKIIYATQTVKYINTNDIPLKEIYFHLYPNAFKTQENL
PFTKEELPFAYPNGFQPGFIEIEKVTFDKDIPATYELEEPNEEILKINLPKELKKGETIEINMTYKVQIPPCRSRFGYGN
NTVQIGNWYPILSVYDKNGWNNDPYYIFGDPFYSDIANYKVKLSVPKKMIVASTGEIKQEKNYGDSKELVIEAQKVRDFA
MVLSTKFKIAEQQVDGIKVKSYYFTEGYGDKALKFAVDAIKFYNDYIGKYPYKQYSVVQTDFYMGGMEYPNLVMISKDLY
TKANLFHLEYVIAHETAHQWWYGVVGNNQIKESWLDEGLTEYTTIMYIERYYGKATADEIYRLVIEGEFNKFLNTNSDIS
LAKTLADFKEWKEYTNIAYNKGAMVFYNLRNLIGDEEFKKVLQNYYDKYKYKIATTQDLIDVVDSVTGKDTGGFFQEWFY

Specific function: Aminopeptidase with broad substrate specificity to several peptides. It has more affinity for oligopeptides than for dipeptides. It plays an essential role in the metabolism, it may be involved in nitrogen supply or protein turnover [H]

COG id: COG0308

COG function: function code E; Aminopeptidase N

Gene ontology:

Cell location: Cytoplasm. Note=It may be secreted through an unknown mechanism [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M1 family [H]

Homologues:

Organism=Homo sapiens, GI158937236, Length=308, Percent_Identity=25.974025974026, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI4505029, Length=281, Percent_Identity=27.4021352313167, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI310133497, Length=287, Percent_Identity=25.0871080139373, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI94818891, Length=244, Percent_Identity=24.5901639344262, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI94818901, Length=244, Percent_Identity=24.5901639344262, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI194306629, Length=218, Percent_Identity=26.605504587156, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI11641261, Length=218, Percent_Identity=26.605504587156, Blast_Score=70, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI71984353, Length=192, Percent_Identity=28.125, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI71984339, Length=192, Percent_Identity=28.125, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6321837, Length=256, Percent_Identity=25, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI9755335, Length=235, Percent_Identity=25.531914893617, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24646514, Length=259, Percent_Identity=25.8687258687259, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24646516, Length=259, Percent_Identity=26.6409266409266, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24646518, Length=259, Percent_Identity=26.6409266409266, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24585062, Length=188, Percent_Identity=28.7234042553192, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24585064, Length=188, Percent_Identity=28.7234042553192, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24585066, Length=188, Percent_Identity=28.7234042553192, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI45550350, Length=188, Percent_Identity=28.7234042553192, Blast_Score=69, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001930
- InterPro:   IPR014782 [H]

Pfam domain/function: PF01433 Peptidase_M1 [H]

EC number: =3.4.11.2 [H]

Molecular weight: Translated: 56082; Mature: 56082

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIKQKALLGLVIIVIIGLVLYLLPEETQLTSYTIEAKYDDQNKIIYATQTVKYINTNDI
CCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEECCCCCEEEEEEEEEEECCCCC
PLKEIYFHLYPNAFKTQENLPFTKEELPFAYPNGFQPGFIEIEKVTFDKDIPATYELEEP
CHHHHHEEECCCHHCCCCCCCCCHHHCCCCCCCCCCCCEEEEEEEEECCCCCCEEECCCC
NEEILKINLPKELKKGETIEINMTYKVQIPPCRSRFGYGNNTVQIGNWYPILSVYDKNGW
CCEEEEEECCHHHCCCCEEEEEEEEEEECCCHHHHCCCCCCEEEECCEEEEEEEEECCCC
NNDPYYIFGDPFYSDIANYKVKLSVPKKMIVASTGEIKQEKNYGDSKELVIEAQKVRDFA
CCCCEEEECCCHHHHHHCCEEEEECCCEEEEECCCCHHHHCCCCCCHHEEEEHHHHHHHH
MVLSTKFKIAEQQVDGIKVKSYYFTEGYGDKALKFAVDAIKFYNDYIGKYPYKQYSVVQT
HHHHHHHHHHHHHCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEE
DFYMGGMEYPNLVMISKDLYTKANLFHLEYVIAHETAHQWWYGVVGNNQIKESWLDEGLT
EEEECCCCCCCEEEEECCCCCCCCEEEEEEEEEECCCCCEEEEECCCCHHHHHHHHCCHH
EYTTIMYIERYYGKATADEIYRLVIEGEFNKFLNTNSDISLAKTLADFKEWKEYTNIAYN
HHHHHEEHHHHHCCCCHHHHEEEEEECCHHHHCCCCCCHHHHHHHHHHHHHHHHHCCEEC
KGAMVFYNLRNLIGDEEFKKVLQNYYDKYKYKIATTQDLIDVVDSVTGKDTGGFFQEWFY
CCCEEEEEHHHHHCCHHHHHHHHHHHHHHEEEEECHHHHHHHHHHCCCCCCCCHHHHHCC
>Mature Secondary Structure
MKIKQKALLGLVIIVIIGLVLYLLPEETQLTSYTIEAKYDDQNKIIYATQTVKYINTNDI
CCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEECCCCCEEEEEEEEEEECCCCC
PLKEIYFHLYPNAFKTQENLPFTKEELPFAYPNGFQPGFIEIEKVTFDKDIPATYELEEP
CHHHHHEEECCCHHCCCCCCCCCHHHCCCCCCCCCCCCEEEEEEEEECCCCCCEEECCCC
NEEILKINLPKELKKGETIEINMTYKVQIPPCRSRFGYGNNTVQIGNWYPILSVYDKNGW
CCEEEEEECCHHHCCCCEEEEEEEEEEECCCHHHHCCCCCCEEEECCEEEEEEEEECCCC
NNDPYYIFGDPFYSDIANYKVKLSVPKKMIVASTGEIKQEKNYGDSKELVIEAQKVRDFA
CCCCEEEECCCHHHHHHCCEEEEECCCEEEEECCCCHHHHCCCCCCHHEEEEHHHHHHHH
MVLSTKFKIAEQQVDGIKVKSYYFTEGYGDKALKFAVDAIKFYNDYIGKYPYKQYSVVQT
HHHHHHHHHHHHHCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEE
DFYMGGMEYPNLVMISKDLYTKANLFHLEYVIAHETAHQWWYGVVGNNQIKESWLDEGLT
EEEECCCCCCCEEEEECCCCCCCCEEEEEEEEEECCCCCEEEEECCCCHHHHHHHHCCHH
EYTTIMYIERYYGKATADEIYRLVIEGEFNKFLNTNSDISLAKTLADFKEWKEYTNIAYN
HHHHHEEHHHHHCCCCHHHHEEEEEECCHHHHCCCCCCHHHHHHHHHHHHHHHHHCCEEC
KGAMVFYNLRNLIGDEEFKKVLQNYYDKYKYKIATTQDLIDVVDSVTGKDTGGFFQEWFY
CCCEEEEEHHHHHCCHHHHHHHHHHHHHHEEEEECHHHHHHHHHHCCCCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA