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The map label for this gene is hom [H]

Identifier: 167040925

GI number: 167040925

Start: 2331258

End: 2332514

Strand: Reverse

Name: hom [H]

Synonym: Teth514_2311

Alternate gene names: 167040925

Gene position: 2332514-2331258 (Counterclockwise)

Preceding gene: 167040926

Following gene: 167040924

Centisome position: 94.92

GC content: 36.6

Gene sequence:

>1257_bases
ATGAAGATAGGACTAATGGGCCTTGGCACAGTTGGAACAGGTGTAGTTCATTTAATCAACCAAAACGGTAAAAACATTGA
AAAAAAGATAGGTGAAAAGATTGAGATAAAGAAGATACTTGTGAAAGACCCCAATAAAAAGAGGACACCTCTTGCAGAGG
GAAAAATAACTTTTGATGCAAATGATATTTTAGAAGATGAAGAAATAGATGTAGTGGTAGAAGTGATGGGGAAAGAACAT
CCTGCTTTAGAATATATCATAAAAGCTCTCAAAAAAGGTAAGCATGTTGTCACTGCAAACAAAGAAGTCATAGCAGTTCA
CGGTAAAGAGCTAATAAAACTTGCGACAGAAAATAAAGTAAGTCTTCTCTATGAAGCATCAGTTGGTGGTGGTATTCCCA
TCATCAGGCCATTAAAACAATGTCTTGCGGCAAATAAAATATACGAAATCAAAGGAATATTAAACGGAACTACAAATTAT
ATATTAACAGAAATGAAAGAAAAAGGTTTTGACTTTGAAGAAGTCTTAAAGGAGGCTCAGCAAAAGGGTTACGCAGAAGC
AGACCCGACAGATGACGTGGAAGGTTTTGATGCGGCAAGAAAACTTGCTATACTGTCCACTTTAGCTTTTAACAAATTCA
TTTTGCCTGAAAAAATTTACACAAAAGGTATAAAGTCTATTTCTAAAGCTGACATAAAATATGCGGAAGAATTGGGGTAC
AATGTAAAACTCATTGCTTACGCAAAAATTGATGAAGAAGACCGTTTAGAAGCGTGGGTACATCCTGTCATGATAAAGAA
AGATAATCCTTTAAACGGTGTAAATGGGGTTTTTAACGCTATTTTAGTTGATGGAAATGCAGTAGGGGAAGTCATGTTTT
ATGGTCAAGGTGCAGGTATGATGCCTACTGCCAGCGCAGTTGTTGCGGACATAATGGATGTAAAAAACCATATTGTAATT
CAAAATGGGTGCGAAGATGGAGACCTTCTCCCTATTGTGGATACTGTATCCAAATATTATATAAGACTCATAGCCTTTGA
TAAACCTGGCGTAATGAGCAAAATTACTGGCATATTAGGAGATAAGGGAATAAGTCTTTTGTCTGTGGTGCAGAAAGGGG
TTTTGGGAGATACTGCGGAGATTGTTTTGATCACTCATATTGCGAATACAGGGAAGGTATTTGAAGCCTTAGAGGAAATA
CAAAATCTGAAGGAAGTAGAATGTATAGAAAGTGTCATAAGAGTAGAGGGGGAATAA

Upstream 100 bases:

>100_bases
CCAGTACATGGAAATGAGTTTGGAAAATTTCCTTGAGAAATTATCCAGTCAAAACGGAGTTAGGAAAATAGAAATTTTAG
GAGAATGAGAGGGATTGAGA

Downstream 100 bases:

>100_bases
TTAATGGGATGGGAAGGTCTAATAAAAGCTTATAGAGAATTTATGCCTAAAATAAAAGAGGAAAACATAGTTACATTAAA
AGAAGGCAATACACCTCTTT

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 418; Mature: 418

Protein sequence:

>418_residues
MKIGLMGLGTVGTGVVHLINQNGKNIEKKIGEKIEIKKILVKDPNKKRTPLAEGKITFDANDILEDEEIDVVVEVMGKEH
PALEYIIKALKKGKHVVTANKEVIAVHGKELIKLATENKVSLLYEASVGGGIPIIRPLKQCLAANKIYEIKGILNGTTNY
ILTEMKEKGFDFEEVLKEAQQKGYAEADPTDDVEGFDAARKLAILSTLAFNKFILPEKIYTKGIKSISKADIKYAEELGY
NVKLIAYAKIDEEDRLEAWVHPVMIKKDNPLNGVNGVFNAILVDGNAVGEVMFYGQGAGMMPTASAVVADIMDVKNHIVI
QNGCEDGDLLPIVDTVSKYYIRLIAFDKPGVMSKITGILGDKGISLLSVVQKGVLGDTAEIVLITHIANTGKVFEALEEI
QNLKEVECIESVIRVEGE

Sequences:

>Translated_418_residues
MKIGLMGLGTVGTGVVHLINQNGKNIEKKIGEKIEIKKILVKDPNKKRTPLAEGKITFDANDILEDEEIDVVVEVMGKEH
PALEYIIKALKKGKHVVTANKEVIAVHGKELIKLATENKVSLLYEASVGGGIPIIRPLKQCLAANKIYEIKGILNGTTNY
ILTEMKEKGFDFEEVLKEAQQKGYAEADPTDDVEGFDAARKLAILSTLAFNKFILPEKIYTKGIKSISKADIKYAEELGY
NVKLIAYAKIDEEDRLEAWVHPVMIKKDNPLNGVNGVFNAILVDGNAVGEVMFYGQGAGMMPTASAVVADIMDVKNHIVI
QNGCEDGDLLPIVDTVSKYYIRLIAFDKPGVMSKITGILGDKGISLLSVVQKGVLGDTAEIVLITHIANTGKVFEALEEI
QNLKEVECIESVIRVEGE
>Mature_418_residues
MKIGLMGLGTVGTGVVHLINQNGKNIEKKIGEKIEIKKILVKDPNKKRTPLAEGKITFDANDILEDEEIDVVVEVMGKEH
PALEYIIKALKKGKHVVTANKEVIAVHGKELIKLATENKVSLLYEASVGGGIPIIRPLKQCLAANKIYEIKGILNGTTNY
ILTEMKEKGFDFEEVLKEAQQKGYAEADPTDDVEGFDAARKLAILSTLAFNKFILPEKIYTKGIKSISKADIKYAEELGY
NVKLIAYAKIDEEDRLEAWVHPVMIKKDNPLNGVNGVFNAILVDGNAVGEVMFYGQGAGMMPTASAVVADIMDVKNHIVI
QNGCEDGDLLPIVDTVSKYYIRLIAFDKPGVMSKITGILGDKGISLLSVVQKGVLGDTAEIVLITHIANTGKVFEALEEI
QNLKEVECIESVIRVEGE

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=140, Percent_Identity=35.7142857142857, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790376, Length=358, Percent_Identity=23.463687150838, Blast_Score=72, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6322599, Length=131, Percent_Identity=30.5343511450382, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 45684; Mature: 45684

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIGLMGLGTVGTGVVHLINQNGKNIEKKIGEKIEIKKILVKDPNKKRTPLAEGKITFDA
CEEEEEECCCHHHHHEEEECCCCCHHHHHCCCCEEEEEEEECCCCCCCCCCCCCEEEECH
NDILEDEEIDVVVEVMGKEHPALEYIIKALKKGKHVVTANKEVIAVHGKELIKLATENKV
HHCCCCCCHHHHHEECCCCCHHHHHHHHHHHCCCEEEECCCCEEEECCHHHHHHHCCCCE
SLLYEASVGGGIPIIRPLKQCLAANKIYEIKGILNGTTNYILTEMKEKGFDFEEVLKEAQ
EEEEEECCCCCCHHHHHHHHHHHHCCEEEEEEEECCCHHHHHHHHHHCCCCHHHHHHHHH
QKGYAEADPTDDVEGFDAARKLAILSTLAFNKFILPEKIYTKGIKSISKADIKYAEELGY
HCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCC
NVKLIAYAKIDEEDRLEAWVHPVMIKKDNPLNGVNGVFNAILVDGNAVGEVMFYGQGAGM
CEEEEEEEECCCHHHHHHHHCCEEEECCCCCCCHHHHEEEEEECCCCEEEEEEEECCCCC
MPTASAVVADIMDVKNHIVIQNGCEDGDLLPIVDTVSKYYIRLIAFDKPGVMSKITGILG
CCHHHHHHHHHHHCCCCEEEECCCCCCCEEHHHHHHHHHEEEEEEECCCCHHHHHHHHHC
DKGISLLSVVQKGVLGDTAEIVLITHIANTGKVFEALEEIQNLKEVECIESVIRVEGE
CCCHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKIGLMGLGTVGTGVVHLINQNGKNIEKKIGEKIEIKKILVKDPNKKRTPLAEGKITFDA
CEEEEEECCCHHHHHEEEECCCCCHHHHHCCCCEEEEEEEECCCCCCCCCCCCCEEEECH
NDILEDEEIDVVVEVMGKEHPALEYIIKALKKGKHVVTANKEVIAVHGKELIKLATENKV
HHCCCCCCHHHHHEECCCCCHHHHHHHHHHHCCCEEEECCCCEEEECCHHHHHHHCCCCE
SLLYEASVGGGIPIIRPLKQCLAANKIYEIKGILNGTTNYILTEMKEKGFDFEEVLKEAQ
EEEEEECCCCCCHHHHHHHHHHHHCCEEEEEEEECCCHHHHHHHHHHCCCCHHHHHHHHH
QKGYAEADPTDDVEGFDAARKLAILSTLAFNKFILPEKIYTKGIKSISKADIKYAEELGY
HCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCC
NVKLIAYAKIDEEDRLEAWVHPVMIKKDNPLNGVNGVFNAILVDGNAVGEVMFYGQGAGM
CEEEEEEEECCCHHHHHHHHCCEEEECCCCCCCHHHHEEEEEECCCCEEEEEEEECCCCC
MPTASAVVADIMDVKNHIVIQNGCEDGDLLPIVDTVSKYYIRLIAFDKPGVMSKITGILG
CCHHHHHHHHHHHCCCCEEEECCCCCCCEEHHHHHHHHHEEEEEEECCCCHHHHHHHHHC
DKGISLLSVVQKGVLGDTAEIVLITHIANTGKVFEALEEIQNLKEVECIESVIRVEGE
CCCHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]