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The map label for this gene is nuoF2 [H]

Identifier: 167040762

GI number: 167040762

Start: 2143574

End: 2145364

Strand: Reverse

Name: nuoF2 [H]

Synonym: Teth514_2139

Alternate gene names: 167040762

Gene position: 2145364-2143574 (Counterclockwise)

Preceding gene: 167040763

Following gene: 167040761

Centisome position: 87.31

GC content: 38.58

Gene sequence:

>1791_bases
ATGCTTTATAGGTCACACGTAATGGTATGCGGTGGTACCGGATGTACATCTTCAGATTCTGATAAAGTAGCAGAGCGTTT
TACGGAGGAAATAAAAAAAGCTGGTTTAGATAAGGAAGTATTAGTTGTTAGGACAGGGTGTTTTGGCCTTTGCGAATTAG
GACCAGTTGTTGTAGTGTATCCTGAAGGAGTTTTTTATAGCAGAGTTAAACCTGACTATGTTCCTGAAATTGTAGAAGAG
CACTTGCTAAAAGGAAGACCTGTTAAGAAATATCTCTATGGGGAAAGCGTGACAGAAAGAGAAATAAAGCCATTGGAAGA
AACTCCTTTCTTTAGGAAACAAAAGAGGATTGCCCTTAGAAACTGCGGTATTATCAATCCTGAAGATATAAGAGAAGCAA
TTGCTTTTGACGGATATAAGGCGTTAGCAAAGGTTCTTACTCAAATGACTCCTAAAGAGGTTATTGACGAGGTAAAGAAA
TCCGGGCTAAGGGGTAGAGGTGGTGGAGGATTCCCAACAGGTGTAAAATGGGAATTTGCTTACAACCAGAAAGAAACTCC
TAAATATGTAGTCTGCAACGCCGATGAAGGTGACCCTGGTGCTTTTATGGATAGAAGCATATTGGAAGGAGACCCTCACA
GTGTTTTAGAGGCAATGGCAATAGCAGGATACGCAATTGGAGCAAACCATGGATATATTTATGTAAGGGCAGAATATCCT
TTGGCAGTAAAAAGGCTTAAAATTGCTATTGAACAGGCAAGAGAATATGGTCTTTTAGGGAAAGACATATTTGGGACAGG
TTTTGATTTTGACATTGAGATAAGATTAGGAGCAGGTGCTTTTGTCTGTGGAGAAGAGACTGCACTTTTAAATTCAGTAA
TGGGAAGAAGAGGAGAACCAAGACCAAGACCTCCATTTCCTGCTGTAAAAGGTGTATGGGATAAACCAACAATTATAAAT
AATGTAGAGACATTTGCTAATATTCCACCAATTATTTTAAATGGTGCTGAGTGGTTTTCAAGCATAGGTACAGAAAAATC
AAAAGGGACAAAAGTTTTTGCCTTAACTGGTAAAGTAAACAACACAGGTCTTATTGAAGTTCCAATGGGAACTACTTTAA
GAGAAATTATCTACGAAATAGGTGGAGGAATACCTAACGGAAAGAAATTTAAAGCTGCTCAAACTGGAGGACCTTCAGGT
GGATGTATTCCTGCAGAGCATTTAGATACACCAATCGATTACGATTCTTTAATAAATGTAGGTTCTATGATGGGGTCAGG
TGGACTTGTTGTAATGGACGAAGACACCTGTATGGTCAATGTTGCAAAATTTTTCCTTGAGTTTACAGTTGATGAGTCCT
GTGGTAAATGTGCACCTTGTAGGATTGGCACAAGAAGGATGTTGGAAGTTTTAGATAAGATAACTTCTGGTAAAGGTGAG
GAAGGAGACATTGAAAGATTAGAAGAACTTGCTAAAACCATTAAGGCTACAGCTTTATGTGGACTTGGACAGACAGCGCC
AAATCCGGTTTTATCTACAATTAGATATTTTAGAGATGAATATGAGGCGCATATAAAAGAAAAAAGATGCCCAGCTGGTG
TATGCCAAGCCCTCTTAAGATTTTATATTGCCCCAGATAAGTGTAAAGGCTGTGGAATTTGCGCTAAAAATTGCCCTGTC
AATGCAATTTCTGGAAAGACAAAAGAGCCTTATGTAATTGACCAAGACAAATGTATCAAGTGCGGCACATGTATTGAAAA
ATGTCCATTTGGCGCAATATACAAAAAATAA

Upstream 100 bases:

>100_bases
TGAGAAAAAGGCAAGGCAAATAGTTGTTGAACATGTTATAAATGGCCATCCAATCAGAGAATGGACTATTGAAAATTACG
AATAGAGGAGGGGAAATAGC

Downstream 100 bases:

>100_bases
TTGAGGAAGGAGTGTAAAAGATGGACAAAGTTCGTGTTATGATAGACAGCATCACTGTAGAAGTTCCCTCCCATTACACG
GTATTGGAAGCAGCAAAAGA

Product: NADH dehydrogenase (quinone)

Products: NA

Alternate protein names: NADH dehydrogenase I subunit F 2; NDH-1 subunit F 2 [H]

Number of amino acids: Translated: 596; Mature: 596

Protein sequence:

>596_residues
MLYRSHVMVCGGTGCTSSDSDKVAERFTEEIKKAGLDKEVLVVRTGCFGLCELGPVVVVYPEGVFYSRVKPDYVPEIVEE
HLLKGRPVKKYLYGESVTEREIKPLEETPFFRKQKRIALRNCGIINPEDIREAIAFDGYKALAKVLTQMTPKEVIDEVKK
SGLRGRGGGGFPTGVKWEFAYNQKETPKYVVCNADEGDPGAFMDRSILEGDPHSVLEAMAIAGYAIGANHGYIYVRAEYP
LAVKRLKIAIEQAREYGLLGKDIFGTGFDFDIEIRLGAGAFVCGEETALLNSVMGRRGEPRPRPPFPAVKGVWDKPTIIN
NVETFANIPPIILNGAEWFSSIGTEKSKGTKVFALTGKVNNTGLIEVPMGTTLREIIYEIGGGIPNGKKFKAAQTGGPSG
GCIPAEHLDTPIDYDSLINVGSMMGSGGLVVMDEDTCMVNVAKFFLEFTVDESCGKCAPCRIGTRRMLEVLDKITSGKGE
EGDIERLEELAKTIKATALCGLGQTAPNPVLSTIRYFRDEYEAHIKEKRCPAGVCQALLRFYIAPDKCKGCGICAKNCPV
NAISGKTKEPYVIDQDKCIKCGTCIEKCPFGAIYKK

Sequences:

>Translated_596_residues
MLYRSHVMVCGGTGCTSSDSDKVAERFTEEIKKAGLDKEVLVVRTGCFGLCELGPVVVVYPEGVFYSRVKPDYVPEIVEE
HLLKGRPVKKYLYGESVTEREIKPLEETPFFRKQKRIALRNCGIINPEDIREAIAFDGYKALAKVLTQMTPKEVIDEVKK
SGLRGRGGGGFPTGVKWEFAYNQKETPKYVVCNADEGDPGAFMDRSILEGDPHSVLEAMAIAGYAIGANHGYIYVRAEYP
LAVKRLKIAIEQAREYGLLGKDIFGTGFDFDIEIRLGAGAFVCGEETALLNSVMGRRGEPRPRPPFPAVKGVWDKPTIIN
NVETFANIPPIILNGAEWFSSIGTEKSKGTKVFALTGKVNNTGLIEVPMGTTLREIIYEIGGGIPNGKKFKAAQTGGPSG
GCIPAEHLDTPIDYDSLINVGSMMGSGGLVVMDEDTCMVNVAKFFLEFTVDESCGKCAPCRIGTRRMLEVLDKITSGKGE
EGDIERLEELAKTIKATALCGLGQTAPNPVLSTIRYFRDEYEAHIKEKRCPAGVCQALLRFYIAPDKCKGCGICAKNCPV
NAISGKTKEPYVIDQDKCIKCGTCIEKCPFGAIYKK
>Mature_596_residues
MLYRSHVMVCGGTGCTSSDSDKVAERFTEEIKKAGLDKEVLVVRTGCFGLCELGPVVVVYPEGVFYSRVKPDYVPEIVEE
HLLKGRPVKKYLYGESVTEREIKPLEETPFFRKQKRIALRNCGIINPEDIREAIAFDGYKALAKVLTQMTPKEVIDEVKK
SGLRGRGGGGFPTGVKWEFAYNQKETPKYVVCNADEGDPGAFMDRSILEGDPHSVLEAMAIAGYAIGANHGYIYVRAEYP
LAVKRLKIAIEQAREYGLLGKDIFGTGFDFDIEIRLGAGAFVCGEETALLNSVMGRRGEPRPRPPFPAVKGVWDKPTIIN
NVETFANIPPIILNGAEWFSSIGTEKSKGTKVFALTGKVNNTGLIEVPMGTTLREIIYEIGGGIPNGKKFKAAQTGGPSG
GCIPAEHLDTPIDYDSLINVGSMMGSGGLVVMDEDTCMVNVAKFFLEFTVDESCGKCAPCRIGTRRMLEVLDKITSGKGE
EGDIERLEELAKTIKATALCGLGQTAPNPVLSTIRYFRDEYEAHIKEKRCPAGVCQALLRFYIAPDKCKGCGICAKNCPV
NAISGKTKEPYVIDQDKCIKCGTCIEKCPFGAIYKK

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI260656005, Length=393, Percent_Identity=41.9847328244275, Blast_Score=312, Evalue=5e-85,
Organism=Homo sapiens, GI20149568, Length=393, Percent_Identity=41.9847328244275, Blast_Score=312, Evalue=6e-85,
Organism=Escherichia coli, GI1788620, Length=404, Percent_Identity=43.8118811881188, Blast_Score=366, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17531727, Length=377, Percent_Identity=41.6445623342175, Blast_Score=300, Evalue=2e-81,
Organism=Drosophila melanogaster, GI45550452, Length=395, Percent_Identity=42.0253164556962, Blast_Score=308, Evalue=5e-84,
Organism=Drosophila melanogaster, GI19920794, Length=376, Percent_Identity=41.4893617021277, Blast_Score=303, Evalue=2e-82,
Organism=Drosophila melanogaster, GI24653819, Length=385, Percent_Identity=32.987012987013, Blast_Score=238, Evalue=8e-63,
Organism=Drosophila melanogaster, GI24653817, Length=355, Percent_Identity=31.2676056338028, Blast_Score=206, Evalue=3e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 65124; Mature: 65124

Theoretical pI: Translated: 7.38; Mature: 7.38

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00645 COMPLEX1_51K_2 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
3.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYRSHVMVCGGTGCTSSDSDKVAERFTEEIKKAGLDKEVLVVRTGCFGLCELGPVVVVY
CCEECEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHCCCCEEEEC
PEGVFYSRVKPDYVPEIVEEHLLKGRPVKKYLYGESVTEREIKPLEETPFFRKQKRIALR
CCCCEECCCCCCHHHHHHHHHHHCCCCHHHHHCCCCCCHHHCCCCCCCCHHHHHHHHHHH
NCGIINPEDIREAIAFDGYKALAKVLTQMTPKEVIDEVKKSGLRGRGGGGFPTGVKWEFA
HCCCCCHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEE
YNQKETPKYVVCNADEGDPGAFMDRSILEGDPHSVLEAMAIAGYAIGANHGYIYVRAEYP
CCCCCCCCEEEEECCCCCCCHHHCCHHHCCCHHHHHHHHHHHHEEEECCCCEEEEEECCC
LAVKRLKIAIEQAREYGLLGKDIFGTGFDFDIEIRLGAGAFVCGEETALLNSVMGRRGEP
HHHHHHHHHHHHHHHHCCCCCHHCCCCCCEEEEEEECCCEEEECCHHHHHHHHHCCCCCC
RPRPPFPAVKGVWDKPTIINNVETFANIPPIILNGAEWFSSIGTEKSKGTKVFALTGKVN
CCCCCCCHHCCCCCCCCHHCCHHHHHCCCCEEEECHHHHHHHCCCCCCCCEEEEEECCCC
NTGLIEVPMGTTLREIIYEIGGGIPNGKKFKAAQTGGPSGGCIPAEHLDTPIDYDSLINV
CCCEEEECCCHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCHHHCCCCCCHHHHHHH
GSMMGSGGLVVMDEDTCMVNVAKFFLEFTVDESCGKCAPCRIGTRRMLEVLDKITSGKGE
HHHCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCC
EGDIERLEELAKTIKATALCGLGQTAPNPVLSTIRYFRDEYEAHIKEKRCPAGVCQALLR
CCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
FYIAPDKCKGCGICAKNCPVNAISGKTKEPYVIDQDKCIKCGTCIEKCPFGAIYKK
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCEEHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MLYRSHVMVCGGTGCTSSDSDKVAERFTEEIKKAGLDKEVLVVRTGCFGLCELGPVVVVY
CCEECEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHCCCCEEEEC
PEGVFYSRVKPDYVPEIVEEHLLKGRPVKKYLYGESVTEREIKPLEETPFFRKQKRIALR
CCCCEECCCCCCHHHHHHHHHHHCCCCHHHHHCCCCCCHHHCCCCCCCCHHHHHHHHHHH
NCGIINPEDIREAIAFDGYKALAKVLTQMTPKEVIDEVKKSGLRGRGGGGFPTGVKWEFA
HCCCCCHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEE
YNQKETPKYVVCNADEGDPGAFMDRSILEGDPHSVLEAMAIAGYAIGANHGYIYVRAEYP
CCCCCCCCEEEEECCCCCCCHHHCCHHHCCCHHHHHHHHHHHHEEEECCCCEEEEEECCC
LAVKRLKIAIEQAREYGLLGKDIFGTGFDFDIEIRLGAGAFVCGEETALLNSVMGRRGEP
HHHHHHHHHHHHHHHHCCCCCHHCCCCCCEEEEEEECCCEEEECCHHHHHHHHHCCCCCC
RPRPPFPAVKGVWDKPTIINNVETFANIPPIILNGAEWFSSIGTEKSKGTKVFALTGKVN
CCCCCCCHHCCCCCCCCHHCCHHHHHCCCCEEEECHHHHHHHCCCCCCCCEEEEEECCCC
NTGLIEVPMGTTLREIIYEIGGGIPNGKKFKAAQTGGPSGGCIPAEHLDTPIDYDSLINV
CCCEEEECCCHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCHHHCCCCCCHHHHHHH
GSMMGSGGLVVMDEDTCMVNVAKFFLEFTVDESCGKCAPCRIGTRRMLEVLDKITSGKGE
HHHCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCC
EGDIERLEELAKTIKATALCGLGQTAPNPVLSTIRYFRDEYEAHIKEKRCPAGVCQALLR
CCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
FYIAPDKCKGCGICAKNCPVNAISGKTKEPYVIDQDKCIKCGTCIEKCPFGAIYKK
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCEEHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481432 [H]