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The map label for this gene is pyrE

Identifier: 167040446

GI number: 167040446

Start: 1823885

End: 1824457

Strand: Reverse

Name: pyrE

Synonym: Teth514_1813

Alternate gene names: 167040446

Gene position: 1824457-1823885 (Counterclockwise)

Preceding gene: 167040447

Following gene: 167040443

Centisome position: 74.25

GC content: 34.55

Gene sequence:

>573_bases
ATGGAAAAAGAAGAAGTCTTAGAGATTTTTAGCAAGTTAGGAGTAATTAACAAAGGACATTTTTTATTGACATCAGGAAA
ACACAGCGATACCTATTTGCAGTGTGCGAAAATATTTCAATATCCTAAATACAGCGAAATTTTTAGTAAAGAATTGGCAT
TAAAATTTAAAGGCCACGAAATAGATGTTGTAATAGGGCCTGCAATTGGAGGAATTATATTGGCCTATGAAGTTGCTCGT
CAAGTTGGAGCAAAAGCTCTTTTTGCAGAAAGAGAAGAAGGGGTGATGAAGCTAAGAAGAGGGTTTGAAATCAAAGAAGG
AGAAAATGTATTAGTGGTAGAAGATGTTGTTACTACAGGAGGTTCTGTAAAAGAGGTTATAAATTTAGTCAATTCTTTAA
AAGGCAATGTTATAGGAGTTGGAAGTATAGTTGATAGAAGCGACGGAAAGGTAAATTTTGAAGTTCCTTTTAAGTCTGTA
GTAAGTTTGTATGTTGAGACATATGAAAAAGAGGAATGTCCTCTTTGCAAAGAAGGCATTCCTCTTGTAAAGCCGGGAAG
CAGGAAATTTTAA

Upstream 100 bases:

>100_bases
GAAGTTATTGAGGGCATAAAACAATATATGGTTTTAAACAATATAGAAGACATAAATGAGATTATAGGTTCTTTAAAGGT
TGATTAAAGGGGATGAGAAA

Downstream 100 bases:

>100_bases
GGTATGAGCATATTTATAACTCTCATTGTTTCTGGTCCTACAATTCCATCCACTTTAAGACCATTGTCTCTTTGAAATCT
CATGACGGCGTTTTTGGTTC

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase

Number of amino acids: Translated: 190; Mature: 190

Protein sequence:

>190_residues
MEKEEVLEIFSKLGVINKGHFLLTSGKHSDTYLQCAKIFQYPKYSEIFSKELALKFKGHEIDVVIGPAIGGIILAYEVAR
QVGAKALFAEREEGVMKLRRGFEIKEGENVLVVEDVVTTGGSVKEVINLVNSLKGNVIGVGSIVDRSDGKVNFEVPFKSV
VSLYVETYEKEECPLCKEGIPLVKPGSRKF

Sequences:

>Translated_190_residues
MEKEEVLEIFSKLGVINKGHFLLTSGKHSDTYLQCAKIFQYPKYSEIFSKELALKFKGHEIDVVIGPAIGGIILAYEVAR
QVGAKALFAEREEGVMKLRRGFEIKEGENVLVVEDVVTTGGSVKEVINLVNSLKGNVIGVGSIVDRSDGKVNFEVPFKSV
VSLYVETYEKEECPLCKEGIPLVKPGSRKF
>Mature_190_residues
MEKEEVLEIFSKLGVINKGHFLLTSGKHSDTYLQCAKIFQYPKYSEIFSKELALKFKGHEIDVVIGPAIGGIILAYEVAR
QVGAKALFAEREEGVMKLRRGFEIKEGENVLVVEDVVTTGGSVKEVINLVNSLKGNVIGVGSIVDRSDGKVNFEVPFKSV
VSLYVETYEKEECPLCKEGIPLVKPGSRKF

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRE_THEP3 (B0KA31)

Other databases:

- EMBL:   CP000924
- RefSeq:   YP_001665330.1
- ProteinModelPortal:   B0KA31
- SMR:   B0KA31
- GeneID:   5875066
- GenomeReviews:   CP000924_GR
- KEGG:   tpd:Teth39_1340
- HOGENOM:   HBG404341
- OMA:   FYLQSAK
- ProtClustDB:   PRK00455
- BioCyc:   TPSE340099:TETH39_1340-MONOMER
- HAMAP:   MF_01208
- InterPro:   IPR023031
- InterPro:   IPR006273
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01367

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.10

Molecular weight: Translated: 20998; Mature: 20998

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: BINDING 118-118 BINDING 146-146

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKEEVLEIFSKLGVINKGHFLLTSGKHSDTYLQCAKIFQYPKYSEIFSKELALKFKGHE
CCHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHEEECCCE
IDVVIGPAIGGIILAYEVARQVGAKALFAEREEGVMKLRRGFEIKEGENVLVVEDVVTTG
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEHHHCC
GSVKEVINLVNSLKGNVIGVGSIVDRSDGKVNFEVPFKSVVSLYVETYEKEECPLCKEGI
CCHHHHHHHHHHHCCCEEEECCEEECCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCCC
PLVKPGSRKF
CCCCCCCCCC
>Mature Secondary Structure
MEKEEVLEIFSKLGVINKGHFLLTSGKHSDTYLQCAKIFQYPKYSEIFSKELALKFKGHE
CCHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHEEECCCE
IDVVIGPAIGGIILAYEVARQVGAKALFAEREEGVMKLRRGFEIKEGENVLVVEDVVTTG
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEHHHCC
GSVKEVINLVNSLKGNVIGVGSIVDRSDGKVNFEVPFKSVVSLYVETYEKEECPLCKEGI
CCHHHHHHHHHHHCCCEEEECCEEECCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCCC
PLVKPGSRKF
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA