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The map label for this gene is pyrD [H]

Identifier: 167040447

GI number: 167040447

Start: 1824471

End: 1825379

Strand: Reverse

Name: pyrD [H]

Synonym: Teth514_1814

Alternate gene names: 167040447

Gene position: 1825379-1824471 (Counterclockwise)

Preceding gene: 167040448

Following gene: 167040446

Centisome position: 74.29

GC content: 35.86

Gene sequence:

>909_bases
TTGAATTTACAAGTTGAAGTTGGGGGACTTAAGTTAAAAAATCCGGTGATGACAGCTTCAGGTACTTTTGGGTTTGGAAG
AGAGTACGGAGAATATATTGATTTAAATCAATTAGGGGCAATAGTTGTAAAAGGACTTACAGTAAAACCTAAAGAAGGTA
ATCCACCTCCACGAGTTTATGAAACTCCTTGTGGAATGCTAAACAGTGTAGGGCTTCAAAATTCGGGTGTAGATGCTTTC
ATTGAGAAAGAGCTGCCCTTTTTAAGAGATTATGATGTTGCTGTAATAGTAAATATTGCAGGAGAAACCATTGAGGAATT
TGCTTACATGGCAAAGAAGCTTGATATAGATGGTGTTGATGGAATTGAAATAAATGTCTCCTGTCCAAATGTAAAAAAAG
GTGGTATGGCTTTTGGAATAAATCCTGAGGATATATTTAATATAACAAAAGAAGTAAAAAAAGTTACACAAAAAACTGTC
ATTGTAAAATTAACTCCAAATGTAGGAGATATTGGAGTTTGTGCTAAAGCAGCAGAAGATGGAGGAGCAGATGCTGTATC
TTTAATTAATACAATTGCAGGAATGGCTATAAATATTGATACAAGAACCCCTGTTTTTAAGAACGTGATTGCGGGTTTGT
CTGGACCTGCTATAAAGCCTATTGCCCTTAGGATGGTGTATGAGGCAGCGAGAGCCGTGAAAATTCCTGTTATAGGTATG
GGCGGTATAAGTTCATTTAAAGATGCATTAGAGTTTATGATTGCGGGGGCGAAGGCAGTGGCAATTGGCACTTGTAATTT
TGTGAATCCCAATTGCACAATTGAAGTTATTGAGGGCATAAAACAATATATGGTTTTAAACAATATAGAAGACATAAATG
AGATTATAGGTTCTTTAAAGGTTGATTAA

Upstream 100 bases:

>100_bases
CTTGTCTTGTATGCGCTTGCAAAGTGAAAAAAGATGGTGGTTTTGCGTACAAAAGAGTGTGCAAAGATGGTCCCGTCTTT
TGGGCAGAGGAGGTGGAGTT

Downstream 100 bases:

>100_bases
AGGGGATGAGAAAATGGAAAAAGAAGAAGTCTTAGAGATTTTTAGCAAGTTAGGAGTAATTAACAAAGGACATTTTTTAT
TGACATCAGGAAAACACAGC

Product: dihydroorotate dehydrogenase 1B

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MNLQVEVGGLKLKNPVMTASGTFGFGREYGEYIDLNQLGAIVVKGLTVKPKEGNPPPRVYETPCGMLNSVGLQNSGVDAF
IEKELPFLRDYDVAVIVNIAGETIEEFAYMAKKLDIDGVDGIEINVSCPNVKKGGMAFGINPEDIFNITKEVKKVTQKTV
IVKLTPNVGDIGVCAKAAEDGGADAVSLINTIAGMAINIDTRTPVFKNVIAGLSGPAIKPIALRMVYEAARAVKIPVIGM
GGISSFKDALEFMIAGAKAVAIGTCNFVNPNCTIEVIEGIKQYMVLNNIEDINEIIGSLKVD

Sequences:

>Translated_302_residues
MNLQVEVGGLKLKNPVMTASGTFGFGREYGEYIDLNQLGAIVVKGLTVKPKEGNPPPRVYETPCGMLNSVGLQNSGVDAF
IEKELPFLRDYDVAVIVNIAGETIEEFAYMAKKLDIDGVDGIEINVSCPNVKKGGMAFGINPEDIFNITKEVKKVTQKTV
IVKLTPNVGDIGVCAKAAEDGGADAVSLINTIAGMAINIDTRTPVFKNVIAGLSGPAIKPIALRMVYEAARAVKIPVIGM
GGISSFKDALEFMIAGAKAVAIGTCNFVNPNCTIEVIEGIKQYMVLNNIEDINEIIGSLKVD
>Mature_302_residues
MNLQVEVGGLKLKNPVMTASGTFGFGREYGEYIDLNQLGAIVVKGLTVKPKEGNPPPRVYETPCGMLNSVGLQNSGVDAF
IEKELPFLRDYDVAVIVNIAGETIEEFAYMAKKLDIDGVDGIEINVSCPNVKKGGMAFGINPEDIFNITKEVKKVTQKTV
IVKLTPNVGDIGVCAKAAEDGGADAVSLINTIAGMAINIDTRTPVFKNVIAGLSGPAIKPIALRMVYEAARAVKIPVIGM
GGISSFKDALEFMIAGAKAVAIGTCNFVNPNCTIEVIEGIKQYMVLNNIEDINEIIGSLKVD

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=332, Percent_Identity=30.7228915662651, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI45006951, Length=323, Percent_Identity=25.077399380805, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI87082059, Length=234, Percent_Identity=32.0512820512821, Blast_Score=110, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI71984108, Length=331, Percent_Identity=25.6797583081571, Blast_Score=89, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6322633, Length=268, Percent_Identity=33.955223880597, Blast_Score=114, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24640763, Length=184, Percent_Identity=37.5, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI18858217, Length=184, Percent_Identity=37.5, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.3.1 [H]

Molecular weight: Translated: 32111; Mature: 32111

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLQVEVGGLKLKNPVMTASGTFGFGREYGEYIDLNQLGAIVVKGLTVKPKEGNPPPRVY
CCEEEEECCEEECCCEEECCCCCCCCHHHCCEECHHHHHHHEEECEEECCCCCCCCCCEE
ETPCGMLNSVGLQNSGVDAFIEKELPFLRDYDVAVIVNIAGETIEEFAYMAKKLDIDGVD
ECCCCHHHHCCCCCCCCCHHHHHCCCCCCCCCEEEEEEECHHHHHHHHHHHHHCCCCCCC
GIEINVSCPNVKKGGMAFGINPEDIFNITKEVKKVTQKTVIVKLTPNVGDIGVCAKAAED
CEEEEEECCCCCCCCEEECCCHHHHHHHHHHHHHHHHCEEEEEECCCCCCHHHHEECCCC
GGADAVSLINTIAGMAINIDTRTPVFKNVIAGLSGPAIKPIALRMVYEAARAVKIPVIGM
CCHHHHHHHHHHCCEEEEECCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHEEEEEEEEC
GGISSFKDALEFMIAGAKAVAIGTCNFVNPNCTIEVIEGIKQYMVLNNIEDINEIIGSLK
CCHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCC
VD
CC
>Mature Secondary Structure
MNLQVEVGGLKLKNPVMTASGTFGFGREYGEYIDLNQLGAIVVKGLTVKPKEGNPPPRVY
CCEEEEECCEEECCCEEECCCCCCCCHHHCCEECHHHHHHHEEECEEECCCCCCCCCCEE
ETPCGMLNSVGLQNSGVDAFIEKELPFLRDYDVAVIVNIAGETIEEFAYMAKKLDIDGVD
ECCCCHHHHCCCCCCCCCHHHHHCCCCCCCCCEEEEEEECHHHHHHHHHHHHHCCCCCCC
GIEINVSCPNVKKGGMAFGINPEDIFNITKEVKKVTQKTVIVKLTPNVGDIGVCAKAAED
CEEEEEECCCCCCCCEEECCCHHHHHHHHHHHHHHHHCEEEEEECCCCCCHHHHEECCCC
GGADAVSLINTIAGMAINIDTRTPVFKNVIAGLSGPAIKPIALRMVYEAARAVKIPVIGM
CCHHHHHHHHHHCCEEEEECCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHEEEEEEEEC
GGISSFKDALEFMIAGAKAVAIGTCNFVNPNCTIEVIEGIKQYMVLNNIEDINEIIGSLK
CCHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCC
VD
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA