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The map label for this gene is fmt [H]

Identifier: 167040392

GI number: 167040392

Start: 1758596

End: 1759528

Strand: Reverse

Name: fmt [H]

Synonym: Teth514_1755

Alternate gene names: 167040392

Gene position: 1759528-1758596 (Counterclockwise)

Preceding gene: 167040394

Following gene: 167040391

Centisome position: 71.61

GC content: 36.66

Gene sequence:

>933_bases
TTGTTGAAAATTGTCTTTATGGGGACGCCTGAATTTGCCGTCCCCTCTTTGCAAAAGCTTTTTGAAGAAGGATATGATGT
AGCTGCAGTGGTTACGCAGCCAGATAAACAGAAAGGAAGAGGAATGAAATTTAGCTTTTCTCCTGTCAAAGAAGTGGCAT
TGCAAAAAGGAGTAGAAATTTTACAGCCGGAGAAAATAAAAAACAACCCAGAGTTTTTAAACAGATTAGAAGAGATAAAT
CCTGACGCCATAGTTGTTGTAGCCTATGGAAAGATTTTACCTGAAGAGATTTTGACTCTTCCTAAATATGGTTGTATCAA
TGTCCACGCTTCTCTTTTGCCAAAATATAGAGGAGCCGCTCCAATTAATTGGGCTATAATCAATGGTGAAAAAGAAACGG
GTATTACTACAATGCTTATGGACAAGGGATTGGATACAGGAGATATGCTTATCAAAAAATCTATTCCTATTTTAGAGGAA
GATGATGCGGAAACACTTCATGATAAGCTTTCTCGATTAGGAGCAGAAGTTTTGATAGAAACGTTAAAAGGGTTAGAAAA
AGGCAGTTTGACTCCCGTGAAACAGCGGGAAGAGGAGGCTTCTTATTCACCAATACTTACTAAAGAAATGGGACATATAG
ATTGGAACAAAACGGCAGAAGAAATCCGAAATTTGATAAGGGGAATGAAACCTTGGCCTGGTTGTTACACGTTTTATGGA
GATAAAATGTTAAAAATTTGGAAAGGCGAGATAGTTGAATACAATGGGAATGAAGAAAATGGAACAGTTTTAAAGTCAAA
AGGCGACTTAATTGTGAAATGCGATAAAGACGCCCTAAAGATAGTAGAAATTCAACAAGAAGGTTCTAAAAAAATGGGTA
TTAGGGAATATTTAATAGGTCACAATATACCTGAAGGGACAATCTTTAGATAA

Upstream 100 bases:

>100_bases
AGAATATTAAAGATTTCCAGTTATAAATGCACTTTATTAAATTTTTAAGAAGTGAGACAAATTTATTGTCTTTAAAATTA
ATTATACGAGGAGGTATGAC

Downstream 100 bases:

>100_bases
TTTAAAAAGGAGAATTACTTTTGAAGGGGAAAAAAAGAATTTTTTTGGGGATATTGGCAGTTACCTTTTTGGTTTTTACT
TTAGTTGTTTTGGGAATTTT

Product: methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MLKIVFMGTPEFAVPSLQKLFEEGYDVAAVVTQPDKQKGRGMKFSFSPVKEVALQKGVEILQPEKIKNNPEFLNRLEEIN
PDAIVVVAYGKILPEEILTLPKYGCINVHASLLPKYRGAAPINWAIINGEKETGITTMLMDKGLDTGDMLIKKSIPILEE
DDAETLHDKLSRLGAEVLIETLKGLEKGSLTPVKQREEEASYSPILTKEMGHIDWNKTAEEIRNLIRGMKPWPGCYTFYG
DKMLKIWKGEIVEYNGNEENGTVLKSKGDLIVKCDKDALKIVEIQQEGSKKMGIREYLIGHNIPEGTIFR

Sequences:

>Translated_310_residues
MLKIVFMGTPEFAVPSLQKLFEEGYDVAAVVTQPDKQKGRGMKFSFSPVKEVALQKGVEILQPEKIKNNPEFLNRLEEIN
PDAIVVVAYGKILPEEILTLPKYGCINVHASLLPKYRGAAPINWAIINGEKETGITTMLMDKGLDTGDMLIKKSIPILEE
DDAETLHDKLSRLGAEVLIETLKGLEKGSLTPVKQREEEASYSPILTKEMGHIDWNKTAEEIRNLIRGMKPWPGCYTFYG
DKMLKIWKGEIVEYNGNEENGTVLKSKGDLIVKCDKDALKIVEIQQEGSKKMGIREYLIGHNIPEGTIFR
>Mature_310_residues
MLKIVFMGTPEFAVPSLQKLFEEGYDVAAVVTQPDKQKGRGMKFSFSPVKEVALQKGVEILQPEKIKNNPEFLNRLEEIN
PDAIVVVAYGKILPEEILTLPKYGCINVHASLLPKYRGAAPINWAIINGEKETGITTMLMDKGLDTGDMLIKKSIPILEE
DDAETLHDKLSRLGAEVLIETLKGLEKGSLTPVKQREEEASYSPILTKEMGHIDWNKTAEEIRNLIRGMKPWPGCYTFYG
DKMLKIWKGEIVEYNGNEENGTVLKSKGDLIVKCDKDALKIVEIQQEGSKKMGIREYLIGHNIPEGTIFR

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family [H]

Homologues:

Organism=Homo sapiens, GI21614513, Length=315, Percent_Identity=28.8888888888889, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI238814322, Length=312, Percent_Identity=29.4871794871795, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI164663775, Length=236, Percent_Identity=31.3559322033898, Blast_Score=104, Evalue=9e-23,
Organism=Escherichia coli, GI1789683, Length=298, Percent_Identity=42.6174496644295, Blast_Score=244, Evalue=6e-66,
Organism=Escherichia coli, GI1788589, Length=285, Percent_Identity=31.9298245614035, Blast_Score=180, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI133930964, Length=265, Percent_Identity=31.3207547169811, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI45550868, Length=302, Percent_Identity=31.4569536423841, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI28571984, Length=222, Percent_Identity=31.981981981982, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24585660, Length=282, Percent_Identity=24.822695035461, Blast_Score=91, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24582400, Length=131, Percent_Identity=27.4809160305344, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR001555
- InterPro:   IPR015518 [H]

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N [H]

EC number: =2.1.2.9 [H]

Molecular weight: Translated: 34788; Mature: 34788

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: PS00373 GART

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKIVFMGTPEFAVPSLQKLFEEGYDVAAVVTQPDKQKGRGMKFSFSPVKEVALQKGVEI
CEEEEEECCCCCCHHHHHHHHHCCCCEEEEEECCCHHHCCCCEEECCHHHHHHHHCCCHH
LQPEKIKNNPEFLNRLEEINPDAIVVVAYGKILPEEILTLPKYGCINVHASLLPKYRGAA
CCCHHCCCCHHHHHHHHHCCCCEEEEEEECHHCHHHHHHCCCCCEEEEHHHHCCHHCCCC
PINWAIINGEKETGITTMLMDKGLDTGDMLIKKSIPILEEDDAETLHDKLSRLGAEVLIE
CEEEEEECCCCCCCCEEEHHHCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
TLKGLEKGSLTPVKQREEEASYSPILTKEMGHIDWNKTAEEIRNLIRGMKPWPGCYTFYG
HHHCCCCCCCCCHHHHHHHCCCCCCHHHHCCCCCCCHHHHHHHHHHHCCCCCCCEEEHHC
DKMLKIWKGEIVEYNGNEENGTVLKSKGDLIVKCDKDALKIVEIQQEGSKKMGIREYLIG
CCEEEEECCEEEEECCCCCCCEEEECCCCEEEEECCCCEEEEEEHHCCCCCCCHHHHHHC
HNIPEGTIFR
CCCCCCCCCC
>Mature Secondary Structure
MLKIVFMGTPEFAVPSLQKLFEEGYDVAAVVTQPDKQKGRGMKFSFSPVKEVALQKGVEI
CEEEEEECCCCCCHHHHHHHHHCCCCEEEEEECCCHHHCCCCEEECCHHHHHHHHCCCHH
LQPEKIKNNPEFLNRLEEINPDAIVVVAYGKILPEEILTLPKYGCINVHASLLPKYRGAA
CCCHHCCCCHHHHHHHHHCCCCEEEEEEECHHCHHHHHHCCCCCEEEEHHHHCCHHCCCC
PINWAIINGEKETGITTMLMDKGLDTGDMLIKKSIPILEEDDAETLHDKLSRLGAEVLIE
CEEEEEECCCCCCCCEEEHHHCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
TLKGLEKGSLTPVKQREEEASYSPILTKEMGHIDWNKTAEEIRNLIRGMKPWPGCYTFYG
HHHCCCCCCCCCHHHHHHHCCCCCCHHHHCCCCCCCHHHHHHHHHHHCCCCCCCEEEHHC
DKMLKIWKGEIVEYNGNEENGTVLKSKGDLIVKCDKDALKIVEIQQEGSKKMGIREYLIG
CCEEEEECCEEEEECCCCCCCEEEECCCCEEEEECCCCEEEEEEHHCCCCCCCHHHHHHC
HNIPEGTIFR
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]