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The map label for this gene is proC [H]

Identifier: 167040252

GI number: 167040252

Start: 1632581

End: 1633375

Strand: Direct

Name: proC [H]

Synonym: Teth514_1615

Alternate gene names: 167040252

Gene position: 1632581-1633375 (Clockwise)

Preceding gene: 167040251

Following gene: 167040253

Centisome position: 66.44

GC content: 35.72

Gene sequence:

>795_bases
ATGAAGATTGGTTTCATAGGTGTTGGCAATATGGGCCTTGCCCTTATAAAGGGCATATTAAAAGCGGATTTTATAGAGGC
AGAAGATCTAATTCTTTACGATCCAGTGAAAGAAAAAACAGCGGGATTAGAGAAAGAATTTGGAGTTGCTATTGCAAAAG
ACAATATTGATTTAACTGAAAAGTCGGACATTATCATCTTAGCAGTAAAACCTAACATCTACGACGTTGTTTTGGAGGAA
ATAAGAGCAAAAGTAACTGATAAAAAGATAATAATCATTATAGCTCCAGGTATAACTATAAGCCATGTCAAAGATATTTT
AAAAGCAGGAAAAATAGTGAGAACAATACCTAATACTCCTGCTTTAATAGGAGAAGGTGTTACTGCTATAAGTTACTCAC
AAGAGATACAACAAGAGGATAAAGAAATTGTGGAGAAGATTTTTAAAACCTGTGGGGAAATTGTAGAAGTAGAAGAAAAG
TTAATTGATGCTGCAATGGCTGTCTCTAGTTGTAGTCCAGCATTTGTGTACATGTTTATTGAAGCATTGGCAGATGGTGG
TGTACTATTGGGATTACCAAGAGATGTTGCGTATAAATTAGCTTCAAAGGCTGTAGCTGGTGCAGGTAACATGGTATTAA
AAACAGGTTTTCATCCTGGCCAATTAAAAGACATGGTAACATCTCCAGGTGGTACAACTATTGAAGGTATAAGGATTTTG
GAAAAAAATGCAATGAGAAGTGCAGTGATTGAAGCAGTGGCTGCAGCATATCAAAAAACAAAGGGATTGAAGTAA

Upstream 100 bases:

>100_bases
GATAAAGATGAGAAGAGAGAAGAGTGAAAAAAACAAAAAAACAGTATTAGGGCAACTAATACTGTTTTTTTGAAATAATA
AAGTAAGGGAGTTTGCCAAA

Downstream 100 bases:

>100_bases
AAATGTCAAATAATATCGATGTTGTTGAAATATACACAGATGGAGCTTGTAGTGGTAATCCTGGTCCAGGTGGCTGGGCA
GCAGTTTTACTGTACAAAGG

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MKIGFIGVGNMGLALIKGILKADFIEAEDLILYDPVKEKTAGLEKEFGVAIAKDNIDLTEKSDIIILAVKPNIYDVVLEE
IRAKVTDKKIIIIIAPGITISHVKDILKAGKIVRTIPNTPALIGEGVTAISYSQEIQQEDKEIVEKIFKTCGEIVEVEEK
LIDAAMAVSSCSPAFVYMFIEALADGGVLLGLPRDVAYKLASKAVAGAGNMVLKTGFHPGQLKDMVTSPGGTTIEGIRIL
EKNAMRSAVIEAVAAAYQKTKGLK

Sequences:

>Translated_264_residues
MKIGFIGVGNMGLALIKGILKADFIEAEDLILYDPVKEKTAGLEKEFGVAIAKDNIDLTEKSDIIILAVKPNIYDVVLEE
IRAKVTDKKIIIIIAPGITISHVKDILKAGKIVRTIPNTPALIGEGVTAISYSQEIQQEDKEIVEKIFKTCGEIVEVEEK
LIDAAMAVSSCSPAFVYMFIEALADGGVLLGLPRDVAYKLASKAVAGAGNMVLKTGFHPGQLKDMVTSPGGTTIEGIRIL
EKNAMRSAVIEAVAAAYQKTKGLK
>Mature_264_residues
MKIGFIGVGNMGLALIKGILKADFIEAEDLILYDPVKEKTAGLEKEFGVAIAKDNIDLTEKSDIIILAVKPNIYDVVLEE
IRAKVTDKKIIIIIAPGITISHVKDILKAGKIVRTIPNTPALIGEGVTAISYSQEIQQEDKEIVEKIFKTCGEIVEVEEK
LIDAAMAVSSCSPAFVYMFIEALADGGVLLGLPRDVAYKLASKAVAGAGNMVLKTGFHPGQLKDMVTSPGGTTIEGIRIL
EKNAMRSAVIEAVAAAYQKTKGLK

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI24797095, Length=269, Percent_Identity=38.2899628252788, Blast_Score=199, Evalue=3e-51,
Organism=Homo sapiens, GI24797097, Length=269, Percent_Identity=38.2899628252788, Blast_Score=198, Evalue=3e-51,
Organism=Homo sapiens, GI21361454, Length=269, Percent_Identity=38.6617100371747, Blast_Score=193, Evalue=1e-49,
Organism=Homo sapiens, GI198041662, Length=264, Percent_Identity=30.3030303030303, Blast_Score=170, Evalue=1e-42,
Organism=Escherichia coli, GI1786585, Length=264, Percent_Identity=43.1818181818182, Blast_Score=219, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI17569021, Length=263, Percent_Identity=38.7832699619772, Blast_Score=194, Evalue=6e-50,
Organism=Caenorhabditis elegans, GI17540664, Length=273, Percent_Identity=37.7289377289377, Blast_Score=151, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6320861, Length=273, Percent_Identity=30.7692307692308, Blast_Score=130, Evalue=2e-31,
Organism=Drosophila melanogaster, GI21358587, Length=262, Percent_Identity=38.1679389312977, Blast_Score=186, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24648116, Length=269, Percent_Identity=34.5724907063197, Blast_Score=167, Evalue=5e-42,
Organism=Drosophila melanogaster, GI24647700, Length=166, Percent_Identity=41.566265060241, Blast_Score=140, Evalue=8e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 28267; Mature: 28267

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIGFIGVGNMGLALIKGILKADFIEAEDLILYDPVKEKTAGLEKEFGVAIAKDNIDLTE
CEEEEEEECCHHHHHHHHHHHHHCCCCCCEEEECCCHHHHCCCCHHHCEEEEECCCCCCC
KSDIIILAVKPNIYDVVLEEIRAKVTDKKIIIIIAPGITISHVKDILKAGKIVRTIPNTP
CCCEEEEEECCCHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHCCEEEECCCCC
ALIGEGVTAISYSQEIQQEDKEIVEKIFKTCGEIVEVEEKLIDAAMAVSSCSPAFVYMFI
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
EALADGGVLLGLPRDVAYKLASKAVAGAGNMVLKTGFHPGQLKDMVTSPGGTTIEGIRIL
HHHHCCCEEEECCHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHCCCCCCCHHHHHHH
EKNAMRSAVIEAVAAAYQKTKGLK
HHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKIGFIGVGNMGLALIKGILKADFIEAEDLILYDPVKEKTAGLEKEFGVAIAKDNIDLTE
CEEEEEEECCHHHHHHHHHHHHHCCCCCCEEEECCCHHHHCCCCHHHCEEEEECCCCCCC
KSDIIILAVKPNIYDVVLEEIRAKVTDKKIIIIIAPGITISHVKDILKAGKIVRTIPNTP
CCCEEEEEECCCHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHCCEEEECCCCC
ALIGEGVTAISYSQEIQQEDKEIVEKIFKTCGEIVEVEEKLIDAAMAVSSCSPAFVYMFI
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
EALADGGVLLGLPRDVAYKLASKAVAGAGNMVLKTGFHPGQLKDMVTSPGGTTIEGIRIL
HHHHCCCEEEECCHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHCCCCCCCHHHHHHH
EKNAMRSAVIEAVAAAYQKTKGLK
HHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6296787; 9278503 [H]